Ultrashort and Zero Echo Time MRIinst.eecs.berkeley.edu/~ee225e/sp16/notes/UTE_ZTE.pdfUltrashort and...
Transcript of Ultrashort and Zero Echo Time MRIinst.eecs.berkeley.edu/~ee225e/sp16/notes/UTE_ZTE.pdfUltrashort and...
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UltrashortandZeroEchoTimeMRI
PederE.Z.Larson,Ph.D.SurbeckLaboratoryofAdvancedImaging,DepartmentofRadiologyand
BiomedicalImaging,UniversityofCalifornia,SanFrancisco,CA,[email protected]
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2
Semi-solid Tissues
Tendons
Meniscus
Sig
nal
t Data
Acquisition
Examples: Cortical Bone Tendons Lung Tissue Myelin
Cortical bone
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3
Ultra-short/Zero Echo Time Imaging
Sig
nal
t Data
Acquisition
Potential Clinical Applications: Bone mapping Tendinopathy Cancerous Lung Nodules Fibrotic Lung Disease Demyelination/dysmyelination
Tendons
Meniscus
Cortical bone
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4
Dipole Field
Magnetic dipole produces local (~nm) magnetic field variations, ΔB0
µ
ΔB0(r)
z
x-y
~nm
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5
Dipolar Coupling
Frequency ω0
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6
Dipolar Coupling
∆B0,2
∆ω1
Dipoles couple, which induces resonance frequency shifts, Δω
Frequency ω0
∆ω2
Δω = γΔB0
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Dipolar Coupling
Frequency ω0
∆ω1
∆ω2
∆ω3
Dipoles couple, which induces resonance frequency shifts
Δω = γΔB0
Dipoles couple, which induces resonance frequency shifts, Δω
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8
Precession
• “on-resonance” – ω = ω0 , acquires no phase • “off-resonance” – ω = ω0 + ∆ω , dephases from resonant spins
ΔB0 > 0
Spins precess around B0 at their resonance frequency, ω Rotating Frame: Demodulate precession at Larmor frequency ω0 = γB0
ΔB0 < 0 time
ω = γ(B0+ΔB0) B0
ΔB0 – variations in magnetic field
∆ω1
∆ω2
∆ω3
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9
Dephasing
Net magnetization is reduced over time by varying precession rates
ω = γ(B0+ΔB0)
time B0
∆ω1
∆ω2
∆ω3
time
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T2 Relaxation
t
Tran
sver
se
Mag
netiz
atio
n
exp(-t/T2)
T2 relaxation is caused by local field shifts from dipolar coupling → Dephasing and reductions of the transverse magnetization (MXY)
B0 ∆ω1
∆ω2
∆ω3
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11
T2 for Mobile Spins
Long T2 relaxation time
Frequency
Num
ber
of
Spi
ns
t
MXY
ω0
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12
T2 for Spins in Solids
Frequency
Num
ber
of
Spi
ns
t
MXY
ω0
Short T2 relaxation time
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2DUltrashortTEPulseSequence
13
Half-pulse excitation
PR (radial) acquisition
Conventional UTE
Full-pulse excitation
Cartesian acquisition
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ConvenMonalExcitaMon
14
RF t
GZ t
RF
kZ
kZ = 0
Always ends at center of excitation k-space
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2DUTEExcitaMon
15
RF t
GZ t
RF
kZ
kZ = 0
Half-pulses
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16
Half-pulse Slice Profile Positive Gradient Negative Gradient
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UTEAcquisiMons
17
Start at k-space origin for minimum TE
echo echo
kx
ky
t
GX, GY
t
kx
ky
GX, GY
Ultra-short t
DAQ
t
DAQ
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18
3D UTE Excitation • Excites everything • Short • Minimum TE = 0
• Excites a slab • Minimum TE
and duration increased (~100 µs)
• Limits FOV and artifacts (gradient non-linearity)
RF t
RF t
t GZ
Images courtesy of Paul Gurney
Hard Pulse
Minimum-phase Slab Pulse
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3DUTEAcquisiMon
19
kx
kz
ky
kz
kx ky
3D Radial Trajectory
3D Cones Trajectory Gurney et al. MRM 2006.
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T2SliceProfiles
20
Slice profile blurs as T2 decreases and as RF duration increases
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T2DecayduringAcquisiMon
• LoseResoluMonwithT2decay• Tread«T2requiresmassive
gradientsandlowersSNR(sqrt(Tread))
• UseTread≈T2foropMmalSNR
21
t
Gread Fourier Transform
kx
exp(-t / T2)
t
Tread « T2
Tread = T2 Tread = 2T2
Sig
nal
Nor
mal
ized
PSF
Pixels
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3D UTE image, TE=229 µsa b
TE=2.2 ms
c T1-weighted FSE T2-weighted FSE
d
VaryingTEAnkleImages
22
Sig
nal
t
Achilles’ tendon (T2 ≈ 1 ms)
TE=226µs
Sig
nal
t
TE=2.2ms
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ProblemwithUTEImaging
23
Poor short-T2 component contrast Signal from all tissues
Myelin? tendons (T2 ≈ 1 ms)
cortical bone (T2 ≈ 500 µs)
meniscus (T2 ≈ 4 ms)
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Long-T2Suppression
24 Rahmer J, et al. Magn Reson Mater Phy.
Fat T2 ≈ 80 ms
Muscle T2 ≈ 50 ms
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RFPulseT2Contrast
25
Short-T2
RF Pulse
Long-T2
Frequency
Num
ber
of
Spi
ns
z
x-y
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RFPulseT2Contrast
26
RF Pulse
Frequency
Num
ber
of
Spi
ns
z
x-y
Short-T2 Long-T2
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Long-T2SuppressionPulses
27
Dephasing gradient: destroys MXY
Suppression pulse: contrast preparation
z
x-y
Half-pulse excitation
Signal = MXY
Contrast in MZ
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ImprovedSuppressionPulses• DesignedwithShinnar-Le
Roux(SLR)Transform(PaulyJMetal.IEEE-TMI10:53-65(1991).)
• Preciselymatchdesiredspectralprofile
• Time-bandwidth(TBW)-controlssharpnessofprofile
28
RF t
TBW = 2.0
TBW = 3.0
Off-resonance Frequency
MZ
Rectangular (TBW ≈ 1.0)
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SuppressionResults
29
Rectangular pulse failures
No Suppression Rectangular Suppression Pulse
SLR-designed Suppression Pulse
TE = 80 us, TR = 500 ms, flip = 60 degrees, 5 mm slice thickness, 1 mm in-plane resolution, transmit/receive head coil, 1.5T GE Scanner 4:15 min acquisition
Consistent white matter contrast (likely Myelin)
Falx Cerebri
Dura Matter
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AddingFatSuppression
30
z
x-y
ω0
(water)
Num
ber
of
Spi
ns
Frequency ω0 - Δωfat
(fat)
Short-T2 Fat
Long-T2
Water Long-T2
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Dual-BandSuppressionPulses
31
RF
Using SLR pulse design
TBW = 3.4 + Fat suppression
band
- Additional short-T2 signal loss
t
Off-resonance Frequency
MZ
0 -Δωfat
real imag
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3DAnkleImages(1.5T,2005)
32
No Suppression Dual-band Long-T2 Suppression Pulse
Achilles’ tendon
Fat
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3DAnkleImages(1.5T,2005)
33
tendons
plastic boot
Achilles’ tendon
Peroneal tendons
No Suppression Dual-band Long-T2 Suppression Pulse
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3DAnkleImages(7T,2014)
34Han et al. Inv Radiology, 2014.
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UTELungImaging
35Jiang et al. Proc ISMRM 2016.
1.25mm resolution, Resolved over 5 respiratory phases
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UTELungImaging
36Jiang et al. Proc ISMRM 2016.
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ZeroEchoTime(ZTE)MRI
• ZeroechoMme:crosscenterofk-spaceduringRFpulse
• Butdon’tacquirecenterofk-space– AlgebraicreconstrucMon– FillinwithsinglepointacquisiMons– Fillinwithlow-resoluMonprojecMons
37
RF
DAQ
GX
GY
GZ
RF
DAQ¨7
GX
UTE
GZ
GY
ZTE
kx
ky
kx
ky
¨7� �7(
UTEor
ZTE(1 TR)
Fat Saturationx Nsat x Nproj
/Nsat
Inversion Pulse
TI TDUTEor
ZTE(1 TR)
Fat Saturationx Nsat x Ninv
x Nproj/Nsat/Ninv
a
b
c
d
RF
G
100º
RF
DGLDEDWLF�����
RF
G
100º
Miss center of k-space
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ZeroEchoTime(ZTE)MRI
• Silentscanduetoslowrampingofgradients
• Limitedflipangleandvolumetriccoveragedueto“sliceselecMon”duringRFpulse
• “Slice”changeseveryTR!BlurringarMfacts38
y
x
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ZTEBoneImaging
39
Wiesinger,etal.MRM(2015).Delso,etal.JNucMed(2015).Leynes,etal.ProcISMRM2016.
June 3, 2015
midres=2.4mm highres=1.35mm (39sec) (2min:53sec)
09/01/2015
4
ZTE -log(ZTE) Pseudo-CT
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Fat sat, 0.65 mm isotropic resolution, 32 projections/fat sat, 1.3ms readout duration, TR = 2.3ms (ZTE), 2.2ms (UTE) 4:45 5:15
ZTE Tendon Imaging
§ Excellent tendon visualization, including fascicular structure of Achilles’ tendon
§ 0.7mm isotropic resolution
§ 4:45 scan time
Achilles tendon (T2* ≈ 0.85 ms)
tendons
40 Larson et al. MAGMA 2015.
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ZTE Knee Imaging
§ Excellent tendon, ligament, cartilage, and meniscus visualization
§ 0.6 mm isotropic resolution
§ 4:45 scan time
Larson et al. MAGMA 2015. 41
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OtherUTEImages
42
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43
3DUTEViolinImages
Barral et al. Proc 49th ENC 2008.
3D PR acquisition with FOV tailored to the violin shape Larson et al. IEEE Trans Med Imag 2008; 27:47-57.
TE = 64 us, TR = 5.2 ms, 1.3-1.8 mm in-plane resolution, 3” surface coil, transmit/receive head coil, 1.5T GE Scanner 1 min 43 s and 19 min acquisition
k-space PSF