van Erp, T. G. M., Hibar, D. P., Rasmussen, J. M., Glahn ... · Table S4a Absolute Volume AMC...
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van Erp, T. G. M., Hibar, D. P., Rasmussen, J. M., Glahn, D. C., Pearlson, G. D., Andreassen, O. A., Agartz, I., Westlye, L. T., Haukvik, U. K., Dale, A. M., Melle, I., Hartberg, C. B., Gruber, O., Kraemer, B., Zilles, D., Donohoe, G., Cannon, D. M., Corvin, A., Machielsen, M. W. J., ... Hashimoto, R. (2016). Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortium. Molecular Psychiatry, 21(4), 585. https://doi.org/10.1038/mp.2015.118 Publisher's PDF, also known as Version of record License (if available): CC BY-NC-ND Link to published version (if available): 10.1038/mp.2015.118 Link to publication record in Explore Bristol Research PDF-document This is the final published version of the article (version of record). It first appeared online via Springer Nature at https://www.nature.com/articles/mp201563. Please refer to any applicable terms of use of the publisher. University of Bristol - Explore Bristol Research General rights This document is made available in accordance with publisher policies. Please cite only the published version using the reference above. Full terms of use are available: http://www.bristol.ac.uk/pure/user-guides/explore-bristol-research/ebr-terms/
Transcript of van Erp, T. G. M., Hibar, D. P., Rasmussen, J. M., Glahn ... · Table S4a Absolute Volume AMC...
van Erp, T. G. M., Hibar, D. P., Rasmussen, J. M., Glahn, D. C.,Pearlson, G. D., Andreassen, O. A., Agartz, I., Westlye, L. T.,Haukvik, U. K., Dale, A. M., Melle, I., Hartberg, C. B., Gruber, O.,Kraemer, B., Zilles, D., Donohoe, G., Cannon, D. M., Corvin, A.,Machielsen, M. W. J., ... Hashimoto, R. (2016). Subcortical brainvolume abnormalities in 2028 individuals with schizophrenia and 2540healthy controls via the ENIGMA consortium. Molecular Psychiatry,21(4), 585. https://doi.org/10.1038/mp.2015.118
Publisher's PDF, also known as Version of recordLicense (if available):CC BY-NC-NDLink to published version (if available):10.1038/mp.2015.118
Link to publication record in Explore Bristol ResearchPDF-document
This is the final published version of the article (version of record). It first appeared online via Springer Nature athttps://www.nature.com/articles/mp201563. Please refer to any applicable terms of use of the publisher.
University of Bristol - Explore Bristol ResearchGeneral rights
This document is made available in accordance with publisher policies. Please cite only thepublished version using the reference above. Full terms of use are available:http://www.bristol.ac.uk/pure/user-guides/explore-bristol-research/ebr-terms/
Table S4. Absolute Sample Size-Weighted Means by Group and Region
SZ HV
Region Mean
Volume
SD N Mean
Volume
SD N
Mean Accumbens 599 108 2018 635 109 2535
Mean Amygdala 1621 223 2024 1649 220 2535
Mean Caudate 3815 543 2024 3833 518 2540
Mean Hippocampus 4098 457 2021 4203 433 2531
Mean Lateral Ventricle 8395 4911 2028 7088 4071 2539
Mean Pallidum 1787 251 2015 1753 241 2538
Mean Putamen 5783 753 2023 5795 719 2536
Mean Thalamus 6903 820 2022 7126 823 2533
Left Accumbens 579 122 2023 615 121 2537
Left Amygdala 1580 232 2025 1615 232 2536
Left Caudate 3786 547 2025 3800 520 2540
Left Hippocampus 4059 478 2023 4157 454 2533
Left Lateral Ventricle 8705 5188 2028 7363 4371 2539
Left Pallidum 1862 283 2022 1835 271 2538
Left Putamen 5898 785 2027 5920 752 2536
Left Thalamus 7256 904 2022 7424 900 2534
Right Accumbens 619 117 2023 655 118 2538
Right Amygdala 1661 241 2027 1683 237 2537
Right Caudate 3843 558 2027 3866 533 2540
Right Hippocampus 4138 476 2026 4247 450 2538
Right Lateral Ventricle 8085 4992 2028 6815 4110 2539
Right Pallidum 1715 252 2020 1671 240 2540
Right Putamen 5672 754 2024 5670 719 2538
R Thalamus 6548 788 2025 6825 798 2537
ICV 1520 186 2028 1476 196 2539
The across sample volume means are weighted by sample size. Prefixes M, L, and R = mean,
left, and right, respectively. ICV = Intracranial Volume.
Table S4a Absolute Volume AMC Sample
SZ HV
Region Volume SD Range N Volume SD Range N
LLatVent 7889 (4229) 1993-27123 213 7589 (3959) 1823-23509 169
Lthal 7503 (852) 5779-9684 210 7170 (797) 5188-9186 169
Lcaud 4047 (538) 2674-5772 213 4018 (481) 2896-5656 169
Lput 6161 (795) 3861-8995 213 6541 (879) 4472-8444 169
Lpal 1922 (230) 1280-2555 211 1919 (239) 1157-2487 169
Lhippo 4231 (534) 2357-6315 213 4210 (498) 1761-5336 169
Lamyg 1672 (222) 1180-2300 212 1849 (282) 1249-2585 167
Laccumb 637 (137) 330-1045 213 711 (173) 368-1284 169
RLatVent 7493 (4163) 1216-27783 213 7429 (4153) 1526-36454 169
Rthal 7257 (739) 5628-9240 212 7189 (708) 5573-9233 168
Rcaud 4095 (553) 2730-5855 213 4142 (498) 2792-5492 169
Rput 5983 (778) 3524-8604 213 6278 (832) 4263-8006 169
Rpal 1730 (189) 1047-2185 210 1647 (204) 1127-2213 169
Rhippo 4255 (508) 2790-6221 213 4239 (472) 2561-5405 169
Ramyg 1730 (236) 1231-2333 213 1850 (284) 1155-2481 167
Raccumb 691 (137) 325-1225 213 794 (191) 417-1253 169
Mvent 7691 (4005) 1604-26814 213 7509 (3775) 2042-27284 169
Mthal 7372 (748) 5714-9153 210 7175 (724) 5380-8938 168
Mcaud 4071 (531) 2702-5758 213 4080 (477) 2914-5370 169
Mput 6072 (767) 3692-8800 213 6409 (845) 4435-8137 169
Mpal 1822 (188) 1164-2328 208 1783 (202) 1173-2314 169
Mhippo 4243 (497) 2744-6268 213 4225 (451) 2978-5269 169
Mamyg 1700 (213) 1224-2302 212 1850 (261) 1226-2523 167
Maccumb 664 (126) 338-1125 213 752 (173) 406-1259 169
ICV 1534 (187) 921-2190 213 1477 (259) 788-2060 168
Table S4b Absolute Volume CLiNG Sample
SZ HV
Region Volume SD Range N Volume SD Range N
LLatVent 10829 (5144) 3077-26538 47 7044 (4594) 1836-46035 321
Lthal 7444 (779) 5593-9280 47 7745 (889) 5461-10590 321
Lcaud 3981 (465) 3022-5132 47 3993 (484) 2791-5347 321
Lput 5877 (752) 4554-7774 47 6060 (697) 4162-8370 321
Lpal 2078 (273) 1325-2621 47 2151 (255) 1595-2867 321
Lhippo 3829 (336) 3018-4673 47 4095 (462) 1982-5470 317
Lamyg 1453 (167) 1043-1735 47 1499 (227) 878-2373 320
Laccumb 575 (83) 393-773 47 624 (103) 376-979 321
RLatVent 9855 (5370) 3501-27678 47 6221 (3833) 1748-35282 321
Rthal 7759 (810) 5528-9393 47 8110 (913) 5760-11344 321
Rcaud 4072 (468) 2970-5324 47 4082 (497) 3111-5690 321
Rput 5681 (762) 3908-7165 47 5791 (636) 4206-7469 321
Rpal 1733 (233) 973-2189 47 1759 (205) 1290-2512 321
Rhippo 3917 (369) 2987-4427 47 4171 (452) 3059-5602 321
Ramyg 1470 (149) 1206-1826 47 1504 (214) 962-2298 321
Raccumb 596 (82) 464-834 45 670 (115) 394-1155 320
Mvent 10342 (5007) 3352-27108 47 6632 (4071) 1792-40658 321
Mthal 7601 (773) 5560-9324 47 7927 (883) 5610-10967 321
Mcaud 4026 (463) 2996-5148 47 4037 (484) 2970-5518 321
Mput 5779 (748) 4318-7470 47 5925 (653) 4283-7826 321
Mpal 1906 (243) 1149-2405 47 1955 (215) 1496-2598 321
Mhippo 3873 (328) 3002-4510 47 4134 (438) 3096-5536 317
Mamyg 1461 (146) 1164-1738 47 1502 (211) 1015-2336 320
Maccumb 586 (72) 456-760 45 647 (101) 420-1025 320
ICV 1401 (221) 707-1851 47 1333 (208) 748-1851 321
Table S4c Absolute Volume Dublin Sample
SZ HV
Region Volume SD Range N Volume SD Range N
LLatVent 12827 (6715) 2150-30035 57 7833 (4288) 2107-28258 227
Lthal 7110 (1055) 4614-9635 57 7396 (816) 5118-9512 227
Lcaud 3679 (665) 1178-5362 57 3770 (488) 2504-5472 227
Lput 6188 (915) 4414-8591 57 6405 (812) 3885-8281 227
Lpal 1899 (494) 1174-3713 57 1754 (310) 904-2689 227
Lhippo 3800 (498) 2392-5663 57 4073 (504) 2236-5204 227
Lamyg 1493 (270) 737-2061 57 1600 (240) 916-2333 227
Laccumb 670 (195) 36-1159 57 801 (150) 400-1372 227
RLatVent 11305 (5550) 2916-28666 57 7402 (3880) 1879-24286 227
Rthal 6669 (898) 4517-8435 57 7144 (744) 4836-9147 227
Rcaud 3968 (735) 1165-5789 57 4011 (519) 2690-5414 227
Rput 6068 (1012) 3887-8868 57 6204 (769) 3260-7961 227
Rpal 1819 (372) 1031-3057 57 1745 (285) 915-2760 227
Rhippo 3908 (483) 2446-5440 57 4141 (460) 2598-5452 227
Ramyg 1630 (279) 629-2366 57 1703 (247) 1165-2546 227
Raccumb 645 (160) 158-962 57 730 (123) 395-1113 227
Mvent 12066 (6002) 2655-29350 57 7617 (3913) 2099-25553 227
Mthal 6889 (935) 4566-8785 57 7270 (742) 4977-9151 227
Mcaud 3824 (692) 1171-5575 57 3890 (493) 2722-5443 227
Mput 6128 (940) 4485-8729 57 6304 (768) 3722-7960 227
Mpal 1859 (412) 1102-3385 57 1749 (278) 1054-2618 227
Mhippo 3854 (461) 2970-5552 57 4107 (462) 2639-5207 227
Mamyg 1561 (260) 683-2213 57 1651 (228) 1059-2341 227
Maccumb 658 (162) 97-1041 57 766 (125) 411-1156 227
ICV 1491 (213) 956-2010 57 1429 (195) 1050-1950 227
Table S4d Absolute Volume Edinburgh Sample
SZ HV
Region Volume SD Range N Volume SD Range N
LLatVent 7210 (3554) 3417-14330 16 5437 (2574) 2081-10272 20
Lthal 4253 (1074) 2528-6476 16 4448 (1391) 2117-7667 20
Lcaud 3408 (551) 2489-4402 16 3921 (617) 2901-5243 20
Lput 4730 (700) 3755-5916 16 4904 (671) 3928-6321 20
Lpal 1201 (260) 720-1547 16 1348 (336) 688-1839 20
Lhippo 3634 (606) 2503-4536 16 3791 (500) 2966-4685 20
Lamyg 1116 (263) 717-1563 16 1166 (193) 805-1469 20
Laccumb 104 (140) 33-610 16 74 (48) 36-234 20
RLatVent 6819 (3019) 3495-14646 16 5553 (2201) 2230-9448 20
Rthal 4376 (806) 3005-5633 16 4622 (1319) 2376-7554 20
Rcaud 3517 (543) 2657-4287 16 3982 (688) 2991-5647 20
Rput 4637 (645) 3655-5595 16 4824 (579) 4143-6081 20
Rpal 1188 (277) 712-1926 16 1349 (321) 807-1868 20
Rhippo 3453 (612) 2457-4334 16 3820 (502) 2911-4663 20
Ramyg 1146 (249) 844-1731 16 1224 (240) 842-1687 20
Raccumb 131 (160) 35-710 16 113 (64) 53-276 20
Mvent 7015 (3013) 3456-12502 16 5495 (2229) 2486-9010 20
Mthal 4314 (902) 2766-6003 16 4535 (1334) 2246-7610 20
Mcaud 3463 (541) 2573-4344 16 3951 (644) 2946-5445 20
Mput 4684 (670) 3705-5732 16 4864 (616) 4056-6137 20
Mpal 1194 (250) 782-1717 16 1348 (324) 748-1812 20
Mhippo 3543 (584) 2508-4333 16 3806 (491) 2970-4606 20
Mamyg 1131 (246) 792-1612 16 1195 (190) 899-1526 20
Maccumb 117 (149) 34-660 16 93 (54) 46-255 20
ICV 1405 (253) 760-1695 16 1525 (196) 1075-1874 20
Table S4e Absolute Volume FBIRN Sample
SZ HV
Region Volume SD Range N Volume SD Range N
LLatVent 8710 (5539) 1499-33702 186 7500 (3952) 2254-21117 177
Lthal 7096 (883) 4899-10424 185 7226 (846) 4799-9261 177
Lcaud 3706 (545) 2307-5574 185 3699 (490) 2403-5276 178
Lput 5947 (809) 4032-8048 186 5831 (683) 4290-7612 178
Lpal 1890 (260) 1182-2662 185 1811 (233) 1248-2658 178
Lhippo 4102 (511) 3007-5799 186 4275 (490) 3000-5530 177
Lamyg 1630 (227) 1070-2301 186 1663 (222) 1207-2251 178
Laccumb 580 (115) 226-930 184 606 (119) 301-1035 176
RLatVent 7943 (4774) 1258-27876 186 6853 (3850) 1418-25623 177
Rthal 7316 (907) 5177-10398 185 7401 (833) 4803-9806 177
Rcaud 3721 (535) 2388-5770 186 3739 (522) 2455-5705 178
Rput 5586 (783) 3770-7722 185 5426 (634) 3799-6778 178
Rpal 1715 (237) 1200-2416 184 1619 (206) 1045-2117 178
Rhippo 4205 (515) 3146-6133 186 4338 (458) 3049-5527 178
Ramyg 1686 (242) 1103-2334 185 1718 (230) 1235-2337 178
Raccumb 619 (126) 364-1033 185 649 (119) 387-1013 178
Mvent 8327 (5026) 1424-30789 186 7176 (3726) 1890-22976 177
Mthal 7206 (874) 5171-10411 185 7313 (799) 5011-9433 177
Mcaud 3717 (527) 2352-5672 185 3719 (496) 2429-5490 178
Mput 5762 (775) 3953-7700 185 5629 (639) 4044-7157 178
Mpal 1801 (232) 1206-2539 184 1715 (198) 1248-2214 178
Mhippo 4153 (494) 3109-5966 186 4309 (456) 3044-5414 177
Mamyg 1658 (221) 1098-2318 185 1690 (209) 1246-2224 178
Maccumb 599 (108) 385-884 183 628 (107) 415-1002 176
ICV 1540 (173) 981-1914 186 1561 (156) 1195-1968 178
Table S4f Absolute Volume Galway Sample
SZ HV
Region Volume SD Range N Volume SD Range N
LLatVent 8523 (4509) 2213-23165 80 6653 (4276) 1793-20223 74
Lthal 7111 (3457) 1582-22682 80 5959 (4024) 1804-19143 74
Lcaud 7675 (1005) 5667-10588 80 8262 (1218) 6129-12440 74
Lput 3961 (573) 2761-5331 80 4049 (663) 2809-6480 74
Lpal 6077 (879) 3771-8177 80 6055 (888) 4339-9307 74
Lhippo 2013 (391) 1267-3152 80 2081 (469) 1429-4173 74
Lamyg 4209 (419) 3344-5402 80 4402 (453) 3418-5655 74
Laccumb 1654 (213) 1199-2229 80 1686 (211) 1269-2178 74
RLatVent 614 (113) 361-899 80 641 (123) 381-985 74
Rthal 7775 (1027) 5499-10531 80 8082 (1205) 5970-12193 74
Rcaud 3990 (534) 2797-5378 80 4071 (683) 2919-6465 74
Rput 5783 (833) 3702-7722 80 5834 (928) 4391-8833 74
Rpal 1879 (367) 1066-3006 80 1879 (422) 1310-3815 74
Rhippo 4289 (460) 2828-5119 80 4439 (436) 3074-5779 74
Ramyg 1743 (225) 1209-2245 80 1800 (211) 1427-2269 74
Raccumb 642 (111) 394-964 80 645 (109) 438-932 74
Mvent 7817 (3811) 1898-22924 80 6306 (4030) 2014-18716 74
Mthal 7725 (972) 5583-10358 80 8172 (1166) 6256-12316 74
Mcaud 3975 (548) 2779-5354 80 4060 (663) 2864-6472 74
Mput 5930 (826) 3736-7774 80 5945 (873) 4421-8636 74
Mpal 1946 (358) 1212-2857 80 1980 (424) 1433-3994 74
Mhippo 4249 (412) 3518-5243 80 4420 (420) 3485-5533 74
Mamyg 1698 (197) 1204-2148 80 1743 (194) 1408-2221 74
Maccumb 628 (99) 406-915 80 643 (103) 441-925 74
ICV 1523 (146) 1190-1950 80 1543 (162) 1240-1900 74
Table S4g Absolute Volume HMS Sample
SZ HV
Region Volume SD Range N Volume SD Range N
LLatVent 7658 (4923) 2211-26143 46 7148 (3943) 1445-22310 55
Lthal 7910 (974) 5438-10153 46 7429 (1030) 5493-10778 55
Lcaud 3954 (501) 3016-5372 46 3787 (637) 2827-5900 55
Lput 5810 (708) 4207-7583 46 5468 (802) 4044-8894 55
Lpal 1961 (315) 1366-3125 46 1799 (268) 1269-2548 55
Lhippo 4135 (455) 3110-5109 46 4119 (444) 3049-5236 55
Lamyg 1570 (223) 1037-2279 46 1517 (195) 1229-2208 54
Laccumb 569 (96) 334-807 46 546 (112) 369-888 55
RLatVent 6938 (4646) 1918-25380 46 6187 (3432) 1391-20007 55
Rthal 8281 (1013) 5561-10480 46 7713 (1014) 5780-11136 55
Rcaud 4015 (556) 2767-5325 46 3827 (600) 2923-5728 55
Rput 5649 (645) 4619-7401 46 5251 (773) 3879-7811 55
Rpal 1785 (293) 1363-2701 46 1625 (266) 1264-2411 55
Rhippo 4208 (501) 3269-5717 46 4211 (439) 3565-5437 55
Ramyg 1651 (228) 1172-2323 46 1565 (197) 1154-2136 55
Raccumb 571 (94) 344-729 46 538 (100) 376-821 55
Mvent 7298 (4719) 2064-25762 46 6668 (3537) 1504-21158 55
Mthal 8095 (970) 5500-10316 46 7571 (1005) 5636-10957 55
Mcaud 3984 (521) 2938-5334 46 3807 (615) 2875-5814 55
Mput 5729 (665) 4419-7416 46 5360 (774) 3962-8352 55
Mpal 1873 (289) 1374-2661 46 1712 (259) 1310-2480 55
Mhippo 4172 (460) 3264-5413 46 4165 (428) 3318-5336 55
Mamyg 1611 (213) 1123-2166 46 1544 (187) 1192-2147 54
Maccumb 570 (87) 339-753 46 542 (99) 383-821 55
ICV 1606 (162) 1215-1988 46 1517 (159) 1153-1899 55
Table S4h Absolute Volume HUBIN Sample
SZ HV
Region Volume SD Range N Volume SD Range N
LLatVent 11733 (6607) 2735-44147 94 8354 (4805) 1816-24446 102
Lthal 7711 (849) 5820-9912 94 7866 (971) 5848-10965 102
Lcaud 3841 (444) 2912-4780 94 3644 (505) 2472-4823 102
Lput 5586 (672) 4228-7583 94 5322 (647) 3961-7420 102
Lpal 1842 (270) 1345-2589 94 1652 (275) 1027-2934 102
Lhippo 4238 (511) 3044-5684 94 4425 (435) 3432-5372 102
Lamyg 1520 (211) 1127-2309 94 1552 (202) 1132-1983 102
Laccumb 493 (93) 239-773 94 502 (87) 296-711 102
RLatVent 11542 (7230) 2270-51616 94 7854 (4646) 1312-21761 102
Rthal 7458 (788) 5760-9144 94 7417 (818) 5723-9908 102
Rcaud 3891 (468) 2950-4899 94 3648 (500) 2544-4928 102
Rput 5469 (648) 4086-6904 94 5116 (595) 3892-6965 102
Rpal 1731 (235) 1147-2322 94 1567 (201) 895-2037 102
Rhippo 4280 (481) 3055-5270 94 4498 (424) 3354-5456 102
Ramyg 1554 (205) 1105-2044 94 1590 (198) 1117-2194 102
Raccumb 517 (95) 343-729 94 539 (95) 350-815 102
Mvent 11638 (6461) 2659-40466 94 8104 (4475) 1818-22347 102
Mthal 7584 (775) 5790-9491 94 7642 (852) 5786-10436 102
Mcaud 3866 (443) 2931-4820 94 3646 (496) 2551-4876 102
Mput 5527 (643) 4237-7243 94 5219 (596) 4047-7193 102
Mpal 1786 (237) 1344-2455 94 1610 (214) 1128-2392 102
Mhippo 4259 (460) 3049-5127 94 4462 (413) 3578-5402 102
Mamyg 1537 (198) 1138-2174 94 1571 (186) 1215-2078 102
Maccumb 505 (80) 291-703 94 521 (83) 340-731 102
ICV 1628 (151) 1347-1978 94 1619 (154) 1272-1973 102
Table S4i Absolute Volume MCIC Sample
SZ HV
Region Volume SD Range N Volume SD Range N
LLatVent 8266 (5541) 1935-43482 158 6306 (3430) 1515-17849 165
Lthal 7431 (1046) 5273-10132 158 7651 (1008) 5873-12698 165
Lcaud 3867 (607) 2670-5625 158 3847 (519) 2774-5289 165
Lput 5821 (873) 2688-8075 158 5679 (692) 2597-7681 165
Lpal 1840 (376) 681-3048 158 1776 (343) 588-2923 165
Lhippo 4080 (481) 2902-5340 158 4246 (402) 3340-5246 165
Lamyg 1762 (263) 1159-2537 158 1795 (229) 1366-2575 165
Laccumb 532 (120) 239-926 158 529 (111) 270-936 165
RLatVent 7675 (5094) 1673-42736 158 5886 (3406) 1329-29697 165
Rthal 7389 (1011) 4988-9928 158 7602 (964) 5667-12177 165
Rcaud 3874 (602) 2727-5548 158 3852 (523) 2744-5136 165
Rput 5564 (769) 4013-7772 158 5457 (684) 4169-7664 165
Rpal 1743 (341) 878-2755 158 1729 (318) 691-3091 165
Rhippo 4385 (529) 3135-5731 158 4590 (458) 3578-5726 165
Ramyg 1802 (238) 1252-2435 158 1839 (234) 1271-2591 165
Raccumb 626 (117) 303-981 158 638 (112) 390-1060 165
Mvent 7970 (5194) 1806-43109 158 6096 (3208) 1438-23547 165
Mthal 7410 (1013) 5130-9712 158 7627 (971) 5883-12438 165
Mcaud 3871 (598) 2734-5586 158 3849 (513) 2765-5174 165
Mput 5693 (804) 3443-7924 158 5568 (671) 3776-7672 165
Mpal 1791 (346) 814-2902 158 1752 (317) 716-2998 165
Mhippo 4233 (491) 3037-5452 158 4418 (414) 3459-5486 165
Mamyg 1782 (241) 1214-2420 158 1817 (220) 1318-2512 165
Maccumb 579 (106) 316-848 158 584 (98) 354-976 165
ICV 1678 (199) 1256-2232 158 1713 (213) 1272-2733 165
Table S4j Absolute Volume NU Sample
SZ HV
Region Volume SD Range N Volume SD Range N
LLatVent 7936 (3485) 2613-18109 108 7992 (5170) 2106-31250 92
Lthal 6776 (866) 4833-8994 108 7186 (782) 5500-9670 92
Lcaud 3653 (493) 2310-4937 108 3675 (489) 2513-4974 92
Lput 6254 (820) 4051-7952 108 6303 (902) 4186-9259 92
Lpal 1789 (275) 1088-2474 108 1686 (249) 1132-2254 91
Lhippo 3682 (449) 2632-4831 108 3861 (412) 2813-4982 92
Lamyg 1434 (229) 907-2075 108 1465 (197) 990-1912 92
Laccumb 726 (151) 443-1178 108 767 (148) 421-1094 92
RLatVent 7733 (4051) 2862-20899 108 7740 (5032) 1886-26799 92
Rthal 6674 (857) 5042-9379 108 7028 (775) 5438-9359 92
Rcaud 3917 (533) 2708-5306 108 3996 (526) 2755-5339 92
Rput 6061 (821) 4286-7837 108 6037 (816) 4271-8693 92
Rpal 1889 (297) 1248-2682 108 1837 (268) 1254-2652 92
Rhippo 3794 (432) 2888-4712 108 3947 (393) 3119-4986 92
Ramyg 1680 (292) 1131-2707 108 1707 (238) 1257-2343 92
Raccumb 700 (125) 440-958 108 728 (122) 396-1055 92
Mvent 7835 (3652) 3065-18610 108 7866 (4957) 1996-27100 92
Mthal 6725 (841) 5010-9063 108 7107 (752) 5469-9237 92
Mcaud 3785 (506) 2509-5121 108 3835 (498) 2654-5156 92
Mput 6158 (807) 4247-7869 108 6170 (846) 4318-8976 92
Mpal 1839 (271) 1214-2574 108 1764 (246) 1260-2453 91
Mhippo 3738 (422) 2787-4771 108 3904 (386) 3135-4762 92
Mamyg 1557 (246) 1019-2391 108 1586 (203) 1126-2056 92
Maccumb 713 (128) 444-1057 108 747 (127) 438-1074 92
ICV 1493 (164) 1125-1876 108 1538 (140) 1198-1887 92
Table S4k Absolute Volume Olin Sample
SZ HV
Region Volume SD Range N Volume SD Range N
LLatVent 8545 (5616) 1857-38400 321 7413 (4660) 1700-31141 442
Lthal 6515 (874) 4395-9412 321 6907 (921) 4346-9571 442
Lcaud 3574 (595) 1495-5422 321 3691 (535) 2198-5239 442
Lput 5977 (889) 4014-9157 321 5963 (798) 4075-8484 442
Lpal 1769 (288) 965-2557 321 1723 (242) 1117-2621 442
Lhippo 3770 (480) 1811-5151 321 3978 (466) 2234-5569 442
Lamyg 1557 (278) 705-2392 321 1618 (261) 512-2375 442
Laccumb 694 (148) 332-1316 321 680 (128) 367-1113 442
RLatVent 7822 (5363) 1626-41454 321 6727 (4200) 1297-25629 442
Rthal 6643 (890) 4633-9226 321 7013 (906) 4376-9790 442
Rcaud 3674 (605) 1885-5315 321 3754 (547) 2355-5490 442
Rput 5729 (848) 3700-8606 321 5692 (750) 3863-7610 442
Rpal 1609 (234) 1059-2268 321 1597 (215) 1053-2710 442
Rhippo 3895 (479) 2115-5164 321 4107 (442) 2948-5508 442
Ramyg 1713 (294) 1012-2504 321 1770 (271) 1086-2528 442
Raccumb 694 (148) 350-1086 321 707 (125) 317-1037 442
Mvent 8184 (5314) 1747-38613 321 7070 (4295) 1724-27240 442
Mthal 6579 (860) 4638-8840 321 6960 (883) 4361-9432 442
Mcaud 3624 (593) 1690-5344 321 3722 (533) 2372-5340 442
Mput 5853 (858) 3857-8882 321 5828 (762) 3969-8004 442
Mpal 1689 (247) 1142-2412 321 1660 (217) 1135-2665 442
Mhippo 3832 (462) 2131-5105 321 4042 (437) 2611-5501 442
Mamyg 1635 (271) 928-2405 321 1694 (251) 936-2406 442
Maccumb 694 (138) 392-1182 321 693 (117) 370-1070 442
ICV 1331 (180) 912-1872 321 1257 (212) 617-1788 442
Table S4l Absolute Volume PAFIP Sample
SZ HV
Region Volume SD Range N Volume SD Range N
LLatVent 5946 (3248) 1543-18260 147 5388 (3380) 1531-23247 81
Lthal 7169 (758) 5026-9053 147 7431 (627) 5722-9392 81
Lcaud 3674 (498) 2204-5277 147 3704 (512) 2279-4732 81
Lput 5715 (654) 4116-7363 147 5793 (677) 3418-7530 81
Lpal 1860 (197) 1309-2367 147 1882 (215) 1435-2460 81
Lhippo 4497 (469) 3209-5551 147 4569 (408) 3449-5288 81
Lamyg 1627 (218) 1081-2124 147 1628 (202) 1210-2189 81
Laccumb 574 (100) 302-914 147 593 (100) 356-894 81
RLatVent 5612 (3484) 1470-28796 147 5062 (3529) 1416-24425 81
Rthal 7393 (814) 5032-9595 147 7695 (691) 5920-9351 81
Rcaud 3673 (505) 2329-5280 147 3621 (520) 2168-4642 81
Rput 5469 (627) 3779-7617 147 5539 (681) 3306-7058 81
Rpal 1711 (209) 1151-2317 147 1736 (209) 1288-2322 81
Rhippo 4487 (432) 3288-5674 147 4560 (454) 2581-5380 81
Ramyg 1674 (217) 1095-2172 147 1681 (209) 1197-2268 81
Raccumb 600 (87) 385-893 147 611 (89) 354-801 81
Mvent 5779 (3106) 1840-19574 147 5225 (3350) 1600-23836 81
Mthal 7281 (766) 5029-9316 147 7563 (640) 5821-9372 81
Mcaud 3674 (493) 2266-5278 147 3662 (505) 2312-4685 81
Mput 5592 (628) 3948-7490 147 5666 (664) 3362-7294 81
Mpal 1786 (192) 1230-2249 147 1809 (205) 1380-2320 81
Mhippo 4492 (431) 3346-5530 147 4565 (415) 3049-5316 81
Mamyg 1650 (208) 1088-2095 147 1655 (195) 1212-2156 81
Maccumb 587 (84) 390-884 147 602 (84) 406-844 81
ICV 1503 (151) 1183-1877 147 1517 (132) 1211-1886 81
Table S4m Absolute Volume TOP Sample
SZ HV
Region Volume SD Range N Volume SD Range N
LLatVent 9181 (5896) 2008-45815 219 8082 (4823) 1653-32386 305
Lthal 6942 (783) 5151-9375 219 7122 (794) 5245-9343 305
Lcaud 3846 (486) 2781-5403 219 3775 (489) 2345-5176 305
Lput 6263 (736) 4422-9914 219 6085 (734) 3492-8408 305
Lpal 1985 (246) 1446-2894 219 1921 (236) 1224-2675 305
Lhippo 3926 (413) 2896-5264 219 4126 (398) 3069-5596 305
Lamyg 1620 (230) 1132-2364 219 1691 (230) 998-2474 305
Laccumb 698 (124) 384-1087 219 706 (121) 307-1093 305
RLatVent 8553 (5774) 1155-47449 219 7417 (4367) 1412-39113 305
Rthal 6969 (776) 5206-9820 219 7145 (798) 5290-9686 305
Rcaud 3971 (520) 2756-5712 219 3883 (516) 2455-5595 305
Rput 6011 (651) 4057-8775 219 5818 (703) 3491-8082 305
Rpal 1786 (224) 1315-2465 219 1705 (224) 1079-2427 305
Rhippo 4007 (427) 2911-5311 219 4228 (422) 3278-6005 305
Ramyg 1666 (231) 1067-2413 219 1714 (235) 996-2380 305
Raccumb 664 (107) 324-1001 219 687 (108) 395-1177 305
Mvent 8867 (5689) 1859-46632 219 7749 (4409) 1538-34653 305
Mthal 6956 (768) 5222-9598 219 7133 (787) 5323-9514 305
Mcaud 3908 (497) 2804-5526 219 3829 (496) 2400-5366 305
Mput 6137 (683) 4374-9344 219 5952 (709) 3492-8240 305
Mpal 1885 (227) 1395-2618 219 1813 (222) 1152-2456 305
Mhippo 3966 (409) 2920-5149 219 4177 (393) 3193-5550 305
Mamyg 1643 (220) 1153-2388 219 1703 (221) 997-2386 305
Maccumb 681 (105) 384-1032 219 696 (102) 351-1055 305
ICV 1575 (206) 947-2180 219 1604 (190) 1040-2230 305
Table S4n Absolute Volume UMCU Sample
SZ HV
Region Volume SD Range N Volume SD Range N
LLatVent 9263 (4966) 1629-29037 159 7103 (4097) 2043-26824 116
Lthal 7950 (874) 5297-10065 159 7963 (890) 5687-10490 114
Lcaud 3682 (513) 2367-5528 159 3501 (558) 2308-5152 116
Lput 5561 (614) 4142-7103 159 5297 (634) 3615-7538 116
Lpal 1845 (218) 1314-2400 159 1765 (237) 1321-2324 115
Lhippo 4565 (473) 3154-6073 155 4621 (404) 3739-5932 115
Lamyg 1548 (192) 1151-2138 159 1560 (204) 1185-2210 116
Laccumb 556 (88) 268-791 159 552 (99) 336-841 115
RLatVent 8574 (5068) 1756-30609 159 6477 (3800) 1695-29883 116
Rthal 7447 (750) 5407-9288 159 7422 (792) 5560-9799 116
Rcaud 3778 (513) 2385-5678 158 3600 (543) 2588-5058 116
Rput 5319 (600) 3823-6677 158 5012 (590) 3527-6904 116
Rpal 1689 (211) 1151-2393 159 1619 (218) 1181-2396 116
Rhippo 4466 (484) 3238-5930 158 4502 (458) 3438-6480 115
Ramyg 1648 (204) 1165-2324 159 1638 (185) 1273-2281 115
Raccumb 546 (86) 364-841 158 543 (93) 328-809 116
Mvent 8919 (4807) 1762-27036 159 6790 (3804) 1987-28354 116
Mthal 7698 (783) 5352-9531 159 7686 (807) 5624-10144 114
Mcaud 3731 (506) 2376-5603 158 3551 (542) 2458-5105 116
Mput 5436 (590) 3982-6890 158 5155 (602) 3571-7008 116
Mpal 1767 (203) 1232-2396 159 1693 (217) 1280-2350 115
Mhippo 4515 (458) 3196-6002 154 4565 (409) 3688-5749 114
Mamyg 1598 (188) 1158-2226 159 1598 (181) 1290-2167 115
Maccumb 552 (76) 352-741 158 548 (86) 348-825 115
ICV 1658 (169) 1240-2070 159 1608 (157) 1180-2120 116
Table S4o Absolute Volume UPENN Sample
SZ HV
Region Volume SD Range N Volume SD Range N
LLatVent 9028 (6146) 2113-37364 177 7361 (4582) 1209-26042 193
Lthal 8130 (1177) 5124-10778 175 8354 (1120) 5533-11406 190
Lcaud 3928 (634) 2601-5587 175 3927 (596) 2544-5725 193
Lput 5363 (796) 3528-7177 176 5226 (726) 3185-6946 189
Lpal 1760 (351) 1036-2670 174 1683 (343) 961-2757 193
Lhippo 3895 (510) 2663-5153 176 4091 (497) 2554-5382 192
Lamyg 1434 (213) 927-2004 175 1477 (217) 864-2250 193
Laccumb 171 (103) 1-353 174 187 (102) 4-356 193
RLatVent 8548 (5734) 1973-37065 177 7166 (5165) 790-35476 193
Rthal 179 (107) 1-363 176 187 (103) 4-364 192
Rcaud 3736 (639) 2297-5375 177 3684 (586) 2395-5476 193
Rput 5232 (819) 3424-7239 175 5140 (796) 3224-7800 191
Rpal 1604 (282) 885-2446 174 1520 (267) 956-2302 193
Rhippo 3970 (467) 2403-5352 176 4191 (506) 2853-5414 192
Ramyg 1450 (224) 1002-2193 177 1498 (239) 895-2269 193
Raccumb 462 (99) 231-817 176 478 (103) 233-843 192
Mvent 8788 (5817) 2043-37215 177 7263 (4711) 999-28422 193
Mthal 4155 (613) 2578-5526 175 4271 (588) 2785-5885 190
Mcaud 3831 (616) 2449-5432 175 3805 (578) 2498-5522 193
Mput 5282 (774) 3476-7168 174 5181 (728) 3250-6869 189
Mpal 1669 (272) 1006-2340 171 1601 (288) 963-2480 193
Mhippo 3930 (472) 2551-5149 175 4143 (478) 2766-5382 191
Mamyg 1441 (202) 1017-2097 175 1487 (213) 880-2260 193
Maccumb 314 (88) 126-521 173 332 (95) 119-594 192
ICV 1496 (250) 708-2120 177 1546 (234) 772-2100 193
