Active form of vitamin D. Two forms of vitamin D Vitamin D2 – ergocalciferol Vitamin D3 -...

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Active form of vitamin D

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Transcript of Active form of vitamin D. Two forms of vitamin D Vitamin D2 – ergocalciferol Vitamin D3 -...

Page 1: Active form of vitamin D. Two forms of vitamin D Vitamin D2 – ergocalciferol Vitamin D3 - cholecalciferol ergocalciferol cholecalciferol.

Active form of vitamin D

Page 2: Active form of vitamin D. Two forms of vitamin D Vitamin D2 – ergocalciferol Vitamin D3 - cholecalciferol ergocalciferol cholecalciferol.

Two forms of vitamin D

•Vitamin D2 – ergocalciferol•Vitamin D3 - cholecalciferol

ergocalciferol

cholecalciferol

Page 3: Active form of vitamin D. Two forms of vitamin D Vitamin D2 – ergocalciferol Vitamin D3 - cholecalciferol ergocalciferol cholecalciferol.

1,25-dihydroxycholecalciferol

Both ergo-calciferol and cholecalciferol are metabo-lized in liver

Page 4: Active form of vitamin D. Two forms of vitamin D Vitamin D2 – ergocalciferol Vitamin D3 - cholecalciferol ergocalciferol cholecalciferol.

Vit.D acts in concert with parathyroid hormone (PTH)

PTH stimulates the production of 1,25-(OH)2D

Page 5: Active form of vitamin D. Two forms of vitamin D Vitamin D2 – ergocalciferol Vitamin D3 - cholecalciferol ergocalciferol cholecalciferol.

Functions of vitamin D

regulates the Ca and P levels in the

blood•promotes absorption of Ca and P in the intestine•promotes reabsorption of Ca in the kidneys•high levels of serum Ca and P increase the rate of bone mineralization •promote bone resorption (at low Ca in blood)

Page 6: Active form of vitamin D. Two forms of vitamin D Vitamin D2 – ergocalciferol Vitamin D3 - cholecalciferol ergocalciferol cholecalciferol.

•promotes phagocytosis

•immunomodu-latory activity

•induces differentiation of immune cells

Functions of vitamin Daffects immune system

Page 7: Active form of vitamin D. Two forms of vitamin D Vitamin D2 – ergocalciferol Vitamin D3 - cholecalciferol ergocalciferol cholecalciferol.

Functions of vitamin Dprevents tumorgenesis

•inhibits proliferation

•inhibits angiogenesis

•induces differentiation

Page 8: Active form of vitamin D. Two forms of vitamin D Vitamin D2 – ergocalciferol Vitamin D3 - cholecalciferol ergocalciferol cholecalciferol.

Functions of vitamin D

•Activates reabsorption of amino acids, especially prolin

•Activates the monosaccharides phosphorylation (glycogen synthesis)

•Promotes ATP formation

Page 9: Active form of vitamin D. Two forms of vitamin D Vitamin D2 – ergocalciferol Vitamin D3 - cholecalciferol ergocalciferol cholecalciferol.

Ricketssoftening of bones in children

potentially leading to fractures and deformity

Causes: •vitamin D deficiency•lack of calcium in the diet (famine)•severe diarrhea and vomiting •fat malabsorption •alcoholism•severe liver and kidney diseases

Page 10: Active form of vitamin D. Two forms of vitamin D Vitamin D2 – ergocalciferol Vitamin D3 - cholecalciferol ergocalciferol cholecalciferol.

Signs and symptoms of rickets •Bone pain or tenderness •Dental problems •Muscle weakness •Fractures (easily broken bones)•Skeletal deformity •Bowed legs (genu varum) •Knock-knees (genu valgum) or "windswept knees" •Cranial, spinal, and pelvic deformities

•Hypocalcemia•Tetany (uncontrolled muscle spasms)•Craniotabes (soft skull) •Widening of wrist (due to metaphysial cartilage hyperplasia)

http://en.wikipedia.org/wiki/Tooth
http://en.wikipedia.org/wiki/Muscle
http://en.wikipedia.org/wiki/Fracture
http://en.wikipedia.org/wiki/Genu_varum
http://en.wikipedia.org/wiki/Genu_varum
http://en.wikipedia.org/wiki/Genu_varum
http://en.wikipedia.org/wiki/Genu_valgum
http://en.wikipedia.org/wiki/Genu_valgum
http://en.wikipedia.org/wiki/Genu_valgum
http://en.wikipedia.org/wiki/Hypocalcemia
http://en.wikipedia.org/wiki/Tetany_(medical_sign)
http://en.wikipedia.org/wiki/Craniotabes
Page 11: Active form of vitamin D. Two forms of vitamin D Vitamin D2 – ergocalciferol Vitamin D3 - cholecalciferol ergocalciferol cholecalciferol.

Knock knee

deformity (genu

valgum)

Windswept deformity

Page 12: Active form of vitamin D. Two forms of vitamin D Vitamin D2 – ergocalciferol Vitamin D3 - cholecalciferol ergocalciferol cholecalciferol.

Bowing of long bones in legs

Bowleg deformity (genu varum)

Page 13: Active form of vitamin D. Two forms of vitamin D Vitamin D2 – ergocalciferol Vitamin D3 - cholecalciferol ergocalciferol cholecalciferol.

Frontal bossing

Tibial bowing

Wrist enlargement

Ankle enlargemen

t

Page 14: Active form of vitamin D. Two forms of vitamin D Vitamin D2 – ergocalciferol Vitamin D3 - cholecalciferol ergocalciferol cholecalciferol.

Rib beading (rachitic rosary)

Pot belly

Page 15: Active form of vitamin D. Two forms of vitamin D Vitamin D2 – ergocalciferol Vitamin D3 - cholecalciferol ergocalciferol cholecalciferol.

Chest deformity

Scoliosis

Page 16: Active form of vitamin D. Two forms of vitamin D Vitamin D2 – ergocalciferol Vitamin D3 - cholecalciferol ergocalciferol cholecalciferol.

Family of children with rickets

Page 17: Active form of vitamin D. Two forms of vitamin D Vitamin D2 – ergocalciferol Vitamin D3 - cholecalciferol ergocalciferol cholecalciferol.

Rickets in Bangladesh

Page 18: Active form of vitamin D. Two forms of vitamin D Vitamin D2 – ergocalciferol Vitamin D3 - cholecalciferol ergocalciferol cholecalciferol.

Dietary sourses

Daily requirement: 12-25 micrograms

Page 19: Active form of vitamin D. Two forms of vitamin D Vitamin D2 – ergocalciferol Vitamin D3 - cholecalciferol ergocalciferol cholecalciferol.

Hypervitaminosis

•Increase of Ca and P in blood•Demineralization of bones

•Calcification of inner organs•Renal stones


High potency, naturally-emulsified liquid vitamin D3€¦ · Prolonged and severe vitamin D deficiency leads to rickets in children and osteomalacia in adults. Vitamin D2 (ergocalciferol)

High potency, naturally-emulsified liquid vitamin D3€¦ · Prolonged and severe vitamin D deficiency leads to rickets in children and osteomalacia in adults. Vitamin D2 (ergocalciferol)

ZINZINO - Microsoft · Zinzino BalanceOil is a synergistic blend of high-grade fish oil, rich in the omega-3 fatty acids EPA and DHA4, ... flavor, vitamin D3 (cholecalciferol). THE

ZINZINO - Microsoft · Zinzino BalanceOil is a synergistic blend of high-grade fish oil, rich in the omega-3 fatty acids EPA and DHA4, ... flavor, vitamin D3 (cholecalciferol). THE

Breakdown of cyanide and cholecalciferol in Feratox and ... · cholecalciferol in Feratox and ... Wellington 6143, ... The form of cyanide is largely dictated by the solution’s

Breakdown of cyanide and cholecalciferol in Feratox and ... · cholecalciferol in Feratox and ... Wellington 6143, ... The form of cyanide is largely dictated by the solution’s

Effects of Ivermectin-azithromycin-cholecalciferol ... · Study design This was a proof-of-concept study for the evaluation of clinical efficacy of Ivermectin, Azithromycin and Cholecalciferol

Effects of Ivermectin-azithromycin-cholecalciferol ... · Study design This was a proof-of-concept study for the evaluation of clinical efficacy of Ivermectin, Azithromycin and Cholecalciferol

Summary guideline January 2011 Vitamin D guidance · 2020-03-09 · 2 Structure and mechanism In this guidance the term vitamin D refers to cholecalciferol (D 3) and ergocalciferol

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250mg - BENEMAX...Vitamin D2 (Ergocalciferol) is the plant-derived form of Vitamin D, and is used by the body for the development and maintenance of healthy bones and teeth. Vitamin

250mg - BENEMAX...Vitamin D2 (Ergocalciferol) is the plant-derived form of Vitamin D, and is used by the body for the development and maintenance of healthy bones and teeth. Vitamin

THE CLINICAL IMPORTANCE OF VITAMIN D (CHOLECALCIFEROL)

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Breakdown of cyanide and cholecalciferol in Feratox and Feracol ...

Breakdown of cyanide and cholecalciferol in Feratox and Feracol ...

Manufacturers of Vitamin D3 | Cholecalciferol | Enzymes

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Paediatric Endocrine Cases North/Sat_Room12_1630_Wiltshire...Vitamin D Preparations • Vitadol-C (400 IU Vit D/10 drops, +Vits A/C) •“Pentavite” = Cholecalciferol 200 units/5ml

Paediatric Endocrine Cases North/Sat_Room12_1630_Wiltshire...Vitamin D Preparations • Vitadol-C (400 IU Vit D/10 drops, +Vits A/C) •“Pentavite” = Cholecalciferol 200 units/5ml

WALKIN’ ON SUNSHINE…AND Discuss the metabolism of …...ROLE OF VITAMIN D Ergocalciferol (Vitamin D 2) Absorption of calcium & phosphorus Cholecalciferol (Vitamin D 3) Helps body

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R MA ME N D AD O F E R E H W - CPhI Online... VITAMIN DRY BLENDS Vitamin D 2 - Powder (Ergocalciferol) Product Name Packaging Main Application Vitamin D 2 100 CWS 100,000 IU Vitamin

R MA ME N D AD O F E R E H W - CPhI Online... VITAMIN DRY BLENDS Vitamin D 2 - Powder (Ergocalciferol) Product Name Packaging Main Application Vitamin D 2 100 CWS 100,000 IU Vitamin

Rickets. Vitamin D Vitamin D is a group of fat-soluble prohormones the two major forms of which are vitamin D2( ergocalciferol( and vitamin D3( cholecalciferol).

Rickets. Vitamin D Vitamin D is a group of fat-soluble prohormones the two major forms of which are vitamin D2( ergocalciferol( and vitamin D3( cholecalciferol).

Vitamin D3V - ProTec Nutra D3V Presentation... · 2019. 4. 25. · •Vitamin D3V is Cholecalciferol of 100% plant origin, produced from Algae. Vitamin D3V is available in a selection

Vitamin D3V - ProTec Nutra D3V Presentation... · 2019. 4. 25. · •Vitamin D3V is Cholecalciferol of 100% plant origin, produced from Algae. Vitamin D3V is available in a selection

Kocovska, E., Fernell, E., Billstedt, E., Minnis, H., and ...eprints.gla.ac.uk/88618/1/88618.pdf · 25-hydroxy-cholecaciferol (vitamin D2), and calcitriol for 1,25-dihydroxy-cholecalciferol

Kocovska, E., Fernell, E., Billstedt, E., Minnis, H., and ...eprints.gla.ac.uk/88618/1/88618.pdf · 25-hydroxy-cholecaciferol (vitamin D2), and calcitriol for 1,25-dihydroxy-cholecalciferol

•Dietary Supplement - World Health Organization · •Dietary Supplement: cholecalciferol (vitamin D) 14000 IU vitamin D3 weekly Experimental group will receive vitamin D supplement

•Dietary Supplement - World Health Organization · •Dietary Supplement: cholecalciferol (vitamin D) 14000 IU vitamin D3 weekly Experimental group will receive vitamin D supplement

2019/05 VITAMIN D - lipomed.com · Synonym : Cholecalciferol Vitamin D3 (shipment under ice for solution) otes 4 ec or wesite for more information. otes 5 ec or wesite for more information.

2019/05 VITAMIN D - lipomed.com · Synonym : Cholecalciferol Vitamin D3 (shipment under ice for solution) otes 4 ec or wesite for more information. otes 5 ec or wesite for more information.

PROTOCOL: ALL-IN-ONE PRINCIPLE ASSAY PROTOCOL - DIAsource Vitamin …€¦ · Vitamin D3 (cholecalciferol) and Vitamin D2 (ergocalciferol), which are structurally very similar. Vitamin

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Public Assessment Report - GOV.UK · Cholecalciferol Effervescent Tablets are only intended for use in assessed patients for whom the amount of calcium and vitamin D 3 included is

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REFERENCE SHEET: Vitamin D - Fullscript · REFERENCE SHEET: Vitamin D Pronunciation Vitamin D3 (cholecalciferol, koh-luh-kal-sif-uh-rawl) Vitamin D2 (ergocalciferol, er-go-kal-sif-uh-rol)

REFERENCE SHEET: Vitamin D - Fullscript · REFERENCE SHEET: Vitamin D Pronunciation Vitamin D3 (cholecalciferol, koh-luh-kal-sif-uh-rawl) Vitamin D2 (ergocalciferol, er-go-kal-sif-uh-rol)