Transdermal Testing Systems Dissolution Testing Systems · Transdermal Testing Systems Dissolution...
Transcript of Transdermal Testing Systems Dissolution Testing Systems · Transdermal Testing Systems Dissolution...
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Transdermal Testing Systems
Dissolution Testing Systems
Physical Testing Systems
By Logan Instruments
LOGAN PRODUCT LINE
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Transdermal Testing Systems
By Dr. Luke Lee
LOGAN PRODUCT LINES
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LOGAN INSTRUMENTS CORP. 19-C Schoolhouse Rd, Somerset New Jersey 08873 USA
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LOGAN INSTRUMENTS CORP. 19-C Schoolhouse Rd, Somerset New Jersey 08873 USA
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LOGAN INSTRUMENTS CORP. 19-C Schoolhouse Rd, Somerset New Jersey 08873 USA
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LOGAN INSTRUMENTS CORP. 19-C Schoolhouse Rd, Somerset New Jersey 08873 USA
What products need transdermal testing?
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LOGAN INSTRUMENTS CORP. 19-C Schoolhouse Rd, Somerset New Jersey 08873 USA
Users of Transdermal Systems
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Section 1:
Transdermal Diffusion Cells
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LOGAN Vertical Cell
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Vertical Cell / Franz Cell
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Logan Nail Cells
Nail Holder
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LOGAN Horizontal Cells / Side By Side
Cells
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Logan Cornea
Cells
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Horizontal Cells / Side By Side Cells
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LOGAN Bubble Free Cell PATENTED
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Dry Heat Cells
DHC
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SECTION 2:
Filter Paper
Artificial Skin
In-Vitro Skin Models
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Filter Paper
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LOGAN INSTRUMENTS CORP. 19-C Schoolhouse Rd, Somerset New Jersey 08873 USA
Artificial Skin – Strat-M membrane
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LOGAN INSTRUMENTS CORP. 19-C Schoolhouse Rd, Somerset New Jersey 08873 USA
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LOGAN INSTRUMENTS CORP. 19-C Schoolhouse Rd, Somerset New Jersey 08873 USA
Strat-M Membrane
1. Remove the Strat-M Membrane from the plastic bag
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LOGAN INSTRUMENTS CORP. 19-C Schoolhouse Rd, Somerset New Jersey 08873 USA
Strat-M Membrane
2. Place the Strat-M Membrane on the Diffusion Cell
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LOGAN INSTRUMENTS CORP. 19-C Schoolhouse Rd, Somerset New Jersey 08873 USA
Strat-M Membrane
3. Load samples on Strat-M Membrane
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Manual Systems
Transdermal Diffusion Cell Systems
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LOGAN FDC-6
Transdermal Diffusion Cell Drive Console
Temperature Controller Water Tank
FDC-6 Drive Console
Franz cells
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LOGAN SDC-6
Transdermal Diffusion Cell Drive Console ( 6 Side By Side Cells)
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LOGAN SFDC-6
Transdermal Diffusion Cell Drive Console ( 3 Vertical Cells & 3 Side By Side Cells)
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LOGAN DHC-6T
Dry Heat Transdermal System
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LOGAN DHC-6T
Dry Heat Transdermal System
For sampling, the cell support plate lays flat
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LOGAN DHC-6T
Dry Heat Transdermal System
For media replacement, the cell support plate tilts to purge the bubbles
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Semi- Automated Systems
Transdermal Diffusion Cell Systems
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LOGAN FDC-6T
(patents)
A. Bubble Free Cell
B. Tilting Device
C. Manifold system
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LOGAN FDC-6T
Semi- Automated System
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LOGAN FDC-6T
Semi-Automated Systems
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Automated Transdermal
Systems
Transdermal Diffusion Cell Systems
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LOGAN SYSTEM 912-6 Automated
Transdermal Diffusion Cell System
SCT-160V Sample Collector System Controller
FDC-6 T Syringe Pump
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LOGAN SYSTEM 912-12 Automated
Transdermal Diffusion Cell System
SYRINGE
PUMP
SCT-240V SAMPLE
COLLECTOR
SYSTEM CONTROLLER
FDC-6 DIFFUSION CELL DRIVE CONSOLE
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LOGAN SYSTEM 912-24 Automated
Transdermal Systems
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DEAR-1200 ONLINE DEGASSING SYSTEM (Optional)
DEAR-100 w/ Vacuum bottle
Hot Plate (Not included)
LOGAN SYSTEM 912
Automated Transdermal Diffusion Cell Sampling
System
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AUTOMATED DISSO III-7 SYSTEM Transdermal Patch System
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LOGAN SYSTEM 64 Robotic Transdermal System
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USP Apparatus 5,6,
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USP Apparatus 7
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LOGAN INSTRUMENTS CORP. 19-C Schoolhouse Rd, Somerset New Jersey 08873 USA
Data provided by Merck-Millipore
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LOGAN INSTRUMENTS CORP. 19-C Schoolhouse Rd, Somerset New Jersey 08873 USA
Data provided by Merck-Millipore
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USP Dissolution Apparatus
By Logan Instruments
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USP Apparatus 1,2,5,6,
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USP Apparatus 1,2,5,6,
UDT-812GS
Universal Dissolution Tester
With Gas Spring Lift
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USP Apparatus 1,2,5,6,
UDT-814
Universal Dissolution Tester
With Power Lift
Year 2014 model
with color touch
screen display
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UDT-814-12+2 Universal Dissolution Tester
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UDT-804-2L Universal Dissolution Tester
(2L Dissolution Tester)
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UDT-804-4L Universal Dissolution Tester
(4L Dissolution Tester)
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Physical Calibration Tool Set
Centering Shaft
Wobble Gauge & Stand
Speed Tachometer
Thermometer Timer
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SYSTEM 800S with SHIMADZU UV 1600 /1650/1700
Automated Dissolution UV System
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SYSTEM U800S with SHIMADZU UV 1600/1650/1700
Automated Dissolution UV System
Method
Product
Sample
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SYSTEM 850 BDL For HPLC off line analysis
Automated Dissolution Syringe Pump Sampling System
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SYSTEM 860 Automated 3 Speed Zone
Dissolution Sampling System with Center-Point™
Cameras
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MDS 600PL
Media Delivery System
The mobile unit brings pre-heated,
degassed media to dissolution testers.
Fills 6 vessels to the same volume
simultaneously.
Media de-aerated by heat, high speed
circulation, filtration and vacuum.
Temperature accuracy controlled to +/- .2 C.
Simultaneously delivers 6 vessels up to
1000 ml within 2 minutes
Detachable Oxygen meter to check oxygen
Printer report for Date, Time, Media Type.
Media Volume, Temperature, Oxygen
Dissolving Rate, pH, etc.
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MDS 600
Media Delivery System
MDS-600 Delivery
Manifold
UDT-804
Dissolution Tester
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MDS 600T
Media Delivery System
* Table top unit fills media into 6 dissolution vessels
* Six Vessels filled to the same volume simultaneously
* Volume delivered to better than +/-1%
* Deaerated by filtration, circulation, vacuum and heat.
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AVC-100 HTP
Automated Vessel Cleaner
• For Validation
• Color Touch Screen Display
• Mobile unit brings cleaner to bath
• Selectable Methods for different products,
* High pressure turbo wash and vacuum
* Media neutralization in waste tank
• Automatic waste discharge
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AVC-100
Automated Vessel Cleaner
Wash Head
UDT-804
Dissolution Tester
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USP Dissolution Apparatus 3
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LOGAN USP DISSO III Classic
Patented
pH 1.7 pH 4.6-6.1
pH 6.5
pH 5.8
pH 6.5-8.0
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USP Apparatus 3
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For USP Method 3 Tests
In line sampling
Individual vessel
covers
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LOGAN AUTOMATED DISSO III-7
SYSTEM
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For USP Dissolution Method 7
Tests
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USP Apparatus 7
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LOGAN DISSO III-7
Release Rate Tester W/ Auto-Sampler
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USP Dissolution Method 7
Dry Heat System
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LOGAN DISSO III-7 (USP 7) Applications:
Patented !!!!!
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LOGAN SYSTEM 7000-24 Automated Hip Stem Test System
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LOGAN SYSTEM 7000-24 Automated Hip Stem Test System
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LOGAN Fully Automated USP 7
System
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LOGAN Tablet Physical Testing
Products
• Disintegration Tester
• Friability Tester
• Hardness Tester
• Tap Density Tester
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DST-3/6 Disintegration Tester
•Easy-To-Use input keypad
•Audible end of run signal
•Modular design for 1 to 6
simultaneous tests
• 2 Single in-line layout for
easy viewing of all basket
assembles
•Meets or exceeds all USP
requirements and
specifications
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FAB-2S Friability Tester
•As per USP specification
•Adjustable speed at 20-70 rpm
•Test with one or two drums
•Select of counter or timer
•Easy input key pad
•Microprocessor control & LCD
display
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FAB-2SP Friability Tester
•As per USP specification
•Adjustable speed at 20-70 rpm
•Test with one or two drums
•Select of counter or timer
•Easy input key pad
•Microprocessor control & LCD
display
•Printer / report center
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LOGAN HDT-400L
Automated Hardness Tester For: Hardness / Thickness / Diameter / Weight measurements
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LOGAN TAP-2S Automated Tap Density Tester
Meets all current USP, BP, JP
guidelines.
LED Display for TIME or
COUNTER.
Microprocessor Technology
Control System.
Easy To Use Input Keypad.
Modular Design for One or
Two Platforms.
Simultaneous tapping and
rotary motion
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LOGAN TAP-2SP Automated Tap Density Tester w/ Printer
Meets all current USP, BP, JP
guidelines.
LED Display for TIME or
COUNTER.
Microprocessor Technology
Control System.
Easy To Use Input Keypad.
Modular Design for One or
Two Platforms.
Simultaneous tapping and
rotary motion
Report printer
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Prepared by Logan Instruments THANK YOU!
LOGAN INSTRUMENTS CORP.
19-C Schoolhouse Rd, Somerset New Jersey 08873 USA