The University of Iowa Sloan Center | The University …Timothy L Yahr - August 2014 College of...

CARVER COLLEGE OF MEDICINE CURRICULUM VITAE

Timothy L Yahr

August 2014 I. EDUCATIONAL AND PROFESSIONAL HISTORY

A. List of institutions attended (earliest to most recent)

1991 BS (Biology) University of Wisconsin, Stevens Point

1995 MS (Microbiology) Medical College of Wisconsin

1998 PhD (Microbiology)

Medical College of Wisconsin

Post Graduate

1998 - 2001 Post Doctoral (Biochemistry)

Dartmouth Medical School

B. Employment History

1991 - 1994 Laboratory Technician

Medical College of Wisconsin, Milwaukee, WI

2001 - 2006 Assistant Professor

Department of Microbiology, The University of Iowa, Iowa City, IA

2006 - 2013 Associate Professor


2013 - Present Professor


C. Honors, Awards, Recognitions, Outstanding Achievements

1991 Faculty Research Award

University of Wisconsin – Stevens Point

1991 Outstanding Microbiologist


1991 Student Research Fund Grant


1994 - 1998 Scholarship and Fellowship


1995 - 1998 Student Travel Award

Friends of the Medical College of Wisconsin

1995 Pseudomonas Club Graduate Student Award for Best Abstract, Genentech – Cystic Fibrosis Foundation

General Meeting of the American Society for Microbiology, Washington, DC

1998 Sustaining Member Student Travel Grant Award

Timothy L Yahr - August 2014

College of Medicine CV format 04/00

American Society for Microbiology

2004 Merck Irving S. Sigal Memorial Award for Outstanding Research in Microbiology and Infectious Diseases

American Society for Microbiology and American Academy of Microbiology

2012 - 2013 Recognized by the editors of the Journal of Bacteriology as a top-performing member of the Editorial Board

Journal of Bacteriology

2012 Jack Kenney Award for Outstanding Service on the Journal of Bacteriology Editorial Board

Journal of Bacteriology

II. TEACHING

A. Teaching assignments

Classroom, Seminar, Teaching Laboratory

2002 - 2014 Pathogenic Bacteriology

Spring 2002: Lecture 2 x 1 hr


Spring 2004: Course Director 21 x 1 hr and Lab Director 4 hrs/wk




Spring 2008: Course Director 22 x 1 hr, Lab Director 2 hrs/wk, and Grad Discussion 2 hrs/wk

Spring 2009: Course Director 24 x 1 hr and Grad Discussion 2 hrs/wk


Spring 2011: Lecture 9 x 1 hr and Grad Discussion 15 x 2 hr


Spring 2013: Course Director 22 x 1 hr

Spring 2014: Course Director 22 x 1 hr

2002 Advanced Prokaryotic Molecular Biology

1 x 2 hr lecture

2003 Health Sciences Microbiology

7 x 1 hr lecture

2003 Microbial Genetics Lab

1 x 1 hr lecture

2003 - 2005 Genetic Analysis of Biological Systems



1 x 2 hr lecture each Fall

2003 - 2004 M1 Case Based Learning

Facilitator 2 hrs/week each Fall

2009 Topics in Molecular & Cellular Biology

1 hr graduate student discussion

2010 Microbes in Our World

Course Director: 12 x 1 hr lecture

2010 - 2011 M1 Case Based Learning

Facilitator 2 hrs/week each Fall

2011 Graduate Student Research Seminar

4 x 1 hr

2012 - 2013 Advanced Topics in Prokaryotic Biology

Course Director: 2 hrs/week, 8 weeks each semester

B. Student Supervision (* indicates chair of the committee)

Comprehensive Exam Committee

2002 Nathan Ledeboer - Graduate - Microbiology - Degree Objective: PhD

2004 Blaise Boles - Graduate - Microbiology - Degree Objective: PhD

2004 *Grant Balzer - Graduate - Microbiology - Degree Objective: PhD

2005 *Brock Neil - Graduate - Microbiology - Degree Objective: PhD

2006 Blake Buchan - Graduate - Microbiology - Degree Objective: PhD

2006 Megan Falsetta - Graduate - Microbiology - Degree Objective: PhD

2006 Steve Lindemann - Graduate - Microbiology - Degree Objective: PhD

2007 Jodie Scott - Graduate - Microbiology - Degree Objective: PhD

2007 Katherine Lauderdale - Graduate - Microbiology - Degree Objective: MS

2007 *Matthew Thoendel - Graduate - Microbiology - Degree Objective: PhD

2008 Di Li - Graduate - Microbiology - Degree Objective: MS

2008 Jeremiah Johnson - Graduate - Microbiology - Degree Objective: PhD

2009 Jonathan Willett - Graduate - Microbiology - Degree Objective: PhD

2009 Justin Schwartz - Graduate - Microbiology - Degree Objective: PhD

2010 Cynthia Darnell - Graduate - Microbiology - Degree Objective: PhD

2010 Jed Rasmussen - Graduate - Microbiology - Degree Objective: PhD

2010 Joe Mootz - Graduate - Microbiology - Degree Objective: PhD

2010 *Megan Kiedrowski - Graduate - Microbiology - Degree Objective: PhD

2010 *Tiara Pérez-Morales - Graduate - Microbiology - Degree Objective: PhD

2011 *Caitlin Murphy - Graduate - Microbiology - Degree Objective: PhD



2011 Drew Fayram - Graduate - Microbiology - Degree Objective: PhD

2011 Matthew Jorgenson - Graduate - Genetics - Degree Objective: PhD

2012 Alicia Zimbeck - Graduate - Microbiology - Degree Objective: PhD

2012 Bao Vu - Graduate - Microbiology - Degree Objective: PhD

2012 Carolyn Rosenthal - Graduate - Microbiology - Degree Objective: PhD

2012 *Sarah Bahr - Graduate - Microbiology - Degree Objective: PhD

2013 Alfa Herrera - Graduate - Microbiology - Degree Objective: PhD

2013 *Christopher Stach - Graduate - Microbiology - Degree Objective: PhD

2014 Caroline Linke - Graduate - Microbiology - Degree Objective: PhD

Graduate Students

2003 - 2009 Evan Brutinel - Graduate - Microbiology - Degree Objective: PhD

2005 - 2008 Grant Balzer - Graduate - Microbiology - Degree Objective: PhD

2006 - 2010 Chris Vakulskas - Graduate - Microbiology - Degree Objective: PhD

2006 - 2008 Keith Brady - Graduate - Microbiology - Degree Objective: MS

2010 - 2014 Manisha Diaz - Graduate - Microbiology - Degree Objective: PhD

2010 - 2013 Jessica King - Graduate - Microbiology - Degree Objective: PhD

2011 - Present Anne Dressler - Graduate - Microbiology - Degree Objective: PhD

2011 - Present Peter Intile - Graduate - Microbiology - Degree Objective: PhD

Lab Rotation

2001 Catherine Miller - Graduate - Microbiology - Degree Objective: PhD

2003 Brock Neil - Graduate - Microbiology - Degree Objective: PhD

2003 Evan Brutinel - Graduate - Biosciences - Degree Objective: PhD

2004 Blake Buchan - Graduate - Microbiology - Degree Objective: PhD

2006 Chris Vakulskas - Graduate - Microbiology - Degree Objective: PhD


2008 Jonathan Willett - Graduate - Microbiology - Degree Objective: PhD

2008 Tiara Pérez-Morales - Graduate - Microbiology - Degree Objective: PhD

2009 Jessica King - Graduate - Microbiology - Degree Objective: PhD

2009 Manisha Diaz - Graduate - Microbiology - Degree Objective: PhD

2009 Sarah Zeiner - Graduate - Microbiology - Degree Objective: MS

2010 Alexandra Paharik - Graduate - Microbiology - Degree Objective: PhD

2010 Anne Dressler - Graduate - Microbiology - Degree Objective: PhD

2011 Peter Intile - Graduate - Microbiology - Degree Objective: PhD

2013 Haley Seres - Graduate - Microbiology - Degree Objective: PhD

2013 Kayley Schulmeyer - Graduate - Microbiology - Degree Objective: PhD



Master's Thesis Committee

2006 - 2008 *Keith Brady - Graduate - Microbiology - Degree Objective: MS

2008 Katherine Lauderdale - Graduate - Microbiology - Degree Objective: MS

2011 - 2014 Alicia Zimbeck - Graduate - Microbiology - Degree Objective: MS

2013 Drew Fayram - Graduate - Microbiology - Degree Objective: MS

Post Doc Fellows

2006 - 2011 Dilek Ince - Postdoctoral Fellow - infectious Disease

Postdoctoral Research Supervision

2003 - 2005 Nandini Dasgupta - Postdoctoral

2005 - 2006 Bronwyn Ramey - Postdoctoral

2009 - 2010 Evan Brutinel - Postdoctoral

Summer Research Scholars

2002 Derek Zhorne - Undergraduate - Howard Hughes Undergraduate Research

2002 Guinevere Lykken - Undergraduate - REU in Microbiology

2003 Ahn Nguyen - Undergraduate - REU in Microbiology

2007 Jennifer Lambrecht - Undergraduate - REU in Microbiology

2008 Crystal Hopp - Undergraduate - REU in Microbiology

2010 Anna Breard - Undergraduate - REU in Microbiology

2012 Hunter Woodley - Undergraduate - REU in Microbiology

Thesis Committee

2002 Gary Heil - Graduate - Microbiology - Degree Objective: PhD

2003 - 2009 *Evan Brutinel - Graduate - Microbiology - Degree Objective: PhD

2005 - 2008 *Grant Balzer - Graduate - Microbiology - Degree Objective: PhD

2005 Nathan Ledeboer - Graduate - Microbiology - Degree Objective: PhD

2006 - 2010 *Chris Vakulskas - Graduate - Microbiology - Degree Objective: PhD

2006 Blaise Boles - Graduate - Microbiology - Degree Objective: PhD

2007 Carolina Alvarez - Graduate - Microbiology - Degree Objective: PhD

2008 Brock Neil - Graduate - Microbiology - Degree Objective: PhD

2009 - 2014 Cindy Darnell - Graduate - Microbiology - Degree Objective: PhD

2009 Megan Falsetta - Graduate - Microbiology - Degree Objective: PhD

2010 - 2014 Caitlin Murphy - Graduate - Microbiology - Degree Objective: PhD

2010 - 2014 *Manisha Diaz - Graduate - Microbiology - Degree Objective: PhD

2010 - 2014 Matthew Jorgenson - Graduate - Genetics - Degree Objective: PhD

2010 - 2013 *Jessica King - Graduate - Microbiology - Degree Objective: PhD



2010 Sabrina Joseph - Graduate - Microbiology - Degree Objective: PhD

University of Miami

Greg Plano, mentor

2010 Steve Lindemann - Graduate - Microbiology - Degree Objective: PhD

2011 - Present *Anne Dressler - Graduate - Microbiology - Degree Objective: PhD

2011 - Present *Peter Intile - Graduate - Microbiology - Degree Objective: PhD

2011 - Present Sarah Bahr - Graduate - Microbiology - Degree Objective: PhD

2011 Cindy Gode - Graduate - Microbiology - Degree Objective: PhD


2011 Jodie Scott - Graduate - Microbiology - Degree Objective: PhD

2011 Matthew Thoendel - Graduate - Microbiology - Degree Objective: PhD

2012 - Present Alfa Herrera - Graduate - Microbiology - Degree Objective: PhD

2012 - Present Christopher Stach - Graduate - Microbiology - Degree Objective: PhD

2012 Katie Schmalzer - Graduate - Microbiology and Molecular Genetics - Degree Objective: PhD


Dara Frank, mentor

2012 Megan Kiedrowski - Graduate - Microbiology - Degree Objective: PhD

2013 - 2014 Caroline Linke - Graduate - Microbiology - Degree Objective: PhD

2013 Joe Mootz - Graduate - Microbiology - Degree Objective: PhD

2013 Tiara Pérez-Morales - Graduate - Microbiology - Degree Objective: PhD

Undergraduate Honors Thesis

2006 - 2007 Laura Maschmann - Undergraduate - Microbiology - Degree Objective: BS

2013 - 2014 Adam Balin - Undergraduate - Microbiology - Degree Objective: BS

2013 - 2014 Matthew Golden - Undergraduate - Microbiology - Degree Objective: BS

Undergraduate Students

2001 - 2002 Marcella Card - Undergraduate

2002 - 2005 Elizabeth Naylor - Undergraduate

2002 - 2003 Kellen Voss - Undergraduate

2002 Greg Loeffelholz - Undergraduate

2003 - 2004 Mitchell Kang - Undergraduate

2004 - 2005 Jacqueline Adams - Undergraduate

2005 - 2006 Frannie Owens - Undergraduate

2008 - 2009 Makenzie Brown - Undergraduate

2009 - 2010 Michelle Morgan - Undergraduate



C. Other Teaching Contributions

III. SCHOLARSHIP/PROFESSIONAL PRODUCTIVITY

A. Publications or creative works (earliest to most recent)

Peer-reviewed papers

1. Kulich SM, Yahr TL, Mende-Mueller LM, Barbieri JT, Frank DW. Cloning the structural gene for the 49-kDa form of exoenzyme S (exoS) from Pseudomonas aeruginosa strain 388, J Biol Chem. 1994 April 8;269(14):10431-7. PMID:8144626

My contribution to this manuscript was sequencing the exoS gene.

2. Yahr TL, Frank DW. Transcriptional organization of the trans-regulatory locus which controls exoenzyme S synthesis in Pseudomonas aeruginosa, J Bacteriol. 1994 July;176(13):3832-8. PMC:PMC205579

I conducted all of the experiments and started to learn the art of authoring a manuscript through writing and proofreading.

3. Yahr TL, Hovey AK, Kulich SM, Frank DW. Transcriptional analysis of the Pseudomonas aeruginosa exoenzyme S structural gene, J Bacteriol. 1995 March;177(5):1169-78. PMC:PMC176720

I conducted the majority of the experiments and wrote much of the manuscript.

4. Yahr TL, Barbieri JT, Frank DW. Genetic relationship between the 53- and 49-kilodalton forms of exoenzyme S from Pseudomonas aeruginosa, J Bacteriol. 1996 March;178(5):1412-9. PMC:PMC177816

I conducted all of the experiments and wrote most of the manuscript.

5. Yahr TL, Goranson J, Frank DW. Exoenzyme S of Pseudomonas aeruginosa is secreted by a type III pathway, Mol Microbiol. 1996 December;22(5):991-1003. PMID:8971719

This was the first description of a type III secretion system in P. aeruginosa. I conducted most of the experiments and wrote the manuscript.

6. Liu S, Yahr TL, Frank DW, Barbieri JT. Biochemical relationships between the 53-kilodalton (Exo53) and 49-kilodalton (ExoS) forms of exoenzyme S of Pseudomonas aeruginosa, J Bacteriol. 1997 March;179(5):1609-13. PMC:PMC178873

I generated two figures for this manuscript and critically reviewed the final draft of the manuscript.

7. Yahr TL, Mende-Mueller LM, Friese MB, Frank DW. Identification of type III secreted products of the Pseudomonas aeruginosa exoenzyme S regulon, J Bacteriol. 1997 November;179(22):7165-8. PMC:PMC179660

This paper was the first to demonstrate that an entire set of proteins is secreted by the P. aeruginosa type III secretion proteins. I conducted all of the experiments and wrote most of the manuscript.

8. Yahr TL, Vallis AJ, Hancock MK, Barbieri JT, Frank DW. ExoY, an adenylate cyclase secreted by the Pseudomonas aeruginosa type III system, Proc Natl Acad Sci U S A. 1998 November 10;95(23):13899-904. PMC:PMC24955



Personally, this study was the most exciting to result from my graduate work as it described the first (and thus far only) adenylate cyclase toxin to be secreted by a type III system. I conducted the majority of the experiments and wrote most of the manuscript.

9. Finck-Barbançon V, Yahr TL, Frank DW. Identification and characterization of SpcU, a chaperone required for efficient secretion of the ExoU cytotoxin, J Bacteriol. 1998 December;180(23):6224-31. PMC:PMC107707

I provided technical advice during the progression of these studies, generated and characterized mutants for these studies, and contributed to the writing of this manuscript.

10. Vallis AJ, Yahr TL, Barbieri JT, Frank DW. Regulation of ExoS production and secretion by Pseudomonas aeruginosa in response to tissue culture conditions, Infect Immun. 1999 February;67(2):914-20. PMC:PMC96404

I generated P. aeruginosa strains for these studies and helped write the manuscript.

11. Sawa T, Yahr TL, Ohara M, Kurahashi K, Gropper MA, Wiener-Kronish JP, Frank DW. Active and passive immunization with the Pseudomonas V antigen protects against type III intoxication and lung injury, Nat Med. 1999 April;5(4):392-8. PMID:10202927

Originally submitted to Nature Medicine as two back-to-back manuscripts (I was first author on one), the papers ended up being combined into a single manuscript. A notation indicates that Dr. Sawa and I contributed equally to this manuscript.

12. Vallis AJ, Finck-Barbançon V, Yahr TL, Frank DW. Biological effects of Pseudomonas aeruginosa type III-secreted proteins on CHO cells, Infect Immun. 1999 April;67(4):2040-4. PMC:PMC96567

I generated P. aeruginosa strains for these studies and contributed technical advice for this study.

13. Olson JC, Fraylick JE, McGuffie EM, Dolan KM, Yahr TL, Frank DW, Vincent TS. Interruption of multiple cellular processes in HT-29 epithelial cells by Pseudomonas aeruginosa exoenzyme S, Infect Immun. 1999 June;67(6):2847-54. PMC:PMC96591

I generated P. aeruginosa strains for these studies but contributed minimally to the writing of this manuscript.

14. Yahr TL, Wickner WT. Evaluating the oligomeric state of SecYEG in preprotein translocase, EMBO J. 2000 August 15;19(16):4393-401. PMC:PMC302025

I conceived of and conducted all of the experiments for this study and wrote the manuscript.

15. Yahr TL, Wickner WT. Functional reconstitution of bacterial Tat translocation in vitro, EMBO J. 2001 May 15;20(10):2472-9. PMC:PMC125449

I conceived of and conducted all of the experiments for this study and wrote the manuscript.

16. McCaw ML, Lykken GL, Singh PK, Yahr TL. ExsD is a negative regulator of the Pseudomonas aeruginosa type III secretion regulon, Mol Microbiol. 2002 November;46(4):1123-33. PMID:12421316

I conceived of and conducted most of the experiments for this study and wrote the manuscript.

17. Dasgupta N, Lykken GL, Wolfgang MC, Yahr TL. A novel anti-anti-activator mechanism regulates expression of the Pseudomonas aeruginosa type III secretion system, Mol Microbiol. 2004 July;53(1):297-308. PMID:15225323



I conceived of and conducted most of the experiments for this study and worked with Dr. Dasgupta in the writing of the manuscript.

18. Urbanowski ML, Lykken GL, Yahr TL. A secreted regulatory protein couples transcription to the secretory activity of the Pseudomonas aeruginosa type III secretion system, Proc Natl Acad Sci U S A. 2005 July 12;102(28):9930-5. PMC:PMC1175016

I supervised the development of this study, conducted some of the experiments, and worked with Mr. Urbanowski in the writing of the manuscript.

19. Dasgupta N, Ashare A, HUNNINGHAKE GW, Yahr TL. Transcriptional induction of the Pseudomonas aeruginosa type III secretion system by low Ca2+ and host cell contact proceeds through two distinct signaling pathways, Infect Immun. 2006 June;74(6):3334-41. PMC:PMC1479281

I supervised the development of this study, conducted some of the experiments, and worked with Dr. Dasgupta in the writing of the manuscript. Alix Ashare (Hunninghake lab) performed the animal experiment.

20. Lykken GL, Chen G, Brutinel ED, Chen L, Yahr TL. Characterization of ExsC and ExsD self-association and heterocomplex formation, J Bacteriol. 2006 October;188(19):6832-40. PMC:PMC1595525

I supervised the development of this study, conducted some of the experiments, and wrote the manuscript. Ms. Lykken was an RA in my lab at the time.

21. Zheng Z, Chen G, Joshi S, Brutinel ED, Yahr TL, Chen L. Biochemical characterization of a regulatory cascade controlling transcription of the Pseudomonas aeruginosa type III secretion system, J Biol Chem. 2007 March 2;282(9):6136-42. PMID:17197437

This was a collaborative effort in which we provided reagents and technical advise during the development of the study. I played a significant role in writing this manuscript (~50%).

22. Wu Y, Xu Z, Henderson FC, Ryan AJ, Yahr TL, Mallampalli RK. Chronic Pseudomonas aeruginosa infection reduces surfactant levels by inhibiting its biosynthesis, Cell Microbiol. 2007 April;9(4):1062-72. PMID:17166234

I provided P. aeruginosa strains for these studies, contributed technical advice, and proofread the manuscript.

23. Ashare A, Monick MM, Nymon AB, Morrison JM, Noble M, Powers LS, Yarovinsky TO, Yahr TL, Hunninghake GW. Pseudomonas aeruginosa delays Kupffer cell death via stabilization of the X-chromosome-linked inhibitor of apoptosis protein, J Immunol. 2007 July 1;179(1):505-13. PMID:17579071


24. Urbanowski ML, Brutinel ED, Yahr TL. Translocation of ExsE into Chinese hamster ovary cells is required for transcriptional induction of the Pseudomonas aeruginosa type III secretion system, Infect Immun. 2007 September;75(9):4432-9. PMC:PMC1951186

I supervised the development of this study, conducted some of the experiments, and worked with Mr. Urbanowski in the writing of the manuscript. This article was identified as a "Spotlight" article of Significant Interest selected from this issue by the editors.

25. Brutinel ED, Vakulskas CA, Brady KM, Yahr TL. Characterization of ExsA and of ExsA-dependent promoters required for expression of the Pseudomonas aeruginosa type III secretion system, Mol Microbiol. 2008 May;68(3):657-71. PMID:18373522



I supervised the development of this study, conducted some of the experiments, and worked with Mr. Brutinel in the writing of this manuscript.

26. Brutinel ED, Vakulskas CA, Yahr TL. Functional domains of ExsA, the transcriptional activator of the Pseudomonas aeruginosa type III secretion system, J Bacteriol. 2009 June;191(12):3811-21. PMC:PMC2698394

I supervised the development of this study and worked with Mr. Brutinel in the writing of the manuscript.

27. Vakulskas CA, Brady KM, Yahr TL. Mechanism of transcriptional activation by Pseudomonas aeruginosa ExsA, J Bacteriol. 2009 November;191(21):6654-64. PMC:PMC2795306

I supervised the development of this study and worked with Mr. Vakulskas in the writing of the manuscript.

28. Brutinel ED, Vakulskas CA, Yahr TL. ExsD inhibits expression of the Pseudomonas aeruginosa type III secretion system by disrupting ExsA self-association and DNA binding activity, J Bacteriol. 2010 March;192(6):1479-86. PMC:PMC2832532

I supervised the development of this study and worked with Mr. Brutinel in the writing of the manuscript. This article was identified as a "Spotlight" article of Significant Interest selected from this issue by the editors. This article was featured in the ASM publication Microbe in the Journal Highlights section.

29. Anderson GG, Yahr TL, Lovewell RR, O'Toole GA. The Pseudomonas aeruginosa magnesium transporter MgtE inhibits transcription of the type III secretion system, Infect Immun. 2010 March;78(3):1239-49. PMC:PMC2825933

I worked with Dr. O'Toole during the developmental phase of this study, conducted several of the experiments, and worked with Drs. O'Toole and Anderson in the writing of the manuscript.

30. Fuchs EL, Brutinel ED, Klem ER, Fehr AR, Yahr TL, Wolfgang MC. In vitro and in vivo characterization of the Pseudomonas aeruginosa cyclic AMP (cAMP) phosphodiesterase CpdA, required for cAMP homeostasis and virulence factor regulation, J Bacteriol. 2010 June;192(11):2779-90. PMC:PMC2876501

I worked with Dr. Wolfgang during the developmental phase of this study, several experiments were conducted in my lab by Mr. Brutinel, and I worked with Drs. Wolfgang and Fuchs in the writing of the manuscript.

31. Vakulskas CA, Brutinel ED, Yahr TL. ExsA recruits RNA polymerase to an extended -10 promoter by contacting region 4.2 of sigma-70, J Bacteriol. 2010 July;192(14):3597-607. PMC:PMC2897327

I supervised the development of this study and worked with Mr. Vakulskas in the writing of the manuscript.

32. Fuchs EL, Brutinel ED, Jones AK, Fulcher NB, Urbanowski ML, Yahr TL, Wolfgang MC. The Pseudomonas aeruginosa Vfr regulator controls global virulence factor expression through cyclic AMP-dependent and -independent mechanisms, J Bacteriol. 2010 July;192(14):3553-64. PMC:PMC2897347

This project resulted from a conversation with Dr. Wolfgang in which he expressed a desire to produce apo-Vfr (lacking bound cAMP). I suggested two approaches, denaturation of cAMP-bound Vfr followed by refolding in the absence of cAMP and treatment of Vfr with a cAMP phosphodiesterase. I found that both approaches worked. The first 6 figures in this paper were



generated in my lab by Mr. Brutinel. I worked with Drs. Wolfgang and Fuchs in the writing of the manuscript.

33. Jones AK, Fulcher NB, Balzer GJ, Urbanowski ML, Pritchett CL, Schurr MJ, Yahr TL, Wolfgang MC. Activation of the Pseudomonas aeruginosa AlgU regulon through mucA mutation inhibits cyclic AMP/Vfr signaling, J Bacteriol. 2010 November;192(21):5709-17. PMC:PMC2953679

My lab made substantial contributions to this study but most of the data was unpublished. I worked with Drs. Wolfgang and Fuchs in the writing of the manuscript.

34. Pezzulo AA, Gutiérrez J, Duschner KS, McConnell KS, Taft PJ, Ernst SE, Yahr TL, Rahmouni K, Klesney-Tait J, Stoltz DA, Zabner J. Glucose depletion in the airway surface liquid is essential for sterility of the airways, PLoS One. 2011 January 20;6(1):e16166. PMC:PMC3029092


35. Zheng Z, Ma D, Yahr TL, Chen L. The transiently ordered regions in intrinsically disordered ExsE are correlated with structural elements involved in chaperone binding, Biochem Biophys Res Commun. 2012 January 6;417(1):129-34. PMID:22138394

This was a collaborative effort in which I provided reagents and technical advise during the development of the study. I played a significant role in editing this manuscript.

36. King JM, Brutinel ED, Marsden AE, Schubot FD, Yahr TL. Orientation of Pseudomonas aeruginosa ExsA monomers bound to promoter DNA and base-specific contacts with the P(exoT) promoter, J Bacteriol. 2012 May;194(10):2573-85. PMC:PMC3347218

I supervised the development of this study and worked with Ms. King in the writing of the manuscript.

37. Brutinel ED, King JM, Marsden AE, Yahr TL. The distal ExsA-binding site in Pseudomonas aeruginosa type III secretion system promoters is the primary determinant for promoter-specific properties, J Bacteriol. 2012 May;194(10):2564-72. PMC:PMC3347217

I supervised the development of this study and worked with Ms. King in the writing of the manuscript.

38. Berhards RC, Marsden AE, Esher SK, Yahr TL, Schubot FD. Self-trimerization of ExsD limits inhibition of the Pseudomonas aeruginosa transcriptional activator ExsA in vitro, FEBS J. 2013 February;280(4):1084-94. PMC:PMC3621117

39. Olson ME, King JM, Yahr TL, Horswill AR. Sialic Acid Catabolism in Staphylococcus aureus, J Bacteriol. 2013 April;195(8):1779-88. PMC:PMC3624546

40. Marden JN, Diaz MR, Walton WG, Gode CJ, Betts L, Urbanowski ML, Redinbo MR, Yahr TL, Wolfgang MC. An unusual CsrA family member operates in series with RsmA to amplify posttranscriptional responses in Pseudomonas aeruginosa, Proc Natl Acad Sci U S A. 2013 September 10;110(37):15055-60. PMC:PMC3773774

41. Heimer SR, Evans DJ, Stern ME, Barbieri JT, Yahr T, Fleiszig SM. Pseudomonas aeruginosa Utilizes the Type III Secreted Toxin ExoS to Avoid Acidified Compartments within Epithelial Cells, PLoS One. 2013 September 18;8(9):e73111. PMC:PMC3776860



42. King JM, Schesser Bartra S, Plano G, Yahr TL. ExsA and LcrF recognize similar consensus binding sites, but differences in their oligomeric state influence interactions with promoter DNA, J Bacteriol. 2013 December;195(24):5639-50. PMC:PMC3889609

43. Intile PJ, Diaz MR, Urbanowski ML, Wolfgang MC, Yahr TL. The AlgZR Two-Component System Recalibrates the RsmAYZ Posttranscriptional Regulatory System To Inhibit Expression of the Pseudomonas aeruginosa Type III Secretion System, J Bacteriol. 2014 January;196(2):357-66. PMID:24187093

Chapters

1. Yahr TL, Parsek MR. Pseudomonas aeruginosa. In: M. Dworkin, S. Falkow, E. Rosenberg, K.-H. Schleifer, E. Stackebrandt, editors. The Prokaryotes. Springer. 2006. p. 704-13

I wrote the majority of this chapter. Abstracts

1. Hovey AK, Yahr TL, Frank DW. Functional analysis of ExsA of Pseudomonas aeruginosa, General Meeting of the American Society for Microbiology, Atlanta, GA. 1992.

2. Yahr TL, Frank DW. Transcriptional control of the trans-regulatory locus required for exoenzyme S synthesis in Pseudomonas aeruginosa, Gordon Research Conference on Microbial Toxins and Pathogenesis, Colby-Sawyer College, NH. 1992.

3. Yahr TL, Frank DW. Transcriptional organization of the exoenzyme S trans-regulatory locus in Pseudomonas aeruginosa, General Meeting of the American Society for Microbiology, Atlanta, GA. 1992.

4. Yahr TL, Frank DW. Transcriptional analysis of the exoenzyme S structural gene, Gordon Research Conference on Microbial Toxins and Pathogenesis, Colby-Sawyer College, NH. 1994.

5. Yahr TL, Barbieri JT, Frank DW. The genetic relationship between the 49- and 53-kDa forms of exoenzyme S, General Meeting of the American Society for Microbiology, Washington, DC. 1995.

6. Liu S, Knight DA, Yahr TL, Barbieri JT. Biochemical properties of the 53-kDa form of Pseudomonas aeruginosa exoenzyme S, General Meeting of the American Society for Microbiology, New Orleans, LA. 1996.

7. Yahr TL, Goranson J, Frank DW. Exoenzyme S of Pseudomonas aeruginosa is secreted by a type III pathway, General Meeting of the American Society for Microbiology, New Orleans, LA. 1996.



8. Yahr TL, Goranson J, Frank DW. Exoenzyme S of Pseudomonas aeruginosa is secreted by a type III pathway, Gordon Research Conference on Microbial Toxins and Pathogenesis, Colby-Sawyer College, NH. 1996.

9. Vallis AJ, Yahr TL, Frank DW. Development of in vitro methodologies to study type III-mediated translocation of Pseudomonas aeruginosa ExoS, Midwest Microbial Pathogenesis Meeting, Ann Arbor, MI. 1997.

10. Yahr TL, Vallis AJ, Friese MB, Mende-Mueller LM, Frank DW. Identification and characterization of type III secreted products of the Pseudomonas aeruginosa exoenzyme S region, Midwest Microbial Pathogenesis Meeting, Ann Arbor, MI. 1997.

11. Yahr TL, Friese MB, Mende-Mueller LM, Frank DW. Pseudomonas aeruginosa encodes homologs to the Yersinia lcrGVHyopBD locus, General Meeting of the American Society for Microbiology, Miami Beach, FL. 1997.

12. Finck-Barbançon V, Yahr TL, Frank DW. Characterization of the exoU locus from Pseudomonas aeruginosa, General Meeting of the American Society for Microbiology, Atlanta, GA. 1998.

13. Vallis AJ, Yahr TL, Barbieri JT, Frank DW. Contact-mediated regulation of ExoS production by Pseudomonas aeruginosa, General Meeting of the American Society for Microbiology, Atlanta, GA. 1998.

14. Yahr TL, Vallis AJ, Hancock MK, Frank DW. ExoY, a novel type III secreted adenylate cyclase from Pseudomonas aeruginosa, General Meeting of the American Society for Microbiology, Atlanta, GA. 1998.

15. Sawa T, Ohara M, Kurahashi K, Yahr TL, Gropper MA, Frank DW, Wiener-Kronish JP. Pathogenesis of acute lung injury caused by Pseudomonas aeruginosa major contribution of type III secretory system, American Federation of Biomedical Research, Biomedicine. 1998.

16. Ohara M, Sawa T, Kurahashi K, Yahr TL, Frank DW, Wiener-Kronish JP, Gropper MA. Pseudomonas aeruginosa inhibits Fc receptor-mediated phagocytosis, American Federation of Biomedical Research, Biomedicine. 1998.

17. Holder IA, Neely AN, Yahr TL, Frank DW. Genetic analysis of the type III effectors of P. aeruginosa in the burned mouse model, General Meeting of the American Society for Microbiology, Chicago, IL. 1999.



18. Frank DW, Yahr TL, Sawa T, Barbancon-Finck V, Wiener-Kronish JP. Type III intoxication and Pseudomonas pathogenesis, Pseudomonas '99: Biotechnology and Pathogenesis, American Society for Microbiology, Maui, Hawaii. 1999.

19. Yahr TL, Wickner WT. Investigations of the Escherichia coli twin-arginine protein translocase, General Meeting of the American Society for Microbiology, Orlando, FL. 2001.

20. Yahr TL. ExsD is a negative regulator of type III secretion in Pseudomonas aeruginosa, General Meeting of the American Society for Microbiology, Salt Lake City, UT. 2002.

21. Dasgupta N, Wolfgang M, Yahr TL. ExsC is required for expression of the Pseudomonas aeruginosa type III secretion system, Pseudomonas 2003 Meeting, Quebec City, Canada. 2003.

22. Lykken GL, Yahr TL. Role of an anti-activator and an anti-anti-activator in controlling expression of Pseudomonas aeruginosa type III secretion, General Meeting of the American Society for Microbiology, New Orleans, LA. 2004.

23. Urbanowski ML, Yahr TL. The ExsE regulatory protein is translocated into host cells by the Pseudomonas aeruginosa type III secretion system, Midwest Microbial Pathogenesis Meeting, Minneapolis, MN. 2005.

24. Urbanowski ML, Yahr TL. ExsE is translocated into host cells by the Pseudomonas aeruginosa type III secretion system, General Meeting of the American Society for Microbiology, Orlando, FL. 2006.

25. Dasgupta N, Ashare A, Hunninghake G, Yahr TL. Induction of the Pseudomonas aeruginosa type III secretion system by low Ca2+ and host cell contact proceeds through two distinct signaling pathways, General Meeting of the American Society for Microbiology, Orlando, FL. 2006.

26. Song Y, Fairman J, Sawa T, Liggitt D, Yahr TL, Wiener-Kronish J. Cationic lipid DNA complexes (CLDC)/PcrV as a vaccine against Pseudomonas aeruginosa pneumonia, Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), San Francisco, CA. 2007.

27. Brutinel E, Vakulskas C, Yahr TL. Characterization of the ExsA Box, a Promoter Element Required for Transcription of Genes Encoding the Pseudomonas aeruginosa Type III Secretion System, General Meeting of the American Society for Microbiology, Toronto, Canada. 2007.



28. Brutinel E, Vakulskas C, Yahr TL. DNA Binding Characteristics of ExsA; The Transcriptional Regulator of Type III Secretion in Pseudomonas aeruginosa, Phage Meeting, Madison, WI. 2007.

29. Jones AK, Balzer G, Yahr TL, Fulcher N, Wolfgang MC. Mechanism for Reciprocal Regulation of Pseudomonas aeruginosa Virulence Factors that Contribute to Acute and Chronic Respiratory Infection, Mid-Atlantic Microbial Pathogenesis Meeting, Wintergreen, VA. 2007.

30. Brutinel E, Yahr TL. Characterization of ExsA functional domains, the Transcriptional Activator of the Pseudomonas aeruginosa Type III Secretion System, General Meeting of the American Society for Microbiology, Boston, MA. 2008.

31. Brady K, Yahr TL. Identifying intrinsic structural properties in type III secretion promoters and the role they play in ExsA-dependent transcriptional activation in Pseudomonas aeruginosa, General Meeting of the American Society for Microbiology, Boston, MA. 2008.

32. Vakulskas C, Brady KM, Yahr TL. Mechanism of Transcriptional Activation by Pseudomonas aeruginosa ExsA, Gordon Research Conference on Microbial Toxins and Pathogenesis, Andover, NH. 2008.

33. Vakulskas C, Yahr TL. Mechanism of Transcriptional Activation of T3SS Promoters in Pseudomonas aeruginosa by ExsA, General Meeting of the American Society for Microbiology, Boston, MA. 2008.

34. Anderson G, Yahr TL, O'Toole GA. The Pseudomonas aeruginosa Magnesium Transporter MgtE Affects Type III Secretion, North American Cystic Fibrosis Conference, Orlando, FL. 2008.

35. Anderson GG, Yahr TL, O'Toole GA. Inhibition of Pseudomonas aeruginosa Toxicity Toward Airway Epithelial Cells, North American Cystic Fibrosis Conference, Minneapolis, MN. 2009.

36. Ince D, Wang D, Hopp C, Yahr TL. Secretion of flagellar proteins through the Pseudomonas aeruginosa injectisome system, Midwest Microbial Pathogenesis Meeting, West Lafayette, IN. 2009.

37. Jones AK, Balzer G, Yahr TL, Fulcher NB, Wolfgang MC. The MucA pathway contributes to reciprocal regulation of acute and chronic virulence factors in Pseudomonas aeruginosa, Mid-Atlantic Microbial Pathogenesis Meeting, Wintergreen Conference Center, VA. 2009.

38. Brutinel ED, King J, Yahr TL. The affinity of ExsA for promoter DNA, promoter strength, and the degree of promoter bending are determined by the distal ExsA binding site of T3SS



promoters in Pseudomonas aeruginosa, Midwest Microbial Pathogenesis Meeting, Washington University, St Louis, MO. 2010.

39. Urbanowski ML, Balzer G, Wolfgang MC, Yahr TL. The RsmA and MucA/AlgU Regulatory Systems Independently Control ExsA Expression at the Post-transcriptional Level, General Meeting of the American Society for Microbiology, San Diego, CA. 2010.

40. Urbanowski ML, Balzer G, Wolfgang MC, Yahr TL. The RsmA and MucA/AlgU Regulatory Systems Independently Control ExsA Expression at the Post-transcriptional Level, Midwest Microbial Pathogenesis Meeting, Washington University, St Louis, MO. 2010.

41. Diaz MR, Urbanowski ML, Wolfgang MC, Yahr TL. RsmA exerts a positive regulatory effect on ExsA expression at a post-transcriptional level, General Meeting of the American Society for Microbiology, New Orleans, LA. 2011.

42. Brutinel ED, King J, Yahr TL. The affinity of ExsA for promoter DNA, promoter strength, and the degree of promoter bending are determined by the distal ExsA binding site of T3SS promoters in Pseudomonas aeruginosa, General Meeting of the American Society for Microbiology, New Orleans, LA. 2011.

43. Ahlgren H, Bauerle E, Yahr TL, Singh P, Nguyen D. The stringent response controls virulence in Pseudomonas aeruginosa, The 25th Annual North American Cystic Fibrosis Conference, Anaheim, CA. 2011.

44. Marsden AE, Schubot F, Yahr TL. Identification of residues in the Pseudomonas aeruginosa transcriptional activator ExsA involved in self-association and interaction with the inhibitor ExsD, Midwest Microbial Pathogenesis Meeting, Medical College of Wisconsin, Milwaukee, WI. 2012.

45. Diaz MR, Urbanowski ML, Wolfgang MC, Yahr TL. RsmA exerts a positive regulatory effect on ExsA expression at the post-transcriptional level, Midwest Microbial Pathogenesis Meeting, Medical College of Wisconsin, Milwaukee, WI. 2012.

46. Intile PJ, Urbanowski ML, Wolfgang MC, Yahr TL. The AlgZR two-component system recalibrates the RsmAYZ post-transcriptional regulatory system to inhibit ExsA expression in Pseudomonas aeruginosa ΔmucA isolates, Midwest Microbial Pathogenesis Meeting, Medical College of Wisconsin, Milwaukee, WI. 2012.

47. King JM, Bartra SS, Plano GV, Yahr TL. The transcriptional activators of T3SS gene expression in Pseudomonas aeruginosa, Yersinia pestis, Aeromonas hydrophila, Photorhabdus luminescens, and Vibrio parahaemolyticus recognize a common sequence, Midwest Microbial Pathogenesis Meeting, Medical College of Wisconsin, Milwaukee, WI. 2012.



48. King JM, Bartra SS, Plano GV, Yahr TL. Reexamining the DNA binding properties of LcrF from Yersinia pestis, General Meeting of the American Society for Microbiology, Denver, CO. 2013.

49. Marsden AE, Yahr TL. Residues in the amino-terminal domain of ExsA are required for self-association and interaction with the ExsD anti-activator, Molecular Genetics of Bacteria and Phages Meeting, Madison, WI. 2013.

50. Intile PI, Diaz MR, Urbanowski ML, Wolfgang MC, Yahr TL. The AlgZR two-component system recalibrates the RsmAYZ post-transcriptional regulatory system to inhibit expression of the Pseudomonas aeruginosa type III secretion system, Molecular Genetics of Bacteria and Phages Meeting, Madison, WI. 2013.

51. Marsden AE, Yahr TL. Amino-Terminal Residues of ExsA Are Required for Self-Association and Interaction with the ExsD Anti-Activator, General Meeting of the American Society for Microbiology, Boston, MA. 2014.

Reviews

1. Yahr TL, Wolfgang MC. Transcriptional regulation of the Pseudomonas aeruginosa type III secretion system, Mol Microbiol. 2006 November;62(3):631-40. PMID:16995895

This was a solicited peer-reviewed article to discuss the newest developments in our understanding of regulatory mechanisms that control T3SS gene expression. Dr. Wolfgang and I shared equally responsibility in writing this review.

2. Brutinel ED, Yahr TL. Control of gene expression by type III secretory activity, Curr Opin Microbiol. 2008 April;11(2):128-33. PMC:PMC2387186

This was a solicited peer-reviewed article to discuss the newest developments in our understanding of regulatory mechanisms that couple secretory activity to gene expression. Mr. Brutinel and I shared equal responsibility in writing this review.

3. Diaz MR, King JM, Yahr TL. Intrinsic and Extrinsic Regulation of Type III Secretion Gene Expression in Pseudomonas aeruginosa, Front Microbiol. 2011;2:89. PMC:PMC3153048

This was a solicited peer-reviewed article to provide a comprehensive overview of regulatory mechanisms that regulate T3SS gene expression. The authors shared equal responsibility in writing this review. Other

Commentary

1. Yahr TL, Greenberg EP. The genetic basis for the commitment to chronic versus acute infection in Pseudomonas aeruginosa, Mol Cell. 2004 November 19;16(4):497-8. PMID:15546607

This was a solicited commentary to discuss a newly identified regulator of the Pseudomonas aeruginosa type III secretion and biofilm formation. I wrote most of this commentary.



2. Yahr TL. A critical new pathway for toxin secretion?, N Engl J Med. 2006 September 14;355(11):1171-2. PMID:16971725

3. Urbanowski ML, Yahr TL. Limiting too much of a good thing: a negative feedback mechanism prevents unregulated translocation of type III effector proteins, J Bacteriol. 2008 April;190(8):2643-4. PMC:PMC2293263

This was a solicited commentary to discuss the finding that translocated ExoS inhibits further rounds of translocation. I wrote the commentary while receiving valuable input from Mr. Urbanowski. Intellectual Property (e.g. Patents, Copyrights)

1. Frank, D. W., Yahr, T. L., Sawa, T., Wiener-Kronish, J. 6,309,651 B1 (Oct 30, 2001), 6,827,935 B2 (Dec 7, 2004), and 7,494,653 (Feb 24, 2009), "Method of and compositions for immunization with the Pseudomonas V antigen."

B. Areas of Research Interest

Inflammasome activation by P. aeruginosa flagellin.

Regulatory networks in P. aeruginosa.

Structural studies of the ExsA-ExsD protein complex.

The Pseudomonas aeruginosa type III secretion system.

Variability of T3SS gene expression in cystic fibrosis.

C. Grants

Grant Completed

Regulation of Pseudomonas aeruginosa Type III Secretion

US Department of Health & Human Services, National Institutes of Health

R01 AI055042

$1,875,000.00 Direct

May 15, 2003 - June 30, 2013

Percent effort: 40

Yahr, Timothy L (Principal)

Funded

Cystic Fibrosis Foundation Research & Development Program

Cystic Fibrosis Foundation

R458-CR02

$6,989,762.00 Direct, $0.00 Indirect



July 1, 1997 - June 30, 2015

Percent effort: 0

Welsh, Michael J (Principal)

Post-Transcriptional Regulation of Pseudomonas Virulence Gene Expression


R01 AI097264

$1,646,969.00 Direct

December 1, 2012 - November 30, 2017

Percent effort: 20


Not Funded

Determinants of Host Contact-Dependent Virulence Gene Expression

W. M. Keck Foundation

$1,000,000.00 Direct, $0.00 Indirect

June 1, 2005 - May 31, 2010

Percent effort: 35


Determinants of Host Contact-Dependent Virulence Gene Expression

Burroughs Wellcome Fund

$400,000.00 Direct, $0.00 Indirect

July 1, 2006 - June 30, 2011

Percent effort: 15


Structure and Function of the Yersinia pestis Type III Export Complex


$375,000.00 Direct, $178,125.00 Indirect

July 1, 2006 - June 30, 2011

Percent effort: 15

Plano, Gregory V (Principal)



Pseudomonas Control of Surfactant Synthesis


R01 HL086592

$1,250,000.00 Direct, $593,750.00 Indirect

July 1, 2007 - June 30, 2012

Percent effort: 5

Mallampalli, Rama (Principal)

Bacterial Respiratory Pathogens Research Center (BRPRC)


R01 AI024616

$28,426,078.00 Direct, $9,862,897.00 Indirect

November 1, 2011 - October 31, 2018

Percent effort: 30

Apicella, Michael A (Principal)

Contract Completed

Basic and Clinical Approaches to Controlling Human Respiratory Pathogens


N01-AI-30040

$17,771,162.00 Direct

August 1, 2003 - July 31, 2010

Percent effort: 15

Apicella, Michael A (Principal)

D. Presentations Invited Lectures/Guest Speaker

2002 9th Annual Midwest Microbial Pathogenesis Meeting, Indianapolis, IN.

2003 Iowa State University, Ames, Iowa.

2004 Dartmouth College.

2004 University of California - San Francisco.



2005 Annual Meeting of the American Society for Microbiology, Atlanta, GA.

2005 Midwest Prokaryotic Molecular Genetics and Physiology Meeting, Bloomington, IN.

2005 University of Chicago, Chicago, IL.

2006 13th Biennial UAUC Conference on Infectious Diseases, Banff, Alberta, Canada.

2006 Montana State University.

2006 Northwestern University.

2006 University of Nebraska.

2007 ASM Conference on Pseudomonas, Seattle, WA.

2008 University of Eastern Carolina, Greenville, NC.

2009 16th Annual Midwest Microbial Pathogenesis Meeting, West Lafayette, IN.

2010 University of Miami, Department of Microbiology, Miami, FL.

2011 Department of Microbiology & Molecular Genetics, Dartmouth Medical School, Hanover, NH.

2011 Deptartment of Biological Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA.

2012 Center for Microbial Interface Biology, Ohio State University, Columbus, OH.

2012 Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, WI.

2014 Department of Microbiology and Cell Science, University of Florida, Gainesville, FL.

IV. SERVICE

A. Memberships, Services, and Committees Memberships in Professional Organizations

1992 - Present American Society for Microbiology, Member

1999 - 2005 American Association for the Advancement of Science, Member

2004 - Present Pseudomonas aeruginosa community annotation project (PseudoCAP), Member

Offices Held in Professional Organizations

2005 - 2006 American Society for Microbiology, Chair-elect, Division D (General Medical Microbiology)

2006 - 2007 American Society for Microbiology, Chair, Division D (General Medical Microbiology)

2007 - 2008 American Society for Microbiology, Division Advisor, Division D (General Medical Microbiology)



Editorships

2009 - 2014 Journal of Bacteriology, Editorial Board

2010 - Present Frontiers in Cellular and Infection Microbiology, Editorial Board

2012 - 2014 Infection and Immunity, Editorial Board

Review Panels

2001 - 2002 EMBO Journal, Reviewer

2001 Applied and Environmental Microbiology, Reviewer

2002 - 2006 Molecular Microbiology, Reviewer

2002 Journal of Biological Chemistry, Reviewer

2002 National Academy of Science (PNAS), Reviewer

2003 - 2014 Journal of Bacteriology, Reviewer


2004 - 2008 Infection and Immunity, Reviewer

2004 - 2008 Microbiology, Reviewer

2004 - 2005 Wellcome Trust, Ad hoc reviewer

2004 FEMS Microbiology Letters, Reviewer

2004 Journal of Clinical Microbiology, Reviewer

2004 Microbial Pathogenesis, Reviewer


2005 Cystic Fibrosis Foundation, Ad hoc reviewer

2005 EMBO Journal, Reviewer

2005 National Academy of Science (PNAS), Reviewer

2007 - 2010 Antimicrobial Agents and Chemotherapy, Reviewer

2007 - 2008 Alberta Heritage Foundation, Ad hoc reviewer

2007 - 2008 Cellular Microbiology, Reviewer

2007 Nature, Reviewer

2007 PLoS ONE, Reviewer

2007 The Singapore Agency for Science, Technology and Research Biomedical Research Council, Ad hoc reviewer

2007 Wellcome Trust, Ad hoc reviewer

2008 - 2009 Canadian Cystic Fibrosis Foundation, Ad hoc reviewer

2008 - 2009 International Immunology, Reviewer

2008 Journal of Clinical Microbiology, Reviewer

2008 Journal of Experimental Medicine, Reviewer

2008 Journal of Infectious Disease, Reviewer

2008 Molecular Microbiology, Reviewer



2008 University of Wisconsin-Milwaukee, Research Growth Initiative, Ad hoc reviewer

2008 NIH Study Section, BACP, Ad hoc member

2009 - 2011 Nature Reviews Microbiology, Reviewer

2009 - 2010 FEBS Letters, Reviewer

2009 - 2010 FEMS Microbiology Letters, Reviewer

2009 NSF Study Section, Ad hoc reviewer

2009 University of Wisconsin-Milwaukee, Bradley Catalyst Awards, Ad hoc reviewer

2009 Wellcome Trust, Ad hoc reviewer

2009 NIH Study Section, BACP, Ad hoc member

2010 - 2013 Applied and Environmental Microbiology, Reviewer

2010 - 2013 Infection and Immunity, Reviewer

2010 Molecular Microbiology, Reviewer

2010 NIH Study Section, Centers for High-Throughput Structure Determination, Ad hoc reviewer

2010 University of Washington, Cystic Fibrosis Research and Development Program, Ad hoc reviewer

2011 - 2014 MBio, Reviewer

2011 - 2012 Canadian Cystic Fibrosis Foundation, Ad hoc reviewer

2011 Frontiers in Cellular and Molecular Microbiology, Reviewer

2012 - 2014 PLoS Pathogens, Reviewer

2013 Cell Host-Microbe, Reviewer

2013 NIH Study Section, Special Emphasis Panel/Scientific Review Group, ZRG1 F13-C, Ad hoc reviewer

2013 NIH Study Section, Special Emphasis Panel/Scientific Review Group, ZRG1 IDM-V, Ad hoc reviewer

2013 PLoS ONE, Reviewer

2014 NIH Study Section, Special Emphasis Panel/Scientific Review Group, Ad hoc reviewer

Departmental, Collegiate, University and National Committees

2001 - 2006 Department of Microbiology Graduate Student Admissions Committee, Member

2001 - 2002 Department of Microbiology Faculty Search Committee, Member

2003 Cystic Fibrosis Foundation Research & Research Training Committee, Member


2005 - 2011 Department of Microbiology Graduate Advisory Committee, Member

2005 - 2006 Department of Microbiology Comprehensive Examination Process Committee,



Member



2007 - 2010 Department of Microbiology Graduate Student Admissions Committee, Chair

2008 - 2009 Department of Microbiology Faculty Search Committee, Chair

2009 - 2014 Department of Microbiology Financial Review Committee, Member

2009 - 2014 Department of Microbiology Undergraduate Research Award Committee, Member

2009 - 2013 Michael A. Apicella Endowed Lecture Series Selection Committee, Member

2009 - 2012 American Society for Microbiology Membership Committee, Member

2010 - 2013 Dr. John P. Long Teaching Award Committee, Member

2010 - 2011 Department of Microbiology Graduate Student Admissions Committee, Member

2011 CCOM Faculty Performance Standards, Member

2013 - 2014 Faculty Senate, Member

Service Positions

2002 College of Medicine, Medical School Admissions Interviewer



B. Clinical assignments since last promotion (if applicable)

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