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This article and any supplementary material should be cited as follows: Sandroff BM, Hubbard MS, Pilutti LA, Motl RW. No association between body composition and cognition in ambulatory persons with multiple sclerosis: A brief report. J Rehabil Res Dev. 2015;52(3):XX-XX.http://dx.doi.org/10.1682/JRRD.2014.09.0208
Slideshow ProjectDOI:10.1682/JRRD.2014.09.0208JSP
No association between body composition and cognition in
ambulatory persons with multiple sclerosis: A brief report
Brian M. Sandroff, MS; Elizabeth A. Hubbard, MS; Lara A. Pilutti, PhD; Robert W. Motl, PhD
This article and any supplementary material should be cited as follows: Sandroff BM, Hubbard MS, Pilutti LA, Motl RW. No association between body composition and cognition in ambulatory persons with multiple sclerosis: A brief report. J Rehabil Res Dev. 2015;52(3):XX-XX.http://dx.doi.org/10.1682/JRRD.2014.09.0208
Slideshow ProjectDOI:10.1682/JRRD.2014.09.0208JSP
• Aim– Investigate the associations between measures of body
composition and domains of cognitive function in ambulatory persons with multiple sclerosis (MS).
• Relevance
– Evidence suggests body fat is inversely associated with cognitive functioning.
– This association might further be augmented in presence of immune-mediated, inflammatory disease such as MS.
This article and any supplementary material should be cited as follows: Sandroff BM, Hubbard MS, Pilutti LA, Motl RW. No association between body composition and cognition in ambulatory persons with multiple sclerosis: A brief report. J Rehabil Res Dev. 2015;52(3):XX-XX.http://dx.doi.org/10.1682/JRRD.2014.09.0208
Slideshow ProjectDOI:10.1682/JRRD.2014.09.0208JSP
Method• Cross-sectional study investigating associations between
objective measures of body composition and cognitive function in 60 persons with MS.
• Following tests performed:– Neurological examination for Expanded Disability Status Scale scores.– Brief International Cognitive Assessment in Multiple Sclerosis
neuropsychological battery for measurement of cognitive processing speed, verbal learning and memory, and visual learning and memory.
– Whole-body fat mass, percent body fat, lean body mass, and bone mineral density measured using dual-energy X-ray absorptiometry.
This article and any supplementary material should be cited as follows: Sandroff BM, Hubbard MS, Pilutti LA, Motl RW. No association between body composition and cognition in ambulatory persons with multiple sclerosis: A brief report. J Rehabil Res Dev. 2015;52(3):XX-XX.http://dx.doi.org/10.1682/JRRD.2014.09.0208
Slideshow ProjectDOI:10.1682/JRRD.2014.09.0208JSP
Results• Whole-body fat mass and percent body fat not
associated with any cognitive outcome.• Lean body mass associated with cognitive
processing speed and bone mineral density associated with cognitive processing speed and verbal learning and memory.− Associations attenuated and nonsignificant after
controlling for age and Expanded Disability Status Scale scores.
This article and any supplementary material should be cited as follows: Sandroff BM, Hubbard MS, Pilutti LA, Motl RW. No association between body composition and cognition in ambulatory persons with multiple sclerosis: A brief report. J Rehabil Res Dev. 2015;52(3):XX-XX.http://dx.doi.org/10.1682/JRRD.2014.09.0208
Slideshow ProjectDOI:10.1682/JRRD.2014.09.0208JSP
Conclusion
• Body composition might not represent a target of interventions for improving cognitive processing speed or learning and memory in MS.