The Methodology of Conducting Systematic Reviews David Scalzitti, PT, PhD, OCS [email protected]...
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Transcript of The Methodology of Conducting Systematic Reviews David Scalzitti, PT, PhD, OCS [email protected]...
The Methodology of Conducting Systematic Reviews
David Scalzitti, PT, PhD, [email protected]
Lunch and LearnOctober 15, 2014
Key Points
•Identify the uses of systematic reviews
•Differentiate systematic reviews, meta-analyses, and clinical practice guidelines
•Identify/perform valid methods for a systematic review
When to Read a Systematic Review?
Relative Hierarchy of Intervention Evidence based on www.cebm.net
•Systematic reviews of RCTs•Randomized controlled trials or an
observational study with dramatic effect•Cohort study•Case-control study or Case series•Mechanism-based reasoning
When to Write a Systematic Review?
Systematic Review
A summary of the medical literature that uses EXPLICIT methods to perform a thorough literature search AND critical appraisal of
individual studies AND that uses appropriate techniques to combine these valid studies.
Meta-Analysis
A systematic review that incorporates a quantitative strategy for combining the results of several studies into a single
pooled or summary estimate.
All MA should be based on a SR.All SR do not include a MA.
Systematically developed statements to assist practitioner and patient decisions about
appropriate health care for specific clinical circumstances.
All clinical practice guidelines should include a systematic review of the literature PLUS a
recommendation.
Clinical Practice Guideline
How I got involved
Systematic Review Methods
PRISMA
•Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)• www.prisma-statement.org▫27 item checklist▫Flow diagram
PRISMA
Define a Clinical Question - PICOTS
•P - Participants •I - Interventions•C - Comparisons•O - Outcomes•(T – Timing)•(S – Setting or Study Design)
Assemble a Team
Develop the Protocol for the SR•Set inclusion/exclusion criteria•Define evaluation method•Draft evidence tables
▫Good resource: Mlika-Cabanne N, Harbour R, de Beer H, Laurence M, Cook R, Twaddle S; Guidelines International Network (GIN) Working Group on Evidence Tables. Sharing hard labour: developing a standard template for data summaries in guideline development. BMJ Qual Saf. 2011 Feb;20(2):141-5.
Develop the Search Strategy
•Select keywords•Identify databases
▫PubMed▫Scopus▫CINAHL▫SPORTDiscus▫Cochrane Controlled Trial Registry
((“Anterior cruciate ligament” [TW] OR “posterior cruciate ligament” [TW] OR “medial collateral ligament” [TW] OR “lateral collateral ligament” [TW] OR “tibial collateral ligament” [TW] OR “fibular collateral ligament” [TW] OR “posterolateral corner” [TW] OR “arcuate complex” [TW] OR “posteromedial corner” [TW]) OR ((knee joint [MH]) AND (ligaments, articular [MH] OR ACL [TW] OR PCL [TW] OR MCL [TW] OR LCL [TW] OR TCL [TW] OR FCL [TW]))) AND (physical therapy modalities [MH] OR recovery of function [MH] OR rehabilitation [MH] OR therapeutics [MH] OR “physical therapy” [TW] OR physiother* [TW] OR recovery [TW] OR restoration [TW] OR re-education [TW] OR early ambulation [MH] OR strengthening [TW] OR resistance training [MH] OR “resistance methods” [TW] OR exercise therapy [MH] OR biofeedback, psychology [MH] OR “neuromuscular electrical stimulation” [TW] OR pain management [MH] OR pain measurement [MH] OR mobilization* [TW] OR “continuous passive motion” [TW] OR manipulation, spinal [MH] OR ultrasonography [TW] OR ultrasound [TW] OR acupuncture [TW] OR laser* [TW] OR patient education as topic [MH] OR electrical stimulation [MH] OR electrical stimulation therapy [MH] OR Transcutaneous electric nerve stimulation [MH] OR taping [TW] OR bracing [TW] OR orthotic* [TW] OR weight-bearing [MH] OR Range of motion [MH] OR Treatment Outcome [MH] OR Exercise [MH] OR “physical therapy treatments” [TW] OR “training program” [TW])
To be continued - November 5, 2014…Systematic Reviews Part 2
Translating Evidence to Practice and Policy