Up-Beat UK

A programme of research into the relationship between coronary heart disease and depression in primary care patients.

André Tylee, Mark Ashworth, Elizabeth Barley, June Brown, John Chambers, Anne Farmer, Zoe Fortune, Mark Haddad, Sally Hampshire, Rebecca Lawton, Anthony Mann Anita Mehay,, Paul McCrone, Joe Mirza, Joanna Murray, Morven Leese, Carmine M Pariante, Diana Rose, Gill Rowlands, Hannah Sims, Alison Smith, John Weinman and Paul Walters,

Funded by: NIHR 5-year Programme Grant, NIHR Research Methods Fellowship

UPBEAT Cohort DemographicsTable of basic demographics: Figures are numbers (%) of subjects unless stated otherwise

n= 803 (unless stated otherwise) from CHD registers in 17 practices in South London

     

Age at referral Mean (SD) (range) 71.06 (10.93) (27.11 - 98.94)

Gender Male 561 (69.86%)

  Female 242 (30.14%)  

Ethnicity White 701 (87.30%)  

  Other 102 (12.70%)  

Chest pain No 447 (55.67%)

(Rose angina questionnaire) Yes 356 (44.33%)  

PHQ9 (n=801) No depression 665 (83.02%)  

(cut off ≥10) Depressed 136 (16.98%)  

HADS

Depression scale (n=799) No depression 696 (87.11%)

(cut off ≥8) Depressed 103 (12.89%)  

HADS        

Anxiety Scale (n=800) No anxiety 601 (75.13%)  

(cut off ≥8) Anxious 199 (24.88%)  

Parsimonious multivariate logistic regression model for associations between participant

characteristics and a CIS-R diagnosis of depression (n=802).

Variable Odds Ratio Standard

Error

z- value 95% confidence

interval

p-value

Current chest pain 3.27 1.21 3.20 1.58-6.76 0.001

Age at referral (years) 0.95 0.01 -3.63 0.93-0.98 <0.001

Lives alone 5.50 2.68 3.49 2.11-14.29 <0.001

Problems carrying out usual activities 3.71 1.24 3.94 1.93-7.14 <0.001

Pain and discomfort 3.39 1.50 2.74 1.41-8.10 0.006