THORACOABDOMINAL AORTIC ANEURYSMS HYBRID REPAIR · Vascular Surgery, Università VitaSalute -...
Transcript of THORACOABDOMINAL AORTIC ANEURYSMS HYBRID REPAIR · Vascular Surgery, Università VitaSalute -...
Roberto Chiesa Vascular Surgery, Università Vita-Salute
Scientific Institute San Raffaele – Milan, Italy
THORACOABDOMINAL AORTIC ANEURYSMS HYBRID REPAIR
Update on Open and Endovascular Therapeutic Option for Aortic Repair
CENTRE CARDIO-TORACIQUE DE MONACO
Friday November 7th, 2014
- PI / Co-PI for several thoracic and abdominal aortic stent graft
trials (Cook, Inc, Cordis® Corporation, Bolton Medical)
- Proctor and lecturer at symposia hosted by Cook, Inc., Bolton,
W.L. Gore and Associates, Jotec and Medtronic, Inc.
- Educational grants from Cook, Inc.
Conflict of interest
Open TAAA repair
Safi et al., Ann Surg 2014
“Extensive aortic aneurysm
is a complex problem,
but it can be managed safely”
Alternative strategies?
Total endovascular repair
Branched stent-graft (Zenith® t-BranchTM)
Chimney-graft (Gore c-TAG + Viabahn & Fluency)
• No thoracotomy • No laparotomy • No aortic cross-clamping • No LHBP / ECC
Total endovascular repair Selected cases
• Anatomic suitability
• Material availability
• Costs
• X-rays exposure
• Follow up? Eagleton, Greenberg, Sem Vasc Surg 2009
Late rupture
Third option?
Hybrid surgery
Open Surgery +
Endovascular Repair
“The way to a wider application of endovascular technology for management of complex
aortic disease”
Hollier LH. J Endovasc Surg 1998
Operative technique
Visceral arteries
rerouting
Stage 1
Operative technique
TAAA
stent-graft repair
Stage 2
Selection criteria OSR experience
Systemic conditions • Advanced age • Severe COPD • ↓Ejection fraction • CAD • Valvulopathy
Local conditions • Frozen chest • Redo TAAA
Redo thoracotomy
Oxygen therapy / Dilated ventricle
No BEVAR / FEVAR
Case reports
• Female, 22
• Marfan syndrome • Previous multiple thoracic aortic interventions
• Thoracic wall infection • Collapsed true lumen
#1 Dissecting type II TAAA
Infrarenal aortic grafting with custom made graft
Trans-peritoneal vessels exposure
Celiac trunk
Pancreas
#1 Dissecting type II TAAA
Post-op (Stent-graft in FL) Pre-op
Patent debranching grafts
#1 Dissecting type II TAAA
“In-graft” landing zones (Cook TX2)
#2 Visceral aortic patch aneurysm
Tshomba, Chiesa et al., J Vasc Surg 2008
• Male, 68
• Severe COPD, left nephrectomy
• Previous TAAA III open repair
• Previous aorto-bifemoral bypass
RRA
SMA
CT
• Inflow:
iliac prosthetic
branch
• Sequential bypass
SMA CT
Medtronic Valiant
#2 Visceral aortic patch aneurysm
Tshomba, Chiesa et al., J Vasc Surg 2008
• Male, 59
• Previous left lung resection (“frozen chest”)
• Retroperitoneal fibrosis
• Previous TAAA IV open repair
• Hypotrophic left kidney
Chiesa et al., Eur J Surg Endovasc Surg 2009
#3. Type II TAAA (Alternative in-flow)
CT
SMA RRA
Ascending ao
Diaphragm
Chiesa et al., Eur J Surg Endovasc Surg 2009
#3. Type II TAAA (Alternative in-flow)
Cook TX2
#3. Type III TAAA (Alternative in-flow)
Chiesa et al., Eur J Surg Endovasc Surg 2009
Sutureless distal anastomosis
Gore Hybrid Vascular Graft (GHVG)
#3. Type II TAAA (Gore Hybrid Vascular Graft)
#3. Type II TAAA (Gore Hybrid Vascular Graft)
Open 81 384 522
TEVAR 203 261 65
Tot: 1516 pts 284 645 587
(’93-’14)
(’98-’14)
(987 pts – 65.1%)
(529 pts – 34.9%)
Arch DTA TAAA
OSR series 1993-2014 Thoracic aorta – 1516 patients
65
56 Hybrid
9 FEVAR/BEVAR
TAAA hybrid repair: 56 patients 30-day results
N° patients (%)
Mortality 7 (12.5) Multiorgan failure 2 (3.6)
Myocardial infaction 2 (3.6)
Coagulopathy 1 (1.8)
Bowel infarction 1 (1.8)
Pancreatitis 1 (1.8)
TAAA hybrid repair: 56 patients 30-day results
N° patients (%)
Complications 15 (28.8) Renal failure 5 (8.9) Pancreatitis 3 (5.8) Respiratory failure 3 (5.3) Transient paraparesis 2 (3.6) Paraplegia 1 (1.7) Dysphagia 1 (1.7)
TAAA hybrid repair: 56 patients Mid-term results (mean follow-up 36.3±19 mts)
N° patients (%)
Related mortality 4 (7.1) Aortic rupture 2 (3.6) Visceral graft occlusion 2 (3.6)
Non-related mortality 9 (16.0) Complications 9 (16.0) Endoleak/migration 5 (8.9) Visceral bypass stenosis/kinking 2 (3.6) Renal failure 1 (1.7) Pancreatitis 1 (1.7)
Graft occlusion 9.8% (16/163) Assisted patency 15.6% (23/147 grafts)
6-months FU: SMA anastomosis angulation
12-months FU: SMA stenting, graft to CT occlusion
Visceral bypass long-term patency
Chiesa et al., J Cardiovasc Surg 2010
Discussion
Chiesa et al., Eur J Vasc Endovasc Surg 2009
Technical issues
1. CT revascularization
2. Renal protection
3. Intraoperative angiography
4. Timing
1. CT revascularization Associated CT and SMA revascularization
Always when possible!
CT SMA
20 days later… Retro-pancreatic routing
1. CT revascularization
Graft to CT Acute pancreatitis
Ante-pancreatic routing
CT
1. CT revascularization
2. Renal protection
Tshomba, […], & Chiesa. J Vasc Surg 2013
Custodiol®
(Histidine-Tryptophan-Ketoglutarate)
• Significantly reduced acute kydney injury compare to Ringered Lactated solution during TAAA repair
Intraoperative quality check
3. Intraoperative angiography
LRA
RRA
SMA CT
4. Timing
Strategy to be chosen patient by patient
SIMULTANEOUS
• Single anesthesia
• ↑ Bleeding
• ↑ Coagulopathy
• ↑ Risk of paraplegia
STAGED
• ↓ Operative time/bleeding
• ↓ Invasiveness
• Spinal cord conditioning
• Intersurgical rupture
%
30-day mortality 12.8
Irreversible paraplegia 4.5
Renal failure 8.8
Visceral graft patency 96.5
19 publications - 507 cases
Moulakakis, Liapis et al., Circulation 2011
TAAA hybrid repair Metanalysis 2000-2011
%
30-day mortality 26.7
Irreversible paraplegia 10
Chronic hemodialysis 6.7
One-year graft patency 97.3
30 patients
Gkremoutis A, et al., Eur J Vac Endovasc Surg 2014
TAAA hybrid repair Emergency TAAA treatment (2007-2013)
TAAA hybrid repair Conclusions
• Current highly selective indications
• Technical challenge
• Good long-term grafts patency
• Careful follow-up
Milano, December 11th - 13th, 2014
Waiting for you…