The role of who in leg imaginal disc morphogenesis.
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Transcript of The role of who in leg imaginal disc morphogenesis.
The role of who in leg imaginal disc
morphogenesis
The Drosophila who gene has pleiotropic functions
during metamorphosis• who (wings-held-out) also named how, struthio,
qkr93F• Encodes KH RNA binding protein • Strong similarity to nematode GLD-1 and mouse
QK1• Required for tendon cell differentiation in
embryos• who mutants exhibit defects in muscle, muscle
attachment, wing development and adult leg development
who mutants show multiple lethal phases
who is expressed during metamorphosis
who mutants show defects in leg development
who
Stubble
control
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Conclusions
• who mutants show multiple lethal phases and pleiotropic effects during metamorphosis.
• who is expressed during metamorphosis.
• who mutant leg discs undergo proper cell shape changes during morphogenesis but do not extend fully at the prepupal-pupal transition.
• This defect is associated with inappropriate orientation of leg imaginal discs.
• The pleiotropic function of who suggests that KH proteins play essential roles in development of numerous cell types.
Acknowledgments
Mount Holyoke College
Tina Fortier
Craig Woodard
University of Maryland Biotechnology Institute
Runa Chatterjee
Susan Klinedinst
Eric Baehrecke