The Neck Jochen A. Werner Marburg, Germany. The Neck in squamous cell carcinoma (HNSCC) in cancer of...

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The Neck Jochen A. Werner Marburg, Germany

Transcript of The Neck Jochen A. Werner Marburg, Germany. The Neck in squamous cell carcinoma (HNSCC) in cancer of...

Page 1: The Neck Jochen A. Werner Marburg, Germany. The Neck in squamous cell carcinoma (HNSCC) in cancer of unknown primary in skin cancer in salivary gland.

The Neck

Jochen A. Werner

Marburg, Germany

Page 2: The Neck Jochen A. Werner Marburg, Germany. The Neck in squamous cell carcinoma (HNSCC) in cancer of unknown primary in skin cancer in salivary gland.

The Neck

• in squamous cell carcinoma (HNSCC)

• in cancer of unknown primary

• in skin cancer

• in salivary gland cancer

• in thyroid cancer

• in the future

Page 3: The Neck Jochen A. Werner Marburg, Germany. The Neck in squamous cell carcinoma (HNSCC) in cancer of unknown primary in skin cancer in salivary gland.

The Neck

• in squamous cell carcinoma (HNSCC)

• in cancer of unknown primary

• in skin cancer

• in salivary gland cancer

• in thyroid cancer

• in the future

Page 4: The Neck Jochen A. Werner Marburg, Germany. The Neck in squamous cell carcinoma (HNSCC) in cancer of unknown primary in skin cancer in salivary gland.

The prognostic factor in head and neck cancer

The Neck

STATEMENTS 2008

Page 5: The Neck Jochen A. Werner Marburg, Germany. The Neck in squamous cell carcinoma (HNSCC) in cancer of unknown primary in skin cancer in salivary gland.

N0 Neck

STATEMENTS 2008

N+ Neck

Page 6: The Neck Jochen A. Werner Marburg, Germany. The Neck in squamous cell carcinoma (HNSCC) in cancer of unknown primary in skin cancer in salivary gland.

• NO Definition of N0 neck ! Standards in Staging

N0 Neck

STATEMENTS 2008

• NO Sufficient Data for Sentinel Node

• NO Proven Selection Criteria for Wait and See

• NO Consensus about the Extent of SND

Page 7: The Neck Jochen A. Werner Marburg, Germany. The Neck in squamous cell carcinoma (HNSCC) in cancer of unknown primary in skin cancer in salivary gland.

is still an individual topic regarding definition and strategy in HNSCC

N0 Neck

STATEMENTS 2008

Page 8: The Neck Jochen A. Werner Marburg, Germany. The Neck in squamous cell carcinoma (HNSCC) in cancer of unknown primary in skin cancer in salivary gland.

N0 Neck

STATEMENTS 2008

N+ Neck

Page 9: The Neck Jochen A. Werner Marburg, Germany. The Neck in squamous cell carcinoma (HNSCC) in cancer of unknown primary in skin cancer in salivary gland.

• Extension of ND is still unclear

• ND as the only treatment (1-2 mets) ?

• Role of micrometastes ?

• Radiotherapy > 1 node or > 2 ?

• Management of persisting LN after RT ?

N+ Neck

STATEMENTS 2008

Page 10: The Neck Jochen A. Werner Marburg, Germany. The Neck in squamous cell carcinoma (HNSCC) in cancer of unknown primary in skin cancer in salivary gland.

A lot of controversies on important questions

N+ Neck

STATEMENTS 2008

Page 11: The Neck Jochen A. Werner Marburg, Germany. The Neck in squamous cell carcinoma (HNSCC) in cancer of unknown primary in skin cancer in salivary gland.

The Neck

• in squamous cell carcinoma (HNSCC)

• in cancer of unknown primary

• in skin cancer

• in salivary gland cancer

• in thyroid cancer

• in the future

Page 12: The Neck Jochen A. Werner Marburg, Germany. The Neck in squamous cell carcinoma (HNSCC) in cancer of unknown primary in skin cancer in salivary gland.

The Neck in CUP

• NO Standards for Staging of CUP

• Lymph Node Extirpation Followed by ND ?

• Extension of Radiation Fields ?

• Radiation after Neck Dissection?

Page 13: The Neck Jochen A. Werner Marburg, Germany. The Neck in squamous cell carcinoma (HNSCC) in cancer of unknown primary in skin cancer in salivary gland.

is still an individual topic regarding definition and strategy

Neck in CUP

STATEMENTS 2008

Page 14: The Neck Jochen A. Werner Marburg, Germany. The Neck in squamous cell carcinoma (HNSCC) in cancer of unknown primary in skin cancer in salivary gland.

The Neck

• in squamous cell carcinoma (HNSCC)

• in cancer of unknown primary

• in skin cancer

• in salivary gland cancer

• in thyroid cancer

• in the future

Page 15: The Neck Jochen A. Werner Marburg, Germany. The Neck in squamous cell carcinoma (HNSCC) in cancer of unknown primary in skin cancer in salivary gland.

The Neck in Skin Cancer

• Sentinel Node in melanoma patients (Session 3)

• Parotideal lymph nodes

Page 16: The Neck Jochen A. Werner Marburg, Germany. The Neck in squamous cell carcinoma (HNSCC) in cancer of unknown primary in skin cancer in salivary gland.

The Neck

• in squamous cell carcinoma (HNSCC)

• in cancer of unknown primary

• in skin cancer

• in salivary gland cancer (Session 14)

• in thyroid cancer

• in the future

Page 17: The Neck Jochen A. Werner Marburg, Germany. The Neck in squamous cell carcinoma (HNSCC) in cancer of unknown primary in skin cancer in salivary gland.

The Neck

• in squamous cell carcinoma (HNSCC)

• in cancer of unknown primary

• in skin cancer

• in salivary gland cancer

• in thyroid cancer (Session 13)

• in the future

Page 18: The Neck Jochen A. Werner Marburg, Germany. The Neck in squamous cell carcinoma (HNSCC) in cancer of unknown primary in skin cancer in salivary gland.

The Neck

• in squamous cell carcinoma (HNSCC)

• in cancer of unknown primary

• in skin cancer

• in salivary gland cancer

• in thyroid cancer

• in the future

Page 19: The Neck Jochen A. Werner Marburg, Germany. The Neck in squamous cell carcinoma (HNSCC) in cancer of unknown primary in skin cancer in salivary gland.

Clinical and Basic Research

• Identification of high risk patients

• Molecular imaging

• Sentinel Node (Endoscopically)

The Neck - Perspectives

Aim for STATEMENTS 2020 (Hamburg)

Consensus based on Multicenter Trials

Page 20: The Neck Jochen A. Werner Marburg, Germany. The Neck in squamous cell carcinoma (HNSCC) in cancer of unknown primary in skin cancer in salivary gland.
Page 21: The Neck Jochen A. Werner Marburg, Germany. The Neck in squamous cell carcinoma (HNSCC) in cancer of unknown primary in skin cancer in salivary gland.
Page 22: The Neck Jochen A. Werner Marburg, Germany. The Neck in squamous cell carcinoma (HNSCC) in cancer of unknown primary in skin cancer in salivary gland.
Page 23: The Neck Jochen A. Werner Marburg, Germany. The Neck in squamous cell carcinoma (HNSCC) in cancer of unknown primary in skin cancer in salivary gland.

1906 – 2008

RND - MRND

Page 24: The Neck Jochen A. Werner Marburg, Germany. The Neck in squamous cell carcinoma (HNSCC) in cancer of unknown primary in skin cancer in salivary gland.

Endoscopic SSND

SND

MRND

SNB

SSND

RND

New more

Individual

Concepts

Page 25: The Neck Jochen A. Werner Marburg, Germany. The Neck in squamous cell carcinoma (HNSCC) in cancer of unknown primary in skin cancer in salivary gland.

The Neck


Distinct Subpopulations of Head and Neck Cancer Cells ... · Sphere cultures define CIC in HNSCC cell populations ... enhancing cisplatin-induced cell death. Overall, our work defined

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Development of New Chemotherapeutics for Head & Neck ...d-scholarship.pitt.edu/18473/1/Thesis-3.pdfDevelopment of New Chemotherapeutics for Head & Neck Squamous Cell Carcinoma (HNSCC)

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Brain metastasis from squamous cell carcinoma of the head ...neck (HNSCC) affects nearly 500,000 individuals glob-ally each year.46 In general, the current management of HNSCC revolves

Brain metastasis from squamous cell carcinoma of the head ...neck (HNSCC) affects nearly 500,000 individuals glob-ally each year.46 In general, the current management of HNSCC revolves

Neck Node Assessment in Head and neck Cancer

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Head and neck cancer - NICE

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Research Paper Toward the use of precision medicine for ......Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer all over the world. It remains a serious

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HEAD NECK CANCER- AWARENESS DRIVE

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TNM Staging of Head and Neck Cancer and Neck Dissection ...

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Head and Neck Cancer Program

Head and Neck Cancer Program

Head Neck Cancer Dr P.K

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Head & Neck Cancer Clinical Guidelines - NECN NECNnecn.nhs.uk/wp-content/uploads/2015/02/Head-Neck... · Head & Neck Cancer Clinical Guidelines Head & Neck NSSG on behalf of NECN

Head & Neck Cancer Clinical Guidelines - NECN NECNnecn.nhs.uk/wp-content/uploads/2015/02/Head-Neck... · Head & Neck Cancer Clinical Guidelines Head & Neck NSSG on behalf of NECN

Surveillance Head and Neck Cancer

Surveillance Head and Neck Cancer

Reirradiation in head and neck cancer. Introduction Last decade witnessed major progress in management of pts with HNSCC – The addition of concomitant.

Reirradiation in head and neck cancer. Introduction Last decade witnessed major progress in management of pts with HNSCC – The addition of concomitant.

Head and Neck Cancer Guidelines

Head and Neck Cancer Guidelines