Making Bone Regeneration

The Synthetic Solution to Bone Regeneration

Putty In Your Hands

DENTAL PUTTY

The unique solution topredictable bone regeneration

NovaBone Dental Putty increases productivity with its ease of use and superlative handling characteristics. It delivers predictable bone fast.

NovaBone Dental Putty is available in multiple delivery mechanisms including syringes, clam shells and “Centrix-like” cartridge delivery systems to suit various clinical applications.

The “Cartridge” delivery system is unique and an industry first! NovaBone Dental Putty is the only graft material in the world that is available in disposable uni-dose ‘Cartridges’ that will significantly simplify the delivery of graft to the defect site following minimally invasive surgical techniques that will reduce morbidity and enhance healing at the defect site.

Feature Benefit

Superlative Handling No mixing is required. Putty can be placed directly into the defect.

Completely Resorbable Putty resorbs completely and gets replaced by bone. Re-entry time is about 4-5 months and is dependent on the size and site of the defect

Retention & Adaptability Putty stays together after placement and irrigation. It is moldable into different shapes and adapts well to the defects and implant surfaces

Osteostimulation Putty exhibits enhanced bone regeneration rates compared to other bone graft substitutes by a unique phenomenon: Osteostimulation

Storage & Shelf Life Putty does not require special storage conditions. It can be stored at room temperature. 4-year shelf life.

Manufactured by:NovaBone Products, LLC

w.nbputty.com 0D8334

NovaBone Dental Putty: Cartridge SystemEU3620 0.5cc Cartridges (blue) 2/pkg EU3640 0.5cc Cartridges (blue) 4/pkg EU3621 1.0cc Cartridges (orange) 2/pkg NA3600 Centrix Applicator Gun each

NovaBone Dental Putty: Syringe EU1610 0.5cc Syringe 1/Pack EU1620 0.5cc Syringe 2/Pack

NovaBone Dental Putty: Clam Shell EU0610 0.5cc Shell 1/Pack EU0620 0.5cc Shell 2/Pack EU0611 1.0cc Shell 1/Pack

Cartridges

Cartridge Applicator Gun

Clam Shell

Syringes

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NovaBone Dental Putty vs. Bio-Oss: HistomorphometryNovaBone Dental Putty was significantly superior to Bio-Oss at both 6 and 12 weeks following implantation. Comparative histological

analysis and histomorphometry revealed excellent bone regeneration after use of NovaBone Dental Putty, occurring simultaneously

with graft resorption. Also, a reduction in size of putty particles in the histology sections indicated that putty is being absorbed. Sections

of Bio-Oss revealed very minimal graft absorption with particles occupying the majority of the graft area at both 6 and 12 weeks.

“Evaluation of Alloplast Putty and Xenograft Particulate as

Bone Graft Substitutes in a Sheep Lumbar Spine Model.”

Aron Gonshor, Jipin Zhong, David Gaisser

Poster presented at the Academy of Osseointegration, Phoenix, March 2012.

Nova Bone Dental PuttyAfter 6 weeks After 12 weeks

Bio-OssAfter 6 weeks After 12 weeks

Unique FormulationNovaBone Dental putty is the only commercially available non-settable completely synthetic bone graft substitute. Quite simply, it is

designed to deliver unprecedented ease-of-handling without compromising on the quality of the outcome. It is not just a ‘bone void

filler’; rather, it is a calcium phosphosilicate composed of minerals found naturally in the body that allow for rapid bone regeneration.

NovaBone contains a binder that helps maintain space between the particles to allow for vascularization, tissue growth and new bone

formation. It is indicated for all periodontal, implant related and craniofacial defects.

OsteostimulationNovaBone Dental Putty belongs to the class of bioactive regenerative materials that not only acts as an osteoconductive scaffold

but also imparts an osteostimulatory effect. Release of Si from the putty particles is the key in signaling & recruitment of

bone precursor cells to the defect site and stimulate osteoblast differentiation and proliferation; the basis for new bone grow .ht

Gaisser DM, Katta SA, Greenspan DC NovaBone Mechanisms of Osteostimulation, White Paper, NovaBone, Alachua, FL.

Uncompromised Regeneration The CPS particles in NovaBone Dental Putty has more than 20 years of international clinical use behind it with over 50 studies on

file. Data shows that NovaBone Dental Putty is clinically superior to the granular particulate alternatives with regard to the ultimate

end result—the successful regeneration of bone between the implant and the existing bone structure. Yet Putty is dramatically more

convenient to use.

Uncommon handling.Uncompromised results.

% New Bone % Residual Graft

Weeks 6 12 6 12

NB Dental Putty 33.78 52.90 30.66 24.42

Bio-Oss 18.06 23.01 66.72 57.98

Making Bone RegenerationPutty In Your Hands

Bioactive Healing

NovaBone Dental Putty Case Study (Case Courtesy: Dr. Frederic Joachim)

Patient presented with a decayed

mandibular premolar that required

extraction. Upon extraction, it was

noticed that the buccal wall was

missing and the area was grafted

with NovaBone Dental Putty. The

mucosa was sutured to obtain pri-

marily closure without the use of a

membrane. A six month post-opera-

tive radiograph demonstrates good

trabecular pattern and Radiodensity

comparable to the adjacent native

bone. The mucosa was exposed

and upon visual confirmation of the

regenerated ridge an implant was

placed in the area.

NovaBone Dental Putty Testimonial“I have worked with several bone graft substitutes over the years for Socket Preservation surgeries and found NovaBone Dental Putty

to be a revelation. I currently am using NovaBone Putty exclusively and love the cartridge system. I find the handling, healing with

good clinical & histological results far superior to any bone grafts that I have used.”

Dr. Frederic Joachim, Lille, France

1. Extraction and putty placement 2. Suturing – no membrane used

3. Regenerated Buccal Ridge 4. 6 month Post-Operative Radiograph

A Timeline of Bioactive Healing

Initial burst of NA+ CA+ & Po4- ions from smaller CPS particles

Within Minutes

Interaction of larger

CPS particles

20 Hours

Precipitation of calcium phosphate nodules &

Clot stabilization

6 Hours

Differentiation

of the stem cells

100 Hours

1 Hour

Initiation of Glycerin/PEG absorption cascade

(continues for 3-5 days)

50 Hours

Recruitment and fixation of stem cells

10 Hours

Crystallization of Hydroxy carbonate

apatite layer

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