Understanding Cancer and Related Topics Understanding Nanodevices Developed by: Jennifer...
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Transcript of Understanding Cancer and Related Topics Understanding Nanodevices Developed by: Jennifer...
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Understanding Cancer and Related Topics
Understanding Nanodevices
Developed by:Jennifer Michalowski, M.S.Donna Kerrigan, M.S.Jeanne KellyBrian HollenExplains nanotechnology and its potential to improve cancer detection, diagnosis, and treatment. Illustrates several nanotechnology tools in development, including nanopores, quantum dots, and dendrimers.
These PowerPoint slides are not locked files. You can mix and match slides from different tutorials as you prepare your own lectures. In the Notes section, you will find explanations of the graphics. The art in this tutorial is copyrighted and may not be reused for commercial gain.Please do not remove the NCI logo or the copyright mark from any slide. These tutorials may be copied only if they are distributed free of charge for educational purposes.
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What Is NanoBiotechnology?
NanodevicesNanoporesDendrimersNanotubesQuantum dotsNanoshells
Tennis ballA periodWhite blood cell
Water molecule
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Designing Nanodevices for Use in the Body
Too BigToo Small
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Manufacturing Nanodevices
Scattered X-rays
Atoms in crystal
Detector
NanodevicesCrystal White blood cell
CrystalX-ray beam
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Nanodevices Are Small Enough to Enter Cells
Cell
White blood cell
Water molecule
Nanodevices
Nanodevices
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Nanodevices Can Improve Cancer Detection and Diagnosis
ImagingNanoBiotechnology Physical Exam,Symptoms
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Nanodevices Can Improve Sensitivity
and determinewhich cells arecancerous orprecancerous.
Precancerous cells
Normal cells
Nanodevices could potentiallyenter cells
Precancerous cells
Normal cells
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Nanodevices Can Preserve Patients’ Samples
Cells from patientCells preserved
Active state preserved
Cells altered Active state lost
Additional tests
Cells from patient
Nanotechnology Tests
Traditional Tests
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Nanodevices Can Make Cancer TestsFaster and More Efficient
Patient A Patient B
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Cantilevers Can Make Cancer TestsFaster and More Efficient
Cancer cell
Watermolecule
NanodevicesCantilevers
Antibodieswith proteins
Antibodies
Whiteblood cell
Bent cantilever
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Nanopores
ASingle-strandedDNA molecule
Single-strandedDNA molecule
Whiteblood cell
Watermolecule
NanodevicesNanopores
Single-strandedDNA molecule
ATCGNanopore Nanopore
Nanopore
T
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Quantum DotsUltraviolet
light off
Whiteblood cell
Watermolecule
NanodevicesQuantum dots
Quantum dots emit light
Ultravioletlight on
Quantumdots
Quantum dotbead
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Quantum Dots Can Find Cancer Signatures
Cancer cells
Healthy cells
Quantum dot beads
Quantum dot beads
Healthy cells
Cancer cells
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Improving Cancer TreatmentNanotechnology TreatmentTraditional Treatment
Intact noncancerous cells
Noncancerous cells
Toxins Nanodevices
Cancercells
Dead noncancerous cells
Noncancerous cells
Drugs
Deadcancercells
Deadcancercells
ToxinsCancercells
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Nanoshells
Nanoshell
Whiteblood cell
Watermolecule
Nanodevices Nanoshells
Gold
Near-infrared light onNear-infrared light off
Nanoshell absorbs heat
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Nanoshells as Cancer TherapyNanoshells
Dead cancer cells
Nanoshells
Cancer cells
Healthy cells
Intact healthy cells
Near-infrared light
Healthy cells
Cancer cells
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Nanodevices as a Link BetweenDetection, Diagnosis, and Treatment
Nanodevice
Reporting
TargetingDetection
Imaging
NanoBiotechnologyCancer Treatment
Cancer cell
TraditionalCancer Treatment
Cancer cell
Drug
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Dendrimers
Dendrimer
Whiteblood cell
Watermolecule
Nanodevices Dendrimer
Cancer cell
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Dendrimers : Highly Branched Dendritic Macromolecules
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● Characteristics Monodisperse macromolecule Globular (Spherical) Facile surface bio-functionalization Similar molecular size to biomolecules (Glucose oxidase 65.27.7 nm)
Molecular carriers for chemical catalysts(Core, Peripheral)
Medical applications (MRI contrast enhancer)
Biomimetic catalysts(Peptides-, Glycodendrimers)
Vehicles for delivery of genes and drugs
Poly (amido amine) Dendrimers
4.5 nm
G4 Poly(amidoamine) Dendrimer
● Applications
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Dendrimers as Cancer Therapy
Cell deathmonitor
Reporter
Therapeuticagent
Cancerdetector
Watermolecule
Whiteblood cell
Nanodevices Dendrimer
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NanoBiotechnologies in Patient Care
Today 2020
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