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True Room Temperature Bonding a novel process for the creation of health tech consumables ATB ir. Richard Bijlard Technogation - Invenios Technogation Invenios Dec 2014 Slide 2 Presentation Overview Invenios Group From Lab to POC Challenges at creating advanced consumables ATB (True Room Temperature Bonding) Applications Slide 3 Invenios Worldwide Santa Barbara, California, USA Langen (Hessen) Germany Eindhoven Netherlands Slide 4 Health Tech Trends: from Lab to POC Laboratory: Large degree of freedom, versatile, high-end Stationary, expensive, specialist-use.. Slide 5 Lab-On-a-Chip Select necessary functionalities for test Shrinkin size and in price! possible to scale down? absolutely necessary? combination possible? controllable -> pre-programmed! inputs and outputs? unambiguous interpretation of results! reproducible? mass-producible? low cost? Slide 6 Some necessary L-O-C functions I/O sample intake: capillary, active pump, process sequence control: valves,.. reagent availability: pre-loaded / externally connected Heating/cooling electrodes? fluid? Measurement / readout sample processing: separation? chemical / electical / optical on-chip, external display, Slide 7 And if you do it right, you get a solution that is: Very portable! (true Point-of-care solution) Cheap (uses less reagents, sample..) Fast Easy-to-use Safe Slide 8 Design & Construction of Consumables Base material: Paper: very cheap! Plastic: cheap, easy to process Glass: transparancy, low autofluorescence, thermally stable, resistant against solvents Silicon: very mature semiconductor processes and tools available Construction: depends on material(s) ideal situation: combine materials! application dictates formfactor. the smaller, the better ! (cheaper, portable,..!) FOTURAN PSGC Slide 9 Pre-loaded Consumables / Sensors Problem -Need to have locally coated/functionalised structuresbut chip needs to be hermetically closed -Glueing introduces toxicity -Anodic Bonding and Diffusion Bonding are NOT options: Slide 10 Ambient (Room) Temperature Bonding (patented) (->2) True Room temperature < 30 o C (->1) Two or more substrates (different CTEs possible!) Thin film blocking layer on interface No glue or high temperatures Appropriate wavelength laser Very locally created plasma, so bulk of the material stays at room temperature Slide 11 Room Temperature Bonding - Characteristics High bond strength > strength of the base material Low temperatures, heat impacted zone < 1 m of bond joint Possible to create electrical leads in the same process step Embed fluids or biomaterial/-coatings (Fibronectin, Poly-acrylamide gel, PFTE / Teflon,) Seals hermetically and in a vacuum, inert gas or even under water, if required Scalable process, designed for operating in clean room production lines Slide 12 What can you bond? The following substrates can be bonded together in any combination: Several types of Glasses Quartz/Fuzed Silica Sapphire Silicon Silicon Nitride Silicon Oxide Metals (Gold, Titanium,) Several plastics Slide 13 Properties Comparison DIFFUSIONANODICADHESIVEAmbient Temperature (ATB ) High bond stability XXX Simple, low-cost process ?X Surface Prep XX Applicable for materials with mismatched CTEs XX Chemically resistant ?X Hermetically seals XX High transparency XX Temperature stable X Proprietary X Bonds in a vacuum XXX Slide 14 DNA sequencing Chips, Lab-on-a-chip Dispensing Cancer Research Chip Electrofluidic lens Slide 15 Application: Pressure Control Valve Made of glass Opening controlled by reference pressure Wavefront guides prevent bubbles Passive, implantable Very durable Slide 16 Pressure Control Valve Slide 17 Conclusions Trend towards Point Of Care requires small, smart and dedicated solutions All materials have pros and cons. advanced consumables combine best properties ATB enables connection of multiple materials on room temperature and does not harm biocoatings or materials Slide 18 Thank you for your attention! Richard Bijlard Business Development Europe Technogation ( an Invenios company ) phone: 06-4759 4741 email: bijlard@technogation.com www.technogation.com Technogation Invenios Dec 2014