The many faces of What is Endometriosis? Endometriosis Endometriosis is a common cause of chronic !

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Transcript of The many faces of What is Endometriosis? Endometriosis Endometriosis is a common cause of chronic !

  • The many faces of��� Endometriosis

    Beryl Benacerraf M.D��� Harvard Medical School

    What is Endometriosis? •  Endometriosis is defined as the

    presence of normal endometrial tissue occurring outside of the endometrial cavity.

    •  This tissue responds to cyclic hormonal changes resulting in localized bleeding, inflammation and adhesion formation.

    Common sites of endometriosis •  Ovaries •  Uterine surface •  Peritoneum •  Uterosacral ligaments •  Cul de sac •  Bladder •  Bowel wall •  Scars in anterior abdominal wall •  Rare – outside pelvis

    Common sites of endometriosis

    McKinney et al., 2000.

    How Common is Endometriosis?

    •  Prevalence in the general population is estimated at 10% of women.

    •  Present in up to 80% in patients with pelvic pain.

    •  Present in up to 20% in infertility patients but in 3% of multiparous women.

    • Unknown •  Reflux of menstrual tissue and blood

    through the fallopian tubes during menses. •  Müllerian remnants in the rectovaginal

    region differentiate into endometrial tissue. •  Lymphatics may be the conduate •  shorter menstrual cycles, longer bleeding,

    and early menarche are risk factors – supports reflux theory

    Etiology

  • Endometriosis is a common cause of chronic ��� pelvic pain in premenopausal women

    •  The most recognized ultrasound appearance of endometriosis is the cyst known as an endometrioma.

    •  Traditionally, the sonographic diagnosis of endometriosis was reserved for patients with endometriomas, thus missing the cause of pelvic pain in many patients.

    Endometrioma of the ovary

    Deep implants •  The pain associated with these implants

    may be intense but these are small lesiona often not detected by a standard pelvic scan.

    •  Some patients with large endometriomas may have few symptoms whereas others with small deep implants have severe dysmenorrhea, dyspareunia and chronic pelvic pain.

    Example: bowel endo

    Adenomyosis: •  Thought of as endometriosis of

    the uterus. • Characterized by invasion of

    endometrial glands into the neighboring myometrium.

    •  Symptoms: Dysmenorrhea ��� abnormal bleeding, uterine enlargement and tenderness.

  • The curse of pelvic pain •  Many patients never get a diagnosis and

    live with chronic pain •  15% of women - as defined by pain for

    > 6 months in women 18-50 years old. (Matthias et al OB GYN 1996;87:321)

    •  Pelvic pain accounts for 10% of referrals to a gynecologist and more than 40% of diagnostic laparoscopies

    (Shwayder JM. Semin Reprod Med. 2008;26:25)

    The examination ��� of the patient���

    suspected of endometriosis

    Get a history during the exam •  Acute or chronic •  Diffuse or focal •  Cyclical or constant •  Sharp or dull or cramping •  ? Prior surgery •  Menopausal and hormonal status •  Could she be pregnant?

    During the scan •  How tender is the patient? •  Where is the tenderness? Focal? •  Do organs slide past each other? •  Push deliberately on each part of the

    pelvis with the probe and other hand to determine where the pain comes from.

    •  Talk to the patient!

    Adenomyosis: Invasion of ��� endometrial glands into myometrium

    Ultrasound appearance: – Mottled inhomogeneous myometrium – globular & asymmetrical uterus, – small subendometrial cysts – indistinct endometrial stripe.

  • Fuzzy borders of cavity due to adenomyosis

    Adenomyoma versus fibroid

    AshermansIs this adenomyosis?

  • Normal Asherman’s Is this adenomyosis?

    Submucous fibroid

    Typical endometriomas

    Typical endometrioma with hydrosalpinx (common)

    EndometriomaCystadenoma EndometriomaOv Cancer

  • Pitfall - struma ovariiIs this endometriosis? Endometrioma mimicking

    dermoid

    Is this a dermoid ?

    Is this endometriosis?

    Hint: Patient is pregnant

    Decidualized endometrioma

    Decidualized Endometrioma

    • Cystic masses mimicking an ovarian malignancy during pregnancy, due to areas of nodularity containing blood flow by color Doppler. • A prospective diagnosis is possible when a pregnant women has a cyst with solid smoothly lobulated nodules and internal vascularity, stable over several weeks.

  • 22 masses in 17 pregnant pts •  8 pts went to surgery, 9 (14 masses), had f/u

    scans and surgery 3-34 weeks later •  8 of these masses showed no change and

    one became smaller. •  There were no characteristic sono features

    identified to distinguish decidualized endometriomas from ovarian malignancy.

    •  Lesions showing no change over 4 weeks, or lacking solid components and vascularity are more likely to be benign.

    Groszmann, Howitt, Bromley, Feltmate, Benacerraf, et al. In press JUM

    Invasive ovarian cancer at 8 wks

    Endo implant in CDS

    Unusual appearances of endo implants anywhere

    Endo in bowel wall

    Endometriosis of the bladder wall

    Tubal endometriosis

  • Extensive endometriosis 24 year old

    Endo implant in utero-sacral ligament

    Endo implant on appendix

    Appendicitis!

    Anterior abdominal wall scar

    The comet shape

    Endo in wall of sigmoid adherant to back of uterus

  • The comet-sign of endometriosis of the bowel wall

  • Bowel endo vs tumor

    • Ultrasound sensitivity and specificity for detecting the disease was 78.5% and 95.2% respectively.

    • The sensitivity was best for intestinal and bladder disease and slightly less accurate for utero-sacral and - rectovaginal lesions

    Ultrasound for detecting deep pelvic endometriosis in 79 cases

    Bazot et al. Obstet Gynecol 2004;24:180-5

    Detection of Bowel Endometriosis��� 10 prospective studies – 1106 pts – ��� prevalence of bowel endo 24-73%���

    Sensitivity 71-98% (pooled data 91%) Specificity 92-100%(pooled data 98%)Accuracy 81-99% +LR 30.36 -LR 0.09 Hudelist et al UOG 2011;37;257

    Transvaginal scan in deep endometriosis��� in 10 different pelvic sites

    420 pts having ultrasound and laparoscopy (gold standard) for pelvic pain and infertility. Endo focus Sensitivity % Specificity % Bladder 61 99 Recto-vaginal septum

    52 96

    Rectal 65 99 Sigmoid 69 98

    Fratelli et al. UOG 2013;41:69-75

  • Recto- vaginal septum

    Ultrasound vs. MR��� I98 pts with surgically ���

    confirmed endometriosis Abrao et al. found that transvaginal ultrasound had a sensitivity, specificity and accuracy of 98%, 100% and 99% respectively compared to MRI’s sensitivity, specificity and accuracy of 83% 98% and 90% for recto-sigmoid endometriosis.

    Abrao et al. Hum Reprod. 2007;22:3092-7

    The sensitivity and specificity for detecting deep endometriosis by tenderness guided ultrasound was - 86% and 73% respectively while for MRI it was - 90% and 73% respectively.

    Ultrasound vs. MR��� for detecting endometriosis

    Saba et al. J Magn Reson Imaging. 2012 35:352-60.

    Tubal disease and infertility with endometriosis

    How to test tubal patency with ultrasound

  • Conclusions •  Pelvic pain in endometriosis is common

    and impairs quality of life. •  Accurate Dx requires an extended

    ultrasound and history. •  Patients with endometriosis deserve

    more than just a series of standard pictures of the uterus and ovaries.

    •  Those that we help are among the most grateful of all our patients!

    Long segment of bowel wall endo

    Colon cancer

    Crohn’s