Time-to-Digital Converter - qutools.com · of time correlated single photon counting (TCSPC)....

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Time-to-Digital Converter Time tagging device with picosecond precision Applications: Time-Correlated Single Photon Counting (TCSPC) Quantum Optics & Communication Single Photon Emitter Characterisation Photon Anti-Bunching Time Resolved Fluorescence Satelite Laser Ranging DNA Sequencing

Transcript of Time-to-Digital Converter - qutools.com · of time correlated single photon counting (TCSPC)....

Page 1: Time-to-Digital Converter - qutools.com · of time correlated single photon counting (TCSPC). TC-SPC was introduced in the late 60s and was primarily used for recording fluorescence

Time-to-Digital Converter

Time tagging device with picosecond precision

Applications:• Time-Correlated Single Photon

Counting (TCSPC)

• Quantum Optics & Communication

• Single Photon Emitter Characterisation

• Photon Anti-Bunching

• Time Resolved Fluorescence

• Satelite Laser Ranging

• DNA Sequencing

Page 2: Time-to-Digital Converter - qutools.com · of time correlated single photon counting (TCSPC). TC-SPC was introduced in the late 60s and was primarily used for recording fluorescence

quTAG - the Time to Digital Converter

Time Tagging in the Picosecond RegimeTime tagging measurements determine the exact time of electrical events with picosecond precision. This universal method allows versatile setups and experiments with high timing resolution.

Every electrical event, e.g. from a single photon detector, is recognized and measured by the time tagging elec-tronics. These events are marked with a timestamp and a list of events is created and sent to the computer for further evaluation.

The new generation of detectors are featuring a very low timing jitter and low dead times for more accurate and faster results. To use the full capacity of these detectors, the electronics have to match the requirements. We of-fer our time tagging systems with a jitter as low as 3 ps (RMS) and dead times less than 1 ns.

Our universal approach allows various and versatile applications with time resolution from picosec-onds up to days. The method allows correlation, coincidence and lifetime measurements within one experimental run. And even application we did not think of yet! You can decide, even after the mea-surement, what kind of analysis will be performed since all information needed for any application is included in the time tag stream.

TCSPC

Together with the use of a single photon detector, like Photomultipliers, Single Photon Avalanched Diodes or superconducting nanowire detectors, the time tagging unit can be used to perform the well-known technique of time correlated single photon counting (TCSPC). TC-SPC was introduced in the late 60s and was primarily used for recording fluorescence decay curves.

A typical TCSPC measurement involves a pulsed light source and a single photon detector. The trigger signal from the pulsed source and the detector signal is fed into the electronics and the time difference between the detector signal and the latest trigger signal is retrieved. These measurements are sorted into a histogram and the fluorescence lifetime can be determined. Our time tagging device in start-stop mode allows the direct out-put of the timing difference and easy calculation of the histogram.

Time

The electrical signals at the input channels are processed and a time-stamp for each event is created. This list of tim-ing events is then sent to the PC for further evaluation.

Start-Stop-Time

Laser /Trigger

Photon

A typical TCSPC measurement: the electronics mea-sures the timing difference between a photon event and the latest trigger pulse from the light source.

Time

The TCSPC measurement is repeated many times and in every period the differential time is added to a start-stop histogram resulting in the original waveform of the fluorescent probe. From this, the lifetime of the fluorophore can easily be extracted.

Channel Timestamp

1 42 ps

2 71 ps

3 97ps

1 112 ps

3 153 ps

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Time Tagging

The time tagging mode is the simplest but also the most versatile mode. All incoming events are time tagged relative to one starting point - normally the start of the device. This mode records all event data without even knowing what kind of evaluation is done. All measurement data is still available and the evaluation can be done on this raw data. On the other hand, the data stream can also be filtered al-ready within the hardware to keep the recorded data as low as possible.

Correlation

The time-tagged event stream can be used to construct a correlation curve of the incoming data, as used in fluores-cence correlation spectroscopy or photon (anti-)bunch-ing experiments. Our time tagging electronic allows the calculation of the correlation function on-the-fly and re-cords only the relevant histogram data without the need of recording all these timing events.

Application Area of Time Tagging

The measurement of the cross-correlation of two detector in a Hanbury Brown-Twiss setup. The data clearly show the existence of a single photon emitter.

Picosecond measurements are used in many different kinds of experiments and applications.

Time Delay

Quantum Information Processing

LIDAR

DNA sequencing

Quantum Key Distribution

Quantum Communication

Semiconductor analysis

Mass Spectroscopy

Time Resolved Photoluminescence

FLT & FLIM

FCS & FLCS

FRET

Single Photon Emitter Characterisation

Bunch Purity

STED

ToF

Picosecond TimeMeasurement

OTDRSatellite Laser Ranging

Photon Anti-Bunching

Neutrino - Cherenkov radiation detection

Detector calibration Time-resolved Raman spectroscopy

Dynamic Light Scattering

Diffuse optical Tomography

PALS Particle PhysicsBiology

Quantum OpticsRanging

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quTAG - the Time to Digital Converter

Standard

Our time tagger for most applications in the standard version. The four stop channels and one start channel are sufficient for a lot of appli-cations and the timing jitter of <10ps RMS fits to many detectors.

It can be synchronized with other standard de-vices to up to 16 stop channels.

LowRes

The low-resolution time tagger for the cost-sen-sitive user with a timing jitter of <150ps RMS. All features of the standard version are available for this device as well.

Additional output channels are available that re-act directly on incoming signals or to be used as a pattern generator.

quTAG - the Time to Digital ConverterThe quTAG is a versatile time tagging device which can be configured directly to your needs. The easy-to-use device allows any application you can think of.

The quTAG is a family of high-end, easy-to-use time tagging devices, directly tailored to your needs. The four members of the family differ in its timing resolution and counting rate, but have the core in common.

Input specifications

Input signals may vary from -3V to +3V, the individual channel thresholds can be user-defined. A de-lay is adjustable for each channel from -100ns to +100ns. This feature compensates different cable lengths or delays from the used detectors. The delay is adjustable in steps of the digital resolution.

Connections

All devices come with SMA connectors for the timing channels and an USB3.0 connection for simple and easy connection to a PC. The stan-dard USB connection allows a sustained trans-mitting rate of 100 million timing events per second.

Digital resolution 1 ps

Timing jitter < 10 ps (RMS)

Event rate per channel 25 Mcps

Dead time < 40 ns

Up to 16 stop channels, 1 start channel

Digital resolution 25 ps

Timing jitter < 150 ps (RMS)

Event rate per channel 25 Mcps

Dead time < 40 ns

Output channels available

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HighRes

This device is optimized for the most precise tim-ing resolution we offer. With a jitter of <3ps RMS, it can handle even the best available single pho-ton detectors.

It features 2 channels which can be synchronized to other highres devices.

HighSpeed

This is the choice when you have high event rates. This time tagging device is optimized for ultrashort dead times of <1ns.

The device features a ultra-large onboard memo-ry for buffering large burst events.

Jitter measurement

In order to measure the jitter, we generate an electrical pulse with steep edges. This pulse gets split into two by a power split-ter and sent into two different inputs of the quTAG (i.e. Start and Stop-X or Stop-X and Stop-Y). Then we use the quTAG software to gener-ate a startstop-histogram. We fit a Gauss-ian function to this histogram and deter-mine FWHM and RMS. The single channel jitter corresponds to from this two channel measurement.

Software

The quTAG includes a software bundle with an easy-to-use GUI and a powerful API allowing all functions to be controlled via external software routines. The timing events are stored in a sim-ple file format that can easily be used in other programs as well.

Digital resolution 0,5 ps

Timing jitter < 3 ps (RMS)

Event rate per channel 10 Mcps

Dead time < 100 ns

Constant Fraction Discrimination (CFD)

Digital resolution 25 ps

Timing jitter < 150 ps (RMS)

Event rate per channel 100 Mcps

Dead time < 1 ns

Output channels available

pulse generator

power splitter

quTAGtimestamps

PChistogram

-40 -20 0 20 40time [ps]

StandardExtendedExtended 2 ChannelsGaussian Fit

σ = 8.07 psσ = 4.57 psσ = 3.28 ps

𝜎𝜎/√2

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quTAG - the Time to Digital Converter

Options and FeaturesThe quTAG offers a lot of optional features making it the most versatile device on the market. You can decide which features are essential for your experiments and choose to tailor the device specific to your needs.

Every experiment is different and so are the requirements to a time-to-digital converter. The quTAG is developed with your needs in the focus. It offers a lot of optional features that fit directly to your needs – you get your optimal solution with only the features you really need. And if your plans change, you can upgrade most of the features directly at your place – it is flexible and grows with your require-ments.

Input Channel

The quTAG can be configured with your needs of input channels. The start channel can be converted to a full stop channel and used in the time tagging mode with the full resolution of the other channels. All channels are completely independent but synchronized internally.

Synchronization

The quTAG offers a synchronization feature, where up to four devices are connected and share the same time base and the same internal clock. This enhances the number of available stop channels which may be needed for your experiment.

Filter Extension Package

A lot of experiments produce data that are irrelevant for any evaluation. The quTAG has a built-in filter routine that already filters any signal you don’t need. This can be unused trigger signals in one channel, coincidence mea-surements between two channels or gating filters. This filtering happens already inside the quTAG, so bandwidth on your USB connection and processing power on your PC also are saved.

Time

Start

Stop 1

Stop 2

Stop 3

Stop 4

Stop 1

Stop 20

...

Stop 1

Stop 2

Time

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Jitter Upgrade Extension Package

This feature allows lower jitter at < 4.5 ps (RMS) on all four input channels. For lowest jitter of < 3.0 ps, two channelscan be combined, leaving two stop-channels of one de-vice for measurements. For optimal jitter results, recali-bration with external signals might be necessary.

External Clock Extension Package

The internal timing of the quTAG is crystal calibrated to provide very good timing accuracy. An external time base, e.g. from an atomic clock, can be used to synchronize this internal clock to gain even better resolution. The external frequency can be adjusted to any frequency between 1 MHz and 100 MHz.

Marker Extension Package

Additionally to the stop channels with full resolution, we added marker inputs to the quTAG. These low-resolution inputs recognize (LV)TTL signals and insert them into your time tag stream. The marker inputs are for the use of any marker or trigger signals which sort the relevant part of your data.

Output Channels Extension Package

The quTAG can be enhanced with up to 4 output chan-nels which generate TTL pulses as a function of the in-put channels. Several detection patterns can trigger an output pulse train depending on your needs and exactly tailored to your experiments.

Absolute Time Tagging Extension Package

The quTAG can decode GPS signals by its optional mod-ule. This feature exactly synchronizes the internal clock of the quTAG with the time delivered by the GPS receiver. Synchronization of time tagging devices far away from each other has never been so easy!

Stop 1

Stop 3

Time

Time

Clock

Stop 1

Stop 2

Time

Start

Stop 1

Marker 1

Marker 2

Time

Stop 1

Stop 2

Out 1

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quTAG - the Time to Digital Converter

SoftwareThe quTAG comes with a huge and powerful software solution. The intui-tive GUI allows control and setup of many experiments with a simple click. The included API easily integrates the device into your environment.

The perfect device is useless when the software is not useful. Every quTAG includes a huge and pow-erful software solution with an intuitive GUI and an API to integrate the quTAG easily and simple into your environment. All functions are included in the packages, you can get the timestamps directly or save it in a simple file format to your hard disc for later processing by your own analysis software. Our software is available for Windows and Linux in 32bit and 64bit.

GUI

The GUI is the simplest form to work with the quTAG. All functions can be used with a simple click. All parameter of all input channels can be assessed easily and adjusted with the graphical interface. No need for compensation cables, no need for voltage adaption.

The delay, the threshold and an artificial dead time is ad-justable with just one click. The analysis of the data or just the storage of raw timestamps is possible and saved in a universal file format, either in ASCII or in a packed bi-nary format that is completely described and accessible via your own software.

API

The quTAG API is a powerful library for complete con-trol and handling measurement results from the quTAG hardware. The library is written in C/C++ and can be integrated in various programming environments like python, Labview and Matlab. A wrapper for python and Labview is available. The API allows easy integration into your environment, supported by various example codes.

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Coincidences & Counting

One of the most needed functions is the determination of count rates of each stop channel (singles) and the co-incidence counting of two or more channels. The quTAG determines all of these count rates already in the device, so there is no need for evaluation of the time tags in the PC. The coincidence window can be freely adjusted by the user with the step size of the digital resolution.

Lifetime Extension Package

The lifetime software extension of the quTAG easily ana-lyzes the lifetime of your probe. You just select the start and the stop channel and the width of your data. The software calculates the histogram (start-multistop) and fits the appropriate function to the data. The lifetime val-ues are available with just one click in the software or can be called by one function in the API.

Correlations Extension Package

The second order correlation function - as used e.g. for the characterization of a single photon emitter in a Han-bury Brown-Twiss setup - can be generated easily with this software extension. You just have to set the two in-put channels and the width of your data and the software calculates the histogram including normalization and fits the appropriate function. This is also available as a func-tion call in the API.

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quTAG - the Time to Digital Converter

ApplicationsThe quTAG is a versatile device that is used in a broad range of experiments. These examples give you an overview what is possible. Contact us with your application idea and together we will make that possible!

Fluorescence Correlation Spectroscopy

Information about the diffusion, concentration and binding prop-erties of a biological sample can be acquired by the temporal fluc-tuations of fluorescence emission. The setup of this fluorescence correlation spectroscopy experiment is very similar to a FLIM set-up. In a FCS measurement, a small volume of the sample is an-alyzed. The concentration of the fluorophores is typically so low that at most one fluorescent molecule is excited and its emission is recorded with single photon detectors.

FCS can also be combined with lifetime measurements which al-lows a better assignment of photon arrivals to a specified fluoro-phore or measurements of protein-protein interactions. Therefore, a pulsed laser is needed and the relative time to the last pulse and beginning of the experiment is measured.

Fluorescence Life-Time

Fluorophores have beside a distinct excitation and emission spec-tra a specific lifetime. Measuring this lifetime allows to distin-guish between two fluorophores with the same measured emis-sion spectra. Fluorophores with a difference in lifetime can be imaged simultaneously with a much higher signal-to-noise ratio compared to conventional fluorescence microscopy.

In the time-domain fluorescence lifetime imaging, a pulsed exci-tation source with short pulses is needed and the time between laser excitation and fluorescence emission is measured for each photon. Every arrival time is added to a histogram which provides the lifetime curve of the fluorophore. Analysis software fits an ex-ponential curve to determine the lifetime – in many cases more than one lifetime is fitted giving rise to different pathways of de-cay.

∆t n

ener

gy

time [ns]

cou

nts

histogram datalifetime fit

G(τ)

τ [ms]

diffusion

concentration

∆t n

ener

gy

time [ns]

cou

nts

histogram datalifetime fit

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NV Centre Microscope

In one of its allotropes, carbon forms a cubic lattice, called dia-mond. Within the diamond lattice numerous types of defects can exist. One of these defects is the nitrogen-vacancy (NV) center. It is formed by a substitutional nitrogen atom associated with a neighboring vacancy.

The electron spins of the NV center can be manipulated at room temperature with microwave radiation or by applying magnetic or electric fields. Therefore, the NV center is suitable for quantum sensing applications and is also a promising candidate for quan-tum information processing.

Quantum Key Distribution

Quantum Key Distribution (QKD) enables secure communication by sharing an encryption key based on quantum mechanical prin-ciples. The communication between two parties needs a shared secret key for encryption. By using QKD any attempt of eavesdrop-ping of a third party is detected. The actual transmission of data is usually done by using the distributed key to encrypt the message to be sent. Most quantum cryptography protocols rely on single photons and its detection in a precise timing resolution.

LIDAR

Light detection and ranging - short LIDAR - is a method measuring the round-trip time of a light pulse to acquire the distance to an object. Combined with rotating mirrors - often referred as “3D la-ser scanning” - the measurement direction and the distance to the object assign coordinates in the room.

A special application of LIDAR is the satellite laser ranging where a laser beam is aligned to a satellite and its position is precisely de-termined to avoid collisions. This method is also be used to deter-mine the tectonic drift on a global scale or map forest structures and characterize wildlife habitats.

0 0

Alice1

Bob1

Entangled Photon Source

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quTAG - the Time to Digital Converter

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