UK – Dutch collaboration
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Transcript of UK – Dutch collaboration
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Planet 2 /MATISSEUK – Dutch collaboration
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RESEARCH STAFF
Karin (K) FijnvandraatPediatric hematologistAcademic Medical Center (Amsterdam) Sanquin blood supply
Enrico (E) LoprioreNeonatologistLeiden University Medical Center
Anske (JG) van der BomProfessor of Clinical EpidemiologyLeiden University Medical CenterSanquin Blood Supply
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HISTORY OF MATISSE TRIAL• 2011 - 2012: Idea plus funding• 2013: PhD student + Planet-2 • Jan 2014: ethical approval• Feb 2014: start study in Amsterdam
Managing Thrombocyte transfusions In a Special Subgroup: nEonates
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STUDY DESIGNS IDENTICAL
Transfusion thresholds
Inclusion criteria
Transfusion dose
?Outcome
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PARTICIPATING CENTERSGroningen
Zwolle
Veldhoven
Nijmegen
Maastricht
RotterdamLeiden
Amsterdam
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PARTICIPATING PI’S
…
E. Lopriore
A. Kroon
A. Van Kaam
W. de Boode M. vd Hoeven
A. Donker
E. D’Haens
C. Hulzebos
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PARTICIPATING CENTERS• 8 level II/III neonatal intensive care units• 4000 admission per year• 2000 < 34 weeks GA
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PLANNING• February 18 start in Amsterdam• February – september: start other centers• Datasharing• Expected inclusions: 65 / year
Inclusions
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MONET: MONITORING OUTCOME IN NEONATAL THROMBOCYTOPENIA
• Retro/prospective observational cohort• Goal: prediction model neonatal bleeding• Design phase, 1000-2000 inclusions
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Questions?
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