Translation from mRNA to Protein
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Translation from mRNA to Protein
Transcript of Translation from mRNA to Protein
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TRANSLATION
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What is Translation?The synthesis of polypeptides using the genetic code from RNA.
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The Genetic CodeFive Major Features of the Genetic CodeTripletNonoverlappingCommalessDegenerateUniversal
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The Genetic Code
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Codon-Anticodon Pairing
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The Wobble Hypothesis
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Requirements for TranslationRibosomeRNAs (mRNA, tRNA, rRNA)Protein FactorsActivated Substances
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The Ribosome
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Phases of Translation
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Serves as the adapter moleculeContains the anticodonCovalently bonded to aa by aminoacyl tRNA synthetase
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INITIATION COMPLEXmRNA30S & 50 S ribosomal unitfmet-tRNAfmetGTP, Mg+2IF-1, IF-2, IF-3
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Shine-Dalgarno sequence
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Three Steps:aa-tRNA bindingPeptide bond formationTranslocation
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EF-Tu recycling