KORISNIK I OTVORENI PRISTUP

Vera Zdravković 

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Otvoreni pristup je posebno neophodan u zemlji kao Srbija

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Medicina 314 Pedijatrija 43 Clinical Pediatric endocrinolgy (Japan) International Journal of Pediatric endocrinology 

(US) International Journal of Pediatrics (US)

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U toku dežurstva dobijate poziv za konsultaciju Mlado muško odojče primljeno zbog izmenjenog 

stanje svesti Laboratorijske analize: nizak Na i visok K Treba da isključite adrenalnu insuficijenciju Ne postoje svi elementi kliničke slike Konsultujete Pubmed

International Journal of Pediatric EndocrinologyVolume 2009 (2009), Article ID 195728, 4 pagesdoi:10.1155/2009/195728Case Report

Transient Pseudohypoaldosteronism due to Urinary Tract Infection in Infancy: A Report of 4 CasesRadha Nandagopal,1 Priya Vaidyanathan,2 and Paul Kaplowitz2

1Inter-Institute Pediatric Endocrinology Training Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA2Department of Endocrinology, Children's National Medical Center, Washington, DC 20010, USA

Received 5 December 2008; Revised 10 March 2009; Accepted 23 April 2009

Academic Editor: Christa Flueck

Copyright © 2009 Radha Nandagopal et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

AbstractHyponatremia with hyperkalemia in infancy is an uncommon but life-threatening occurrence. In the first weeks of life, this scenario is often associated with aldosterone deficiency due to salt-wasting congenital adrenal hyperplasia. However, alternative diagnoses involving inadequate mineralocorticoid secretion or action must be considered, particularly for infants one month of age or older. We report four infants who presented with profound hyponatremia accompanied by urinary tract infection, ultimately leading to the diagnosis of transient pseudohypoaldosteronism. Our cases provide support for the idea that the renal tubular resistance to aldosterone is due to urinary tract infection itself rather than to underlying urinary tract anomalies typically found in these infants. Awareness of this condition is important so that serum aldosterone, urine sodium, and urine cultures may be obtained immediately in any infant presenting with hyponatremia and hyperkalemia in whom a diagnosis of congenital adrenal hyperplasia was not found. Adequate replacement with intravenous saline and antibiotic therapy is sufficient to correct sodium levels over 24–48 hours.

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Neželjena dejstva leka

Inicijalno lečenje hipertireoize - lekovi

Propiltiouracil i metimazolski preparati

Poslednjih godina je prijavljeno 14 slučajeva insuficijencije jetre kod dece usled primene PTU

U registru pacijenata kojima je iz ovog razloga transplantirana jetra postoji 8 dece

ZAKLJUČAK WORKSHOPA ODRŽANOG 2008

Considering the above, we believe that PTU should never be used as first line treatment in children. PTU use should only be considered in rare circumstances, such as preparation for surgery in a patient allergic to MMI or in pregnancy.

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Kako alarmirati javnost

S. Rivkees koji ima 140 radova na Pubmedu, u časopisima koji imaju IF i 50 se odlučuje za OA časopis

International Journal of Pediatric EndocrinologyVolume 2009 (2009), Article ID 132041, 8 pagesdoi:10.1155/2009/132041

Commentary

Propylthiouracil (PTU) Hepatoxicity in Children and Recommendations for Discontinuation of Use

Scott A. Rivkees1 and Donald R. Mattison2

1Yale Pediatric Thyroid Center, Yale University School of Medicine, New Haven, CT 06520, USA2Obstetric and Pediatric Pharmacology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA

Received 5 April 2009; Accepted 7 April 2009

Izveštaj workshop-a koji je održan pod pokroviteljstvom Best Pharmaceuticals for Children Act, oktobra 2008 da bi se procenila bezbednost primene PTU kod dece

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