Updated Jan 08 - idiCV/Bibliography Herbert L. Bonkovsky Page 3 17. Project Cork (to improve medical...

CV/Bibliography Herbert L. Bonkovsky

Extracted from 58 pages of entire CV

Updated Jan 08

Herbert L. Bonkovsky, A.B., M.D., F.A.C.G., F.A.C.P.

PERSONAL Marital Status: Married, Marilyn Cahoon, B.S., R.N., Three Children MAILING ADDRESS Carolinas Healthcare Systems 1000 Blythe Ave. Charlotte, NC CURRENT POSITIONS Herbert L. Bonkovsky, M.D. VP for Research Carolinas Health Care System Adjunct Professor, Univ of North Carolina Professor, Univ of CT Phone 704 355 3959 Fax 704 355 7648 Email [email protected] EDUCATION Undergraduate: Earlham College A.B. Merit Scholar All four years Varsity athlete in basketball and baseball All four years Departmental honors in Chemistry Valedictorian of graduating class Graduate: Western Reserve Univ. School of Medicine, M.D. Emma and Frank Binz Memorial Scholar All four years Borden Award for excellence in research as a medical student Mosby Award for scholastic excellence Alpha Omega Alpha, elected to membership in Junior Year


POSITIONS AND EXPERIENCE 1. Intern in Medicine, 1967-1968 Duke University Medical Center (Chiefs: E. Stead and J. Wyngaarden) 2. Resident in Medicine, 1968-1969 Western Reserve University School of Medicine at Cleveland Metropolitan General Hospital (Chief: C.

Rammelkamp, Jr.) 3. Public Health Service, 1969-1971 Clinical Associate, National Institutes of Health National Cancer Institute, Metabolism Branch (Chief: N. Berlin) Laboratory of D. Tschudy 4. Fellow, Dartmouth Medical School, 1971-1972 Department of Medicine (Chief: T. Almy) 5. Chief Resident in Medicine, 1972-1973 Dartmouth Medical School and Dartmouth Affiliated Hospitals (Chief: T. Almy) 6. NIH Clinical Trainee, Yale Liver Study Unit, 1973-1974

(Chief: G. Klatskin) 7. Research Associate, VA Medical and Regional Office Center White River Junction, Vermont, 1974-1976 8. Instructor, Department of Medicine, Dartmouth Medical School, 1972-1974 9. Assistant Professor, Department of Medicine Dartmouth Medical School, 1974-1979 10. Attending Physician, VA Medical and Regional Office Center White River Junction, Vermont, 1974-1985 11. Consulting Physician, Mary Hitchcock Memorial Hospital Hanover, New Hampshire, 1974-1983 12. Attending Physician, Mary Hitchcock Memorial Hospital Hanover, New Hampshire, 1983-1985 13. Associate, Hitchcock Clinic, Hanover, New Hampshire, 1976-1985 14. Chief, Division of Digestive Disease, VA Medical and Regional Office Center, White River Junction, Vermont, 1976-1985 15. Member, Research and Development Committee, VA Medical and Regional Office Center White River Junction, Vermont, 1974-1980, 1982-1984 a. Chairman, R&D Committee, 1978-1980; 1983-1985 b. Member, Animal Care Subcommittee, 1974-1984 c. Chairman, Animal Care Subcommittee, 1974-1977 d. Member, Space and Planning Subcommittee, 1978-1983

e. Member, Resources (Space and Budget) Subcommittee, 1983-1985 16. Director, Hepatology Laboratory of the Dartmouth-Hitchcock Medical Center, 1976--1985


17. Project Cork (to improve medical teaching on alcoholism, supported by Kroc Foundation), Dartmouth Medical School, 1977--1981

a. Chairman, Committee to develop model curriculum b. Chairman, Committee to develop clinical teaching c. Director of Program Development and Editor of the Alcohol Slide/Teaching Library: Alcohol and its Medical Consequences d. Member, Executive Steering Committee of Project Cork 18. Associate Professor, Department of Medicine, Dartmouth Medical School, 1979-1983 19. Professor of Medicine, Dartmouth Medical School, 1983-1985 a. Member, GI Committee for Scientific Basis of Medicine, 1983-1985 b. Member, Dean's Advisory Board of Multipurpose Arthritis Center, 1982-1985 20. Member, Scientific Review Board, Hitchcock Foundation, 1983-1985 21. Professor of Medicine, Associate Professor of Biochemistry, Emory University School of Medicine,

1985-1990 a. Member, University Research Committee, 1985-1990 b. Member, University Promotions Committee, 1986 - 1990 c. Member, M.D.-Ph.D. Advisory Committee, 1985-1990 d. Director, General Clinical Research Center, 1985-1988 e. Executive Secretary, Advisory Council, Clinical Research Center, 1985-1988 f. Director, Liver Study Unit, 1988-1990 22. Attending Physician, Emory University Hospital, 1985-1990 a. Member, Quality Assurance Committee, 1986-1988 23. Attending Physician, Grady Memorial Hospital, 1985-1990 24. Member (Part-Time) Emory Clinic, 1985-1988 Partner (Part-Time) Emory Clinic, 1988-1990 Director, Digestive Disease Laboratory, 1988-1990 25. Professor of Medicine, Biochemistry and Molecular Biology, University of Massachusetts Medical School a. Director, Division of Digestive Disease and Nutrition,1990 -- 1999 b. Medical Director, Digestive Disease Laboratory, 1990--1999 c. Director, Center for Disorders of Iron and Porphyrin Metabolism, 1991--2002 d. Member, Committee to Promote Clinical Research, 1990--2002 e. Member, Promotions Committee, 1991--93 Chair, Promotions Committee, 1992--93. f. Director, Liver-Biliary-Pancreatic Center, 1992--2002. g. Member, Chancellor’s Clinical Services Task Force,1993--94 h. Member, Genl. Clin. Res.Ctr. Advisory Committee, 1994--2002 26. Attending Physician, Hospital of Univ. of Mass., 1990--2002 27. Consulting Physician, Nashoba Valley Hospital, 1990--2002 28. Consulting Physician, Memorial Health System and Hospital, 1996--1998 29. Consulting Physician, St. Vincent Hospital/Fallon Healthcare, 1996—2001 30. Attending Physician, John Dempsey Hospital, 2002—present


31. Consulting Staff, Hartford Hospital, 2005--present NATIONAL AND INTERNATIONAL PROFESSIONAL ACTIVITIES AND SERVICE American Association for the Study of Liver Diseases: a. Member of the Nominating Committee, 1982, 2005 b. Member of the Editorial Board of Hepatology, 1987 - 1990 c. Associate Editor, Hepatology, 1990-1997 d. Member - Committee on Membership, 1991-1994 e. Chair - Committee on Membership, 1993-1994 f. Frequent invited speaker for Post-Graduate Courses, Single Topic Conferences g. Frequent leader of early morning workshops h. Frequent presenter at Meet the Professor luncheons, etc. i. Member, Committee on Program Evaluation, 2003—2006 j. Member and Chair of Abstract Selection Groups, 1985--present American Liver Foundation: Member of the Professional and Patient Education Committee, 1987 - 2000 Editorial Committee, Liver Update, 1987—2000 Medical Advisory Committee, NE Chapter, 1990—2002; CT Chapter, 2002--present American Porphyria Foundation: Chairman of the Professional Education Committee, 1985 –present Member, Scientific Advisory Board, 1985--present Liver Center of the University of Minnesota: Member of the Advisory Board and Steering Committee, 1989 -- 1992 Iron Overload Diseases Association: Member of Board of Directors, 1987 - 1997 Hemochromatosis Research Foundation: Member of Scientific Advisory Board, 1988 -- present National Institutes of Health: Ad hoc reviewer and site visitor for numerous grant applications, 1979 -- present National Institutes of Health: Member of the General Medicine A2 Initial Review Group (Digestive Disease and Nutrition Study Section) a. Ad Hoc Member 1989 --1990; b. regular member, 1990--1994 National Institutes of Health: Invited plenary lecturer and discussant--NIH International Consensus Conference on Hepatitis C, 1997 Iron Disorders Institute, Member, Scientific Advisory Board, 1997—present a. Chair, Scientific Advisory Board, IDI, 2000—present American College of Gastroenterology a. Member and Fellow b. Member, Scientific Review Committee, 2003—2006 Chair, International Scientific Advisory Group regarding possible uses of deferasirox (Exjade) in liver disorders, at request of Novartis Pharmaceuticals, October, 2004—present Chair, Hepatology Expert Panel regarding safety and tolerability of dabigatran, Boehringer-Ingelheim Pharmaceutical Company, October, 2005—present


Member Steering Committee and Writing Group on Genetic Liver Disease for NIH (NIDDK) Action Plan for Liver Disease Research, 2005—present Member Editorial Board Gene Regulation and Systems Biology, 2006—present Member, Editorial Board, World Journal of Gastroenterology, 2006--present

CV/Bibliography Herbert L. Bonkovsky Research Presentations

CERTIFICATION Diplomate, National Board of Medical Examiners July 1, 1968 Certificate 101431, Diplomate, American Board of Internal Medicine June 20, 1973 Certificate 41514 Subspecialty Certification - Gastroenterology October 18, 1977 Registration to practice medicine State of Ohio, certificate 31175 September 9, 1968 State of Vermont, certificate 4916 March 9, 1973 State of New Hampshire, certificate 5669 January 18,1979 State of Georgia, certificate 27501 June 10, 1985 Commonwealth of Mass., certificate 72873 June 20,1990 State of Connecticut, certificate 037512 February 12, 1999 SOCIETIES Alpha Omega Alpha Honorary Medical Society—elected in Junior year of Medical School American Association for the Study of Liver Diseases Member, Editorial Board of Hepatology, 1987-1990 Associate Editor of Hepatology, 1990--1997 Nominating Committee, 1982, 1995, 2004 Membership Committee, 1991-1993 Chair, 1993 Member, Program Evaluation Committee, 2002-2005 Member, Scientific Review Committee, 2003—2006 American College of Gastroenterology, Fellow Member, Research Committee, 2004--2006 American College of Physicians, Fellow American Federation for Clinical (Medical) Research American Gastroenterological Association American Liver Foundation Member, Medical Advisory Committee Member-Professional/Patient Education Committee American Medical Association, Lifetime Member American Porphyria Foundation Chairman, Professional Education Committee

American Society of Biological Chemistry and Molecular Biology American Society for Clinical Investigation (The ‘Young Turks’) Association of American Physicians (The ‘Old Turks’) European Association for the Study of the Liver Hemochromatosis Research Foundation

Member, Scientific Advisory Board Iron Disorders Institute Chair, Scientific Advisory Board International Association for the Study of Disorders of Iron Metabolism International Association for the Study of the Liver Massachusetts Medical Society

Connecticut Medical Society Hartford Medical Society


HONORS AND AWARDS Earlham Merit Scholar, 1959-1963 College Valedictorian Case Western Reserve Univ. School of Medicine Binz Memorial Scholar, , 1963--1967 Mosby Award for scholastic excellence Alpha Omega Alpha, 1966 (Junior Year) Borden Award for excellence in research as a medical student, 1967 "Golden Apple" (Teacher-of-the-Year) Runner-up, Department of Medicine, Dartmouth-Hitchcock Medical Center, 1976--1977 Elected to The American Society of Clinical Investigation, 1987 Member, Editorial Board of Hepatology, 1987-1990 Member, NIH General Medicine A-2 Initial Review Group (Study Section), 1990--1994 Associate Editor, Hepatology, 1990 -- 1997 Elected to Association of American Physicians, 1998 Selected by peers as one of the Best Doctors in America, 1995—present Listed in Who’s Who in the U.S.A., Who’s Who in Science and Technology, Who’s Who in the Northeast, 1990—present Gold Record of Achievement for 2001—American Biographical Institute Who’s Who in the World, 1998—present Selected as one of the 2000 Outstanding Scientists of the 20

th Century

International Biographical Centre (IBC), Cambridge, England, 2000 Selected as one of the 2000 Outstanding Intellectuals of the 21

st Century, IBC, 2001

Recipient of 21st Century Award for Achievement from the IBC, 2001

Nominated as an International Man of the Year for 2001, IBC, Cambridge, England Admitted to Medicine on Earth—Persons dedicated to Scientific Medicine, 2001 Finalist for The American Council for Graduate Medical Education’s Palmer “Courage to Teach” Award, 2001 Elected to America’s Registry of Outstanding Professionals, 2003 Member #54338 2

nd John W. Harris Visiting Professor of Medicine and Lecturer, Case Western Reserve Univ and Metro

Health, Cleveland, OH, 2004 Outstanding Alumnus of 2004, Earlham College, Richmond, IN Winner of Elsevier Research Initiative Award, 2006, from the AGA Foundation for Digestive Health and Nutrition, in recognition of commitment to scientific excellence VISITING PROFESSORSHIPS AND INVITED LECTURES Visiting Professor, Department of Medicine and Pharmacology, University of Zurich, Zurich, Switzerland, 1982-1983 Visiting Professor, University of Bern School of Medicine, Bern, Switzerland, 1982 Visiting Professor, Welsh National School of Medicine, Cardiff, Wales, 1983 Invited Lecturer, University of Paris, Hospital L. Mourier, 1983 Invited Lecturer, Medical Research Council Laboratories, Surrey, England, 1983 Invited Lecturer, King's College Hospital and Medical School, London, England, 1983 Invited Lecturer, Royal Free Hospital and Medical School, London, England, 1983 Visiting Professor, University of Alabama, Birmingham, Alabama, 1984 Visiting Professor, Emory University School of Medicine, Atlanta, GA, 1984 Visiting Professor, University of Vermont School of Medicine, Burlington, VT, 1984 Visiting Professor, University of Kentucky School of Medicine, Lexington, KY, 1985


Invited Lecturer, International Symposium on Mechanisms of Chemical-Induced Porphyrinopathies, Ryebrook, NY, 1986 Co-Chair and Lecturer, AGA Symposium on Iron-Storage Diseases, National Meeting of the AGA, Chicago, IL, 1987 Co-Chair and Speaker, Iron-Overload Diseases Association Symposium, Chicago, IL, 1987 Visiting Professor, University of Minnesota and Invited Lecturer, Core Liver Center of University of Minnesota, Minneapolis, MN, 1988 Visiting Professor of Medicine, St. Louis University School of Medicine, St. Louis, MO, 1989 Visiting Professor of Medicine, University of Connecticut School of Medicine, Farmington, CT, 1989 Invited Speaker, Combined meeting of the Tetrapyrrole Research Group of the United Kingdom and the International Porphyria Symposium, Glasgow, Scotland, 1989 Co-Chair and Speaker, Educational Update on Hemochromatosis, Gold Coast, Queensland, Australia, 1989 Invited Speaker, 2nd International Conference on Hemochromatosis, Gold Coast, Queensland, Australia, 1989 Invited Lecturer, IXth International Conference on the Proteins of Iron Metabolism, Brisbane, Queensland, Australia, 1989 Visiting Professor, Harvard University and Massachusetts General Hospital, Boston, MA, 1991 Visiting Professor, Boston University and University Hospital, Boston, MA, 1991 Caldwell Lecturer and Visiting Scientist, Earlham College, Richmond, IN, 1991 Chair and Speaker, 9th Annual Symposium on Hemochromatosis, Marlborough, MA, 1991 Invited Speaker and Session Chair, 3rd International Conference on Hemochromatosis, Duesseldorf, Germany, 1991 Invited Plenary Lecturer, 9th New England Membrane Enzyme Group Meeting, Center Harbor, NH, 1991 Visiting Professor, Brown University School of Medicine, Providence, RI, 1992 Visiting Professor, Mayo Clinic and Medical School, Rochester, MN, 1992 Invited Lecturer, Medical Center of Central Maine, Lewiston, ME, 1992 Invited Lecturer, St. Elizabeth’s Hospital, Boston, MA, 1992 Invited Lecturer, International Porphyrin and Porphyria Meeting, Gottingen University, Gottingen, Germany, 1992 Visiting Professor, Medical College of Virginia, Richmond, VA, 1992 Visiting Professor, Boston University School of Medicine and Boston City Hospital, Boston, MA, 1993 Invited Lecturer--Symposium on Transfusion Medicine, UMASS Medical Center, Worcester, MA, March 1993. Visiting Professor and Lecturer, Brown University, Division of Gastroenterology, Providence, Rhode Island, May, 1993. Meet-the-Professor Workshop Presentation, Annual Meeting of the AASLD, Chicago, IL, November, 1993. Invited Plenary Lecturer, Gordon Research Conference on Pyrroles, Wolfeboro, NH, 1994. Visiting Professor, Mass General Hospital, GI Unit, Boston, MA, 1994 Invited Plenary Lecturer, 8th Annual NUTMEG Conference (New England Membrane Enzyme Group), Woods Hole, MA, 1994. Invited Faculty, Early Morning Research Workshop on Metal Storage Disorders of the Liver, Annual Meeting of the AASLD, Chicago, IL, November, 1994. Chair, Scientific Program Committee and Session Chair, Fifth International Conference on Hemochromatosis and Disorders of Iron Metabolism, Boston, MA, April, 1995. Meet-the-Professor Workshop Presentation, Annual combined meeting of the AGA, AASLD, ASGE, SGS (DDW), San Diego, CA, May, 1995. Invited Session Chair and Plenary Lecturer, International Association for Study of the Liver, Biennial Meeting, Capetown, South Africa, February, 1996. Invited Plenary Lecturer, International Symposium on Chronic Viral Hepatitis, Kaoshiung, Taiwan, September, 1996. Visiting Professor of Medicine, Stanford University School of Medicine, Palo Alto, CA, September, 1996.


Tisdale Visiting Professor of Medicine, University of Vermont School of Medicine, Burlington, VT, February, 1997. Invited Session Chair, New England Consensus Conference on Chronic Hepatitis C, Stowe, VT, March, 1997. Invited Plenary Lecturer, NIH Consensus Conference on Chronic Hepatitis C, Bethesda, MD, March, 1997. Visiting Professor of Medicine (DDN), Yale University and St. Raphael Hospital, New Haven, CT, March, 1998. Invited Plenary Lecturer and Session Chair, NIH Conference on Hemochromatosis, Bethesda, MD, May, 1998. Invited Plenary Lecturer, 4

th Japanese International Symposium on Porphyrin and Heme Metabolism,

Yonago City, Japan, October, 1998. Visiting Professor of Medicine, Tokai University School of Medicine, Tokyo, Japan, October, 1998. Invited Faculty, Post-Graduate Course of the AASLD, Chicago, IL, November, 1998. Invited Plenary Lecturer, NIH Conference on Non-alcoholic Steatohepatitis, Bethesda, MD, December, 1998. Visiting Professor of Medicine, William F. Beaumont Hosptial, Detroit, MI, August, 1999. Visiting Professor of Medicine, West Roxbury VA Medical Center, Boston, MA, October, 1999. Visiting Professor of Medicine, Syracuse University, Syracuse, NY, December, 1999. Visiting Professor of Medicine, Carney Hospital/Tufts Univ., Boston, MA, March, 2000. Visiting Professor of Pharmacology & Toxicology, Tufts Univ, Boston, MA, June, 2000. Visiting Professor of Medicine, University of Bahia, Brazil, School of Medicine, Salvador, Brazil, August, 2000. Session Chair, 2

nd Annual Symposium on Contemporary Issues in Liver Transplantation, Univ. of

Massachusetts School of Medicine, Shrewsbury, MA, October, 2000. Invited Faculty, Post-Graduate Course and Annual Meeting of the AASLD, Dallas, TX, October, 2000. Plenary Lecturer, Nursing Symposium on Trends in Management of GI Disorders, Univ. of Massachusetts School of Medicine, Shrewsbury, MA, November, 2000. Visiting Professor and Grand Rounds Presenter, Heywood Hospital, Gardner, MA, March, 2001. Visiting Professor of Medicine (Gastroenterology and Hepatology), Tufts University—New England Medical Center, Boston, MA, March, 2001. Invited Lecturer, The Green Mountain Gut Club, Burlington, VT, March, 2001. Visiting Professor of Medicine, Univ of Calif, San Diego and San Diego VAMC, March, 2001. Invited Participant and Lecturer, NIH Workshop on Non-invasive Measures of Body Iron, Bethesda, MD, April, 2001. Visiting Professor of Medicine (Gastroenterology and Hepatology), Harvard Medical School and Brigham and Women’s Hospital, Boston, MA, May, 2001. First Koff Lecturer and Visiting Professor, Metrowest Medical Center, Framingham, MA, May, 2001. Visiting Professor and Lecturer, Post-Graduate Course of the Amer. Gastroent.. Assn., Atlanta, GA, May, 2001. Invited Plenary Lecturer and Session Chair, Bioiron, 2001 Intl. Conf., Cairns, Australia, August, 2001. Visiting Professor of Medicine (Gastroenterology and Hepatology), Univ. of CT School of Medicine, Farmington, CT, October, 2001. Visiting Professor of Medicine and Tisdale Lecturer, Univ. of VT School of Medicine, Burlington, VT, October, 2001 Visiting Professor of Medicine, Univ. of Kentucky College of Medicine, Lexington, KY, October, 2001 Visiting Professor Medicine, Medical Univ. of South Carolina, Charleston, SC, November, 2001 Plenary Lecturer, Liver Symposium, Univ. of Louisville, Louisville, KY, January, 2002 Plenary Lecturer and Session Chair, 2

nd Annual Chas. Trey Symposium, “Non-alcoholic Fatty Liver

Disease,” Boston, MA, April, 2002 Invited Lecturer and Session Chair, AASLD Single Topic Conference, “Co-Morbid Factors in Chronic Hepatitis C,” Chicago, IL, April, 2002 Invited Lecturer and Morning Workshop Leader, AASLD Annual Meeting, Boston, MA, Nov., 2002 Visiting Professor, Lahey Clinic, Burlington, MA, Dec., 2002 Visiting Professor, Univ of Missouri School of Medicine at Kansas City, Kansas City, MO, Feb., 2003


Scientific Advisory Board regarding Porphyria and its Management, New York City, NY, October, 2003 Invited Speaker, Annual Meeting of The Iron Disorders Institute, Bethesda, MD, May, 2004 John W. Harris Visiting Professor of Medicine, Case Western Reserve Univ. and Cleveland Metro Health Center, June, 2004 Visiting Professor of Medicine, New Britain General Hospital, New Britain, CT, Sep., 2004 Invited Morning Workshop Leader, AASLD Annual Meeting, Boston, MA, Oct-Nov, 2004 Visiting Professor of Medicine (GI), Yale Univ., New Haven, CT, Dec. 2004 Visiting Professor of Medicine (GI), Baystate Medical Center, Springfield, MA, Mar., 2005 Visiting Professor Medicine (GI), Dartmouth-Hitchcock Medical Center, Lebanon, NH, Mar., 2005 Invited Lecturer and Presenter, Bioiron 2005, Prague, Czech Republic, May, 2005 Invited Plenary Lecturer and Session Chair, AASLD Single Topic Conference, “Drug-Induced Liver Injury,” Atlanta, GA, Sep., 2005 Invited Guest Lecturer, 47

th Annual Meeting of The American Society of Hematology, Atlanta, GA,

Dec., 2005 Invited plenary lecturer, Annual Meeting of AASLD-FDA-NIH-PhRMA Hepatotoxicity Steering Group, North Bethesda, MD, Jan., 2006 Visiting Professor, Univ of Mass Medical School, April, 2006 Visiting Professor and Grand Rounds Speaker, Worcester Medical Center/St. Vincent Hospital, Worcester MA, April, 2006 Invited Plenary Lecturer, Mid-German Congress of Gastroenterology, Chemnitz, Germany, May, 2006 Invited Plenary Lecturer, Czech Society of Hepatology, Prague, Czech Republic, Sept., 2006 RECENT/ONGOING EDUCATIONAL ACTIVITIES Presenter at numerous Medical Grand Rounds, Combined Medical-Surgical GI Grand Rounds, GI

Conferences, Clinical Research Seminars, Journal Clubs and Biochemistry Seminars Lecturer in 1st Year (Medical School) Medical Biochemistry Lecturer in Graduate Intermediate Biochemistry Lecturer in 2nd Year (Medical School) Scientific Basis of Medicine and Clinical Methods Member of numerous Ph.D. and M.S. Committees Member of the Medical Scientist Training Program (M.D-Ph.D.) Advisory Council, Emory University Course Director for GI Pathophysiology and Pathology, U Mass Medical School, year 2 Regular lecturer for Biochemistry, U Mass Medical School, year 1 Invited lecturer for many national meetings of the AGA, the AASLD, and other Societies Invited plenary lecturer and session chair at several Gordon Research Conferences Member, Steering Committee of the MD/PhD Training Program of Univ of CT Lecturer and Group discussion mentor and facilitator, U Conn School of Medicine, years 01-04 TRAINEES Numerous fellows in digestive disease Numerous undergraduate and graduate students Steven I. Shedlofsky, M.D., VA Associate Investigator; now Professor of Medicine with tenure, University of Kentucky School of Medicine Richard W. Lambrecht, Ph.D., Post-doctoral Fellow; now Assistant Professor of Pharmacology,

University of Connecticut Heath Center Beth C. Lincoln, Ph.D., Post-doctoral Fellow and Research Associate Dirk P. Slaker, M.D., Clinical Research Fellow in Digestive Disease. Now a practicing gastroenterologist-hepatologist and Assistant Professor of Medicine, Emory Univ. School of Medicine Isao Okazaki, M.D., Visiting Post-Doctoral Research Fellow; now Professor and Chair of Community Medicine, University of Tokyo School of Medicine, Tokyo, Japan Toshiaki Yoshida, M.D., Visiting Post-Doctoral Research Fellow; now Assistant Professor of Medicine, Niigata University School of Medicine, Niigata, Japan


Yvonne Greene, M.D., M.S. Student, Emory University School of Medicine, Thesis research. Now a practicing internist Edward Cable, Ph.D. Student, Department of Biochemistry & Molecular Biology, Univ. of Massachusetts School of Medicine, Thesis research; now Research Scientist, Metabasis Therapeutics, San Diego, CA Kishore Srivastava, Ph.D., Research Associate; 1991-93; now Research Scientist, All India Inst. Of Research, Lucknow, India Shirley Russo, Ph.D., Research Associate; 1992-94; now Dean for Research, Quinsigamond Community College, Worcester, MA Tze-Hong Lu, Ph.D., Post-doctoral Research Fellow & Research Associate, 1994 – 1997, now Research Scientist, GIBCO, Inc., Buffalo, NY Otto Gildemeister, Ph.D., Research Associate, 1994-2002, now Reseach Instructor, U Mass Medical School Kimberly Gabis Elbirt, Ph.D., Dept of Biochemistry & Molecular Biology, University of Massachusetts School of Medicine, Thesis research, 1994 - 1998. Now, Assistant Professor, Assumption College, Paxton, MA Martin Hahn, M.D., Post-doctoral Research Fellow, 1995-96, now a practicing gastroenterologist-hepatologist, Beverly, MA Cong Zhao, M.D., Post-doctoral Research Fellow, 1996 – 1997, now a resident in Medicine, U Mass Memorial Mercedes Fernandez, Ph.D., Post-doctoral Research Fellow, 1997—2001, now Research Assistant Professor, Univ. of Barcelona and the Clinic Villaroel Liver Unit, Barcelona, Spain Sridevi Kolluri, Ph.D., student, Department of Biochemistry and Molecular Biology, University of Massachusetts School of Medicine, Thesis research, 1997 – 2004, now post-doctoral fellow, New York Medical College, Valhalla, NY Vamsee Alla, M.D., Fellow in Clinical Research and Advanced Hepatology, 2004—2005, Physician, Holyoke Hospital, Holyoke, MA Ying Shan, M.D., Post-doctoral Research Fellow, 1997 – 2001, now Research Assistant Professor of Medicine, Univ.of Connecticut School of Medicine Tahereh Ghaziani, M.D., Visiting Instructor, Univ of CT Health Center, 2003—2005, now Physician-in-training, Cambridge Hospital, Cambridge, MA Olena Lar, Ph.D., Post-doctoral Fellow, 2005, now post-doctoral fellow, Univ of VA School of Medicine, Charlottesville, VA Gennadiy Kovtunovych, Ph.D., Post-doctoral Fellow, 2005—2006, now post-doctoral fellow, NICHD, NIH, Bethesda, MD Jianyu Zheng, Ph.D., Instructor in Genetics and Developmental Biology and Medicine, 2006—present Weihong Hou, Ph.D., Postdoctoral Fellow in Basic Research, 2006—present Manish Thapar, M.D., Fellow in Clinical Research and Advanced Hepatology, 2006—present Vania Bonifaz, B.S., Graduate Student, candidate for M.S. degree, 2006--present RESEARCH INTERESTS Liver biochemistry and physiology Regulation of hepatic porphyrin and heme metabolism Porphyrias and hepatic hemoproteins Drugs and the liver Alcohol and the liver Toxic injury to the liver Iron and the liver Acute and chronic hepatitis Hemochromatosis- - clinical and experimental The kidney in liver disease Pathogenesis and management of immune-mediated liver disease and their complications: chronic active hepatitis, primary biliary cirrhosis, primary sclerosing cholangitis Metabolic bone disease complicating liver disease Management of liver failure, including liver transplantation


Viral hepatitis -- acute and chronic, pathogenesis and management


CURRENTLY ACTIVE FUNDING "Regulation of hepatic heme metabolism", (Competitive Renewal Approved, 15th Percentile) Grant # 2RO1-DK38825-20-24, from NIH (2005-2010). Amount requested first year = $427,198; amount requested all years = $2,360,479 (direct and indirect costs, all years). Role: Principal Investigator. “Longitudinal anti-viral therapy to prevent progression of chronic hepatitis C: The HALT-C Trial.” Contract # NO1-DK29236 from NIH (1999—2008). Amount to all centers = $12,800,000; amount to U Conn = $1,300,000 (approximate total award, all years). Role: PI for U Conn Health Center. “Research network for drug-induced liver disease.” Contract # 1UO1 DK065193 from NIH (NIDDK) (2003—2008). Total amount, all years = $1,503,312 (approximate total award, all years). Role: PI for U Conn Health Center and for northeastern consortium. Protocols for study of entecavir for therapy of chronic hepatitis B. PI or Co-PI for U Conn Health

Center, Bristol Myers Squibb, 2001—2008. Total amount all years = $100,000 (direct costs only). Role: PI at UCHC.

“The REPEAT Trial—retreatment of previous non-responders to pegylated interferon + ribavirin.”

Research contract with Hoffmann-LaRoche, 2004—2007. Total amount all years = $150,000. Role: PI at UCHC.

“Treatment of patients with chronic hepatitis C in methadone maintenance programs.” Research

contract with Hoffmann-LaRoche, 2004—2007. Total amount, all years = $165,000. Role: PI at UCHC.

“Phase 2a, randomized, dose-ranging study of safety and tolerability of consensus interferon-alpha

plus interferon-gamma-1b with or without ribavirin in patients with chronic hepatitis C who are non-responders to Peg-interferon plus ribavirin. Research contract with InterMune, Inc., 2004—2007. Total amount, all years = $160,000. Role: PI at UCHC.

“The METRO Trial: Phase 2 Trial of safety and efficacy of adding meremepodib to pegylated

interferon + ribavirin for previous non-responders to interferon + ribavirin alone.” Research contract with Vertex Pharmaceuticals, 2004—2007. Total amount, all years = $135,000. Role: PI at UCHC.

“Phase 3 international trial of sorafenib for patients with advanced hepatocellular carcinoma.” (PI), Bayer, Inc., 2005—2008. Total amount, all years = $180,000. Role: PI at UCHC. “Clinical research in nutrition and complementary and alternative medicine; development of bionutrition research core for the UCHC GCRC.” The Donaghue Foundation. 2005—2010. Total amount, all years = $500,000. Role: Principal author; co-I. “Association of heme oxygenase-1 polymorphisms and chronic hepatitis C.” The AGA Foundation for Digestive Health and Nutrition, 2006—2007. Total amount = $25,000. Role: PI. PROPOSALS PENDING FUNDING “Alcohol effects on expression and promoter methylation of cytoprotective genes.” RO3 Application

submitted to NIH (NIAAA) in response to RFA-AA-06-005, 2006—2008. Total amount = $275,000, direct costs. Role: PI.


RESEARCH PRESENTATIONS [see also presented Abstracts]

"Biochemical studies in fibroblasts from patients with acute intermittent porphyria". Presented at the annual Eastern Regional Meeting of the American Federation for Clinical Research, Boston, MA, January 11, 1974.

"Control of hepatic heme metabolism". Presented at a meeting honoring Dr. Gerald Klatskin on the occasion of his retirement, Yale University, New Haven, CT, June 2, 1978.

"Acute and long-term effects of iron-overload on hepatic heme metabolism" Presented at Gordon Research Conference on Pyrroles, Wolfeboro, NH, August 4-8, 1980.

"Hepatic heme synthesis in liver homogenates: kinetic studies and effects of iron". Presented at Gordon Research Conference on Pyrroles, Wolfeboro, NH, August 4-8, 1980.

"Lipid peroxidation is not involved in the effect of iron to synergistically increase levels of hepatic delta-aminolevulinic acid synthase." Presented at the Eastern Regional Meeting of the AFCR/ASCI/AAP, Boston, MA, October 8, 1982.

"Experimental porphyria from short chain alcohols: induction of 5-aminolevulinate synthase in cultured hepatocytes." Presented at the Annual National Meeting of the American Association for the Study of Liver Disease, Chicago, IL, November 10-11, 1984.

"Mechanism of iron-potentiation of hepatic uroporphyria: studies in cultured chick embryo liver cells." Presented at International Porphyria Symposium, Glasgow, Scotland, April 4-7, 1989.

"Relationships of hepatic iron and heme metabolism." Presented at 9th New England Membrane Enzyme Group Meeting, Center Harbor, N.H., Nov 10-12, 1991.

"Effect of interferon (IFN) therapy on bile duct inflammation in hepatitis C." Presented at the Annual Meeting of the American College of Pathology, November, 1994.

“Chronic hepatitis and porphyria cutanea tarda in the United States.” Presented at the biennial Gordon Research Conference on tetrapyrroles, Henniker, NH, July, 1996.

Other Options for Treatment of Hepatitis C”. Presented at the NIH Consensus Conference on Hepatitis C, Bethesda, MD, 23-25 March, 1997.

“Heme Oxygenase: Regulation and Role”. Presented at the Department of Pharmacology and Toxicology, Tufts University School of Medicine, Boston, MA, June, 2000 and at the University of Calif., San Diego and San Diego VA Medical Center, March, 2001.

“Iron and the Liver”, Presented at Yale University, the University of Kentucky, University of West Virginia, and other visiting professorships and invited lectures, 1999—present. “Drug-Induced Liver Injury and The DILI Network”, Presented at Baystate, Cornell-New York Hospital, Dartmouth, U Mass, Worcester, Yale, 2004--present


- BIBLIOGRAPHY - ABSTRACTS (* Indicates presented) *1. S.J. Guggenheim, H.L. Bonkovsky, L.T. Webster, Jr. and J.W. Harris: The preparation and

characterization of reticulocyte mitochondria. Clinical Research 14:317, 1966. *2. L. Shear, H.L. Bonkovsky and G.J. Gabuzda: Renal tubular acidosis in patients with cirrhosis: a

determinant of susceptibility to hepatic precoma. Journal of Laboratory and Clinical Medicine 72:1015-1016, 1968.

*3. H.L. Bonkovsky and D.P. Tschudy: Control of ALA-synthase, ALA-dehydrase, and tyrosine

aminotransferase in tumors and livers of tumor-bearing rats. Proceedings of the American Association for Cancer Research 18:8, 1971.

*4. H.L. Bonkovsky, D.P. Tschudy, E. Weinbach and P.S. Ebert: Biochemical studies in fibroblasts

from patients with acute intermittent porphyria. Clinical Research 21:961, 1971. *5. H.L. Bonkovsky and J.R. Bloomer: A sensitive radiochemical assay for ferrochelatase (FC).

Clinical Research 22:692A, 1974. *6. H.L. Bonkovsky, J.R. Bloomer, M.J. Mahoney and P.S. Ebert: Heme synthesis in

protoporphyria: studies in human liver and cultured skin fibroblasts. Abstract for 1st International Porphyrin Meeting, Freiburg, Germany, May 1-4, 1975.

*7. H.L. Bonkovsky, J.R. Bloomer, M.J. Mahoney and P.S. Ebert: Demonstration of deficient heme

synthetase activity in human protoporphyria. Clinical Research 23:261A, 2975. *8. J.R. Bloomer, H.L. Bonkovsky and G. Klatskin: The liver in protoporphyria. Gastroenterology

69:810, 1975. 9. W.G. Frey and H.L. Bonkovsky: Urine iron levels achieved with deferoxamine in a

“transfused anemic patient with iron overload. Clinical Research 23:581A, 1975. *10. H.L. Bonkovsky: Control of liver porphyrin and heme synthesis in human cirrhosis.

Gastroenterology 71:899, 1976. *11. W.H. Ramsay and H.L. Bonkovsky: Varying mechanisms of drug-induced liver injury. Program

of Northeast Regional Meeting of ACP, October 1-2, 1976, Hanover, N.H. *12. P.S. Ebert, H.L. Bonkovsky and A. Deisseroth: Differential control of heme synthesis by DMSO

and butyric acid in Friend erythroleukemia cells. Proceedings of the American Association for Cancer Research 18:136, 1977.

*13. H.L. Bonkovsky and S.S. Bottomley: Evaluation of kindreds with acute intermittent porphyria:

progress and problems. Clinical Research 25:322A, 1977. *14. H.L. Bonkovsky, G.H. Mudge and R.J. McMurtry: Chronic hepatic injury from prescribed doses

of acetaminophen. Clinical Research 25:660A, 1977. *15. H.L. Bonkovsky, G.H. Mudge and R.J. McMurtry: Chronic hepatitis caused by low-dose

acetaminophen. Clinical Research 26:287A, 1978. *16. H.L. Bonkovsky, S.J. Carpenter and J. Healey: Chronic iron overload: hepatic subcellular iron

distribution and alterations in hepatic hemoproteins. Clinical Research 26:316A, 1978.


*17. J.F. Sinclair, P.R. Sinclair, J.S. Pomeroy, W.J. Bement and H.L. Bonkovsky: Induction and

regulation of cytochrome P450 in cultured hepatocytes: effects of hormones, metallic ions and heme. Gastroenterology 75:987, 1978.

*18. H.L. Bonkovsky, G.H. Mudge and R.J. McMurtry: Chronic hepatic inflammation and fibrosis due

to low doses of paracetamol. Abstracted in Toxicology Abstracts, 3159-XI, IRL Pharmaceuticals Abstracts, November, 1978.

*19. F.M. Vincent, C.H. Sadowsky, H.L. Bonkovsky and J. Ochua: The neuropathy of acute

intermittent porphyria: ultrastructure. Abstracts for IVth International Congress on Neuro-Muscular Diseases, #495, Toronto, Canada, 1978.

*20. H.L. Bonkovsky, P.R. Sinclair, S. Emery and J.F. Sinclair: Seizure management in acute

porphyria: still a therapeutic dilemma. Clinical Research 27:228A, 1979. *21. P. Ebert, H.L. Bonkovsky, I. Wars and A. Deisseroth: Stimulation of hemoglobin synthesis in

murine erythroleukemia cells by low molecular weight ketones, ethers, aldehydes and alcohols. Proceedings of the American Association for Cancer Research 20:1979.

*22. H.L. Bonkovsky, J.S. Pomeroy: Assay of 5-aminolaevulinic acid synthetase in homogenates of

mouse, rat, and human liver: species differences in requirements for an exogenous succinyl-CoA-generating system. Abstract #3772-P8, IRL Amino-acid, peptide and protein abstracts, 1979.

*23. P.R. Sinclair, W.J. Bement, J.F. Sinclair, J. Pomeroy and H.L. Bonkovsky: Induction of phenol

red conjugation in chick embryo hepatocytes in culture. Abstract presented at XIth International Congress of Biochemistry, Toronto, Canada, July 8-13, 1979.

*24. H.L. Bonkovsky, J. Healey, P. Sinclair, J. Sinclair and R. Erny: Catabolism of hepatic cytochrome

P450 heme in rats given allylisopropylacetamide (AIA) and ferric citrate: AIA preferentially degrades new P450. Abstract presented at the 4th Symposium on Microsomes, Microsomal Drug Oxidations, and Chemical Carcinogenesis, Ann Arbor, Michigan, July 15-18, 1979.

*25. P. Sinclair, J. Sinclair, J. Bement, A. Farnham, J. Pomeroy and H. Bonkovsky: Coincident

induction of cytochrome P450 and phenol red conjugation in cultured chick embryo hepatocytes. Effects of cobaltous and manganous ions. Abstract presented at the 4th Symposium on Microsomes, Microsomal Drug Oxidations, and Chemical Carcinogenesis, Ann Arbor, Michigan, July 15-18, 1979.

26. P. Forssell, P. Anderson, H. Bonkovsky, R. Cimis, D. Howell and W. Ramsay: Intrahepatic

hematoma after liver biopsy with two different needles: a prospective randomized trial. Clinical Research 27:577A, 1979.

*27. H. Bonkovsky, J. Healey, J. Pomeroy, P. Sinclair and J. Sinclair: Hepatic siderosis decreases

cytochrome P450: a possible basis for toxic and carcinogenic effects of iron excess. Abstract for 4th Regional Cancer Research Symposium, Burlington, Vermont, September 17, 1979.

*28. P.R. Sinclair, W.J. Bement, J.F. Sinclair, J. Pomeroy and H.L. Bonkovsky: Induction of phenol

red conjugation in chick embryo hepatocytes in culture. Abstract for 4th Regional Cancer Research Symposium, Burlington, Vermont, September 17, 1979.

*29. J.F. Sinclair, P.R. Sinclair, W. Bement, A. Farnham, J. Pomeroy and H.L. Bonkovsky:

Reconstitution of cytochrome P450 by hemin in cultured chick embryo hepatocytes. Abstract for 4th Regional Cancer Research Symposium, Burlington, Vermont, September 17, 1979.


*30. M. Kreimer-Birnbaum, H.L. Bonkovsky and S.S. Bottomley: Experience with the red cell

uroporphyrinogen synthase (URO-S) assay. Studies in acute intermittent porphyria (AIP) kindreds. Submitted to 1st International Argentine Meeting on Porphyrins and Porphyrias, Buenos Aires, Argentina, October 29 - November 1, 1979.

*31. S.S. Bottomley, H.L. Bonkovsky and M. Kreimer-Birnbaum: Usefulness and limitations of the

erythrocyte uroporphyrinogen I synthase assay in the diagnosis of acute intermittent porphyria. Clinical Research 27:685A, 1979.

*32. H. Bonkovsky, P. Sinclair, J. Healey, Y. Myer and R. Erny: Kinetics of heme catabolism in rats

given allylisopropylacetamide and iron: a new model for hepatic heme metabolism. Gastroenterology 88:A5, 1979.

*33. P. Forssell, P. Anderson, H. Bonkovsky, R. Cimis, D. Howell and W. Ramsay: A prospective

randomized trial: intrahepatic hematoma with two different liver biopsy needles. Gastroenterology 77:A12, 1979.

*34. H.L. Bonkovsky, J.F. Sinclair, P.R. Sinclair, J. Pomeroy, J. Healey: Acute effects of iron-loading

on hepatic heme metabolism. Clinical Research 28:273A, 1980. *35. J. Sinclair, P. Sinclair, W. Bement, H. Bonkovsky, E.L. Smith: Induction by ethanol of

cytochrome P450 in cultured hepatocytes. Gastroenterology 79:1054, 1980. *36. P. Sinclair, H. Bonkovsky, J. Sinclair, J. Bement, J. Pomeroy: Effects of iron overload on hepatic

heme metabolism and cytochrome P450 in hepatocyte cultures. Gastroenterology 79:1054, 1980.

*37. J. Sinclair, P. Sinclair, W. Bement, H. Bonkovsky and E.L. Smith: Induction by ethanol of

cytochrome P450 in cultured hepatocytes. Paper presented at the 5th Regional Cancer Research Symposium, Burlington, Vermont, October 19, 1980.

*38. P. Sinclair, J. Bement, J. Sinclair, H. Bonkovsky: Induction of cytochrome P450 and P448 by

polybrominated biphenyls in cultured chick hepatocytes. Paper presented at the 5th Regional Cancer Research Symposium, Burlington, Vermont, October 19, 1980.

*39. J. Hines, J. Harris, H. Bonkovsky, J. Grasso, A. Goodman: Intravenous hematin in refractory

sideroblastic anemia (RSA). Clinical Research 28:769A, 1980. *40. I. Okazaki, C.E. Brinckerhoff, J.F. Sinclair, P.R. Sinclair, H.L. Bonkovsky, E.D. Harris, Jr.:

Different effects of iron and ethanol on collagenase production by fibroblasts. Paper presented October 16-18, 1980 at "Connective Tissue of the Normal and Fibrotic Human Liver - present state of biochemistry, clinical evaluation and treatment". Munster, FDR.

*41. P. Sinclair, J. Bement, J. Sinclair, H. Bonkovsky, S. Aust, and G. Dannon: Induction by PBB of

drug-metabolizing enzymes in chick embryo hepatocytes in culture. The Toxicologist 1:71, 1981. *42. P. Sinclair, J. Bement, J. Sinclair, H. Bonkovsky, S. Aust and G. Dannon: Porphyrinogenic

effects of PBB in chick embryo hepatocytes in culture. The Toxicologist 1:72, 1981. *43. H. Bonkovsky, J. Pomeroy, J. Healey P. Sinclair and J. Sinclair: Human hepatic iron overload,

cytochrome P450 and drug metabolism. Gastroenterology 80:1328, 1981.


*44. J. Healey, H. Bonkovsky, P. Sinclair, L. Smith and J. Sinclair: Formation of heme from delta-aminolevulinic by liver homogenates: a tool for elucidating the biochemical defects of hepatic porphyrias. Gastroenterology 80:1335, 1981.

*45. S. Shedlofsky, J. Healey, W. Bement, P. Sinclair, J. Sinclair, H. Bonkovsky: Lipid peroxidation

stimulated by iron in rat liver in hepatocyte cultures. Gastroenterology 809:1348, 1981. *46. H. Bonkovsky, P. Sinclair, J. Healey, S. Shedlofsky and J. Sinclair: How does iron-loading affect

hepatic heme synthesis? Hepatology 1:497, 1981. *47. J. Sinclair, P. Sinclair, J. Healey, H. Bonkovsky and E.L. Smith: Evidence for formation of

cytochrome P450 containing cobalt protoporphyrin (CoPp). Hepatology 1:547, 1981. *48. J. Sinclair, L. Smith, P. Sinclair, J. Bement and H. Bonkovsky: Increases in cytochrome P450

after treatment of hepatocytes with C3-C4 chain alcohols. Hepatology 1:547, 1981. *49. P. Sinclair, J. Bement, J. Sinclair and H. Bonkovsky: Relative affinities for heme of cytochrome

P450 species induced by polybrominated biphenyls (PBB's). Presented at 6th Regional Cancer Research Symposium, Burlington, Vermont, November 1-2, 1981.

*50. J.F. Sinclair, P.R. Sinclair, J.F. Healey, E.L. Smith and H.L. Bonkovsky: Decreases in hepatic

cytochrome P450 by cobalt: evidence for a role of cobalt protoporphyrin. Presented at 6th Regional Cancer Research Symposium, Burlington, Vermont, November 1-2, 1981.

*51. H. Bonkovsky, J. Sinclair, J. Healey, P. Sinclair and J. Pomeroy: Restoration of functional

hepatic cytochrome P450 by incubation with heme. Clinical Research 30:495A, 1982. *52. H. Bonkovsky, J. Sinclair, J. Healey, P. Sinclair and J. Pomeroy: Restoration of functional

hepatic cytochrome P450 by incubation with heme. Gastroenterology 82:1223, 1982. *53. H. Bonkovsky, P. Sinclair, J. Bement, J. Healey and J. Sinclair: Spurious increase in hepatic

cytochrome P450 due to uroporphyrin in porphyria cutanea tarda (PCT): a pitfall in the measurement of P450. VI International Congress of Liver Diseases, Basel, October 15-17, Abst. #27.

*54. H. Bonkovsky, J. Healey, P. Sinclair, G. Elder, J. Sinclair and S. Shedlofsky: Acute effects of

iron-loading on hepatic heme synthesis. the role of decreased activity of 5-aminolevulinate dehydrase. VI International Congress of Liver Diseases, Basel, October 15-17, 1982, Abst. #26.

*55. H. Bonkovsky, J. Sinclair, J. Healey and P. Sinclair: Restoration of functional hepatic

cytochrome P450 by incubation with heme. VI International Congress of Liver Diseases, Basel, October 15-17, 1982, Abst. #28.

*56. S.I. Shedlofsky, H.L. Bonkovsky, P.R. Sinclair, J.F. Sinclair, W.J. Bement, J.S. Pomeroy and

J.F. Healey: Lipid peroxidation is not involved in the effect of iron to synergistically increase levels of hepatic delta-aminolevulinic acid synthase (ALAS) induction. Hepatology 2:732, 1982.

*57. S.I. Shedlofsky, H.L. Bonkovsky, P.R. Sinclair, J.F. Sinclair, and W.J. Bement: Iron loading of

cultured hepatocytes accelerates heme breakdown and enhances delta-aminolevulinic acid synthase (ALAS) induction. Hepatology 2:732, 1982.

*58. H. Bonkovsky, P. Sinclair, J. Bement, J. Healey and J. Sinclair: Spurious increase in hepatic

cytochrome P450 due to uroporphyrin and porphyria cutanea tarda (PCT): a pitfall in the measurement of P450. Hepatology 2:732, 1982.


*59. S. Shedlofsky, P. Sinclair, J. Sinclair and H. Bonkovsky: Glutathione (GSH) is increased in cultured hepatocytes by drugs which induce cytochrome P450, but not P448. Gastroenterology 84:1306, 1983.

*60. B.R. Bacon, J.F. Healey, G.M. Brittenham, A.S. Tavill, and H.L. Bonkovsky: Dietary iron-

overload decreases rat hepatic 5-aminolevulinate dehydrase and cytochrome P450. Gastroenterology 84:1362, 1983.

*61. B.R. Bacon, J.F. Healey, G.M. Brittenham, A.S. Tavill, and H.L. Bonkovsky: Rat hepatic

microsomal lipid peroxidation and cytochrome P-450 levels at increasing liver non-heme iron concentrations. Clinical Research 31:720A, 1983.

*62. J. Sinclair, L. Zaitlin, L. Smith, P. Sinclair and H. Bonkovsky: Lack of inhibition of drug

metabolism by ethanol in cultured hepatocytes. The Toxicologist 4:8, 1984. *63. P.R. Sinclair, H.L. Bonkovsky, W.J. Bement, J.F. Sinclair, A.J. Urquhart and G.H. Elder:

Reversal of halogenated biphenyl inhibition of uroporphyrinogen decarboxylase in chick embryo hepatocyte cultures. Toxicologist 4:132, 1984.

*64. P. Sinclair, W. Bement, H. Bonkovsky, and J. Sinclair: Mechanism of porphyria caused by

halogenated biphenyls: Essential role of cytochrome P448. Clinical Research 32:491A, 1984. *65. H. Bonkovsky, J. Healey, and P. Sinclair: Incorporation of heme and cobalt protoporphyrin into

hepatic cytochrome P450. Clinical Research 32:545A, 1984. *66. H.L. Bonkovsky, H.P. Hauri, U. Marti, R. Gasser, and U.A. Meyer: Cytochrome P-450 of small

intestinal epithelial cells: immunochemical characterization and quantitation of the increase by phenobarbital. Clinical Research 32:548A, 1984.

*67. G.H. Elder, A.J. Urquhart, R.E. DeSalamanca, and H. Bonkovsky (intr. by R. Hall): The

pathogenesis of porphyria cutanea tarda. Submitted to Annual Meeting of Association of Physicians, U.K., 1984.

*68. B.R. Bacon, J.F. Healey, G.M. Brittenham, J. Numari, H.L. Bonkovsky, and A.S. Tavill: Hepatic

microsomal lipid peroxidation in rats with dietary iron overload alters microsomal function. Gastroenterology 68:1310, 1984.

*69. J. Sinclair, L. Zaitlin, L. Smith, P. Sinclair and H. Bonkovsky: Experimental porphyria from short

chain alcohols: induction of 5-aminolevulinate synthase in cultured hepatocytes. Hepatology 4:1060, 1984.

*70. P. Sinclair, J. Bement, R. Lambrecht, J. Frezza, H. Bonkovsky, and J. Sinclair: Hepatotoxicity of

polyhalogenated biphenyls: Relationship between development of porphyria and metabolism of biphenyls in chick embryo liver cells in culture. 8th Regional Cancer Research Symposium, Burlington, VT, November 4-5, 1984.

*71. J.R. Beck, H.L. Bonkovsky, R.A. Cimis, G.G. Cornwell III, D.S. Lawrence, and W.G. Frey: Non-

invasive tests for suspected hemochromatosis: Multivariate and decision analyses. Clinical Research 33:242A, 1985.

*72. H. Bonkovsky, J. Healey, P. Sinclair, and J. Sinclair: Porphyrin and heme synthesis by

homogenates of normal human liver. Gastroenterology 88:1652, 1985. 74. H. Bonkovsky, P. Blanchette, and A. Schned: Pharmacogenetic susceptibility to phenelzine-

induced liver injury with unique histopathology. Gastroenterology 88:1652, 1985.


*75. B.R. Bacon, J.F. Healey, G.M. Brittenham, C.H. Park, H.L. Bonkovsky, A.S. Tavill: Effects of

experimental dietary iron overload on hepatic microsomal function. Presented at 7th International Congress on Proteins of Iron Metabolism, Villeneuve d'Ascq. Fr., July, 1985.

*76. P. Sinclair, J. Bement, R. Lambrecht, H. Bonkovsky, and J. Sinclair: Induction of porphyria in

cultured chick embryo hepatocytes by halogenated aromatic compounds. Proc. of International Symposium on Hexachlorobenzene (HCB), Lyon, Fr., 24-28 June 1985.

*77. J. Sinclair, S. Howell, M. Sinclair, L. Zaitlin, P. Sinclair, H. Bonkovsky and F. Schwerin.

Acetaminophen toxicity in cultured hepatocytes induced for different forms of cytochrome P-450. The Toxicologist, 1985.

*78. J.R. Beck, E.K. Schultz, G.G. Cornwell III, W.G. Frey, R.A. Cimis, and H.L. Bonkovsky: Testing

strategies in the evaluation of suspected hemochromatosis: analytical and clinical approaches. Medical Decision Making 5: 1985.

*79. H.L. Bonkovsky, B. Lincoln, L.C. Ou, P.R. Sinclair, and U. Muller-Eberhard. Hepatic heme and

drug metabolism in an experimental model of chronic mountain sickness. Clinical Research, 34:, 1986.

*80. H.L. Bonkovsky, J.F. Healey, B.R. Bacon, R.J. Desnick and G.H. Elder: Hepatic experimental

hemochromatosis: studies in rats fed finely-divided elemental iron. Gastroenterology 90:1714, 1986.

*81. D. Wolf, M. Bernardino, H. Bonkovsky, and J. Galambos: Magnetic resonance imaging in

diseases of iron overload. Gastroenterology 90:1786, 1986. *82. B. Lincoln, J. Healey, P. Sinclair, J. Frezza, J. Sinclair, and H. Bonkovsky: Drug induction of

heme oxygenase and cytochrome P-450 in chick embryo hepatocytes. Fed. Proceed. 45:1643, 1986.

*83. P. Sinclair, J. Frezza, J. Sinclair, J. Bement, J. Healey, and H. Bonkovsky. Immunochemical

detection of induction of different isozymes of cytochrome P450 in chick hepatocyte cultures. Fed. Proceed. 45:1066, 1986.

*84. H.L. Bonkovsky, P.R. Sinclair, R.W. Lambrecht, and W.J. Bement. Role of cytochrome P-450 in

porphyria caused by halogenated aromatic compounds. Abstracts of N.Y. Acad. Science Symposium, Oct 27-29, 1986, Ryebrook, N.Y.

*85. H. Bonkovsky, D. Hartle, D. Simon, B. Mellen, M. Kutner, J. Galambos. Decreased plasma atrial

natriuretic peptides in cirrhotic ascitic patients. Hepatology 6:1213, 1986. *86. B.C. Lincoln and H.L. Bonkovsky. Pathway and regulation of heme breakdown by hepatocyte

cultures. Gastroenterology 92:1751, 1987. *87. S.I. Shedlofsky, P.R. Sinclair, J.F. Sinclair, H.L. Bonkovsky, J.F. Healey, B. Lincoln, A.T. Swim,

and J.M. Robinson. Cytochrome P450 inducers enhance the conversion of protoporphyrin to heme in cultured chick hepatocytes treated with exogenous 5-amino-levulinate (ALA). Gastroenterology 92:1774, 1987.

*88. D. Simon, H. Bonkovsky, D. Hartle, R. McCain, J. Wells, and J. Galambos. Atrial natriuretic

peptides (ANP) in cirrhosis: Effect of therapeutic paracentesis. Gastroenterology 92:1777, 1987.


*89. D. Slaker, E. Bills, B. Mellen, D. Wolf, M. Bernardino and H. Bonkovsky. The diagnosis of hemochromatosis: Is the liver biopsy passe? Gastroenterology 92:1778, 1987.

*90. D.C. Wolf, R.K. Chawla, H.L. Bonkovsky, and M.E. Bernardino. Induction of plasma choline

deficiency in patients with cirrhosis and correction with enteral choline supplementation. Gastroenterology 92:1792, 1987.

*91. B.C. Lincoln and H.L. Bonkovsky. Hepatic heme catabolism in cultured hepatocytes. Fed.

Proceed. 46:2264, 1987. *92. D.P. Jones, T.Y. Aw, B.C. Lincoln, and H.L. Bonkovsky. Oxygen concentration requirement for

mitochondrial function in rat hepatocytes decreases dramatically during 2 days in primary culture. The Physiologist 30:123, 1987.

*93. B.C. Lincoln, J.F. Healey, and H.L. Bonkovsky. Regulation of hepatic heme metabolism: heme

oxygenase is induced by at least two different mechanisms. Hepatology 7:1053, 1987. 94. K.K. Steinberg and H.L. Bonkovsky. Serum alkaline phosphatase isozymes in cirrhosis:

evidence for defective hepatic clearance. Hepatology 7:1100, 1987. 95. K.K. Steinberg and H.L. Bonkovsky. Metabolic bone disease in cirrhosis. Hepatology 7:1100,

1987. *96. B.C. Lincoln and H.L. Bonkovsky. Mechanisms of iron-stimulated hepatic uroporphyria: studies

in cultured hepatocytes. FASEB Jl 2:A764, 1988. *97. B.C. Lincoln and H.L. Bonkovsky. Mechanisms of iron-stimulated hepatic uroporphyria: studies

in cultured hepatocytes. Clinical Research 36:557A, 1988. *98. B.C. Lincoln, H.L. Bonkovsky and R.W. Lambrecht. Mechanism of iron-stimulated hepatic

uroporphyria: studies in cultured hepatocytes. Gastroenterology 94:A526, 1988. *99. D. Slaker, B. Mellen, D. Wolf and H. Bonkovsky. Evaluation of iron storage disease: usefulness

and limitations of laboratory and hepatic imaging studies. Hepatology 8:1241, 1988. *100. T. Yoshida, H. Bonkovsky, and A. Ansari, D. Danner: Characterization of mitochondrial

antibodies and antigens. Hepatology 8:1266, 1988. *101. D.P. Jones, T.M. Hagen, R. Weber, and G.T. Wierzbicka, H.L. Bonkovsky. Oral administration

of glutathione (GSH) increases plasma GSH in humans. FASEB Jl 3:A1250, 1989. *102. G. Hertzler, R. Pascal, W. Millikan, M. Henderson, M. Bernardino, and H. Bonkovsky. Biopsy

diagnosis of liver allograft dysfunction. Lab Invest 60:40A, 1989. 103. H.L. Bonkovsky, J.F. Healey, C-O. Evans, K. Brown, and K. Wilkinson. The hepatic heat shock

response: activation of ubiquitin-mediated pathways for cell protein break-down without induction of heme oxygenase in cultured liver cells. Gastroenterology 95:A578, 1989.

*104. R.K. Chawla, D.C. Wolf, M.H. Kutner, and H.L. Bonkovsky. Choline-a conditionally essential

nutrient in malnourished patients with cirrhosis. Gastroenterology 95:A583, 1989. *105.K. Steinberg, M. Hawkins, and H. Bonkovsky. Decreased hepatic clearance of glycoproteins: a

cause of increased serum alkaline phosphatase (AP) in cirrhosis. Hepatology 10:680, 1989.


*106. H. Bonkovsky, M. Hawkins, K. Steinberg, T. Hersh, J. Galambos, J. Henderson, and W. Millikan. Prevalence and prediction of osteopenia in chronic liver disease. Hepatology 10: 590, 1989.

*107. K. Steinberg, H. Bonkovsky, M. Hawkins, R. Bernhardt, and S. Jewell. Osteocalcin and bone

alkaline phosphatase in chronic liver disease. Clinical Chemistry 36:990-991, 1990. *108. H. Bonkovsky, D. Fiellin, G. Smith, D. Slaker, D. Simon, and J. Galambos. Treatment of

alcoholic hepatitis with parenteral nutrition and oxandrolone: A randomized controlled trial. I. Short-term effects on liver function. Hepatology 12: 870, 1990.

*109. H. Bonkovsky, I. Jafri, R. Singh, G. Cotsonis, and D. Slaker. Treatment of alcoholic hepatitis

with parenteral nutrition and oxandrolone: A randomized controlled trial. II. Effects on nitrogen metabolism. Hepatology 12: 978, 1990.

*110. J.M. Kinkade, Jr., I.B. Pinnix, S.G. Raju, G.S. Guzman, H.L. Bonkovsky, J.F. Healey, S.R. Zaki,

V.L. Castenada, and R.T. Parmley. Inhibition of heme biosynthesis interferes with the post-translational processing of myeloperoxidase in human leukemic HL-60 cells. J. Cell Biol. 111:456A, 1990.

*111. Y.J. Greene, J.F. Healey, and H.L. Bonkovsky. Preparation and characterization of antibodies to

chick liver heme oxygenase and their use in the detection and quantification of amounts of heme oxygenase protein. FASEB J. 5:A1542, 1991.

*112. E.E. Cable, J.F. Healey, and H.L. Bonkovsky. Relationships between the inductions of 5-

aminolevulinate synthase and heme oxygenase in chicken embryo liver cell cultures. FASEB J. 5:A1542, 1991.

*113. U. Muller-Eberhard, H.H. Liem, P. Sinclair, J.F. Sinclair, W.J. Bement, J.F. Healey, N. Gorman,

H.L. Bonkovsky, R. Reed, C.M.Burrington, Z.C. Chroneos, and S.R. Thorpe. The major serum heme-binding protein hemopexin prevents uptake of heme by hepatocytes and is catabolized diffusely throughout the body. Abstrascts of 15th Intl. Congress of Biochem. Jerusalem, Israel, Aug 4-8, 1991, p.195.

*114. R. Lambrecht, E.Cable, J. Cable, E. Clements, S. Donohue, Y. Greene, K. Srivastava, W.

Arnold, and H. Bonkovsky. Terpene-induced porphyria and the illness of Vincent van Gogh. FASEB J. 6:A207, 1992.

*115. S. Houff, P. Romain, I. Szymanski, and H. Bonkovsky: Hepatitis C: an important cause of

mixed cryoglobulinemia. Gastroenterology 102 (Part 2): A824, 1992. *116. H.L. Bonkovsky, E.E. Cable, J.W. Cable, S.E. Donohue, Y.J. Greene, and W.W. Arnold.

Porphyrogenic properties of terpenes and the illness of Vincent van Gogh. Gastroenterology 102 (Part 2):A784, 1992.

*117. A. Barton, H. Bonkovsky, and B.F. Banner. Pathologic features of liver biopsies pre and post

alpha interferon. Lab. Invest. 68: 107A, 1993. *118. K. Liu, H.L. Bonkovsky, and D.A. Herold. A case of acquired delta-ALA dehydratase deficiency.

Clin. Chem. 1993. *119. H.L. Bonkovsky, K. Srivastava, E. Cable, and S. Dononhue. Molecular basis for heme-

dependent induction of heme oxygenase in normal hepatocytes: Demonstration of acquired refractoriness to heme. Gastroenterology 104 (Part 2): A879, 1993.


*120. E.E. Cable, J.W. Cable, and H.L. Bonkovsky. Repression of hepatic 5-aminolevulinate synthase by heme and metalloporphyrins: Relationship to inhibition of heme oxygenase. Gastroenterology 104 (Part 2): A1031, 1993.

*121. H.L. Bonkovsky, J. Cable, E. Cable, R. Lambrecht, and J. Pepe. Regulation of heme and

cytochrome P-450 metabolism in enterocytes: Studies in CaCo-2 Cell Cultures. Gastroenterology 104 (Part 2): A237, 1993.

*122. S. Russo, J. Pepe, J. Cable, and H. Bonkovsky. Synergism of heme and zinc mesoporphyrin to

repress hepatic 5-aminolevulinate synthase: studies in a cell culture model of acute porphyria. Gastroenterology 104 (Part 2):A982, 1993.

*123. P. Romain, J. Levey, N. Whitman, B. Bjornsson, B. Banner, M. Kuhns, R. Malhotra, and H.

Bonkovsky. Clinical study of the role of hepatitis C viral (HCV) infection in type II mixed cryoglobulinemia (MC). Arthr & Rheumatism 36: S68, 1993.

*124. A. Barton, E. Cable, L. Smith, B. Banner, and H. Bonkovsky. Distribution of iron in the liver

predicts the response of chronic hepatitis C infection to interferon therapy. Hepatology 18: 150A, 1993.

*125. T.H. Pels Rijcken, R. Rubin, A. Davidoff, E.E. Cable, D.A. Davidson, H.L. Bonkovsky, and D.D.

Stark. Quantitative MR: technical aspects. Am. J. Roentgenol. 162: 168, 1994. *126. T.H. Pels Rijcken. R. Rubin. A. Davidoff, E.E. Cable, D.A. Davidson, H.L. Bonkovsky, and D.D.

Stark. Are liver biopsies necessary in the evaluation of iron overload? Am. J. Roentgenol., 162:109 1994.

127. A. Barton, B. Banner, E. Cable, L. Smith, and H. Bonkovsky. A detailed analysis of the Knodell

score and other histologic parameters as predictors of response to interferon therapy in chronic hepatitis C. Gastroenterology 106: (Suppl.) A864, 1994.

*128. E.E. Cable, J. A. Pepe, O.S. Gildemeister, R.W. Lambrecht, and H.L. Bonkovsky. Induction of

heme oxygenase by metalloporphyrins in primary chick embryo liver cells: evidence for a protein--but not a stress--dependent response. Hepatology 20: 179A, 1994.

*129. S.M. Russo, J.A. Pepe, S. Donohue, E.E. Cable, R.W. Lambrecht, and H.L. Bonkovsky. Tissue

distribution of zinc-mesoporphyrin in rats: relationship to inhibition of heme oxygenase. Hepatology 20: 180A, 1994.

*130. T.H. Lu, E.E. Cable, J. Pepe, R.W. Lambrecht, T. Dalton, G. Andrews, and H.L. Bonkovsky.

Regulation of hepatic metallothionein (MT) gene expression: Studies in transfected primary liver cell cultures. Hepatology 20: 227A, 1994.

*131. C. Allen, L. Smith, L. Savas, H. Bonkovsky, and B. Banner. Effect of interferon (IFN) therapy on

bile duct inflammation in hepatitis C. Lab Invest 72: 128A, 1995. *132. K.K. Gabis, O.A. Gildemeister, J.A. Pepe, R.W. Lambrecht, and H.L. Bonkovsky. Induction of

heme oxygenase-1 in LMH cells, a new model for characterization of heme metabolism. Proc of 7th Annual Boston Area Graduate Student Symposium, Boston College, 4 March 1995.

*133. K.V. Kowdley, E.L. Krawitt, T. Trainer, K. Susskind, and D. Pratt, T.A. Knox. M.M. Kaplan, R.

Rubin, J.R. Saltzman, H.L. Bonkovsky, and N.D. Grace. Hepatic iron in hereditary hemochromatosis (HHC): a multicenter United States study. Abstract for 5th Biennial Conference of the Intl. Association for Study of Disorders of Iron Metabolism, April 11-13, 1995, Boston, MA.


*134. R.B. Rubin, T.H. Pels-Rijcken, E.E. Cable, A. Davidoff, D.D. Stark, and H.L. Bonkovsky.

Exclusion of liver iron overload and prediction of liver iron concentrations by MRI study. Abstract for 5th Biennial Conference of the Intl. Association for Study of Disorders of Iron Metabolism, April 11-13, 1995, Boston, MA.

*135. T.H. Pels-Rijcken, R.B. Rubin, A. Davidoff, E.E. Cable, H.L. Bonkovsky, and D.D. Stark.

Optimal MRI sequences for estimation of hepatic iron concentrations. Abstract for 5th Biennial Conference of the Intl. Association for Study of Disorders of Iron Metabolism, April 11-13, 1995, Boston, MA.

*136. H.L. Bonkovsky. Relationships of iron and heme metabolism--an overview. Abstract for 5th

Biennial Conference of the Intl. Association for Study of Disorders of Iron Metabolism, April 11-13, 1995, Boston, MA.

*137. K.K. Gabis, O.S. Gildemeister, S. Donohue, J.A. Pepe, R.W. Lambrecht, and H.L. Bonkovsky.

LMH cells, a new model system for study of heme and iron metabolism. Abstract for 5th Biennial Conference of the Intl. Association for Study of Disorders of Iron Metabolism, April 11-13, 1995, Boston, MA.

*138. O.S. Gildemeister, J.A. Pepe, R.W. Lambrecht, and H.L. Bonkovsky. Induction of

metallothionein mRNA by iron in hepatocyte cultures. Abstract for 5th Biennial Conference of the Intl. Association for Study of Disorders of Iron Metabolism, April 11-13, 1995, Boston, MA.

*139. R.W.Lambrecht, O.S. Gildemeister, J.A. Pepe, and H.L. Bonkovsky. TMH-ferrocene rapidly

induces heme oxygenase mRNA. Abstract for 5th Biennial Conference of the Intl. Association for Study of Disorders of Iron Metabolism, April 11-13, 1995, Boston, MA.

*140. B.D. Clifford, L. Smith, C. Allan, and H.L.Bonkovsky. High dose interferon alfa-2b for

retreatment of patients with chronic HCV: a pilot study. Gastroenterology 108: A1050, 1995. *141. B.D. Clifford, L. Smith, C. Allan, and H.L. Bonkovsky. Levamisole and interferon alfa-2b as

combination therapy for chronic hepatitis C: results of a pilot study. Gastroenterology 108: A1051, 1995.

*142. T.H. Lu, J. Pepe, R.W. Lambrecht, RM Tyrrell, and H.L. Bonkovsky, Regulation of human heme

oxygenase-1 gene in transiently transfected primary cultures of chicken embryo liver cells. Hepatology 22:300A, 1995.

*143. R.W. Lambrecht, O.S. Gildemeister, J.A. Pepe, and H.L. Bonkovsky. Induction of heme

oxygenase-1 mRNA by TMH-ferrocene. Hepatology 22:444A, 1995. *144. O. S. Gildemeister, J.A. Pepe, R.W. Lambrecht, and H.L. Bonkovsky. Induction of

metallothionein mRNA by heme and iron in hepatocyte cultures. Hepatology 22: 301A, 1995.

*145. K.V. Kowdley, E.L. Krawitt, T. Trainer, K. Susskind, D. Pratt, T.A. Knox, M.M. Kaplan, R. Rubin,

J. R. Saltzman, H.L. Bonkovsky, and N. D. Grace. Hepatic iron in hereditary hemochromatosis (HHC): a multi-center United States study. Hepatology 22:371A, 1995.

*146. T.H. Lu, R.W. Lambrecht, and H.L. Bonkovsky. Cloning, characterization and expression of the

chicken heme oxygenase-1 gene. Mol. Biol. of Cell 6:303a, 1995. *147. C. Allan, L. Savas, G. Barnard, H. Bonkovsky, and B. Banner. Inflammatory markers in chronic

hepatitis C. Amer. J. Pathol, 9; 133A #176, 1996.


*148. R. B. Rubin, E.E. Cable, A. Davidoff, D.D. Stark, and H.L. Bonkovsky. Improved MR method for

non-invasive estimation of liver iron. Gastroenterology 110: A491, 1996. *149. F.B. Hollinger, M.J. Tong,K.R. Reddy, W.M.Lee, P.J. Pockros, J.C. Hoefs, E.Keeffe, J.L.

Heathcote, H. White, R.T. Frost, D.M. Jensen, E.L. Krawitt, H. Fromm, M. Black, M. Klein. J. Lubina, C. Manyak, L.M. Blatt and the Consensus Interferon Study Group. A Phase 3 study for the treatment of patients with chronic hepatitis C (HCV) infection with consensus interferon (CIFN). Rome Hepatitis Meeting, Rome, Italy, April, 1996.

*150. O.S. Gildemeister, J.A. Pepe, R.W. Lambrecht, and H.L. Bonkovsky. Evidence of protein

phosphatase activity involvement in the induction of heme oxygenase mRNA by heme in chicken embryo liver cells. Hepatology 24: 362A, 1996.

*151. Krauss, M. Hahn, O.S. Gildemeister, R. W. Lambrecht, J.A. Pepe, S. E. Donohue, and H.L.

Bonkovsky. Poprhyrinogenicity of new anticonvulsants in a liver cell culture model. Epilepsia 37: 204, 1996.

152. H. Bonkovsky, M.Poh-Fitzpatrick, C. Tattrie, A. Di Bisceglie, and the U.S. HCV/PCT Study

Group. Porphyria cutanea tarda and hepatitis C in the USA. Hepatology 24: 486A, 1996. 153. M. Hahn, O.S. Gildemeister, R.W. Lambrecht, J.A. Pepe, S.E. Donohue, G.L. Krauss, and H.L.

Bonkovsky. Porphyrogenicity of new anticonvulsants in a liver cell culture model. Hepatology 24: 519A, 1996.

*154. D.M. Jensen, L.M. Blatt, M.J. Tong, W.M. Lee, K. Mullen, J.C. Hoefs, E. Keeffe, F.B.

Hollinger, E.J.L Heathcote, H. White, R.T. Foust, E.L. Krawitt, H. Fromm, M. Black, D. Albert, T. Gerrard, and the Consensus Interferon Study Group. Treatment of high viral titer chronic HCV patients with consensus interferon (CIFN) results in a significantly greater number of sustained HCV RNA responders as compared to treatment with interferon α-2b. Hepatology 24: 275A, 1996

*155. E. Keeffe, L.M. Blatt, G. Dusheiko, M.J. Tong, F.B. Hollinger, S. James, K. Mullen, G. Everson,

N. Pimstone, E.J.L. Heathcote, J. Donovan, A. Conrad, P. Schmidt, D. Albert, T. Gerrard, and the Consensus Interferon Study Group. Differential response to treatment with consensus interferon (CIFN) and IFN α-2b in chronic HCV patients infected with different HCV serotypes. Hepatology 24: 275A, 1996

*156. P.J. Prockros, M.J. Tong, W.M. Lee, D.J. van Leeuwen, E. Keefe, K. Bala, P.G. Killenberg, R.T.

Foust, H.J. Rosenblate, K.M. Payne, H. Fromm, H.R. Lesesne, M. Black, R. Snyder, T. Gerrard, A Conrad, L.M. Blatt and the Consensus Interferon Study Group. Relationship between biochemical and virological response to type 1 interferon therapy of chronic HCV infection. Hepatology 24: 155A, 1996

*157. K.K. Gabis, H.L. Bonkovsky. Induction of hepatic heme oxygenase-1: role of map kinases.

Gastroenterology 112: A1268, 1997. *158. O.S. Gildemeister, J.A. Pepe, R.W. Lambrecht, and H.L. Bonkovsky. Involvement of protein

phosphatases in the induction of heme oxygenase mRNA by heme in cultured liver cells. Gastroenterology 112: A1271, 1997.

*159. T.H. Lu, J.A. Pepe, R.W. Lambrecht, and H.L. Bonkovsky. Molecular cloning, characterization,

and expression of the chicken heme oxygenase-1 gene in transfected liver primary cell cultures. Gastroenterology 112: A1325, 1997.


*160. JR Craig, VG Bain, M Ehrinpreis, R Foust, W Lee, CI Smith, DJ van Leeuwen and the NIH Consensus Interferon Study Group. Liver histology improves in both cirrhotic and non-cirrhotic patients with chronic HCV infection following consensus interferon (CIFN) therapy. Gastroenterology 112: A1248, 1997.

*161. D. Jensen, D. Shafritz, J.R. Craig, E. Krawitt, and the Consensus Interferon Study Group.

Nonresponders to CIFN show clinically relevent improvements in liver histology. Gastroenterology 112: A1294, 1997.

*162. W.M. Lee, K.R. Reddy, D.J. van Leeuwen, F.B. Hollinger, and the Consensus Interferon Study

Group. Undetectable HCV RNA concentrations at early time points predict sustained virological responses after treatment with consensus interferon (CIFN). Gastroenterology 112: A1317, 1997.

*163. P. Pockros, V. Bain, E. Hunter, A. Conrad, L.A. Balart, F.B. Hollinger, and the Consensus

Interferon Study Group. RT-PCR and bDNA assays for hepatitis C virus correlate at high but not low viral titers. Gastroenterology 112: A1360, 1997.

*164. J. Heathcote, E. Keeffe, S. Lee, S. Feinman, M. Tong, and the Consensus Interferon Study

Group. Retreatment of chronic HCV infection with a higher dose (15 µg) of consensus interferon (CIFN) produces sustained responses to nonresponders and relapsers. Gastroenterology 112: A1280, 1997.

*165. H.L. Bonkovsky, M. Poh-Fitzpatrick, N. Pimstone, J. Obando, A. Di Bisceglie, C. Tattrie. S.

Donohue, and M.G. Mercurio. Porphyria cutanea tarda and hepatitis C in the USA. Presented at International Meeting on Porphyrins and Porphyrias, Hamburg Germany, July 5-7, 1997.

*166. A.M. Di Bisceglie, H. Bonkovsky, E. Krawitt, N. Grace, P. Killenberg, C. Hunt, S. Chopra, R.K.

Reddy, S. Flamm, A.S. Tavill, R. Ferguson, C. Tamburro, P. Osmack, and B.R. Bacon. Iron reduction therapy in chronic hepatitis C. Hepatology 26: 214A, 1997.

*167. H.L. Bonkovsky, J.M. Woolley, and the CIFN Study Group. Health related quality of life in

patients with chronic hepatitis C. Hepatology 26: 187A, 1997. *168. H.L. Bonkovsky, J.M. Woolley, the CIFN Study Group. Sustained virologic response to

treatment with interferon improves health related quality of life in patients with chronic hepatitis C. Hepatology 26: 422A, 1997.

*169. G. Everson, J.R. Craig, D. Jensen, D.J. van Leeuwen, and the CIFN Study Group. Cirrhotic

patients demonstrate similar response pattern compared to noncirrhotic patients when treated with consensus interferon. Hepatology 26: 422A, 1997.

*170. Q. Jawaid, P. LeClair, K. Tortorelli, J. Cobb, R. Lambrecht, H. Bonkovsky. Non-alcoholic

steatohepatitis (NASH) and hereditary hemochromatosis (HHC). Gastroenterology 114: A1264, 1998.

*171. C. Smith, S. Hauser, H. Bonkovsky, W. Cassidy, D. Albert, and the CIFN Study Group.

Successful CIFN retreatment of patients with chronic hepatitis C results in rapid clearance of virus in both prior nonresponders and prior relapsers. Hepatology 27: 508A, 1998.

*172. M. Fernandez and H.L. Bonkovsky. Induction of heme oxygenase (HO) in hepatocytes and

splanchnic organs in portal hypertensive (PH) rats: expression of constitutive HO in hepatic stellate cells. Hepatology 28: 509A, 1998.


*173. A. Davidoff, G.A. Palacios, R.A. Williams, J. Colby, J. Kohlroser, and H.L. Bonkovsky. The use of percutaneous acetic acid injection for the treatment of hepatocellular carcinoma. Am. J. Radiology 209 (P):653 [Abstract 1024GI], 1998.

*174. Herbert L. Bonkovsky. Iron and NASH. Abstract presented at International Symposium on

Non-alcoholic Steatohepatitis, December 10—11, 1998, NIH, Bethesda, MD *175. Herbert L. Bonkovsky, J. Israel, Robert Fontana, N. Grace, R. Levine, P. LeClair, M. Thiim, G.

Fiarman, A. Tavill. Iron reduction prior to and during interferon therapy of chronic hepatitis C: initial results of a multicenter, randomized, controlled trial in previously untreated patients. Gastroenterology 116: A1191, 1999.

*176. James G. Kohlroser, Herbert L. Bonkovsky, John M. Levey. Dermatomyositis: an extrahepatic

manifestation of hepatitis C? American Journal of Gastroenterology xx: yyy, 1999. *177. H.L. Bonkovsky, D. Stefancyk, P. LeClair, G. Zucker, J. Israel, J. Stagias, P. Farkas, and J.

Colker. Low doses (600 mg/d) of ribavirin are superior to high doses (1000-1200 mg/d) with interferon for chronic hepatitis C: results of a controlled, randomized, multi-center trial. Hepatology 30: 265A, 1999.

*178. Ying Shan, Richard W. Lambrecht, Joyce A. Pepe, Herbert L. Bonkovsky. Induction of heme

oxygenase-1 reporter gene constructs by metalloporphyrins in cultured cells. Hepatology 30: 512A, 1999.

*179. B. Banner, J. Obando, P. LeClair, L. Savas, and H.L. Bonkovsky. Correlation of serum HCV

RNA levels with immunoreactive ubiquitin and other histologic features of cell injury in chronic hepatitis C. Modern Pathology 13: 180A, 2000.

*180. B. Banner, L. Savas, P. LeClair, Q. Jawaid, and H.L. Bonkovsky. Ubiquitin as a marker of cell

injury in non-alcoholic steatohepatitis (NASH). Modern Pathology 13:180A, 2000. *181. Adrian M. DiBisceglie, Herbert L. Bonkovsky, Jules L. Dienstag, Gregory T. Everson, Karen L.

Lindsay, David R. Gretch, John C. Hoefs, William M. Lee, Anna S.F. Lok, Tommie S. Tralka, Mitchell L. Shiffman, Elizabeth C. Wright. Design of the HALT-C trial (hepatitis C antiviral long-term treatment to prevent cirrhosis). Gastroenterology 118 (Suppl 2, Part 2): A1435, 2000.

*182. Jorge Obando, Kristina Tortorelli, Barbara Banner, Denise Stefancyk and Herbert Bonkovsky.

Iron, the major HFE gene mutation, and chronic hepatitis C. Gastroenterology 118: A953, 2000. *183. RW Lambrecht, K Tortorelli, HL Bonkovsky. Uroporphyrin accumulation in embryonic stem cells

containing a defective uroporphyrinogen decarboxylase (UROD) gene. FASEB J, 14 (No.8): A1390, abstract # 460, 2000.

*184. S. Kolluri, T.J. Sadlon, B.K. May, H.L. Bonkovsky. Effect of glucose on 5-aminolevulinic acid

synthase. FASEB J, 14 (No.8): A1444, abstract # 764, 2000. *185. M Fernandez, RW Lambrecht, HL Bonkovsky. Role of increased heme oxygenase activity on

splanchnic vascular hyporeactivity in portal hypertensive rats. FASEB J, 14 (No.8): A1390, abstract # 459, 2000.

*186. OS Gildemeister, JM Pepe, and HL Bonkovsky. Induction of heme oxygenase-1 by phenylarsine

oxide in primary liver cells. FASEB J 14 (No.8): A1390, abstract #461, 2000.


*187. AT Chemmanur, KT McNeal, RW Lambrecht, JA Ibdah, and HL Bonkovsky. Relationship between nonalcoholic steatohepatitis and heterozygosity for the LCHAD mutation (G1528C). Paper chosen for oral presentation, Mass Chapter, ACP/ASIM, Fall, 2000.

*188. S Zeuzem, M Manns, V Rustgi, S Aurora, C Smith, M Shiffman, R Reddy, R Reindollar, D

Slaker, R Rai, E Keeffe, and the International Interferon alfacon-1 Study Group. Daily interferon alfacon-1 (Infergen) therapy: interim results from an ongoing international clinical trial to compare daily interferon alfacon-1 therapy (9 mcg/48 weeks) to standard regimens of thrice weekly (TIW) interferon alfacon-1 (9 mcg) for treatment of chronic hepatitis C virus. J Hepatology 34 (Suppl. 1): 177, 2001. (Abstract 1489, presented as poster at 2001 EASL Meeting)

*189. HL Bonkovsky, KT McNeal, S Sharma, B Banner, Q Liu, J Obando, C-C Hsieh. Iron and HFE

mutations as comorbid factors for development and progression of chronic hepatitis C. Hepatology 34: 224A, 2001.

*190. H Bonkovsky, A Rolfs, J Kohlroser, K McNeal, A Sharma, U Berger, M Hediger. Intestinal

expression of genes involved in iron absorption in humans: effects of hemochromatosis and anemia. Hepatology 34: 207A, 2001.

*191. ML Shiffman for HALT-C Trial Investigators. Retreatment of interferon and interferon-ribavirin

non-responders with PEG interferon alpha-2a and ribavirin: initial results from the lead-in phase of the HALT-C trial. Hepatology 34: 43A, 2001.

*192. S Agrawal, J Daly, RC Koff, HL Bonkovsky, S Mehta. Treatment of hepatitis C with interferon

alpha-2b and ribavirin in decompensated cirrhotics listed for transplant—a retrospective study. Hepatology 34: 322A, 2001.

*193. A Rolfs, HL Bonkovsky, J Kohlroser, A Sharma, MA Hediger. Regulation of intestinal iron

transporters in hereditary hemochromatosis. Abstract presented at Meeting of International Union of Physiological Societies, New Zealand, August, 2001.

*194. Fontana RJ, Kronfol Z, Wright E, Lindsay K, Seeff L, Shiffman M, DiBisceglie A, Bonkovsky H,

Everson G, Lok ASF, Lee WM, Dienstag J, Morgan T, Morishima C, and Ghany M for the HALT-C Study Group. There is a high lifetime incidence of substance abuse but not mood disorders in hepatitis C non-responders with advanced fibrosis: results from the HALT-C trial. Gastroenterology 122: A646 [abstract #529], 2002.

*195. Chemmanur AT, McNeal KT, Lambrecht RW, Ibdah JA, Bonkovsky HL. Relationship between

nonalcoholic steatohepatitis and heterozygosity for the LCHAD mutation (G1528C). Abstracts of the American Association for the Study of Liver Diseases’ Single Topic Conference on Nonalcoholic Steatohepatitis, September, 2002, Atlanta, GA., p. 159.

*196. Shiffman M, HALT-C Investigators. Retreatment of HCV non-responders with PEG-interferon

and ribavirin: results from the lead-in phase of the hepatitis C antiviral long-term treatment against cirrhosis (HALT-C) trial. Hepatology 36 (4, Pt 2): 295A [Abstract 527], 2002.

*197. Lok AS, Everhart JE, Everson G, Wright EC, Sterling R, Ghany M, Goodman Z, HALT-C

Investigators. Clinical model to predict cirrhosis in patients in the hepatitis C antiviral long-term treatment against cirrhosis (HALT-C) trial. Hepatology 36 (4, Pt 2): 315A [Abstract 608] 2002.

*198. Shan Y, Bigelow C, Bonkovsky HL. Prevalence of liver disease in the U.S. population and

association with iron homeostasis: analysis of data from NHANES III. Hepatology 36 (4, Pt 2): 409A [Abstract 982], 2002.


*199. Chemmanur AT, Yang Zi, Zhao Y, Gilliam J, McNeal KT, Lambrecht RW, Outlaw WM, Bonkovsky HL, Ibdah JA. Relationship between nonalcoholic steatohepatitis and heterozygosity for the LCHAD mutation (G1528C). Gastroenterology 124: A748 [Abstract M1403], 2003.

*200. Kolluri S, Sadlon TJ, May BK, Bonkovsky HL. Mechanism of regulation of 5-aminolevulinate

synthase-1 gene by glucose and heme. Physiol. Res. 52: 13S; 2003. *201. Shan Y, Lambrecht RW, Bonkovsky HL. Identification of key elements that are responsible for

heme-mediated induction of the heme oxygenase-1 gene. Physiol. Res. 52: 23S; 2003. *202. Rothman AL, Morishima C, Ray R, Chang M, Bonkovsky HL, DiBisceglie A, Lee W, Lindsay KL,

Gretch DG, Sullivan DG, Polyak SJ, Wright E, Koziel MJ, on behalf of the HALT-C investigators. Host immune responses do not correlate with histologic injury: baseline analysis of the HALT-C Trial in advanced hepatitis C disease. Hepatology 38: 467A [Abstract 636], 2003.

*203. DiBisceglie A, Everhart J, Sterling R, Dienstag J, Bonkovsky H, Wright E, for the HALT-C

Investigators. Serum alpha-fetoprotein (AFP) levels in patients with advanced liver disease from hepatitis C without hepatocellular carcinoma: results from the HALT-C Trial. Hepatology 38: 434A [Abstract 567], 2003.

*204. Lok ASF, Everhart JE, Wright E, Chung R, Greenson JK, and the HALT-C Trial Investigators.

Hepatic steatosis in HALT-C patients is common and related to the metabolic syndrome. Hepatology 38: 427A [Abstract 574], 2003.

*205. Fontana RJ, Sanyal AJ, Wright E, and the HALT-C Trial Investigators. Portal hypertensive

gastropathy is prevalent amongst chronic hepatitis C non-responders with bridging fibrosis and early cirrhosis: results from the HALT-C Trial. Hepatology 38: 294A [Abstract 286], 2003.

*206. Sanyal AJ, Fontana RJ, Wright E, and the HALT-C Trial Investigators. Development of varices

preceding the development of cirrhosis: results from the lead-in phase of the HALT-C Trial. Hepatology 38: 218A [Abstract 129], 2003.

*207. Everson GT, Lauriski S, Kennedy C, DeSanto J, Kugelmas M, Shiffman ML, Hofmann C,

Sterling R, Wright EC, Morgan T, Hoefs J, Milne N, Rietkerk W, and the HLAT-C Trial Investigators. Quantitative tests (QLFTs) detect impaired hepatic function in a high proportion of patients with chronic hepatitis C who have fibrosis or compensated cirrhosis (HALT-C cohort). Hepatology 38: 304A [Abstract 309], 2003.

*208. Shan Y, Lambrecht RW, Bonkovsky HL. Identification of key elements that are responsible for

heme-mediated induction of the heme oxygenase-1 gene. Hepatology 38: 586A [Abstract 886], 2003.

*209. Kolluri S, Sadlon TJ, May BK, Bonkovsky HL. Mechanism of regulation of 5-aminolevulinate

synthase-1 gene by glucose and heme. Hepatology 38: 582A [Abstract 879], 2003. *210. Anna S. Lok, James E. Everhart, Raymond T. Chung, Latha Padmanabhan, Elizabeth

C. Wright, Mitchell L. Shiffman, Gregory T. Everson, Karen L. Lindsay, Herbert L. Bonkovsky, Adrian M. Di Bisceglie, William M. Lee, Timothy R. Morgan, Marc G. Ghany. Prevalence of insulin resistance (IR) in chronic hepatitis C (CHC) patients and its impact on treatment response. Hepatology 40: 314A [Abstract 350], 2004.

*211. Ying Shan, Richard W. Lambrecht, Tahereh Ghaziani, Susan E. Donohue, and Herbert

L. Bonkovsky. Role of Bach1 in regulation of heme oxygenase-1 in human liver: insights from studies with siRNAs. Hepatology 40: 527A [Abstract 835], 2004.


*212. Tahereh Ghaziani, Ying Shan, Richard W. Lambrecht, Thomas Pietschman, Ralf

Bartenschlager, Herbert L. Bonkovsky. Hepatitis C proteins increase expression of heme oxygenase-1 (HO-1) and decrease expression of Bach-1 in human hepatocytes. Hepatology 40: 453A [Abstract 667], 2004.

*213. Maria H. Sjogren, Robert Sjogren Jr., Michael F. Lyons, Michael Ryan, John Santoro,

Coleman Smith, K. Rajender Reddy, Herbert L. Bonkovsky, Brooke Huntley, Lani Ibarra,

Sima Faris-Young . Antiviral response of HCV genotype-1 to consensus interferon and ribavirin compared with pegylated interferon and ribavirin. A preliminary report. Hepatology 40: 396A [Abstract 535 ], 2004.

*214. Nadeem Anwar, Savant Mehta, Herbert Bonkovsky. Erythropoietic protoporphyria in

post-liver transplant setting—a case for indefinite hematin infusions. Amer J Gastroent [Abstract P67, presented at 69th Annual Meeting of Amer College of Gastroent], 2004.

*215. Ying Shan, Tahereh Ghaziani, Richard W. Lambrecht, and Herbert L. Bonkovsky. Expression of

hepatic heme oxygenase-1 in chronic hepatitis C Gastroenterology 128 (4, Suppl 2): A-752, 2005 [Abstr M1423].

*216. Richard K. Sterling, Anna S.F. Lok, Leonard B. Seeff, John C. Hoefs, Elizabeth C. Wright, and

the HALT-C Investigators. Clinical utility of alpha fetoprotein (AFP) L3 and des-gamma carboxy prothrombin (DCP) in patients (pts) with hepatitis C (HCV) and advanced fibrosis at risk for hepatocellular carcinoma (HCC): results from the lead-in phase of the HALT-C Trial. Gastroenterology 128 (4, Suppl 2): A-762, 2005 [Abstr M1670].

*217. Junaid Siddiqui, Dimple Raina, Joseph Abraham, Vamsee Alla, Naga P. Chalasani, George Y.

Wu, and Herbert L. Bonkovsky. Autoimmune hepatitis induced by statins. Gastroenterology 128 (4, Suppl 2): A-171, 2005 [Abstr S1043].

*218. Vinod K. Rustgi, Herbert L. Bonkovsky, Sanjeev Arora, Stefan P. Zeuzem, Michael Manns, and

Lawrence M. Blatt. Daily versus three-times-weekly IFN alfacon-1 in previously untreated HCV patients results in a significantly greater rate of SVR: final results of an international, phase 4 study. Gastroenterology 128 (4, Suppl 2): A-716, 2005 [Abstr S1541].

*219. Herbert L. Bonkovsky, Elizabeth C. Wright, Richard W. Lambrecht, Raymond T Chung, John C.

Hoefs, Russell Nash, Thomas Rogers, Barbara F. Banner, Jay Hoofnagle, Anna SF Lok, Karen Lindsay, Mitchell Shiffman, Gregory T. Everson, Adrian DiBisceglie, William Lee, Marc Ghany, and Chihiro Morishima. Iron and HFE gene mutations in advanced chronic hepatitis C (CHC): results from the lead-in phase of the HALT-C Trial. Hepatology 42: 548A, 2005 [Abstract 894].

*220. Chihiro Morishima, Timothy Morgan, David R. Gretch, Elizabeth C. Wright, James E. Everhart,

on behalf of the HALT-C Trial Investigators. Utility of TMA testing during antiviral treatment of advanced hepatitis C. Hepatology 42: 219A, 2005 [Abstract 58].

*221. Ying Shan, Richard W. Lambrecht, and Herbert L. Bonkovsky. Cobalt protoporphyrin up-

regulates heme oxygenase-1 expression via Bach-1 and nuclear factor erythroid 2-related factor 2 (Nrf2) in human hepatoma cells. Hepatology 42: 519A, 2005 [Abstract 825].

*222. Maria H. Sjogren, Robert Sjogren, Michael F. Lyons, Michael Ryan, John Santoro, Coleman

Smith, K. Rajender Reddy, Herbert Bonkovsky, Brooke Huntley, Lani Ibarra, Sima Faris-Young. Sustained virological response rates from a randomized trial of HCV genotype-1 patients treated with either consensus IFN and ribavirin or pegylated interferon alfa-2b and ribavirin. Hepatology 42: 529A, 2005 [Abstract 851].


*223. Norman Gitlin, Adrian DiBisceglie, Patrick Marcellin, Herbert Bonkovsky, Rudra Rai, Mario

Rizetto, Gerlinde Teuber, Donald Jensen. Peginterferon alfa-2a (40 kD) (Pegasys) plus ribavirin (RBV) (Copegus) in pegylated interferon alfa-2b (12kD)/ribavirin non-responders with cirrhosis/advanced fibrosis: interim analysis of the REPEAT study. Gastroenterology 130 (4, Supplement 2): A-838, 2006 [Abstract T1808].

*224. N. Chalasani, R. Fontana, P.B. Watkins, H.L. Bonkovsky, T. Davern, J. Serrano, J. Rochon,

Drug-Induced Liver Injury Network (DILIN). Drug-induced liver injury network (DILIN) prospective study: initial results. Amer J Gastroenterology: 101 (9, Suppl): S169, 2006 [Abstract 375].

*225. Ying Shan, Jianyu Zheng, Richard W. Lambrecht, Susan E. Donohue, Herbert L. Bonkovsky.

Reciprocal effects of the MicroRNA-122 on expression of HO-1 and HCV genes in human hepatocytes. Hepatology 44: xxxA, 2006 [Abstract yyy], in press.

*226. Ying Shan, Richard W. Lambrecht, Susan E. Donohue, and Herbert L. Bonkovsky. Milk thistle

plays a role in defense against oxidative stress and in regulating heme oxygenase-1 gene expression in hepatocytes. Hepatology 44: xxxA, 2006 [Abstract yyy], in press.

*227. Jianyu Zheng, Ying Shan, Susan E. Donohue, Richard W. Lambrecht, and Herbert L.

Bonkovsky. Regulation of 5-aminolevulinate synthase-1 (ALAS1) by metalloporphyrins in Huh7 human hepatoma cells. Hepatology 44: xxxA, 2006 [Abstract yyy], in press.

*228. David E. Kleiner, Naga Chalasani, Hari S. Conjeevaram, Herbert L. Bonkovsky, Mark Russo,

Timothy Davern, John G. McHutchison, and Leonard B. Seeff for the Drug-Induced Liver Injury Network (DILIN). Relationship of biochemical variables to histologic findings and the pathological pattern of injury among cases identified in the NIH DILIN Study. Gastroenterology 132: Axxx, 2007 [Abstract yyy], in press.

*229. Don Rockey, Leonard Seeff, Naga Chalasani, Maurizio Bonacini, Robert Fontana, Mark Russo,

James Freston, for the U.S. Drug-Induced Liver Injury Network (DILIN). Comparison of a structured causality assessment process using expert opinion to RUCAM for assignment of causality in drug-induced liver injury (DILI). Gastroenterology 132: Axxx, 2007 [Abstract yyy], in press.

*230. Gregory T. Everson, Clark Kulig, Mitchell L. Shiffman, Richard K. Sterling, John C. Hoefs,

Timothy R. Morgan, Teresa M. Curto, and the HALT-C Investigators. Hepatic metabolic function is altered in patients with chronic hepatitis C with obesity, insulin resistance, or hepatic steatosis, independent of cirrhosis: results from the HALT-C Trial. Hepatology 44: xxxA, 2006 [Abstract yyy], in press.

*231. Seeff LB, Curto TM, Szabo G, Everson GT, Bonkovsky HL, and the HALT-C Investigators.

Herbal and milk thistle use in the HALT-C Trial of advanced chronic hepatitis C. Gastroenterology 132: Axxx, 2007, [Abstract yyy], in press.

*232. Bonkovsky HL, Tice AD, Yapp RG, Bodenheimer HC, Monto A, Rossi SJ, and Sulkowski MS.

Efficacy and safety of peginterferon alfa-2a/ribavirin in methadone maintenance patients: randomized comparison of direct observed therapy and self administration. Gastroenterology 132: Axxx, 2007, [Abstract yyy], in press.

*233. Rossi L, Shan Y, Lambrecht RW, and Bonkovsky HL. Iron increases HCV and heme

oxygenase-1 (HO-1) expression in HCV-expressing human liver cells. Gastroenterology 132: Axxx, 2007, [Abstract yyy], in press.


*234. Hou W, Shan Y, Zheng J, Lambrecht RW, Donohue SE, and Bonkovsky HL. Zinc mesoporphyrin, a new anti-fibrosis agent, up-regulates the heme oxygenase-1 gene and down-regulates the transcriptional repressor Bach1 protein in NIH 3T3 cells. Gastroenterology 132: Axxx, 2007, [Abstract yyy], in press.

*235. Shan Y, Moschenross D, Lambrecht RW, and Bonkovsky HL. Antagomir of miR-122 down-

regulates hepatitis C virus infection and up-regulates heme oxygenase-1 expression in human hepatocytes. Gastroenterology 132: Axxx, 2007, [Abstract yyy], in press.

*236. Zheng J, Shan Y, Moschenross D, Lambrecht RW, and Bonkovsky HL. Post-transcriptional

regulation of human 5-aminolevulinate synthase 1 (ALAS1) gene expression by heme in Huh7 hepatoma cells. Gastroenterology 132: Axxx, 2007, [Abstract yyy], in press.

*237. M.S. Sulkowski

1; A.D. Tice

2; R.G. Yapp

3; H.C. Bodenheimer, Jr.

4; A. Monto

5; S.J. Rossi

6;

H.L. Bonkovsky. Depression and QoL in Direct Observed Therapy (DOT) as Compared with Self Administration (SA) of PegIFN-α2a in Chronic Hepatitis C (CHC) Patients on Methadone Maintenance. Abstract submitted to 2007 Annual Meeting of the College on Problems of Drug Dependence (CPDD).

*238. Andersson C, Peterson J, Anderson KE, Deybach J-C, Kauppinen R, Skadberg O,

Andersson DEH, Bonkovsky HL, Fogh J, Rejkjaer L. Prospective, randomized, double-blind trial of recombinant human porphobilinogen deaminase (rhPBGD) in acute attacks of porphyria. Abstract submitted to 2007 International Meeting of porphyrins and porphyrias, Rotterdam, Netherlands, April 1-6, 2007.

CV/Bibliography Herbert L. Bonkovsky Research Presentations

BRIEF REPORTS AND LETTERS

1. Herbert L. Bonkovsky and Donald P. Tschudy: Hazard of propranolol in treatment of acute porphyria. British Medical Journal 3:47, 1974.

2. H.L. Bonkovsky and Jane Brisbane: Colitis: a possible by-product of methyldopa use. Modern

Medicine, June 30, 1977, p. 62.

3. H.L. Bonkovsky: Carbamazepine in seizure management in acute intermittent porphyria. Neurology (NY) 31:232-233, 1981.

4. B. Ackerman and H.L. Bonkovsky: Ascorbic acid for urinary acidification. Archives of Internal

Medicine 141:1239, 1981.

5. H.L. Bonkovsky: Magnesium sulfate for AIP seizures. Neurology (NY) 31:1372, 1981.

6. H.L. Bonkovsky: Carbamazepine in seizure management in acute intermittent porphyria. Neurology (NY) 31:1579, 1981.

7. P. Sinclair, J.F. Healey, J. Sinclair, H.L. Bonkovsky: Induction of 5-aminolaevulinic acid

synthase in chick embryo liver by propylisopropylacetamide does not involve destruction of cytochrome P-450. Biochemical Journal 200:709-710, 1981.

8. E.D. Harris, Jr. and H.L. Bonkovsky: Iron in rheumatoid disease. Lancet 1:745-746, 1982.

9. H.L. Bonkovsky, S.I. Shedlofsky and P. Sinclair: Seizure management and hepatic porphyrias.

Neurology (NY) 32:1410, 1982.

10. Steven I. Shedlofsky and Herbert L. Bonkovsky: Seizure management in the hepatic porphyrias: results from a cell-culture model of porphyria. Neurology (NY) 34:399, 1984.

11. Bonkovsky, H.L., Mitchell, W.J. and Healey J.F.: Effect of hemochromatosis on hepatic

cytochrome P450 and antipyrine metabolism in man. Clinical Chemistry 30:1430-1431, 1984.

12. Herbert L. Bonkovsky and Steven I. Shedlofsky: Book review of "Pharmacological, Morphological and Physiological Aspects of Liver Aging", CFA van Bezooijen (ed.), in Gastroenterology 88:594-595, 1985.

13. Herbert L. Bonkovsky: Book review of "Cirrhosis and the Liver: Methods and Fields of

Research", N. Tygstrup and F. Orlandi (eds.), in Hepatology 8:980-981, 1988.

14. Herbert L. Bonkovsky: Atrial natriuretic peptide (ANP) in patients with hepatic cirrhosis. Amer. J. Gastroenterol. 84:981, 1989.

15. Herbert L. Bonkovsky Dirk P. Slaker, Elbridge B. Bills, and Douglas C. Wolf.: Usefulness and

limitations of laboratory and hepatic imaging studies in iron storage disease. Gastroenterology Digest 4:10-11, 1991.

16. Herbert L. Bonkovsky: Activation of the hepatocarcinogen aflatoxin B1 by forms of human

hepatic cytochromes P-450: some do and some don't. Hepatology 13: 1003-1005, 1991.

17. Herbert L. Bonkovsky: Evaluating bone loss in chronic liver disease. National Center for Research Resources Reporter 15 :7-9, 1991.


18. Herbert L. Bonkovsky: Practical advice on porphyria. Southern Medical Association Dial

Access Program, 1988, 1992.

19. Herbert L. Bonkovsky: Detection of alcoholism and problem drinking. Liver Update: Function and Disease 5: 1-3, 1992.

20. Dominic J. Nompleggi, Herbert L. Bonkovsky. Diet and chronic liver disease, an updated

research report. Progress in Liver Disease, 15: 4, 1994 (A publication of the American Liver Foundation).

21. John M. Levey, Paul L. Romain, Herbert L. Bonkovsky. Putting the freeze on hepatitis C virus-

associated mixed cryoglobulinemia. Hepatology 21: 594-597, 1995. (Contribution to “Hepatology Elsewhere”).

22. Herbert L. Bonkovsky. Treatment of chronic hepatitis C: predictors and results. In "Chronic

Hepatitis C" Edward L. Krawitt (ed.), Clinical Advances in Gastroenterology 6: No. 3, 1995. (Instructional audio tape and syllabus sponsored by American College of Gastroenterology), produced by Educational Reviews, Inc., Birmingham, AL.

23. Herbert L. Bonkovsky. Acetaminophen, hepatotoxicity, fasting, and alcohol. J. Amer. Med.

Association 274:301, 1995.

24. J. Levey, B. Banner, J. Darrah, H. Bonkovsky. Inflammatory cloacogenic polyp and solitary rectal ulcer syndrome resemble rectal adenocarcinoma. Response to Dr. Rodriguez-Leal et al. Amer. J. Gastroent. 90: 1363, 1995.

25. Herbert L. Bonkovsky, Otto S. Gildemeister, Joyce A. Pepe, Richard W. Lambrecht, and

Zbynek Hrkal. Haemopexin and uptake of haem by liver cells. Eur. J. Clin. Chem. Clin. Biochem. 34: 931- 932, 1996.

26. Bonkovsky HL, Rubin RB, Cable EE, et al. Hepatic iron concentration: noninvasive estimation

by means of MR imaging techniques. Radiology 1999; 212: 227—234. Featured and summarized in “What’s new in GI,” A. Matamoros, Jr., American Journal of Gastroenterology 94: 3108—3109, 1999.

27. Herbert L. Bonkovsky, Jaroslav Zivny, Kristina Tortorelli, Qin Liu, and Richard W. Lambrecht.

Non-alcoholic steatohepatitis with iron: part of insulin resistance-associated hepatic iron overload? Journal of Hepatology 33: 1025--1026, 2000.

28. Herbert L. Bonkovsky, Ashley Davidoff, and David D. Stark. Hepatic iron concentration and total

body iron stores in Thalassemia major. New England Journal of Medicine 343: 1656, 2000.

29. Herbert L. Bonkovsky, Jaroslav Zivny, Kristina Tortorelli, Qin Liu, and Richard W. Lambrecht. Non-alcoholic steatohepatitis with iron: part of insulin resistance-associated hepatic iron overload?---Reply. J. Hepatology 33: 1025—26, 2000.

30. Herbert L. Bonkovsky and Ajay Batra. Review of Atlas of the Liver, 2

nd Ed. (Maddrey, W.,

Feldman, M., Eds, Current Medicine, Inc., Singapore, 2000.) Gastroenterology 120: 1305—1306, 2001.

31. Morris P. Elevado and Herbert L. Bonkovsky. Hemochromatosis and Iron Overload—Scientific

Update, in Newsletter of New England Chapter of Amer. Liver Foundation, 2001.


32. Roderick Remoroza and Herbert Bonkovsky. Extrahepatic manifestations of chronic hepatitis C. Hepatitis Network Newsletter and website, San Francisco, CA, 2003.

33. Herbert L. Bonkovsky and Richard G. Stevens. Transferrin saturation, dietary iron intake, and

all cause mortality. Annals of Family Medicine, on-line comment, www.annfammed.org, Vol.2, No. 3, May/June 2004.

34. Herbert L. Bonkovsky and Jefrey Salek. No role of the -2518 promoter polymorphism of

monocyte chemotactic protein-1 in chronic hepatitis C. Gastroenterology 129: 361-362, 2005.

35. Karl E. Anderson, Herbert L. Bonkovsky, Joseph R. Bloomer, Steven I. Shedlofsky. Reconstitution of hematin for intravenous infusion. Ann Int Med 144: 537-538, 2006.

36. Herbert L. Bonkovsky and Adnan Javaid. Hepatotoxicity due to extracts of Chinese green tea

(Camellia sinensis): a growing concern. J Hepatology 45: 334-335, 2006.

37. Herbert L. Bonkovsky. Risk of green tea extracts. Letter to the editor, Hartford Courant, Hartford, CT, March 11, 2006, in response to feature article that had appeared in the March 4, 2006, issue of the Courant.

CV/Bibliography Herbert L. Bonkovsky (Books, Chapters)

BOOKS AND BOOK CHAPTERS

1. Herbert L. Bonkovsky: Ionic iron and mitochondria: some aspects of their interactions. Thesis submitted to the faculty of Western Reserve University, 1967, in partial fulfillment of the requirement of the M.D. degree.

2. Herbert L. Bonkovsky, Alan D. Kaplan, Harold C. Sox, Jr., Richard K. Tompkins and Carol H.

Sox: "Chronic Disease Algorithms", Dartmouth Medical School PROMIS Laboratory, Hanover, New Hampshire, 1974.

3. Herbert L. Bonkovsky: "Porphyrin and heme metabolism and the porphyrias", ch. 12, in D.

Zakim and T. Boyer (eds.), Hepatology: A Textbook of Liver Disease, Saunders, Philadelphia, 1982, pp. 351-393.

4. Herbert L. Bonkovsky: Alcohol and the Liver. Unit 2 of "Alcohol Use and Its Medical

Consequences", The Alcohol Slide/Teaching Library, Operation Cork, 1981.

5. Peter B. Anderson and Herbert L. Bonkovsky: Alcohol: The Alimentary Tract and Pancreas. Unit 4 of "Alcohol Use and Its Medical Consequences", The Alcohol Slide/Teaching Library, Operation Cork, 1982.

6. Herbert L. Bonkovsky: Director of Program Development and Editor of all 7 units of the series:

"Alcohol Use and Its Medical Consequences", The Alcohol Slide/Teaching Library, Operation Cork, 1982 and 1983.

7. Unit 1: Biochemistry, Pharmacology and Toxicology of the Alcohols 8. Unit 2: Alcohol and the Liver 9. Unit 3: Hematologic Complications of Alcohol Use 10. Unit 4: Alcohol: The Alimentary Tract and Pancreas 11. Unit 5: Alcohol: Pregnancy and the Fetal Alcohol Syndrome 12. Unit 6: Endocrine and Metabolic Effects of Alcohol 13. Unit 7: The Neurological Complications of Alcohol and Alcoholism

14. Herbert L. Bonkovsky: "The Porphyrias", in R.B. Conn (ed.), Current Diagnosis, Saunders,

Philadelphia, 1985, pp. 799-809.

15. Herbert L. Bonkovsky: "Granulomatous Hepatitis and Hepatic Granulomas", in J.W. Hurst (ed.), Medicine for the Practicing Physician, Second Edition, Butterworth's, London, 1988, pp. 1313-1316.

16. Herbert L. Bonkovsky: "Porphyrin and heme metabolism and the porphyrias", ch. 14, in D.

Zakim and T. Boyer (eds.), Hepatology: A Textbook of Liver Disease, Second Edition, Saunders, Philadelphia, 1990, pp. 378-424.

17. Herbert L. Bonkovsky: "Granulomatous hepatitis and hepatic granulomas", in J.W. Hurst (ed.),

Criteria for Diagnosis, Butterworth's, Boston, 1989, pp. 460-462.

18. Herbert L. Bonkovsky: "Granulomatous hepatitis and hepatic granulomas", in J.W. Hurst (ed.), Medicine for the Practicing Physician, Third Edition, Butterworth's, London, 1991, pp. 1446-1449.

19. Herbert L. Bonkovsky: "The Porphyrias", in R.B. Conn (ed.), Current Diagnosis, 8th Edition,

Saunders, Philadelphia, 1991, pp.799-804.

CV/Bibliography Herbert L. Bonkovsky (Books, Chapters, ctd.)

20. Herbert L. Bonkovsky: Detection of alcoholism and problem drinking. Liver Update: Function and Disease 5:1-3, 1992.

21. Anthony J. Windebank and Herbert L. Bonkovsky. ”Porphyric Neuropathy”, in P.J. Dyck, P.K.

Thomas, J.W.Griffin, P.A. Low, and J.F. Poduslo (eds), Peripheral Neuropathy, Third Edition, Saunders, Philadelphia, 1992, pp. 1161-1168.

22. Herbert L. Bonkovsky. “The Porphyrias”, in R.E. Rakel (ed) Conn’s Current Therapy, 1993,

Saunders, Philadelphia, 1993, pp.427-433.

23. Herbert L. Bonkovsky. “Hemochromatosis,” in T. Bayless (ed) Current Therapy in Gastroenterology and Liver Disease, 4th Edn., Mosby Yearbook Publ, Philadelphia, 1994, pp.580-585.

24. Martin Hahn and Herbert L. Bonkovsky. “Disorders of porphyrin metabolism.” in G. Wu and J.

Israel (eds.). Diseases of the Liver and Bile Ducts: a Practical Guide to Diagnosis and Treatment. Humana Press, Totowa, NJ, 1998, pp.249-272.

25. Herbert L. Bonkovsky and Graham F. Barnard. “The hepatic porphyrias.” In L. Brandt (ed.).

Clinical Practice of Gastroenterology. Current Medicine, Philadelphia, 1998, pp.947-960.

26. Herbert L. Bonkovsky. “Disorders of iron overload (hemochromatosis) and porphyria cutanea tarda.” In J. Bloomer, Z. Goodman, and K. Ishak (eds.) Syllabus of the 1998 Post-graduate Course of the AASLD, Armed Forces Inst of Pathology, Washington, D.C., 1998, pp. 303-329.

27. Herbert L. Bonkovsky and Richard W. Lambrecht. “Hemochromatosis, iron overload, and

porphyria cutanea tarda,.” Chapter 44, In J.C. Barton and C.Q. Edwards (eds.) Hemochromatosis—Genetics, pathophysiology, diagnosis, and treatment, Cambridge University Press, Cambridge, U.K., 2000, pp 453-467.

28. James H. Reichheld and Herbert L. Bonkovsky. “The porphyrias, alpha 1-antitrypsin deficiency,

cystic fibrosis, and other metabolic diseases of the liver.” In B.R. Bacon and A.M. Di Bisceglie (eds.). Liver Disease: Diagnosis and Management, 1

st Edition. Churchill Livingstone, New

York, NY, 2000, pp 165--190.

29. Herbert L. Bonkovsky. “The porphyrias.” In R.E. Rakel (ed.) Conn’s Current Therapy, 52nd

Edn (2000), W.B. Saunders, Philadelphia, 2000, pp. 447--453.

30. Herbert L. Bonkovsky. “Epidemiology of Hepatocellular Carcinoma—Who is at Increased

Risk?” In. R.S. Chari and W.C. Meyers (eds.) Liver Tumor Disease Section of YourDoctor.com, by doctors for patients, YourDoctor, Inc., Sausalito, CA, 2001.

31. Herbert L. Bonkovsky. “Screening for Hepatocellular Carcinoma—Why? How? Who? When?”

In. R.S. Chari and W.C. Meyers (eds.) Liver Tumor Disease Section of YourDoctor.com, by doctors for patients, YourDoctor, Inc., Sausalito, CA, 2001.

32. Herbert L. Bonkovsky and Kimberly K. Elbirt. “Chapter 41--Heme oxygenase: its regulation and

role.” In R.G. Cutler and H. Rodriguez (eds.) Oxidative Stress and Aging: Advances in Basic Science, Diagnostics, and Intervention, World Scientific Publ., River Edge, N.J., 2002, pp. 699-706.

33. Ajay Batra, Richard W. Lambrecht, Herbert L. Bonkovsky. “Drugs and chronic viral hepatitis.”

In R.S. Koff and G. Wu (eds.) Chronic Viral Hepatitis, Humana Press, Totowa, N.J., 2002, pp. 251-271.

CV/Bibliography Herbert L. Bonkovsky (Books, Chapters, ctd.)

34. Herbert L. Bonkovsky. Hepatic manifestations of systemic disease. Editor’s preface to a volume of Clinics in Liver Disease of the same name. Clinics in Liver Disease 6: 1-2, 2002.

35. Morris Elevado and Herbert L. Bonkovsky. “Hemochromatosis” In R.E.Rakel and E.T.Bope

(eds.) Conn’s Current Therapy, 2003, Saunders, Philadelphia, 2003, pp. 454-459.

36. Richard W. Lambrecht, Mercedes Fernandez, Ying Shan, and Herbert L. Bonkovsky. “Heme oxygenase and carbon monoxide in cirrhosis and portal hypertension.” In P. Gines, V. Arroyo, J. Rodes and R.W. Schrier (Eds), Ascites and Renal Dysfunction in Liver Disease, Pathogenesis, Diagnosis & Treatment, Second Edition. Blackwell Publishing, London,. 2005, pp.125--136.

37. Herbert L. Bonkovsky and James H. Reichheld. “The porphyrias, alpha-1 antitrypsin deficiency,

cystic fibrosis, and other metabolic disorders of the liver.” In Bruce R. Bacon, John G. O’Grady, Adrian M. Di Bisceglie, and John R. Lake (Eds), Comprehensive Clinical Hepatology, 2

nd

Edition. Elsevier-Mosby Publishing, London, UK, 2006, pp.369—396. 38. Herbert L. Bonkovsky, Steven I. Shedlofsky, Dean P. Jones, and Douglas LaBrecque.

“Chapter 26--Drug-induced liver injury.” In Thomas D. Boyer, Michael P. Manns, and Teresa L. Wright (Eds), Zakim and Boyer’s Hepatology—a Textbook of Liver Disease, 5

th Edition,

Saunders-Elsevier, Philadelphia, 2006, pp. 503-550.

CV/Bibliography Herbert L. Bonkovsky (Full Papers)

FULL PAPERS

1. S.J. Guggenheim, H.L. Bonkovsky, L.T. Webster, Jr. and J.W. Harris: The preparation and characterization of mitochondria from developing red blood cells. J. Lab. Clin. Med. 69:357-369, 1967.

2. Leroy Shear, Herbert L. Bonkovsky and George J. Gabuzda: Renal tubular acidosis in patients

with cirrhosis: a determinant of susceptibility to recurrent hepatic pre-coma. New Eng. J. Med. 280:1-7, 1969.

3. Joseph R. Bloomer, Paul D. Berk, Herbert L. Bonkovsky, Jeffrey A. Stein, Nathaniel I. Berlin

and Donald P. Tschudy: Blood volume and bilirubin production in acute intermittent porphyria. New Eng. J. Med. 284:17-20, 1971.

4. H.L. Bonkovsky, D.P. Tschudy, A. Collins, J. Doherty, I. Bossenmaier, R. Cardinal and C.J.

Watson: Repression of the overproduction of porphyrin precursors in acute intermittentporphyria by intravenous infusions of hematin. Proc. Natl. Acad. Sci. U.S.A. 62:2725-2729, 1971.

5. Donald P. Tschudy and Herbert L. Bonkovsky: Experimental porphyria. Federation Proceedings

31:147-159, 1972.

6. Herbert L. Bonkovsky, Donald P. Tschudy, Annie Collins and Joyce M. Doherty: Control of delta-aminolaevulinic acid synthetase and tyrosine aminotransferase in tumors and livers of tumor-bearing rats. J. Natl. Cancer Inst. 50:1215-1225, 1972.

7. Herbert L. Bonkovsky, Annie Collins, Joyce M. Doherty and Donald P. Tschudy: The glucose

effect in rat liver: studies of delta-aminolaevulinate synthase and tyrosine aminotransferase. Biochim. Biophys. Acta 320:561-576, 1973.

8. Donald P. Tschudy and Herbert L. Bonkovsky: A steady-state model of sequential irreversible

enzyme reactions. Molec. Cell. Biochem. 2:55-62, 1973.

9. Chull S. Song, Herbert L. Bonkovsky and Donald P. Tschudy: Salicylamide metabolism in acute intermittent porphyria. Clin. Pharmacol. Therap. 15:431-435, 1974.

10. Herbert L. Bonkovsky, Donald P. Tschudy, Eugene C. Weinbach, Paul S. Ebert and Joyce M.

Doherty: Porphyrin synthesis and mitochondrial respiration in acute intermittent porphyria: studies using cultured human fibroblasts. J. Lab. Clin. Med. 85:93-102, 1975.

11. Herbert L. Bonkovsky, Richard V. Lee and Gerald Klatskin: Acute granulomatous hepatitis.

Occurrence in cytomegalovirus mononucleosis. J. Amer. Med. Assocn. 233:1284-1288, 1975.

12. Herbert L. Bonkovsky, Joseph R. Bloomer, Paul S. Ebert and Maurice J. Mahoney: Heme synthetase deficiency in protoporphyria. Demonstration of the defect in liver and cultured skin fibroblasts. J. Clin. Invest. 56:1139-1148, 1975.

13. Herbert L. Bonkovsky, C. Richard Magnussen, Anne R. Collins, Joyce M. Doherty, Richard A.

Hess and Donald P. Tschudy: Comparative effects of glycerol and dextrose on porphyrin precursor excretion in acute intermittent porphyria. Metabolism 25:405-414, 1976.

14. Joseph R. Bloomer, Herbert L. Bonkovsky, Paul S. Ebert and Maurice J. Mahoney: Inheritance

in protoporphyria. Comparison of heme synthetase activity in skin fibroblasts and clinical features. Lancet 2:226-228, 1976.

CV/Bibliography Herbert L. Bonkovsky (Full Papers, ctd.)

15. Herbert L. Bonkovsky and Jane Brisbane: Colitis and hepatitis caused by methyldopa. J.

Amer. Med. Assocn. 236:1602-1603, 1976.

16. Herbert L. Bonkovsky and Joanne S. Pomeroy: Human hepatic delta-aminolaevulinate synthase: requirements of an exogenous system for succinylcoenzyme A generation to demonstrate increased activity in cirrhotic and anticonvulsant-treated subjects. Clin. Sci. Molec. Med. 52:509-521, 1977.

17. Herbert L. Bonkovsky, Gilbert H. Mudge and Randolph J. McMurtry: Chronic hepatic

inflammation and fibrosis due to low doses of paracetamol. Lancet 1:1016-1018, 1978.

18. Herbert L. Bonkovsky, William J. Bement and Raymond Erny: A rapid simple method of obtaining radiochemically pure hepatic heme. Biochim. Biophys. Acta 541:119-123, 1978.

19. Judith Spross and Herbert L. Bonkovsky: Coping with a seductive patient: unique needs of a

patient with acute intermittent porphyria. Nursing 78: July, 1978, pp. 41-45.

20. Herbert L. Bonkovsky and Joanne S. Pomeroy: Assay of delta-aminolevulinic acid synthetase in milligram amounts of mouse, rat, and human liver: species differences in requirement for an exogenous succinyl-CoA generating system. Analyt. Biochem. 91:82-91, 1978.

21. Herbert L. Bonkovsky, Stanley J. Carpenter and John F. Healey: Iron and the Liver: Subcellular

distribution of iron and decreased microsomal cytochrome P450 in livers of iron-loaded rats. Arch. Pathol. Lab. Med. 103:21-29, 1979.

22. J.F. Sinclair, P.R. Sinclair and H.L. Bonkovsky: Hormonal requirements for the induction of

cytochrome P450 in hepatocytes cultured in a serum-free medium. Biochem. Biophys. Res. Commun. 86:710-717, 1979.

23. Herbert L. Bonkovsky, Peter R. Sinclair, Jacqueline F. Sinclair: Hepatic heme metabolism and

its control. Yale J. Biol. Med. 52:13-37, 1979.

24. Paul S. Ebert, Herbert L. Bonkovsky and Albert Deisseroth: Evidence for multiple sites of regulation of heme synthesis in murine erythroleukemia cells. J. Natl. Cancer Inst. 62:1247-1250, 1979.

25. Thomas P. Almy and Herbert L. Bonkovsky: Progress and prospects in digestive diseases.

Drug Therapy (Hosp.), February, 1980, pp. 57-76.

26. J.U. Brisbane, D.A. Howell and H.L. Bonkovsky: Pulmonary hypertension as a presentation of hepatocarcinoma. Amer. J. Med. 68:466-469, 1980.

27. H. Bonkovsky, P. Sinclair, J. Healey, J. Sinclair: Kinetics of hepatic heme turnover in rats given

allylisopropylacetamide: a new model for liver heme catabolism, in Microsomes, Drug Oxidations, and Chemical Carcinogenesis, Vol. I (Coon, M.J., Coinney, A.H., Estabrook, R.W., Gelboin, H.V., Gillette, J.R., O'Brien, P.J., eds). Academic Press, New York, NY, 1980, pp. 571-574.

28. P. Sinclair, J. Sinclair, J. Bement, A. Farnham, J. Pomeroy and H. Bonkovsky: Coincident

induction of cytochromes P450 and phenol red conjugation in cultured chick embryo hepatocytes; effects of cobaltous and manganous ions, in Microsomes, Drug Oxidations, and Chemical Carcinogenesis, Vol. I (Coon, M.J., Conney, A.H., Estabrook, R.W., Gelboin, H.V., Gillette, J.R., O'Brien, P.J., eds). Academic Press, New York, NY, 1980, pp. 893-896.


29. Herbert L. Bonkovsky, Peter R. Sinclair, Scott Emery and Jacqueline F. Sinclair: Seizure management in acute porphyria: risks of valproate and clonazepam. Neurology 30: 588-592, 1980.

30. Herbert L. Bonkovsky, John F. Healey, Peter R. Sinclair, Yash P. Myer and Raymond Erny:

Hepatic haem and "green pigments" metabolism in rats given 2-allyl-2-isopropylacetamide and ferric citrate: a new model for hepatic haem turnover. Biochem. J. 188: 289-295, 1980.

31. L.C. Ou, J. Healey, H.L. Bonkovsky and P.R. Sinclair: Hepatic cytochrome P450 in chronically

hypoxemic rats. Biochem. Biophys. Res. Commun. 96: 1128-1134, 1980.

32. M. Kreimer-Birnbaum, H.L. Bonkovsky and S.S. Bottomley: Experience with the red cell uroporphyrinogen synthase (URO-S) assay in kindreds with acute intermittent porphyria. Intl. J. Biochem. 12: 807-810, 1980.

33. Okazaki, C.E. Brinckerhoff, J.F. Sinclair, P.R. Sinclair, H.L. Bonkovsky and E.D. Harris, Jr.:

Iron increases collagenase production by rabbit synovial fibroblasts. J. Lab. Clin. Med. 97: 396-402, 1981.

34. H.L. Bonkovsky, J.F. Healey, P.R. Sinclair, J.F. Sinclair and J.S. Pomeroy: Iron and the liver II.

Acute and long-term effects of iron loading on hepatic haem metabolism. Biochem. J. 196: 57-64, 1981.

35. P.S. Ebert, H.L. Bonkovsky and I. Wars: Stimulation of hemoglobin synthesis in murine

erythroleukemia cells by low molecular weight ketones, aldehydes, acids, alcohols and ethers. Chemico-Biological Interactions 36: 61-69, 1981.

36. P.L. Forssell, H.L. Bonkovsky, P.B. Anderson and D.A. Howell: Intrahepatic hematoma after

aspiration liver biopsy: a prospective randomized trial using two different needles. Dig. Dis. Sci. 26: 631-635, 1981.

37. J.F. Sinclair, J.F. Healey, R. McCallister, H.L. Bonkovsky and P.R. Sinclair: Improved retention

of heme with increased resolution of microsomal proteins in polyacrylamide gel electrophoresis. Analyt. Biochem. 114: 316-321, 1981.

38. S.S. Bottomley, H.L. Bonkovsky and M. Kreimer-Birnbaum: The diagnosis of acute intermittent

porphyria: usefulness and limitations of the erythrocyte uroporphyrinogen I synthase assay. Amer. J. Clin. Pathol. 76: 133-139, 1981.

39. John F. Healey, Herbert L. Bonkovsky, Peter R. Sinclair, Jacqueline F. Sinclair: Conversion of

5-aminolaevulinate into haem by liver homogenate. Comparison of rat and chick embryo. Biochem. J. 198: 595-604, 1981.

40. J.F. Sinclair, P.R. Sinclair, E.L. Smith, W.J. Bement, J. Pomeroy and H.L. Bonkovsky: Ethanol-

mediated increase in cytochrome P450 in cultured hepatocytes. Biochem. Pharmacol. 30: 2805-2809,

41. Okazaki, C.E. Brinckerhoff, J.F. Sinclair, P.R. Sinclair, H.L. Bonkovsky and E.D. Harris, Jr.:

Different effect of iron and ethanol on collagenase production by fibroblasts; in Connective Tissue of the Normal and Fibrotic Human Liver - Present State of Biochemistry, Clinical Evaluation and Treatment. Gerlach U., Pott G., Rauterberg J & Voss B. (eds). Georg Thieme Verlag, Stuttgart, 1982, pp. 65-66.


42. P.R. Sinclair, J.F. Sinclair, H.L. Bonkovsky, A.H. Gibbs and F. DeMatteis: Formation of cobalt protoporphyrin by chicken hepatocytes in culture. Relationship to decrease of 5-aminolevulinate synthase caused by cobalt. Biochem. Pharmacol. 31:993-999, 1982.

43. J.F. Sinclair, P.R. Sinclair, J.F. Healey, E.L. Smith and H.L. Bonkovsky: Decrease in hepatic

cytochrome P450 by cobalt: evidence for a role of cobalt protoporphyrin. Biochem. J. 204:103-109, 1982.

44. Herbert L. Bonkovsky and Wolfgang Schady: The neurological manifestations of acute

porphyria. Sem. Liver Dis. 2: 108-124, 1982.

45. J.F. Sinclair, E.L. Smith, W.J. Bement, P.R. Sinclair and H.L. Bonkovsky: Increases in cytochrome P450 in cultured hepatocytes mediated by C3-C4 chain alcohols. Biochem. Pharmacol. 31: 2811-2815 1982.

46. Herbert L. Bonkovsky, Joanne S. Pomeroy and Peter R. Sinclair: Comparisons and

modifications of the colorimetric assay for delta-aminolevulinic acid synthetase- confirmation. Enzyme 28: 130-132, 1982.

47. P.R. Sinclair, G.H. Elder, W.J. Bement, S.G. Smith, H.L. Bonkovsky and J.F. Sinclair:

Decreased activity of uroporphyrinogen decarboxylase caused by 2,4,5,3',4'-pentabromobiphenyl in chick embryo hepatocyte cultures: differences in activity in intact or homogenized cells. FEBS Letters 152: 217-221, 1983.

48. Herbert L. Bonkovsky, John F. Healey, Peter R. Sinclair, George H. Elder, Jacqueline F.

Sinclair and Steven I. Shedlofsky: Iron and the liver. Acute effects of iron-loading on hepatic heme synthesis of rats. The role of decreased activity of 5-aminolevulinate dehydrase. J. Clin. Invest. 71: 1175-1182, 1983.

49. Steven I. Shedlofsky, Herbert L. Bonkovsky, Peter R. Sinclair, Jacqueline F. Sinclair, William J.

Bement and Joanne S. Pomeroy: Iron loading of cultured hepatocytes: effect of iron on 5-amino-laevulinate synthase is independent of lipid peroxidation. Biochem. J. 212: 321-330, 1983.

50. Herbert L. Bonkovsky, John F. Healey, William J. Bement, Peter R. Sinclair, Jacqueline F.

Sinclair and Steven I. Shedlofsky: Effect of uroporphyrin on the spectral measurement of cytochrome P450. Biochem. Pharmacol. 33:499-502, 1984.

51. Steven I. Shedlofsky, Peter R. Sinclair, Jacqueline F. Sinclair, and Herbert L. Bonkovsky:

Increased glutathione in cultured hepatocytes associated with induction of cytochrome P450: lack of effect of glutathione depletion on induction of cytochrome P450 and delta-aminolevulinate synthase. Biochem. Pharmacol. 33: 1487-1491, 1984.

52. Herbert L. Bonkovsky, Jacqueline F. Sinclair, John F. Healey, and Peter R. Sinclair: Formation

of cytochrome P450 containing haem or cobalt-protoporphyrin in liver homogenates of rats treated with phenobarbital and allylisopropylacetamide. Biochem. J. 222: 453-462, 1984.

53. Peter R. Sinclair, William J. Bement, Herbert L. Bonkovsky, and Jacqueline F. Sinclair:

Inhibition of uroporphyrinogen decarboxylase by halogenated biphenyls in chick hepatocyte cultures: essential role for induction of cytochrome P448. Biochem. J. 222: 734-748, 1984.

54. Herbert L. Bonkovsky, Hans-Peter Hauri, Ueli Marti, Rudolfo Gasser, and Urs A Meyer:

Cytochrome P450 of small intestinal epithelial cells: immunochemical characterization of the increase in cytochrome P450 caused by phenobarbital. Gastroenterology 88: 458-467, 1985.


55. Herbert L. Bonkovsky, John F. Healey, Peter R. Sinclair, Jacqueline F. Sinclair: Conversion of 5-aminolaevulinate into haem by homogenates of human liver. Comparison with rat and chick embryo liver homogenates. Biochem. J. 227:893-901, 1985.

56. George H. Elder, Andrew J. Urquhart, Rafael E. deSalamanca, Juan J. Munoz, and Herbert L.

Bonkovsky: Immunoreactive uroporphyrinogen decarboxylase in the liver in porphyria cutanea tarda. Lancet 2: 229-232, 1985.

57. Herbert L. Bonkovsky and Alan R. Schned: Fatal liver failure in protoporphyria: synergism

between ethanol excess and the genetic defect. Gastroenterology 90: 191-201, 1986.

58. Herbert L. Bonkovsky, Patricia L. Blanchette, and Alan R. Schned: Severe liver injury due to phenelzine with unique hepatic deposition of extracellular material. Amer. J. Med. 80: 689-692, 1986.

59. Jacqueline F. Sinclair, Linda M. Zaitlin, E. Lucille Smith, Scott K. Howell, Herbert L. Bonkovsky

and Peter R. Sinclair: Induction of 5-aminolaevulinate synthase by two-to five-carbon alcohols in cultured chick embryo hepatocytes. Relationship to induction of cytochrome P450. Biochem. J. 234: 405-411, 1986.

60. Bruce R. Bacon, John F. Healey, Gary M. Brittenham, C.H. Park, Jodi Numari, Anthony S. Tavill

and Herbert L. Bonkovsky: Hepatic microsomal function in rats with chronic dietary iron overload. Gastroenterology 90:1844-53, 1986.

61. Herbert L. Bonkovsky, Sheryl G. Wood, Scott K. Howell, Peter R. Sinclair, Beth Lincoln, John F.

Healey and Jacqueline F. Sinclair: HPLC separation and quantitation of tetrapyrroles from biological materials. Analyt. Biochem. 155: 56-64, 1986.

62. J.F. Sinclair, L.M. Zaitlin, E.L. Smith, S. Howell, H.L. Bonkovsky and P.R. Sinclair: Induction of

delta-aminolevulinate synthase and changes in porphyrin patterns caused by 2- to 5-carbon alcohols: Possible risk factors in patients with hepatic porphyrias, in Y. Nordmann (ed), Porphyrins and Porphyrias, J. Libbey, London, 1986, pp. 137-146.

63. Peter R. Sinclair, William J. Bement, Herbert L. Bonkovsky, Richard W. Lambrecht, Joan E.

Frezza, Jacqueline F. Sinclair, Andrew J. Urquhart and George H. Elder: Uroporphyrin accumulation produced by halogenated biphenyls in chick embryo hepatocytes. Reversal of the accumulation by piperonyl butoxide. Biochem. J. 237: 63-71, 1986.

64. Herbert L. Bonkovsky, Beth Lincoln, John F. Healey, Lo-Chang Ou, Peter R. Sinclair, Ursula

Muller-Eberhard: Hepatic heme and drug metabolism in rats with chronic mountain sickness. Amer. J. Physiol. 251:G467-G474, 1986.

65. P.R. Sinclair, J.F. Sinclair, W.J. Bement, R.W. Lambrecht, and H.L. Bonkovsky: Induction of

porphyria in cultured chick embryo hepatocytes by halogenated aromatic compounds. In: C.R. Morris and J.R.P. Cabrial (eds), Hexachlorobenzene: Proceedings of an International Symposium IARC Scientific Publication No. 77, Lyon, Fr., 1986, pp. 535-542.

66. Douglas M. Simon, J. Ross McCain, Herbert L. Bonkovsky, James O. Wells, Diane K. Hartle,

and John T. Galambos: Effects of therapeutic paracentesis on systemic and hepatic hemodynamics and on renal and hormonal function. Hepatology 7: 423- 429, 1987.

67. Beth Lincoln, Herbert L. Bonkovsky and Lo-Chang Ou: Effects of chronic normobaric hypoxic

and hypercapnic exposure in rats: prevention of experimental chronic mountain sickness by hypercapnia. International Journal of Biometeorology 31: 201-210, 1987.


68. Herbert L. Bonkovsky: Porphyria: practical advice for the clinical gastroenterologist and hepatologist. Digestive Diseases: Current Concepts in Research and Practice 5: 179-192, 1987.

69. Herbert L. Bonkovsky, John F. Healey, Beth Lincoln, Bruce R. Bacon, David F. Bishop, and

George H. Elder: Hepatic heme synthesis in a new model of experimental hemochromatosis: Studies of rats fed finely divided iron. Hepatology 7: 1195-1203, 1987.

70. Stephen I. Shedlofsky, Peter R. Sinclair, Herbert L. Bonkovsky, John F. Healey, Alice T. Swim,

and Jennifer M. Robinson: Haem synthesis from exogenous 5-aminolaevulinate in cultured chick embryo hepatocytes: Effects of inducers of cytochrome P450. Biochem. J. 248: 229-236, 1987.

71. Herbert L. Bonkovsky, Peter R. Sinclair, Richard W. Lambrecht, W. Jay Bement, and

Jacqueline F. Sinclair: Role of cytochrome P450 in porphyria caused by halogenated aromatic compounds. Annals N.Y. Acad. Sci. 514: 96-112, 1987.

72. Beth C. Lincoln, John F. Healey and Herbert L. Bonkovsky: Regulation of hepatic haem

metabolism: disparate mechanisms of induction of haem oxygenase by drugs and metals. Biochem. J. 250: 189-196, 1988.

73. B.C. Lincoln, A. Mayer, and H.L. Bonkovsky. Microassay of heme oxygenase by high

performance liquid chromatography: application to assay of needle biopsies of human liver. Analyt. Biochem. 170: 485-490, 1988.

74. Herbert L. Bonkovsky, Diane K. Hartle, Beverly Mellen, Michael Kutner, and John T. Galambos:

Plasma concentrations of immunoreactive atrial natriuretic peptide in hospitalized cirrhotic and non-cirrhotic patients: evidence for a role of deficient atrial natriuretic peptide in pathogenesis of cirrhotic ascites. Amer. J. Gastroenterology 83: 531-535, 1988.

75. Dirk Slaker and Herbert L. Bonkovsky. Hemochromatosis: the forgotten disease. Emory

Journal of Medicine 2: 177-191, 1988.

76. Herbert L. Bonkovsky: Hemochromatosis: common, but still forgotten. Liver Update: Function and Disease 2: 2, 1988.

77. Herbert L. Bonkovsky, John F. Healey, Beth Lincoln, Bruce R. Bacon and David F. Bishop:

Decreased hepatic 5-aminolevulinate dehydrase in experimental hemochromatosis. Ann. N.Y. Acad. Sci. 526: 365-368, 1988.

78. Beth C. Lincoln, Alan Alvarado, Nick Setty, and Herbert L. Bonkovsky. Tryptophan 2,3-

dioxygenase in chick embryo hepatocytes: studies in ovo and in culture. Proceedings Society Exptl. Med. and Biol. 188: 308-315, 1988.

79. Joseph R. Bloomer and Herbert L. Bonkovsky. The Porphyrias. Disease-a-Month 35: 5-54,

1989.

80. P. Sinclair, J. Frezza, J. Sinclair, W. Bement, S. Haugen, J. Healey and H. Bonkovsky. Immunochemical detection of different isoenzymes of cytochrome P-450 induced in chick hepatocyte cultures. Biochemical J. 258: 237-245, 1989.

81. Herbert L. Bonkovsky, Marilyn L. Bonkovsky, Peter B. Anderson, John F. Erkkinen and Richard

I. Rothstein. Atenolol for prevention of rebleeding from esophageal varices in hepatic cirrhosis: results of a controlled, randomized pilot study. Am. J. Gastroenterol. 84: 681-683, 1989.


82. Beth C. Lincoln, T.K. Aw, and Herbert L. Bonkovsky. Heme catabolism in cultured hepatocytes: evidence that heme oxygenase is the predominant pathway and that a proportion of synthesized heme is converted rapidly to biliverdin. Biochim. Biophys. Acta 992: 49-58, 1989.

83. Herbert L. Bonkovsky. Mechanism of iron-potentiation of hepatic uroporphyria: studies in

cultured chick embryo liver cells. Hepatology 10: 354-364, 1989.

84. Rajender K. Chawla, Douglas C. Wolf, Michael H. Kutner, and Herbert L. Bonkovsky. Choline may be an essential nutrient in malnourished patients with cirrhosis. Gastroenterology 97: 1514-1520, 1989.

85. Edward Cable, Yvonne Greene, John F. Healey, Chheng-Orn Evans, and Herbert L.

Bonkovsky. Mechanism of the synergistic induction of hepatic heme oxygenase by glutethimide and iron: Studies in cultured chick embryo liver cells. Biochem. Biophys. Res. Commun. 168: 176-181, 1990.

86. Herbert L. Bonkovsky, John F. Healey, Jan Pohl. Purification and Characterization of heme

oxygenase from chick liver. Comparison of the avian and mammalian enzymes. Eur. J. Biochem. 189: 155-166, 1990.

87. Toshiaki Yoshida, Herbert L. Bonkovsky, Aftab Ansari, and Dean Danner. Antibodies against

mitochondrial dehydrogenase complexes in primary biliary cirrhosis. Gastroenterology 99: 187-194, 1990.

88. Herbert L. Bonkovsky, Ronald Weber, and Lynn Aaron. Four-hour measurement of urinary iron

excretion after deferoxamine treatment: A rapid, simple method for study of iron excretion. Amer. J. Gastroenterol. 85: 554-557, 1990.

89. J. Cotton Shallcross, Herbert L. Bonkovsky. Recent Advances in therapy for chronic hepatitis.

Emory Journal of Medicine 4: 86-93, 1990.

90. Herbert L. Bonkovsky, Dirk P. Slaker, Elbridge B. Bills, and Douglas C. Wolf. Usefulness and limitations of laboratory and hepatic imaging studies in iron-storage disease. Gastroenterology 99: 1080-1091, 1990.

91. Herbert L. Bonkovsky, Michael Hawkins, Karen Steinberg, Theodore Hersh, John T. Galambos,

J. Michael Henderson, William J. Millikan, and John R. Galloway. Prevalence and prediction of osteopenia in chronic liver disease. Hepatology 12: 273-280,1990.

92. Rajender K. Chawla, Herbert L. Bonkovsky, and John T. Galambos. Biochemistry and

pharmacology of S-adenosyl-L-methionine and rationale for its use in liver disease. Drugs 40 (Suppl. 3): 98-110, 1990.

93. Herbert L. Bonkovsky. Iron and the Liver. Amer. J. Med. Sciences 301:32-43, 1991.

94. J. Van de Water, A.A. Ansari, C.D. Surh, R. Coppel, T. Roche, H.L. Bonkovsky, M.Kaplan, and

M.E. Gershwin. Evidence for the targeting by 2-oxo-dehydrogenase enzymes in the T cell response of primary biliary cirrhosis. J. Immunol. 146: 89-94, 1991.

95. Chheng-Orn Evans, John F. Healey, Yvonne Greene, and Herbert L. Bonkovsky. Cloning,

sequencing and expression of cDNA for chick liver haem oxygenase. Comparison of avian and mammalian cDNAs and deduced proteins. Biochemical J. 273: 659-666, 1991.


96. Herbert L. Bonkovsky, John F. Healey, Adam N. Lourie, and Glynda G. Gerron. Intravenous heme-albumin in acute intermittent porphyria. Evidence for repletion of hepatic hemoproteins and regulatory heme pools. Amer. J. Gastroenterol. 86: 1050-1056, 1991.

97. K.K. Steinberg, H.L. Bonkovsky, S.P. Caudill, R.K. Bernhardt and M. Hawkins. Osteocalcin and

bone alkaline phosphatase in sera of women with liver disease. Annals Clin. Lab. Sci. 21: 305-314, 1991.

98. Herbert L. Bonkovsky. Key relationships of hepatic heme and iron metabolism. New insights

into functions of two old molecules. Viewpoints Dig. Dis. 23: 19-25, 1991.

99. H L. Bonkovsky, David Fiellin, Gregory Smith, Dirk Slaker, Douglas Simon and John T. Galambos. Treatment of alcoholic hepatitis with parenteral nutrition and oxandrolone: A randomized, controlled trial. I. Short-term effects on liver function. Amer. J. Gastroenterol. 86: 1200-1208, 1991.

100. Herbert L. Bonkovsky, Rani H. Singh, Irshad H. Jafri, David A. Fiellin, Gregory S. Smith,

and Dirk P. Slaker. Treatment of alcoholic hepatitis with parenteral nutrition and oxandrolone: A randomized controlled trial. II. Short-term effects of treatment on nitrogen metabolism, metabolic balance and nutrition. Amer. J. Gastroenterol. 86: 1209-1218, 1991.

101. Yvonne J. Greene, John F. Healey, and Herbert L. Bonkovsky. Immunochemical

studies of haem oxygenase. Preparation and characterization of antibodies to chick liver haem oxygenase and their use in detecting and quantifying amounts of haem oxygenase protein. Biochemical J. 279: 849-854, 1991.

102. Alfred H. Merrill, Jr., Elaine Wang, Regina LaRocque, Richard E. Mullins, Edward T.

Morgan, James L. Hargrove, Herbert L. Bonkovsky, and Irena A. Popova. Differences in glycogen, lipids and enzymes in livers from rats flown on Cosmos 2044. J. Appl. Physiol. 73: 1420S-1427S, 1992.

103. Herbert L. Bonkovsky, Edward E. Cable, Julia W. Cable, Susan E. Donohue, Emily C.

White, Yvonne J. Greene, Richard W. Lambrecht, Kishore K. Srivastava, and Wilfred N. Arnold. Porphyrogenic properties of the terpenes camphor, pinene, and thujone (with a note on historic implications for absinthe and the illness of Vincent van Gogh). Biochem. Pharmacol. 43: 2359-2368, 1992.

104. Edward E. Cable, Julia W. Cable, and Herbert L. Bonkovsky. Repression of hepatic

delta-aminolevulinate synthase by heme and metalloporphyrins: relationship to inhibition of heme oxygenase. Hepatology 18: 119-127, 1993.

105. Kishore K. Srivastava, Edward E. Cable, Susan E. Donohue, and Herbert L. Bonkovsky.

Molecular basis for heme-dependent induction of heme oxygenase in primary cultures of chick hepatocytes: demonstration of acquired refractoriness to heme. European J. Biochem. 213: 909-917, 1993.

106. Kishore Srivastava, Edward E. Cable, and Herbert L. Bonkovsky. Purifying nascent

mRNA from nuclear run-on assays using guanidinium isothiocyanate. Biotechniques 15: 226-227, 1993.

107. Herbert L. Bonkovsky. Advances in understanding and treating ‘the little imitator,’ acute

porphyria. Gastroenterology 105: 590-594, 1993.


108. Julia W. Cable, Edward E. Cable, and Herbert L. Bonkovsky. Induction of heme oxygenase in intestinal epithelial cells of human origin: studies in Caco-2 cell cultures. Molec. Cell. Biochem. 129: 93-98, 1993.

109. John M. Levey, Bjorn Bjornsson, Barbara Banner, Mary Kuhns, Rajwant Malhotra,

Nancy Whitman, Paul L. Romain, Thomas G. Cropley, and Herbert L. Bonkovsky, Cryoglobulinemia in chronic hepatitis C infection: A clinico-pathological analysis of 10 cases and review of recent literature. Medicine (Baltimore) 73: 53-67, 1994.

110. Dominic J. Nompleggi and Herbert L. Bonkovsky. Nutritional supplementation in chronic

liver disease. An analytic review. Hepatology 19: 518-533, 1994.

111. Shirley Russo, Joyce A. Pepe, Edward E. Cable, Richard W. Lambrecht, and Herbert L. Bonkovsky. Synergistic repression of ALA synthase by heme and zinc-mesoporphyrin in a chick embryo liver cell culture model of acute porphyria. Eur. J. Clin. Invest. 24: 406-415, 1994.

112. Herbert L. Bonkovsky, Robert E. Kane, Dean P. Jones, Raymond E. Galinsky, and

Barbara Banner. Acute hepatic and renal toxicity from low doses of acetaminophen in absence of alcohol abuse or malnutrition: evidence for increased susceptibility to drug toxicity due to cardiopulmonary and renal insufficiency. Hepatology 19: 1141-1148, 1994.

113. John M. Levey, Barbara Banner, John Darrah, Herbert L. Bonkovsky. Inflammatory

cloacogenic polyp: Three cases and literature review. Amer. J. Gastroenterol. 89: 438-441, 1994.

114. Richard W. Lambrecht, Julia Cable, Joyce A. Pepe, and Herbert L. Bonkovsky. 3,5,5-

Trimethylhexanoylferrocene induction of heme oxygenase activity in normal hepatocytes. Biochem. Pharmacol. 47: 1669-76, 1994.

115. Inga B. Pinnix, Georgianna S. Guzman, Herbert L. Bonkovsky, Sherif R. Zaki, Joseph

M. Kinkade, Jr. The posttranslational processing of myeloperoxidase is regulated by the availability of heme. Arch. Biochem. Biophys. 312: 4457-458,1994.

116. Edward E. Cable, Joyce A. Pepe, Nicholas C. Karamitsios, Richard W. Lambrecht, and

Herbert L. Bonkovsky. Differential effects of metalloporphyrins on mRNA levels of delta-aminolevulinate synthase and heme oxygenase: studies in cultured chick embryo liver cells. J. Clin. Invest. 94: 649-654 ,1994.

117. Peter R. Sinclair, William J. Bement, John F. Healey, Nadia Gorman, Jacqueline F.

Sinclair, Herbert L. Bonkovsky, Heng H. Liem, and Ursula Muller-Eberhard. Effects of hemopexin on heme-mediated repression of ALA synthase and induction of heme oxygenase in cultures of rat and chicken hepatocytes. Hepatology 20: 741-746, 1994.

118. Graham F. Barnard, Irshad Jafri, Barbara Banner and Herbert L. Bonkovsky. Colonic

mucosal appearance of Tangier disease in a new patient. Gastrointest. Endoscopy 40: 628-630, 1994.

119. Edward E. Cable, Joyce A. Pepe, Susan E. Donohue, Richard W. Lambrecht, Herbert L.

Bonkovsky. Effects of mifepristone (RU-486) on heme metabolism and cytochromes P-450 in cultured chick embryo liver cells: Possible implications for acute porphyria. Europ. J. Biochem. 225: 651-657, 1994.

120. Bernard Clifford, Daniel G. Donahue, Lynda Smith, Edward Cable, Brigit Luttig, Michael

Manns, Herbert L. Bonkovsky. High prevalence of serologic markers of auto-immunity in patients with chronic hepatitis C. Hepatology 21: 613-619, 1995.


121. Shirley M. Russo, Joyce A. Pepe. Susan Donohue, Edward E. Cable, Richard W.

Lambrecht, Herbert L. Bonkovsky. Tissue distribution of zinc-mesoporphyrin in rats: relationship to inhibition of heme oxygenase. J. Pharmacol. Exptl. Therap. 272: 766-774, 1995.

122. Ann L. Barton, Barbara F. Banner, Edward E. Cable, Herbert L. Bonkovsky. Distribution

of iron in the liver predicts the response of chronic hepatitis C infection to interferon therapy. Amer. J. Clin. Pathol. 103: 419-424, 1995.

123. Barbara F. Banner, Ann L. Barton, Edward E. Cable, Lynda Smith, Herbert L.

Bonkovsky. A detailed analysis of the Knodell score and other histologic parameters as predictors of response to interferon therapy in chronic hepatitis C. Modern Pathology 8: 232-238, 1995.

124. Herbert L. Bonkovsky, T. Jake Liang, Kiyoshi Hasegawa, Barbara Banner. Chronic

leukocytoclastic vasculitis complicating HBV infection. Possible role of mutant forms of HBV in pathogenesis and persistence of disease. J. Clin. Gastroent. 21: 42-47, 1995.

125. Richard B. Rubin, Ann L. Barton, Barbara F. Banner, Herbert L. Bonkovsky. Iron and

chronic viral hepatitis: emerging evidence for an important interaction. Digestive Diseases 13: 223-238, 1995.

126. Kimberly K. Gabis, Otto S. Gildemeister, Joyce A. Pepe, Richard W. Lambrecht, Herbert

L. Bonkovsky. Induction of heme oxygenase-1 in LMH cells. Comparison of LMH cells to primary cultures of chick embryo liver cells. Biochim. Biophys. Acta 1290: 113-120, 1996.

127. T.Hong Lu, J.Pepe, R.W.Lambrecht, and H.L.Bonkovsky. Regulation of metallothionein

gene expression. Studies in transfected primary cultures of chick embryo liver cells. Biochimie 78: 236-244, 1996.

128. Barbara F. Banner, Carol Allan, Lynda Smith, Louis Savas, Herbert L. Bonkovsky.

Effect of interferon therapy on bile duct inflammation in hepatitis C. Virchows Arch. Intl. J. Pathol. 428: 253-259, 1996.

129. Herbert L. Bonkovsky, Bernard D. Clifford, Lynda J. Smith, Carol Allan, Barbara Banner.

High dose interferon alpha-2b for retreatment of non-responders or relapsing patients with chronic hepatitis C: A controlled randomized trial. Dig. Dis. Sci. 41: 149-154, 1996.

130. Herbert L. Bonkovsky, Barbara F. Banner, Richard W. Lambrecht, and Richard B.

Rubin. Iron in liver diseases other than hemochromatosis. Semin. Liver Dis. 16: 65-82, 1996.

131. Herbert L. Bonkovsky, Prem Ponka, Bruce R. Bacon, James Drysdale, Norman D. Grace, and Anthony S. Tavill. An update on iron metabolism: summary of the 5th conference of the International Association for the Study of Disorders of Iron Metabolism. Hepatology 24: 718-729, 1996.

132. Edward E. Cable, Otto S. Gildemeister, Joyce A. Pepe, Susan E. Donohue, Richard W. Lambrecht, and Herbert L. Bonkovsky. Hepatic delta-aminolevulinic acid synthase mRNA stability is modulated by inhibitors of heme biosynthesis and by metalloporphyrins. European Journal of Biochemistry 240: 112-117, 1996.

133. Dominic J. Nompleggi and Herbert L. Bonkovsky. Nutritional therapy of chronic liver

disease. Nutrition & the M.D. 22 (No.9): 1-5, (Sept.) 1996.


134. Martin Hahn and Herbert L. Bonkovsky. Multiple chemical sensitivity syndrome and porphyria: a note of caution and concern. Arch. Int. Med. 157: 281-285, 1997.

135. Herbert L. Bonkovsky, Barbara F. Banner, and Alan L. Rothman. Iron and chronic viral

hepatitis. Hepatology 25: 759-768, 1997.

136. Martin Hahn, Otto S. Gildemeister, Gregory L. Krauss, Joyce A. Pepe, Richard W. Lambrecht, Susan Donohue, and Herbert L. Bonkovsky. Effects of new anticonvulsant medications on porphyrin synthesis in cultured liver cells--potential implications for patients with acute porphyria. Neurology 49: 97-106, 1997.

137. Tze Hong Lu, Joyce Pepe, Otto Gildemeister, Rex Tyrrell, and Herbert Bonkovsky.

Regulation of expression of the human heme oxygenase-1 gene in transfected chick embryo liver cell cultures. Biochim. Biophys. Acta 1352: 293-302 , 1997.

138. Kris V. Kowdley, Thomas D. Trainer, John R. Saltzman, Edward L. Krawitt, Tamsin A.

Knox, Karen Susskind, Daniel Pratt, Marshall M. Kaplan, Richard B. Rubin, Herbert L. Bonkovsky, and Norman D. Grace. Utility of hepatic iron index in American patients with hereditary hemochromatosis: a multicenter study. Gastroenterology 113: 1270-1277, 1997.

139. Barbara F. Banner, Carol Allan, Louis Savas, Graham Barnard, Steven Baker, and

Herbert L. Bonkovsky. Inflammatory markers in chronic hepatitis C. Virchow’s Arch. Intl. J. Pathol. 431: 181-187, 1997.

140. Emmet B. Keeffe, F. Blaine Hollinger, R. Bailey, V.G. Bain, K. Bala, Luis Balart, Martin

Black, Herbert L. Bonkovsky, W. Cassidy, John R. Craig, J. Donovan, Geoffrey M. Dusheiko, Murray Ehrinpreis, Gregory Everson, S. Feinman, R.T. Foust, Hans Fromm, Steven Hauser, E. Jenny Heathcote, John C. Hoefs, E. Hunter, S. James, Donald M. Jensen, and Paul Killenberg. Therapy of hepatitis C: Consensus interferon trials. Hepatology 26 (Suppl 1): 101S-107S, 1997.

141. Herbert L. Bonkovsky. Chronic hepatitis C: other approaches to therapy. Hepatology

26 (Suppl 1): 143S-1517S, 1997.

142. Edward E. Cable, Otto S. Gildemeister, Joyce A. Pepe, Richard W. Lambrecht, and Herbert L. Bonkovsky. Mechanism of induction of heme oxygenase by metalloporphyrins in primary chick embryo liver cells: Evidence against a stress-mediated response. Molecular and Cellular Biochemistry 169:13-20, 1997.

143. Myron J. Tong, K. Rajender Reddy, William M. Lee, Paul J. Pockros, John C. Hoefs,

Emmett B. Keeffe, F. Blaine Hollinger, E. Jenny Heathcote, Heather White, Robert T. Foust, Donald M. Jensen, Edward L. Krawitt, Hans Fromm, Martin Black, Lawrence M. Blatt, Michael Klein, John Lubina, and the Consensus Interferon Study Group. Treatment of chronic hepatitis C with consensus interferon: a multicenter, randomized, controlled trial. Hepatology 26: 747-754, 1997.

144. Herbert L. Bonkovsky. The alphabet soup of viral hepatitis: Is “G” a new flavi(or) in the

mix? Western J. Med. 167: 50-51, 1997.

145. Herbert L. Bonkovsky and Graham F. Barnard. Diagnosis of porphyric syndromes: a practical approach in the era of molecular biology. Semin. Liver Disease 18: 57--65, 1998.

146. Herbert L. Bonkovsky. Porphyria cutanea tarda and hepatitis C. Viral Hepatitis Reviews

4: 75—95, 1998.


147. Tze H. Lu, Joyce A. Pepe, Richard W. Lambrecht, and Herbert L. Bonkovsky. Molecular cloning, characterization, and expression of the chicken heme oxygenase-1 gene in transfected liver primary cell cultures. Gene (Amst.) 207: 177-186, 1998.

148. David R. Kalman and Herbert L. Bonkovsky. Management of acute attacks in the

porphyrias. Clinics in Dermatology 16: 299--306, 1998.

149. E. Jenny L. Heathcote, Emmet B. Keeffe, Samuel S. Lee, Saya V. Feinman, Myron J. Tong, K. R. Reddy, Donald G. Albert, Jr., Karsten Witt, Lawrence M. Blatt, and the Consensus Interferon Study Group. Retreatment of chronic hepatitis C with consensus interferon. Hepatology 27: 1136-1143, 1998.

150. Herbert L. Bonkovsky, Maureen Poh-Fitzpatrick, Neville Pimstone, Jorge Obando,

Adrian DiBisceglie, Christine Tattrie, Kristina Tortorelli, Paula LeClair, Mary G. Mercurio, and Richard W. Lambrecht. Porphyria cutanea tarda, hepatitis C, and HFE gene mutations in North America. Hepatology 27: 1661-1669, 1998.

151. Kimberly K. Elbirt, Alan J. Whitmarsh, Roger J. Davis, and Herbert L. Bonkovsky.

Mechanism of sodium arsenite-mediated induction of heme oxygenase-1 in hepatoma cells: Role of mitogen-activated protein kinases. J. Biol. Chem. 273: 8922-8931, 1998.

152. Katsuhiro Shimoda, Nasim Ara Begum Kenji Shibuta, Masaki Mori, Herbert L.

Bonkovsky, Barbara F. Banner, and Graham F. Barnard. IL-8 and hIRH (SDF1-alpha/PBSF) mRNA expression and histological activity index in patients with chronic hepatitis C. Hepatology 28: 108-115, 1998.

153. Barbara F. Banner, Nicholas Karamitsios, Lynda Smith, and Herbert L. Bonkovsky.

Enhanced phenotypic expression of alpha-1-antitrypsin deficiency in an MZ heterozygote with chronic hepatitis C. American Journal of Gastroenterology. 93: 1541-1545, 1998.

154. Charles R. Kiefer, James B. McKenney, Jane F. Trainor. Richard W. Lambrecht,

Herbert L. Bonkovsky, Larry M. Lifshitz, C. Robert Valeri, and L. Michael Snyder. Porphyrin loading of lipofuscin granules in inflamed striated muscle. American Journal of Pathology 153: 703-708, 1998.

155. William M. Lee, Rajender Reddy, Myron J. Tong, Martin Black, Dirk J. van Leeuwen, F.

Blaine Hollinger, Kevin D. Mullen, Neville Pimstone, Donald Albert, Sheila Gardner, and the Consensus Interferon Study Group. Early hepatitis C virus-RNA responses predict interferon treatment outcomes in chronic hepatitis C. Hepatology 28: 1411-1415, 1998.

156. Vicki M. Guggio, Herbert L. Bonkovsky, Jesse Smith, and Alan L. Rothman. Inefficient

recognition of autologous viral sequences by intrahepatic hepatitis C virus-specific cytotoxic T lymphocytes in chronically infected subjects. Virology 251: 132-140, 1998.

157. Herbert L. Bonkovsky. Role of iron in porphyrin and heme metabolism with special

reference to porphyria cutanea tarda. Porphyrins (Japan) 7: 105-115, 1998.

158. Herbert L. Bonkovsky, J. Michael Woolley, and the Consensus Interferon Study Group. Reduction of health-related quality of life in chronic hepatitis C and improvements with interferon therapy. Hepatology 29: 264-270, 1999.

159. Joseph R. Bloomer, Herbert L. Bonkovsky, and Maureen Poh-Fitzpatrick. The

diagnostic challenge of porphyria. Patient Care 33: 57-74, 1999.


160. Herbert L. Bonkovsky and Jorge V. Obando. Role of HFE gene mutations in liver diseases other than hereditary hemochromatosis. Current Gastroenterology Reports 1: 30-37, 1999.

161. Kimberly K. Elbirt and Herbert L. Bonkovsky. Heme oxygenase: recent advances in

understanding its regulation and role. Proceedings of the Association of American Physicians 111: 438-447, 1999.

162. James H. Reichheld, Eliezer Katz, Barbara F. Banner, Irma O. Szymanski, John R.

Saltzman, Herbert L. Bonkovsky. The value of intravenous heme-albumin and plasmapheresis in reducing post-operative complications of orthotopic liver transplantation for erythropoietic protoporphyria. Transplantation 67: 922-928, 1999.

163. Herbert L. Bonkovsky, Richard B. Rubin. Edward E. Cable, Ashley Davidoff. Tammo H.

Pels Rijcken, and David D. Stark. Hepatic iron concentration: noninvasive estimation by means of MR imaging techniques. Radiology 212: 227-234, 1999.

164. Mercedes Fernandez and Herbert L. Bonkovsky. Increased heme oxygenase-1 gene

expression in liver cells and splanchnic organs from portal hypertensive rats. Hepatology 29: 1672-1679, 1999.

165. Herbert L. Bonkovsky, Qaiser Jawaid, Kristina Tortorelli, Paula LeClair, Joseph Cobb,

Richard W. Lambrecht, and Barbara F. Banner. Non-alcoholic steatohepatitis and iron: increased prevalence of mutations of the HFE gene in non-alcoholic steatohepatitis. Journal of Hepatology 31: 421-429, 1999.

166. Jijy Mathai, Katsuhiro Shimoda, Barbara F. Banner, Masaki Mori, Herbert L.

Bonkovsky, and Graham F. Barnard. Interferon-alpha receptor mRNA expression in a United States sample with predominantly genotype 1a/I chronic hepatitis C liver biopsies correlates with response to IFN therapy. Journal Interferon & Cytokine Research 19: 1011-1018, 1999.

167. Ying Shan, Richard W. Lambrecht, Tze Hong Lu, and Herbert L. Bonkovsky. Effects of

phenylarsine oxide on expression of heme oxygenase-1 reporter constructs in transiently transfected cultures of chick embryo liver cells. Archives of Biochemistry and Biophysics 372: 224-229,1999.

168. Sridevi Kolluri, Kimberly K. Elbirt, and Herbert L. Bonkovsky. Heme biosynthesis in a

chicken hepatoma cell line (LMH)--comparison with primary chick embryo liver cells (CELC). Biochimica et Biophysica Acta 1472: 658-667, 1999.

169. Richard W. Lambrecht, Otto S. Gildemeister, Joyce A. Pepe, Kristina D. Tortorelli,

Alyssa Williams, and Herbert L. Bonkovsky. Effects of antidepressants and benzodiazepine-type anxiolytic agents on hepatic porphyrin accumulation in primary cultures of chick embryo liver cells. Journal of Pharmacology and Experimental Therapeutics 29:1150-1155, 1999.

170. Richard W. Lambrecht, Otto S. Gildemeister, Alyssa Williams, Joyce A. Pepe, Kristina

D. Tortorelli, and Herbert L. Bonkovsky. Effects of selected antihypertensives and analgesics on hepatic porphyrin accumulation. Biochemical Pharmacology 58:887-896, 1999.

171. Emmet B. Keeffe, Geoffrey M. Dusheiko, Stephen P. James, Kevin D. Mullen, Gregory

T. Everson, Neville R. Pimstone, Jeremiah Donovan, Donald Albert, and the Consensus Interferon Study Group. Utility of hepatitis C virus serotypes in predicting response to treatment of chronic hepatitis C. Cytokines, Cell. & Molec. Therapy 5: 207—210, 1999.


172. Emmet B. Keeffe, Geoffrey M. Dusheiko, Myron J. Tong, F. Blaine Hollinger, E. Jenny L. Heathcote, John McHutchison, Donald Albert, and the Consensus Interferon Study Group. Genotype does not affect pattern of HCV RNA decrease among responders during interferon treatment of chronic hepatitis C. Cytokines, Cell. & Molec. Therapy 5: 211—216, 1999.

173. James Kohlroser, Jijy Mathai, James Reichheld, Barbara F. Banner, and Herbert L.

Bonkovsky. Hepatotoxicity due to troglitazone: report of two cases and review of adverse events reported to the United States Food and Drug Administration. American Journal of Gastroenterology 95: 272-276, 2000.

174. Tze Hong Lu, Ying Shan, Joyce Pepe, Richard W. Lambrecht and Herbert L.

Bonkovsky. Upstream regulatory elements in chick heme oxygenase-1 promoter: a study in primary cultures of chick embryo liver cells. Molecular and Cellular Biochemistry, 209: 17—27, 2000.

175. Herbert L. Bonkovsky and Richard W. Lambrecht. Iron-induced liver injury. Clinics in

Liver Disease 4: 409—429, 2000.

176. Ying Shan, Joyce Pepe, Tze Hong Lu, Kimberly K. Elbirt, Richard W. Lambrecht, and Herbert L. Bonkovsky. Induction of the heme oxygenase-1 gene by metalloporphyrins. Arch. Biochem. Biophys. 380: 219—227, 2000.

177. Robert J. Fontana, Jonathan Israel, Paula LeClair, Barbara F. Banner, Kristina Tortorelli,

Norman Grace, Robert A. Levine, Gale Fiarman, Michael Thiim, Anthony S. Tavill, and Herbert L. Bonkovsky. Iron reduction before and during interferon therapy of chronic hepatitis C: results of a multicenter, randomized, controlled trial. Hepatology 31: 730—736, 2000.

178. Adrian M. Di Bisceglie, Herbert L. Bonkovsky, Sanjiv Chopra, Stephen Flamm, Rajender

K. Reddy, Norman Grace, Paul Killenberg, Christine Hunt, Carolo Tamburro, Anthony S. Tavill, Roy Ferguson, Edward Krawitt, Barbara Banner, and Bruce R. Bacon. Iron reduction as an adjuvant to interferon therapy in patients with chronic hepatitis C who have previously not responded to interferon: a multi-center, prospective, randomized, controlled trial. Hepatology 32: 135--138, 2000.

179. Sarah Childs, Brant M. Weintstein, Manzoor-Ali P.K. Mohideen, Susan Donohue,

Herbert L. Bonkovsky, and Mark C. Fishman. Zebrafish dracula encodes ferrochelatase and its mutation provides a model for erythropoietic protoporphyria. Current Biology 10: 1001—1004, 2000.

180. Gyongyi Szabo, Eliezer Katz, and Herbert L. Bonkovsky. Management of recurrent

hepatitis C after liver transplantation: a concise review. Amer J Gastroent 95: 2164—2170, 2000.

181. Barbara F. Banner, Louis Savas, Jaroslav Zivny, Kristina Tortorelli, and Herbert L.

Bonkovsky. Ubiquitin as a marker of cell injury in non-alcoholic steatohepatitis. American Journal of Clinical Pathology 114: 860--866, 2000.

182. Herbert L. Bonkovsky and Graham F. Barnard. The porphyrias. Current Treatment

Options in Gastroenterology 3: 487—499, 2000.

183. Herbert L. Bonkovsky and Savant Mehta. Hepatitis C: a review and update. Journal of the American Academy of Dermatology 44: 159—179, 2001.


184. Mercedes Fernandez, Richard W. Lambrecht, and Herbert L. Bonkovsky. Increased heme oxygenase activity in splanchnic organs from portal hypertensive rats: role in modulating mesenteric vascular reactivity. Journal of Hepatology 34: 812—817, 2001.

185. Herbert L. Bonkovsky, Denise Stefancyk, Kristina Tortorelli, Barbara F. Banner, Qin Liu,

Geoffrey Zucker, Jonathan Israel, John Stagias, and Joel Colker. Comparative effects of different doses of ribavirin plus interferon alpha-2b for therapy of chronic hepatitis C: results of a controlled, randomized trial. Dig. Diseases & Sciences, 46: 2051--2059, 2001.

186. Savant Mehta, John M. Levey, and Herbert L.; Bonkovsky. Extrahepatic manifestations

of infection with hepatitis C virus. Clin. Liver Disease 5: 979—1008, 2001.

187. Otto S. Gildemeister, Joyce A. Pepe, Richard W. Lambrecht, and Herbert L. Bonkovsky. Induction of heme oxygenase-1 by phenylarsine oxide: studies in cultured primary liver cells. Molecular and Cellular Biochemistry 226: 17--26, 2001.

188. Wei Tian, Herbert L. Bonkovsky, Shigeki Shibahara, and David M. Cohen. Urea and

hypertonicity increase expression of heme oxygenase-1 in murine renal medullary cells. Amer. J. Physiol. Renal Physiol. 281: F983—F991, 2001.

189. Herbert L. Bonkovsky. Iron as a comorbid factor in chronic viral hepatitis. Amer. J.

Gastroenterol. 97: 1--4, 2002.

190. Richard W. Lambrecht and Herbert L. Bonkovsky. Hemochromatosis and porphyria. Seminars Gastroint. Dis. 13: 109—119, 2002.

191. Ying Shan, Joyce Pepe, Richard W. Lambrecht, and Herbert L. Bonkovsky. Mapping of

the chick heme oxygenase-1 proximal promoter for responsiveness to metalloporphyrins. Arch. Biochem. Biophys. 399: 159—166, 2002.

192. Herbert L. Bonkovsky. Congenital erythropoietic porphyria. Handbook of Rare

Disorders, National Organization of Rare Disorders, 2002.

193. Andreas Rolfs, Herbert L. Bonkovsky, James G. Kohlroser, Kristina McNeal, Urs V. Berger, and Matthias A. Hediger. Intestinal expression of genes involved in iron absorption in humans. Amer. J. Physiol.. Gastrointest. Liver Physiol. 282: G598—G607, 2002.

194. Herbert L. Bonkovsky, Riad Azar, Steven Bird, Gyongyi Szabo, and Barbara Banner.

Severe cholestatic hepatitis caused by thiazolidinediones—risks associated with substituting rosiglitazone for troglitazone. Dig. Dis. & Sci. 47: 1632--1637, 2002.

195. Herbert L. Bonkovsky. Beware of iron overload. Bottom Line Health 16 (9): 7—9, Sept.,

2002.

196. Sanjay Agrawal and Herbert L. Bonkovsky. Management of nonalcoholic steatohepatitis: an analytic review. J. Clin. Gastroenterology 35: 253--261, 2002.

197. Khoa D. Do, Barbara F. Banner, Eliezer Katz, Irma O. Szymanski, and Herbert L.

Bonkovsky. Benefits of chronic plasmapheresis and intravenous heme-albumin in erythropoietic protoporphyria after liver transplantation. Transplantation 73: 469—472, 2002.

198. Herbert L. Bonkovsky, Nicole Troy, Kristina McNeal, Barbara F. Banner, Ashish Sharma,

Jorge Obando, Savant Mehta, Raymond S. Koff, Qin Liu, Chung-Cheng Hsieh. Iron and HFE or TfR1 mutations as comorbid factors for development and progression of chronic hepatitis C. J. Hepatol. 37: 848--854, 2002.


199. Herbert L. Bonkovsky. Hepatic manifestations of systemic disease. Clin. Liver Dis. 6: 1-

-2, 2002.

200. Herbert L. Bonkovsky. Optimal management of non-alcoholic fatty liver/steatohepatitis. J. Clin. Gastroenterol. 36: 193--195, 2003.

201. Herbert L. Bonkovsky, Richard W. Lambrecht, and Ying Shan. Iron as a co-morbid

factor in non-hemochromatotic liver disease. Alcohol 30: 137--144, 2003.

202. Mercedes Fernandez and Herbert L. Bonkovsky. Vascular endothelial growth factor increases heme oxygenase-1 protein expression in the chick embryo chorioallantoic membrane. Brit. J. Pharmacol. 139: 634--640, 2003.

203. Mitchell L. Shiffman, Adrian DiBisceglie, Karen L. Lindsay, Chihiro Morishima, Elizabeth

C. Wright, Gregory Everson, Anna Lok, Timothy Morgan, Herbert L. Bonkovsky, William Lee, Jules Dienstag, Marc Ghany, and James Everhart. PEG interferon alfa-2a for retreatment of patients with chronic hepatitis C who have failed prior treatment with interferon or interferon and ribavirin: results from the lead-in phase of the hepatitis C long-term antiviral treatment against cirrhosis (HALT-C) trial. (Publication 2 from the HALT-C Trial Group). Gastroenterology 126: 1015--1023, 2004.

204. Annie T. Chemmanur and Herbert L. Bonkovsky. The hepatic porphyrias: diagnosis

and management. Clinics in Liver Disease 8: 807—838, 2004.

205. Ying Shan, Richard W. Lambrecht, Herbert L. Bonkovsky, Identification of key elements that are responsible for heme-mediated induction of the avian heme oxygenase-1 gene, Biochimica et Biophysica Acta 1679: 87--94, 2004.

206. William M. Lee, Herbert L. Bonkovsky, Adrian DiBisceglie, Jules Dienstag, Gregory T.

Everson, Marc Ghany, Timothy Morgan, Karen L. Lindsay, Anna Lok, Mitchell Shiffman, David Gretch, Elizabeth C. Wright, Jay Everhart, and the HALT-C Trial Group. Evolution of the HALT-C trial: pegylated interferon as maintenance therapy for patients with chronic hepatitis C in previous interferon nonresponders. (Publication 4 from the HALT-C Trial Group) Controlled Clinical Trials 25: 472-492, 2004.

207. Ying Shan, Richard W. Lambrecht, Tahereh Ghaziani, Susan E. Donohue, and Herbert

L. Bonkovsky. Role of Bach-1 in regulation of heme oxygenase-1 in human liver cells: insights from studies with small interfering RNAs. J. Biol. Chem. 279: 51,769—51,774, 2004.

208. Hossein Sendi, Tahereh Ghaziani, Mohammad R. Zali, Peyman Adibi, Mohammad R.

Agah, Maryam Jazayeri, Saeed Shahraz, Lars Magnius, and Herbert L. Bonkovsky. Hemochromatosis mutations in Iranians with hepatitis B virus infection. Clinical infectious Diseases 40: e19-e21, 2005.

209. Alan L. Rothman, Chihiro Morishima, Herbert L. Bonkovsky, Stephen J. Polyak, Ranjit

Ray, Adrian M. DiBisceglie, Karen L. Lindsay, Peter F. Malet, Ming Chang, David R. Gretch, Daniel G. Sullivan, Atul K Bhan, Elizabeth C. Wright, Margaret J. Koziel, and the HALT-C Trial Group. Associations among clinical, histologic, immunologic, and viral quasispecies measures in advanced chronic hepatitis C: baseline analysis of the HALT-C Trial. (Publication 3 from the HALT-C Trial Group). Hepatology 41: 617-624, 2005.

210. Karl E. Anderson, Joseph R. Bloomer, Herbert L. Bonkovsky, James P. Kushner, Claus

A. Pierach, Neville R. Pimstone, and Robert J. Desnick. Recommendations for the diagnosis and treatment of the acute porphyrias. Ann Int Med 142: 439-450, 2005.


211. Stephen J Polyak, Daniel G Sullivan, Michael A Austin, James Y Dai, Margaret C

Shuhart, Karen L Lindsay, Herbert L Bonkovsky, Adrian M Di Bisceglie, William M Lee, Chihiro Morishima, David R Gretch and The HALT-C Trial Group. Comparison of amplification enzymes for hepatitis C virus quasispecies analysis. (Publication 9 from the HALT-C Trial Group) Virology Journal 2: 41—46, 2005.

212. Junaid Siddiqui, Philip E. Jaffe, Khalid Aziz, Faripour Forouhar, Richard Sheppard,

Jonathan Covault, and Herbert L. Bonkovsky. Fatal air and bile embolism after percutaneous liver biopsy and ERCP. Gastrointestinal Endoscopy 61: 153-157, 2005.

213. Adrian M. Di Bisceglie, Richard K. Sterling, Raymond T. Chung, James E. Everhart,

Jules L. Dienstag, Herbert L. Bonkovsky, Elizabeth C. Wright, Gregory T. Everson, Karen L. Lindsay, Anna S. F. Lok, William M. Lee, Timothy R. Morgan, Marc G. Ghany, David R. Gretch, and the HALT-C Trial Group. Serum alpha-fetoprotein levels in patients with advanced hepatitis C: results from the HALT-C Trial. (Publication 7 from the HALT-C Trial Group) J Hepatol 43: 434-441, 2005

214. Anna S. F. Lok, Marc G. Ghany, Zachary D. Goodman, Elizabeth C. Wright, Gregory T.

Everson, Richard K. Sterling, James E. Everhart, Karen L. Lindsay, Herbert L. Bonkovsky, Adrian M. DiBisceglie, William M. Lee, Timothy R. Morgan, Jules L. Dienstag, Chihiro Morishima, and the HALT-C Trial Group. Predicting cirrhosis in patients with hepatitis C based on standard laboratory tests: results of the HALT-C cohort. (Publication 6 from the HALT-C Trial Group) Hepatology 42: 282—292, 2005. [Published online in Wiley InterScience (www.interscience.wiley.com)]

215. Vicki M Giuggio, Herbert L. Bonkovsky, and Alan L. Rothman. Evolution of the

intrahepatic T cell repertoire during chronic hepatitis C virus infection. Viral Immunology 18: 179—189, 2005.

216. Ying Shan, Richard W. Lambrecht, and Herbert L. Bonkovsky. Association of HCV

infection with serum iron status: analysis of data from NHANES III. Clin. Inf. Dis. 40: 834-841, 2005.

217. Sridevi Kolluri, Timothy J. Sadlon, Brian K. May, and Herbert L. Bonkovsky. Haem

repression of the housekeeping 5-aminolaevulinic acid synthase gene in the hepatoma cell line LMH. Biochem J 392 (Pt 1): 173-180, 2005.

218. Vamsee Alla and Herbert L. Bonkovsky. Iron in non-hemochromatotic liver disorders.

Semin Liver Disease 25: 461-472, 2005.

219. Chihiro Morishima, Stephen J. Polyak, Ranjit Ray, Michael C. Doherty, Adrian Di Bisceglie, Peter F. Malet, Herbert L. Bonkovsky, Daniel G. Sullivan, David R. Gretch, Alan L. Rothman, Margaret J. Koziel, Karen L. Lindsay, and the HALT-C Trial Group. HCV-specific immunity and quasispecies variability in advanced chronic hepatitis C are associated with non-response to antiviral therapy. (Publication xx from the HALT-C Trial Group). The Journal of Infectious Diseases, 2005, in press.

220. Robert J. Fontana, Linas A. Bielauskas, Carla Back-Madruga, Karen L. Lindsay, Ziad

Kronfol, Anna S. Lok, Latha Padmanabhan, and the HALT-C Trial Group. Cognitive function in hepatitis C patients with advanced fibrosis enrolled in the HALT-C Trial. (Publication 5 from the HALT-C Trial Group). J. Hepatology 43: 614-622, 2005.

221. Arun J Sanyal, Robert J. Fontana, Adrian M. Di Bisceglie, James E. Everhart, Michael

C. Doherty, Gregory T. Everson, John A. Donovan, Peter F. Malet, Savant Mehta, Timothy R.


Morgan, Andrea E. Reid, Marc G. Ghany, David R. Gretch, and the HALT-C Trial Group. Esophageal varices in subjects with hepatitis C and advanced fibrosis: results from the HALT-C Trial. (Publication xx from the HALT-C Trial Group). Gut, in press, 2007.

222. Tahereh Ghaziani, Saeid Shahraz,, Mohammedreza Agah, Kevin P. Jensen, Shahin

Ansari, Hossein Sendi,, Richard W. Lambrecht, Jonathan Covault, and Herbert L. Bonkovsky. Serum measures of iron status and HFE gene mutations in patients with chronic hepatitis B. Submitted, 2006.

223. Robert J. Fontana, Adrian M. Di Bisceglie, Arun J. Sanyal, Savant Mehta, Michael C.

Doherty, Gregory T. Everson, Jeffrey A. Kahn, Peter F. Malet, Muhammad Y. Sheikh, Raymond Chung, Marc G. Ghany, David R. Gretch, James E. Everhart, and the HALT-C Trial Group. Portal hypertensive gastropathy in chronic hepatitis C patients with bridging fibrosis and compensated cirrhosis: results from the HALT-C Trial. (Publication 12 from the HALT-C Trial Group). Amer J Gastroenterology 101: 983-992, 2006.

224. Herbert L. Bonkovsky. Hepatotoxicity associated with supplements containing Chinese

green tea (Camellia sinensis). Annals of Internal Medicine 144: 68-71, 2006.

225. Herbert L. Bonkovsky. Neurovisceral porphyrias: what a hematologist needs to know. Hematology 2005, The American Society of Hematology Education Program Book, The American Society of Hematology, Washington, D.C., 2005, pp. 24—30.

226. Brendan M. McGuire, Herbert L. Bonkovsky, Robert L. Carithers, Jr., Raymond T.

Chung, Leonard I. Goldstein, John R. Lake, Anna S. Lok, Carol J. Potter, Elizabeth Rand, Michael D. Voigt, Pamela R. Davis, and Joseph R. Bloomer. Liver transplantation for erythropoietic protoporphyria liver disease. Liver Transplantation 11:1590—1596, 2005.

227. Tahereh Ghaziani, Ying Shan, Richard W. Lambrecht, Susan Donohue, Thomas

Pietschmann, Ralf Bartenschlager, and Herbert L. Bonkovsky. HCV proteins increase expression of heme oxygenase-1 and decrease expression of Bach1 in human hepatoma cells. Journal of Hepatology, 45:5-12, 2006.

228. Herbert L. Bonkovsky. Iron metabolism and hereditary hemochromatosis. Czech and

Slovak Journal of Gastroenterology and Hepatology, Supplement, 2006.

229. Gregory T. Everson, John C. Hoefs, Peter Malet, Leonard B. Seeff, Herbert L. Bonkovsky, Elizabeth Wright, and the HALT-C Trial Group. Impact of disease severity on clinical management and outcome of antiviral therapy in patients with chronic hepatitis C lessons from the HALT-C Trial. (Publication xx from the HALT-C Trial Group) Hepatology, 2007, in press.

230. Herbert L. Bonkovsky, Kristin K. Snow, Peter F. Malet, Carla Back-Madruga, Mitchell L.

Shiffman, Gregory T. Everson, Robert J. Fontana, Adrian M. DiBisceglie, Timothy R. Morgan, Jules L. Dienstag, Marc G. Ghany, Chihiro Morishima, and the HALT-C Trial Group. Health-related quality of life in patients with chronic hepatitis C and advanced fibrosis. (Publication 14 from the HALT-C Trial Group) Journal of Hepatology, 46 : 420-431, 2007. [Epub 2006 Nov 27, 2006.]

231. Vamsee Alla, Joseph Abraham, Junaid Siddiqui, Dimple Raina, George Y. Wu, Naga P.

Chalasani, and Herbert L. Bonkovsky. Autoimmune hepatitis triggered by statins. J. Clin. Gastroenterol. 40: 757—761, 2006. [PMID 16940892]

232. Herbert L. Bonkovsky, Deepa Naishadham, Richard W. Lambrecht, Raymond T. Chung,

John C. Hoefs, S. Russell Nash, Thomas E. Rogers, Barbara F. Banner, Richard K. Sterling,


John A. Donovan, Robert J. Fontana, Adrian M. Di Bisceglie, Marc Ghany, Chihiro Morishima, and the HALT-C Trial Group. Influence of iron and HFE gene mutations on severity and response to therapy during retreatment of advanced chronic hepatitis C in the HALT-C Trial. (Publication 17 from the HALT-C Trial Group). Gastroenterology 131: 1440—1451, 2006. [Editorial comment at Gastroenterology 131: 1635--1638, 2006.]

233. Richard W. Lambrecht, Manish Thapar, and Herbert L. Bonkovsky. Genetic aspects of

porphyria cutanea tarda. Semin Liver Dis. 27 : 99-108, 2007. [PMID: 17295179].

234. Anna S. F. Lok, James E. Everhart, Raymond T. Chung, Latha Padmanabhan, Joel K. Greenson, Mitchell L. Shiffman, Gregory T. Everson, Karen L. Lindsay, Herbert L. Bonkovsky, Adrian M. DiBisceglie, William M. Lee, Timothy R. Morgan, Marc G. Ghany, Chihiro Morishima, and the HALT-C Trial Group. Hepatic steatosis in hepatitis C: comparison of diabetic and non-diabetic patients in the hepatitis C antiviral long-term treatment against cirrhosis trial (Publication 13 from the HALT-C Trial Group). Clin Gastroenterol Hepatol 5: 245-254, 2007.

235. Stephan Immenschuh, Ying Shan, Hartmut Kroll, Sentot Santoso, Wilhelm Woessmann,

Karl-Friedrich Tegtmeyer, Gregor Bein, and Herbert L. Bonkovsky. Marked hyperbilirubinemia associated with the heme oxygenase-1 gene promoter microsatellite polymorphism in a boy with autoimmune hemolytic anemia. Pediatrics Electronic Pages, 2006, in press.

236. Herbert L. Bonkovsky Vinod Rustgi, Sanjeev Arora, Larry Blatt, Stefan Zeuzem, Michael

Manns, and Elizabeth Olek. Interferon alfacon-1 (Infergen) thrice weekly for 48 or 72 weeks or once daily for 48 weeks in chronic hepatitis C. In preparation, 2006.

237. Annie T. Chemmanur, Zi Yang, Yiwen Zhao, John H. Gilliam, William M. Outlaw,

Herbert L. Bonkovsky, Richard W. Lambrecht, and Jamal A. Ibdah. Heterozygosity for two prevalent mutations in mitochondrial β-oxidation predisposes to nonalcoholic steatohepatitis.. Submitted, 2006.

238. Karen L. Lindsay, Chihiro Morishima, Elizabeth C. Wright, Jules L. Dienstag, Herbert L.

Bonkovsky, for the HALT-C Trial Group. Systemic factors are associated with lack of virologic response during peginterferon and ribavirin therapy of chronic hepatitis C: results from the lead-in phase of the hepatitis C long-term treatment against cirrhosis (HALT-C) trial. Submitted, 2007.

239. Ying Shan, Richard W. Lambrecht, Susan E. Donohue, and Herbert L. Bonkovsky.

Cobalt protoporphyrin up-regulates heme oxygenase-1 gene by altering levels of Bach1 and Nrf2 proteins in human hepatoma cells. FASEB Jl, 20: Exxx-Exxy, Oct 25, 2006 [Epub ahead of print]. [PMID 17065227].

240. Chihiro Morishima, Timothy R. Morgan, James E. Everhart, Elizabeth C. Wright, David

R. Gretch, Mitchell L. Shiffman, Gregory T. Everson, Karen L. Lindsay, Anna S.F. Lok, Herbert L. Bonkovsky, Adrian M. DiBisceglie, William M. Lee, Jules L. Dienstag, Marc G. Ghany, and the HALT-C Trial Group. Utility of a transcription mediated amplification assay for detection of hepatitis C virus RNA during combination therapy in the hepatitis C antiviral long-term treatment against cirrhosis (HALT-C) trial (Publication 16 from the HALT-C Trial Group). Hepatology, in press, 2007.

241. Mitchell L Shiffman, Marc G Ghany

, Timothy R Morgan, Elizabeth C Wright, Gregory T.

Everson, Karen L. Lindsay, Anna S.F. Lok, Herbert L. Bonkovsky, Adrian M. Di Bisceglie, William M. Lee, Jules L. Dienstag, Chihiro Morishima, James E. Everhart, and the HALT-C Trial Group. Impact of reducing peginterferon alfa-2a and ribavirin dose during retreatment in patients with chronic hepatitis C. (Publication 20 from the HALT-C Trial Group).


Gastroenterology, 132: 103—112, 2007. [Available on-line YGAST 53276; DOI 10.1053/j.gastro.2006.11.011]

242. Maria H. Sjogren, Robert Sjogren, Jr., Michael F. Lyons, Michael Ryan, John Santoro, Coleman smith, K. Rajender Reddy, Herbert L. Bonkovsky, Brooke Huntley, and Sima Faris-Young. Antiviral response of HCV genotype 1 to consensus interferon and ribavirin versus pegylated interferon and ribavirin. Submitted, 2006.

243. Young Moon Lee, Krishnan Venkataraman, Jason Michaud, Youxi Ai, Herbert

Bonkovsky, Nihal Parikh, and Timothy Hla. Liver as a major source of plasma sphingosine 1-phosphate. Submitted, 2006.

244. Tusar K. Desai, Laith H. Jamil, Mamtha Balasubramanian. Raymond S. Koff, and

Herbert L. Bonkovsky. Phlebotomy improves therapeutic response to interferon in patients with chronic hepatitis C: a meta-analysis of six prospective randomized controlled trials. Submitted, 2007.

Updated Jan 08 - idiCV/Bibliography Herbert L. Bonkovsky Page 3 17. Project Cork (to improve medical...

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