(- .AWARD/CONTRACT I. TIllS C(\ . KACT IS A RATED ORDER tATING PAGE OF PAGESUNDER DPAS (IS CFR 3S0) 1 I 26

2. CONTRACffPtVC. flU!. IdMI.1 NO. . EFFECTIVE DATE 14. REQUISITIONJPURCHASE REQUESTIPROJECT 1'0.M67854Q4C-5074 01 Ju120045. ISSUED BY CODE M67854 . ADMINISTERED BY (UOl/urtluulll,,,,,Jj CODI'lMCSC CCNTRACT1!'OG OfFICES 0fF'.cE OF NAVAl. RESEARCHCOOE; CT-IN'~WD TtANTA REGIONAl. OFFICE 100 ALABAMA STREE2ZOO LESTEA ST TLANTA GAJ03OJ..3104QUANTICO VA ZZl34

7. NAME AND ADDRESS OF CONTRACtOR (."10" mm. til)'. NIWItJ. JUllloNivpctKHJ 8. DWVERYUNIVERSITY OF FLORIDA r J FOB ORIGIN I XJ OntER {Ju/Hto"',DIVIs/ON OF SPONSORED RESEARCH, 219 OR1NT 9. DISLVU~'T FOK PROMPT "'MeNIGAIN$VILlE FL 3261 1

N"t30 Days

10. SUbMIT INVOICES 3 ITEM(4 'olU"s lUll'" QtMn>1Jt spw/itdlTO TIlE ADDRESS 5ecUon G

CODE SE687 IFACILITY CODE $HOWN1N:11. SIIIP TOIMARK FOR CODEI 12. PAYMENT WILL BE MADE BY COD MIl7443

OFA~U~BUSceNTERP.O. BQX369Q22ATTN: KANSASCOLUMBUS OH 43236-9022

See Schedule

13. AUTHORITY FOR USING OTHER THAN FUll. AND OPEN 14. ACCOUNTING AN"D APPROPRIATION DATACOMPETmOI': See ScheduleI [ J 10 U.S.C. 2304(c)( ) I J41 u.s.c. 253(c)( I

15A. ITEM NO. 15B. SUPPllESJ SERVICES ISC. QUANTITY ISD. UNIT ISE. UNIT PRICE ISF.AMOUNT

SEE SCHEDULE

15 TOTAL AMOUNT OF CONTRACT ;.0016. TABLE Of CONTENTS

XllsEC.1 DESCRIPTION IPAGEIS ! IXllsEC.1 DESCRIPTION PAGPISPART I THE SCHEDULE PART II CONTRACT CIAU~F$

X A SOLICITATIONI rONTRACT FORM 1 X I I IIYlNTRACT CLAUSES 111-24X B SUPPUES OR SERVICES AND PRICESI COSTS 2 PART 111- LIST OF DOCUMENTS Exumrrs AND OTIIER AlTACIIMENTSX C DESCRIPTIO~' SPECS} WORK SfATEMENT 3 X J IUSTOFAITACHMENTS 12524X D PACKAGING AND MARKING 4 PART IV REPRESENTATIONS AND INSTRUCTION~X E INSPECTION AND ACCEPTANCE S REPRESENTATIONS, CERTIFICATIONS ANDX F DELIVERIES OR PERFORMANCE 6 K OTHER STATEMENTS OFOFFERORSX G CONTRACT ADMINISTRATION DATA 79 L rNSTRS. COf"-'DS. AND NOTICES TO OH"ERORSX Ii SPECiAL CONTRACf REQUmEMENTS 10 M EVALUATION FACfORS FOR AWARD

C:C:NTRA "TINGOFRCER W1LLrOMPLETE ITF.M 7 OR 18 AS APPLICABLE1~7. [ J CO:"ITMACTOK"S NEGOTIATED ....ORf.EMUlT Csmp"!()(pn;Pl!irt4 IQ 111" !hia 111 I AW1JU) (f9O!'l10l j. "O! '59yirl'd 10 'isp Ih;' d NIloIl'lbc:r4ocll"Kot!!!4 "hIm cgrin '9 inu;p' gmn I ContnSTANDAlWFOkMZ6(REV.4-I')/"ro!Kfl'bc4 b)' GSAfAA r48Cl;R)UZI"(I)

cSection B Supplies or Services and Prices

ITEM NO SUPPLIES/SERVICES QUANTITY000 I

UNITLot

C

UNlTPRICE

M67854-04-C-5074

Page 2 of24

AMOUNT

Non-lethal Weapons StudyCOSTSensory Consequences of Electromagnetic Pulses Emitted by Laser InducedPlasmasMILSTRIP: M9545004RCR4DH2

ESTIMATED COST

ACRN AA Funded Amount

FOB: Destination

S514,175.00

S514,OOO.00

Non~lethal Weapons StudyCOSTSensory Consequences of Electromagnetic Pulses Emitled by Laser InducedPlasmas

ITEM NO0002OPTION

SUPPLIES/SERVICES QUANTITY UNITLot

UNITPRlCE AMOUNT

ESTIMATED COST

Funded Amount

FOB: Destination

5351,616.00

SO.OO

M678S4-04-C-S074

Page 3 of24

Section C - DesCriptions and Specifications

STATEMENT OF WORKCl Statement ofWorlc

CLIN 0001 and Option CLIN 0002 shall be in accordance with the Statement of Work attached to this contract.

/\,

Section J - List of Documents. Exhibits and Other Attachments

Exhibit/Attachment Table of Contents

( M67854-04-C-5074Page 24 of24

DOCUMENT TYPEAttachment 1

DESCRIPTIONStatement of Work

PAGES10

DATE

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M67854-04-C5074Attachment 1

Statement of Work

I. Technical

A) Objectivestrasks/Concept. Recent advances in directed energy weapons technology suggests thatscalable, non-lethal to lethal force systems may be possible. Such a system would be useful in manyenvironments. Two systems currently under development, active denial and pulsed ener ADS andPEP offer mainly complementary ca acities that could address multi Ie tasks

ese tasks include theThe full capability of these directed energy

systems (DE) are still being explored. At their current stage ofdevelopment, each system has clear non-lethal (ADS) and lethal (PEP) capacities suitable to the above tasks. Our experiments will examine thefeasibility of PEP as a new generation non-lethal wea on. Pulsed ener can be confi ed to roduce

lasmas of exce tionall hi enerIn the

studies described below we will determine the feasibility of using the plasma derived EMP to induce painsuitable to disarm and deter individuals or form barriers to the movement oflarge hostile groups. Ifsuccessfully deployed, PEP could complement ADS in situations in which the latter is ineffective, lesseffective, or rone to countermeasures. Many of the countermeasures that might be envisioned againstADS offer opportunities for PEP targeting (via plasma induction orablation of the defense). Despite these potential advantages, certain special capabilities and features ofADS offer advantages over PEP in many scenarios. Therefore, the systems are complementary.

The efficiency and lethality of PEP weapons systems lll'0 straightforward. The non-ballistic, instantaneous properties ofDEmake precise tlll'geting a straightforwlll'd matter of line ofsi l. Terrific amounts of ener can be delivered over greatdistances with pinpoint accumc . However, Potentially.the lication of PEP

proposal.

uantify tho. characteristics oflaser induced plasmas created.~withmicro-, nano- ico- and femtosecond lasers ofmulti Ie

These studies will examine the characteristics ofIn the studies described below, we will describe investigations that explore the

human effects ofLIP. Studies are proposed to detennine the capacityof_oevoke pain. These studies will beperformed, in vitro, where the factors such as distance and orientation can be tightly controlled, and whereth~ painsystem components can be isolated for detailed quantitative ",udy. A portion of the investigotions will apply_tosensory eell preparations. These.wi.be generated by conventional means. Subsequent studies will use laser-inducedplasmas to create . the characteristics of which will be well defined andoptimized to produce atraumatic sensory influences.

Objective I: To determine the feature. bat activate nociceptor. and tbe extent to whicb thisactivation Js effective without trau.ma. Pain is a primary component of all NLW. Pain can distract and deter individualsresulting in voluntary immobilization and/or flight. Nociceptors are the fundamental delection component ofthe pain system.Nociceptors transduce a variety of stimuli (gated ionic current) and then encode the pain signal (action potentials). While themechanisms are not fulJy understood. ADS operates mainly on the transduction component by heating biological tissue toactivate heat transducing proteins at asuh-tra~wave Techniques for Stimulation ofNociceptors.NTIC proposal, October, 2003). In contrast, _ could activate nociceptors at the level of

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M67654-04-C-5074Attachment 1

Statement of Work

encoding, thereby bypassing the transduction level. Induction at the encoding level is potentially more advantageous. as itavoids thedirect~d the risk that occurs from this time dependent event. Moreover, by engaging theencoding event, _ will not rely solely on specialized transduction proteins that are selectively expressed in asubpopulntion ofsensory afferents. Although they differ in i."fenn anddi,tri~Uu th.t medi.te eneoding arepresent in all excitable tissue. In objective 1, we will deternllnc the influence~n nociceptor activation,focusing specifically on cutaneous nociceptors that innervate superficial skin (epidenois) and underlying tissue (demtis). The strength required to induce activation, the contribution of pulse duration and burst frequency will be defined in tightlycontrolled experiments, in vitro. These data should prove to be very useful in interpreting the potential bwnan effects of LIP,and its potential as a NLW.

Objective 2: To eJ:amJoe tbe influenceof_laserplasmas, OD nociceptor activation aod determine tbeextent to which tbls activation 10 effective without trauma. Completion ofobjective I will enable a set ofh theses that

~fobjective 2. With an understanding of the 'safe'par~for_, directed choices can be made to study particular laser _ configurations onnocice~identical recordin methods ut lascr stimulation) we will examine the nociceptor activating properties oflaser_

configumtion and stimulation regimes.

B) BackgroundLaser Plasma Technology. There is increasing interest in the use oflasers for non-conventional defense applications. This isnot only a consequence ofthe recent heightened sensitivities in such areas as homeland security. defense force prolection, andlaw enforcement, but it also comes from new technical opportunities becoming available through the increasing pace ofdevelopments in laser technology. Developments in solid state laser technology in particular are leading these advances.Diode-pumping, for instance, for the first tiroe enables electrical pump energy to be selectively channeled to spccific lasertransitions within solid-state laser media, leading to vast improvements in laser efficiency, compactness and stability. Newevolutions in laser architecture, like fiber-lasers, slab-laser amplifiers, active phase control and ultra-short pulse technology arerapidly opening up new parameter space in sciences and technologies having possible relevance to new defense applications.One of these areas is th~ field of laser plusmas.

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M61854-04-G-5014Attachment 1

Statement of Work

In the new realm ofhigh intensity femtosecond laserof laser interaction science has been accessed leadin

Assuming that the cro,,-section ofthese highly transienttargeL Given that they~ times measured in picoseconds, the frequency ofsouree would be in the-",gion. However, to date, little research has verified the

There is extensive interest in developing weapons systems that utilize pulse energy projectiles (PEP). When appropriatelyconfigured, a PEP could serve both lethal and non-lethal lications. The guiding hypothesis of this proposal is that thecreation ofLIP can serve as a NLW by activation ofnocicepoors.

The Peripheral Pain System. The detection ofpain begins with a complex set ofperipheral afferents (nociceptors) that detectand encode a great variety ofstimuli. These peripherally encoded events are relayed by axons into the central nervous system(spinal cord, thalamus, cortex) where the information undergoes the complex assembly required to produce a localized,conscious perception ofpain (Cooper and Sessle, 1993). Nociceptive atferents detect tissue damaging or near tissue damagingconsequences ofmechanica! and thermal events, and the chemical events associated with actual tissue damage. To accomplishthese multilevel tasks, the pain system has evolved a family ofnociceptive neurons with dive"" mechanical, thermal andchemical response capacities. These capacities overlap in a manner that is not completely understood, but it is likely that theyvary for particular tissue sites (skin, joints, muscle, viscera, bone) that have highly specialized nociceptive requirements.Recent advances in nociceptor characterization have permitted classification, In Vi/TO. ofatlcast 8 distinct nociceptivephenotypes. Our laboratory has shown that sensory cells ofthe DRG are comprised ofdiscrete, internally homogenous, classesofcapsaicin (OC) sensitive (types I, 2, S, 7, 8 and 9) and insensitive (types 3, 4, 6) populations with distinct capacities torespond to SHT, PGEz, protons, ACh and ATP (Martenson et al., 1994; Cardenas et al., 1997; Cardenas et ai, 1999; Petruska etaI., 2000, 2002; Cooper and Cooper, 2001). We have used lipid soluble fluorescent tracers to define the specific distribution ofnociceptors into viscera, joints and skin. Prc:liminary studies have indicatedtha~pu1ationsofskinin~~ S. It is these nociceptors that are likely to receive the maximal burst _ from laser plasmas _

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M67854-04-C-5074Attachment 1

Statement of Wor!