THE JOHN CURTIN SCHOOL MEDICAL RESEARCH · 2018. 4. 13. · JCSMR 2006 From the Director It is with...

THE JOHN CURTIN SCHOOL OF MEDICAL RESEARCH

Annual Review 2006

Health Through Discovery

ANU COLLEGE OF MEDICINE & HEALTH SCIENCES

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Introduction

The John Curtin School of Medical Research (JCSMR) was established as a result of the vision of Australian Nobel Laureate Howard Florey and war-time Prime Minister John Curtin. JCSMR researchers continue to strive towards Florey’s vision – of a national medical research school undertaking superlative medical research in fundamental areas. Opened in 1948, the School boasts almost 60 years of prize winning research, including three Nobel Laureates in Physiology or Medicine, The Japan Prize, The Copley Medal, and The Albert Einstein World Award for Science.

The goals of The John Curtin School of Medical Research are to:

• play a leadership role in medical research in Australia

• conduct research of the highest international standard into fundamental life processes and the pathologies of these processes which cause human disease

• provide outstanding training in medical research for young scientists and health professionals

• apply new knowledge for better health outcomes.

The School has three major research divisions, Molecular Bioscience, Immunology and Genetics, and Neuroscience, each comprised of independent research groups and laboratories. The High Blood Pressure Research Unit is headed by the School’s Director. A unique feature and major strength of JCSMR is the diverse nature of the research programs, including genomics, immunity, gene regulation and cell signalling, neuroscience and integrative physiology. These areas benefit enormously from the potential for mutual interaction and collaboration across Divisions, enabling the School to make important contributions to the understanding of many diseases, including diabetes, cancer, asthma and high blood pressure, infectious disease, hearing, vision and memory.

We are committed to training medical researchers of the future, from Australia and overseas. Many of our postgraduate students are carrying out research directed towards a PhD degree and we share supervision of Honours students with the ANU Colleges and other institutions.

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JCSM

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Introduction to The John Curtin School of Medical Research

From the Director . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Highlights . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 Outcomes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 JCSMR Structure . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 Boards and Committees . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7

Research Programs . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 Division of Immunology and Genetics . . . . . . . . . . . . . . . . . . . . . . 10 Division of Molecular Bioscience . . . . . . . . . . . . . . . . . . . . . . . . . . 16 Division of Neuroscience . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 22 High Blood Pressure Research Unit . . . . . . . . . . . . . . . . . . . . . . . . 28

Staff & Student Achievements . . . . . . . . . . . . . . . . . . . . . . . . . 29

Research Collaborations & Visitors . . . . . . . . . . . . . . . . . . . . . . 33 Research Collaborations . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 34 Visitors to JCSMR . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 43

Staff, Students & Invited Presentations . . . . . . . . . . . . . . . . . . 45 Division of Immunology and Genetics . . . . . . . . . . . . . . . . . . . . . . 46 Division of Molecular Bioscience . . . . . . . . . . . . . . . . . . . . . . . . . . 52 Division of Neuroscience . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 56 High Blood Pressure Research Unit . . . . . . . . . . . . . . . . . . . . . . . . 58 Students . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 59 School Administration and Services . . . . . . . . . . . . . . . . . . . . . . . 61

Publications . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 65 Contact with our Community . . . . . . . . . . . . . . . . . . . . . . . . . . 75 Voluntary Service to Organisations outside JCSMR . . . . . . . . . . . 79

Support . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 83 Grants . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 84 Statistics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 89 Donors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 90

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JCSMR 2006

From the Director

It is with great pleasure that I present The John Curtin School of Medical Research Annual Review 2006 to provide an overview of the many and varied research and teaching activities carried out by our staff and students throughout the year, and to highlight our achievements.

2006 saw many changes to the structure of JCSMR, as Stage 1 of our new building reached completion. Staff began the move into the new laboratories in July, and both new and old buildings now house active research programs. The new building itself, designed by Lyons (Melbourne) has attracted an enormous amount of interest and has won Awards for project managers Hindmarsh – including the ACT Master Builders Association Project of the Year, and subsequently the MBA National Presidents Award. There were some nostalgic farewells as staff and students said goodbye to the Florey Lecture Theatre and the old Tea Room. There were also many celebrations. We were very pleased to welcome Drs Alan and Elizabeth Finkel to open The Finkel Lecture Theatre in October and members of the Australian Cancer Research Foundation were present as ACT MLA Katy Gallagher opened the new ACRF funded Biomolecular Resource Facility. Demolition work has commenced once more, and the Wing C footprint will make way for Stage 2 of the new building, due for completion early in 2009.

Research has continued throughout the construction process. Professor Lamb received the Proctor Medal for his vision research and Professor Goodnow was awarded an Australian Research Council Federation Fellowship. We were pleased to present Professor Sam Berkovic with the Curtin Medal for his research into the neurobiology of human epilepsies.

JCSMR researchers continued to enjoy success in attracting grants from national and overseas granting bodies. We are grateful to the friends and donors who support projects within the School, and to those who have chosen to endow Scholarships and Prizes recognising the high calibre of research performed by our staff and students.

Judith Whitworth AC

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Curtin Medal

• TheCurtinMedalwaspresentedtoProfessorSamuelBerkovic,HeadoftheComprehensiveEpilepsyProgramattheAustinHospitalandtheEpilepsyResearchCentreoftheUniversityofMelbourne.ProfessorBerkovicseekstounderstandthebasicneurobiologyofhumanepilepsies,usingvariedapproachestogaininsightsthatcanbeusedfordiagnosisandtreatmentofpatients.Thisresearchhaspioneeredunderstandingofthegeneticbasesforepilepsy.

Proctor Medal

• ProfessorTrevorLamb(DivisionofNeuroscience)andhiscolleagueProfessorEdPugh(UniversityofPennsylvania)wereawardedtheProctorMedaloftheAssociationforResearchinVisionandOphthalmology(ARVO).TheProctorMedalispresentedannuallyforoutstandingresearchinthebasicorclinicalsciencesasappliedtoophthalmology.

Federation Fellowship

• ProfessorChristopherGoodnow(DivisionofImmunologyandGenetics)wasawardedanARCFederationFellowship.ProfessorGoodnow,HeadoftheImmunogenomicsLaboratoryatTheJohnCurtinSchoolofMedicalResearchandDirectoroftheAustralianPhenomicsFacility,willbuildaninternationalImmunityandInfectionGenomicsConsortiumcentredinAustraliatotacklethreefundamentalquestionsaboutthemammalianimmunesystem:howdoesthesystemlearnnottoattackself-components,howdoesitenhancerecallresponsestovaccines,andwhydoesitfailtoeliminateformidableforeignmicrobes?

Graduation success

• Wecongratulatethe15PhDand14HonoursstudentswhosuccessfullycompletedtheirstudiesinTheJohnCurtinSchoolofMedicalResearchduring2006.

Highlights

Highlights & Outcomes 2006

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JCSMR 2006

Significant Outcomes

Stage 1 Complete

• Stage1ofthenewJCSMRBuildingwascompletedinJulyandaroundathirdofourstaffhavemovedintothenewlaboratories.Thebuilding,designedbyLyons(Melbourne)haswonanumberofawards.ProjectmanagersHindmarshwereawardedthe2006ACTMasterBuildersAssociationProjectoftheYear,andsubsequentlytheMBANationalPresident’sAward.DemolitionofWingCoftheoldbuildingwillmakewayforconstructionofStage2.Thissecondstagewillhouseresearchlaboratoriesandcontainmentfacilitiesaswellascoreschoolscientificsupportunits.

Liver cancer trials to begin

• Theanti-cancertherapeuticagentPI-88developedwithintheJCSMRlaboratoryofProfessorChrisParish(DivisionofImmunologyandGenetics)hasshownpromisingresultsinPhaseIItrials,andwillnowmoveintoPhaseIIItrialsasatreatmentforlivercancer.

National Centre for Biosecurity announced

• ANUViceChancellor,ProfessorIanChubbannouncedthecreationofanewNationalCentreforBiosecurity.LedbyJCSMRimmunologistProfessorIanRamshaw,theCentrebringstogethermicrobiologists,epidemiologists,lawyers,ethicists,securityanalysts,infectiousdiseasemodellers,policyexperts,andintegrationandimplementationscientists.TheCentrewilltakea‘realworld’approachtothecomplexproblemsofbiosecurityandprovideanessentiallinkbetweenthemanyrelevantdisciplines.

ANU College of Medicine and Health Sciences

• During2006,JCSMRjoinedtheANUCollegeofMedicineandHealthSciences.AnumberofJCSMRadministrativestafftransferredintothenewlyformedCollegeAdministrativeGroup(CAG)andcontinuetoprovidehighqualityadministrativesupport.

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JCSMR Structure 2006

During 2006, a number of JCSMR administrative staff members were transferred into the newly formed ANU College of Medicine and Health Sciences Administration Group (CAG).

Student Convenoruntil September 2006

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Human Resource Managementuntil July 2006

General Services

Financial and Research Support

until July 2006

Director’s Office

The Australian National University

The John Curtin School of Medical Research

Director

Neuroscience

Molecular Bioscience

Immunology and Genetics

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High Blood Pressure

Research Unit

Technical Services

Microscopy and Cytometry Facility

BiomolecularResource Facility

Animal Services

Information Technology and Communications Unit

until July 2006

Media and Washup

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JCSMR 2006

Boards & Committees 2006

Faculty Board 2006

The Director (Chair), ex officioProfessorJAWhitworth

The Deputy Director, ex officioProfessorSJRedman

Chair of Faculty, ex officioProfessorIARamshaw

The Convenor, Graduate Program in Medical Sciences, ex officioDrAICowan(fromFebruary)

Head, Division of Immunology and Genetics, ex officioProfessorCRParish

Head, Division of Molecular Bioscience, ex officioProfessorMFShannon

Head, Division of Neuroscience, ex officioDrGStuart

Divisional RepresentativesDrABlackburn(MolecularBioscience)(untilFebruary)DrGKarupiah(ImmunologyandGenetics)DrCRaymond(Neuroscience)DrAShield(MolecularBioscience)(fromMarch)

Graduate Student RepresentativesMrKBrown(untilMay)MsLCoupland(fromJune)MrIPoon(fromJune)

General Staff RepresentativesMsMTownsendMrBWebb,BusinessManager

By InvitationDrMJNicol,PublicAffairsManager

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Strategic Advisory Committee

The JCSMR Research Advisory Board provides advice to the Director regarding the advancement of the research programs currently undertaken within the School and on proposals for future projects.

Director,JCSMR(Chair),ex officio

DeputyDirector,JCSMR,ex officio

SirDavidAkers-Jones,HongKong

ProfessorPeterDohertyAC,TheUniversityofMelbourne,Melbourne,VIC

MrAlanEvans,StrategicConsultingServices,Canberra,ACT

MrPeterGordon,Canberra,ACT

MsPruGoward,FederalSexDiscriminationCommissioner,Canberra,ACT

ProfessorColinJohnstonAO,BakerMedicalResearchInstitute,Melbourne,VIC

TheHonDrBarryJonesAO,Melbourne,VIC

DrDenisWKing,StGeorgePrivateMedicalHospital,Sydney,NSW

AssociateProfessorLevonKhachigian,CentreforVascularResearch,TheUniversityofNewSouthWales,Sydney,NSW(ASMRPresident)

MrAndrewPodgerAO,Canberra,ACT

DrJohnRoseAO,DirectorAustralianUnitedInvestmentCompany;Governor,IanPotterFoundation,Melbourne,VIC

MrDavidVos,InspectorGeneralofTaxation,Sydney,NSW

DrCameronWebber,Canberra,ACT

MrRobertWells,ExecutiveDirector,ANUCollegeofMedicineandHealthSciences,Canberra,ACT

Research Advisory Board

The JCSMR Strategic Advisory Committee convenes annually to advise the Director on ways of achieving the School’s strategic direction, including administration and management of the School, and raising the profile of JCSMR nationally and internationally. Members also provide assistance with fundraising activities and advise on commercialisation of research.

Director,JCSMR(Chair),ex officio

DeputyDirector,JCSMR,ex officio

DeputyVice-Chancellor(Research),ANU,ex officio

Chair,JCSMRFaculty,ex officio

ProfessorJerryAdams,TheWalterandElizaHallInstitute,Melbourne,VIC

ProfessorRobBaxter,KollingInstituteofMedicalResearch,Sydney,NSW(NHMRCnominee)

ProfessorSamBerkovic,AustinandRepatriationMedicalCentre,Melbourne,VIC

ProfessorRossCoppel,MonashUniversity,Melbourne,VIC

ProfessorTonyD’Apice,DepartmentofClinicalImmunology,StVincent’sHospital,Melbourne,VIC

ProfessorAnneKelso,QueenslandInstituteofMedicalResearch,Brisbane,QLD

ProfessorKiaranKirk,FacultyofScience,ANUCollegeofScience,Canberra,ACT

DrGeorgeMorstyn,TheUniversityofMelbourne,Melbourne,VIC

ProfessorJonathonStone,ResearchSchoolofBiologicalSciences,ANUCollegeofScience,Canberra,ACT

ProfessorBrandonWainwright,UniversityofQueensland,Brisbane,QLD

TheJohnCurtinSchoolofMedicalResearchisorganised

intothreeDivisions:ImmunologyandGenetics,Molecular

Bioscience,andNeuroscience.TheHighBloodPressure

ResearchUnitisheadedbytheDirector.

WithintheDivisions,staffandstudentsbelongtoGroups

orLaboratories.Membersofthesegroupscollaborateacross

DivisionswithintheSchoolandacrossTheAustralianNational

University,aswellaswithcolleaguesinotherinstitutions.The

followingpagesprovideanoverviewoftheresearchprojects

beingundertakenwithintheSchool.

Research Programs

The John Curtin School of Medical Research Annual Review 2006

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Head of Division Professor Christopher Parish

Cancer and Human Immunology Group

Cancer and Vascular Biology Group

Diabetes/Transplation Immunobiology Group

Immunogenomics Laboratory

• Immune Tolerance and Signalling Group

• Humoral Immunity and Autoimmunity Group

• T- Cell Development and Regulation Group

Immunopathology Group

Infection and Immunity Group

Vaccine Immunology Group

Viral Immunology Group

Molecular Virology Group

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Groups & Laboratories

Division of Immunology & Genetics

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Division of Immunology and Genetics

Division of Immunology & GeneticsImmunogenomics Laboratory

Immunogenomics Laboratory Overviewhttp://jcsmr.anu.edu.au/org/dig/immunogenomics/index.php

Immune Tolerance & Signalling Group

Disruptions to the immune responsehttp://jcsmr.anu.edu.au/org/dig/immunogenomics/people/goodnow/research.php

The Immunogenomics Laboratory comprises four

research groups working together to understand

how the human immune system is controlled at the

cellular and molecular level by circuits specified

in our DNA.

Each group focuses on a different element of a

fundamental set of immune system decisions made

by immune system cells: either to fight or to disarm.

The process of deciding which T cell or B cell should

fight, and which should disarm, is key to our ability

to resist infection, parasitism and cancer. Mistakes

in this process result in incurable illnesses. Drugs

and other ways to alter fight or disarm decisions

are needed to improve the success of organ

transplantation and treatment of autoimmune

diseases and metastatic cancer.

This laboratory has pioneered ways to visualise how

fight or disarm decisions are made in cells and the

molecular circuitry guiding them in genetically

modified laboratory mice.

By studying cells from mice with precise changes

in their molecular circuits, we have discovered that

each immune cell must run through a complex

series of fight or disarm checkpoints before it can

be fully launched into an immune response. In some

ways, the process resembles the sequence of fight/

disarm decisions in a military missile launch, which

serve a similar purpose of preventing friendly fire

and optimising targeting against invaders.

This systems approach, coupled with the close

relationship to the human genome sequence,

provides the Laboratory with a unique opportunity

to discover the molecular circuitry that controls

fight/disarm decisions by immune cells.

Nullmutationsthatknockoutrecognitionof

foreignchemicals(‘antigens’)byTcellsexplainrare

immunodeficiencydiseases,butwehaveremarkably

littleknowledgeoftheimmunologicalconsequences

ofmuchmorecommontypesofgeneticvariationthat

yieldintermediatestatesbetween‘wild-type’and‘null’.

Inthelastyear,acollaborationbyHonours

studentOwenSiggsandpreviousPhDstudentsDr

AdrianListon,DrLisaMiosgeandDrAdeleYates

hassystematicallyanalysedtheimmunological

consequencesofasetofinheritedgenevariantsin

Zap70thatproducegradeddecreasesintheefficiency

ofTcellantigenrecognition.

Moderatedefectsinrecognitiondisruptboththe

arminganddisarmingofasubstantialnumberof

Tcells,butthesecellulardefectsaretoleratedat

thesystemlevelsothatrelativelynormalimmune

Professor Chris Goodnow

responsesaremade.Severedefectsdisruptthe

formationandarmingofTcellssoseverelythat

immuneresponsescannotbemade.Atathreshold

betweenthesetwostates,thedisarmingofTcells

iscompromisedtoamuchgreaterdegreethanthe

armingprocess,andthiscellularimbalancecanno

longerbecontrolledatthesystemlevel,resultingin

overproductionoftheIgEantibodiestypicalofallergic

diseaseandproductionofauto-antibodiestypicalof

systemiclupuserythematosus.

Theseresultsilluminatehowgeneticvariabilityinthe

manycomponentsoftheTcellantigenrecognition

pathwaywillcontributetocommonimmunological

diseases.


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Ourresearchstudiesimmunesystemcells

(lymphocytes)whichdefendthebodyagainstdiseases.

Ourworkaimstounderstanddiabetesandlupus,

whichoccurwhenthebodyhasanautoimmune

responsetoanaturallyproducedsubstance,like

insulin,ortoourowncellcomponents.

Therearetwotypesoflymphocytes–TandB.

SpecificallyweareresearchingasubsetofT

lymphocytescalledTfollicularhelper(TFH)cells,

whichdirectBcellstomakeantibodies.TFHandB

cellencountersoccurin

germinalcentres,which

forminspleenandlymph

nodesduringinfections.

Immunityisafinebalance

betweengeneratinga

protectiveresponseto

diseaseswhileavoiding

aninflammatoryresponse

againstcomponentsof

ourownbody,so-calledautoimmunity.Germinal

centresgeneratelong-lastingBcellsandantibodies

againstlife-threateninginfections,however,asTFH

cellsbecomehighlyactivatedthereisanincreased

riskofgerminalcentresdrivingBcellstogenerate

antibodiestriggeringautoimmunediseases.

WehavediscoveredagenewehavenamedRoquin,

whichappearscrucialtorepressingTFHcells,especially

thosewiththepotentialtoreactagainstselftissues.

Roquinmutationsalsoincreasesusceptibilityto

diseasesresemblingtype1diabetesandrheumatoid

arthritis.Intriguingly,Roquinmutationsappearto

protectagainstdevelopmentofamouseformof

multiplesclerosis.

Nowweareinvestigatingwhichmoleculeshelp

RoquinregulateTFHactivity.Wearecharacterising

thesepathwaysinpatientswithlupusanddiabetes.

Wehopethiswillidentifynewapproachesfortreating

thesediseases.

Humoral Immunity & Autoimmunity Group

Dr Carola G Vinuesa

Dangerous liasons between T & B cellshttp://jcsmr.anu.edu.au/org/dig/immunogenomics/people/vinuesa/index.php

Genetic mutations which cause diseasehttp://jcsmr.anu.edu.au/org/dig/immunogenomics/people/hoyne/index.php

T cell Development & Regulation Group

Identifying genes that oppose Type 1 diabetes

Theimmunesystemhasaremarkableabilityto

educatedevelopingTcellsnottorespondtoany

oftheknownselfproteins.Thisisaphenomenon

describedasimmunologicaltolerance.Sometimes

thiseducationprocessgoeswrongthroughinherited

mutationsandself-reactiveTcellsareallowedto

entertheperipheralcirculationwheretheycancause

autoimmunedisease.Weareusingageneticscreen

toidentifymutationsthatcausearapidonsetofType

1diabetesinmice.Wehaveidentified30different

mousestrainsthatcarrydiabetesinducingmutations

andwearetryingtoidentifythosemutantgenes.

Identification of a novel gene involved in alternative splicing

Wehaveidentifiedamousestrainfromourgenetic

screenthathasamutationinanovelgenethat

regulatestheexpressionofspecificformsofacell

surfacereceptorcalledCD45.DifferentsizedCD45

proteins(calledisoforms)existonthesurfaceofaT

cellandtheexpressionofthesedifferentisoforms

isregulateddependingonthestateofcellular

maturation.Themolecularbasistoexplainhowthese

differentCD45isoformsareproducedhaseluded

immunologistsuntilnow.Wehaveunravelledavital

cluetounderstandinghowCD45becomestobe

expressedatthecellsurface.

How do mutant forms of Ikaros cause T cell leukaemia?

Tcellleukaemiacanarisethroughgeneticmutations

thataffectthecontrolofcellgrowth,differentiation

orsurvival.Ikarosisanuclearproteinthatdirects

thedifferentiationofTcells.MutationsintheIkaros

genecanleadtoTcellleukaemiasbutasyetitisnot

understoodwhyorhowthediseasedevelops.

Dr Gerard F Hoyne



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Themolecularvirologylaboratoryaimstodevise

strategiesforthepreventionofdiseasescausedby

flaviviruses,whichincludedenguefever,yellowfever,

JapaneseencephalitisandWestNilevirus.Thereisan

urgentneedworldwideforneworimprovedmethods

forthepreventionandcontroloftheseinfections.

TheMolecularVirologyLaboratorystudiesthe

flavivirusinfectionsatthemolecular,cellular

andwholeanimallevel,usingacombinationof

recombinantDNA,cellbiological,biochemicaland

immunologicalapproaches

tostudyflavivirus

replication,virulence,

pathogenesisand

immunobiology.

Traditionalapproaches

forthedevelopmentof

newvaccinesagainst

flaviviruseshavehad

limitedsuccessoverthe

pastdecadesandtherapeuticanti-flaviviralagents

arenotyetavailable.Studiesaimedatimproved

understandingofthebiologyofflavivirusesare

essentialandmayleadtonovelwaysofpreventing

disease.

Weareinvestigating:

• themoleculardeterminantsandmechanismsfor

flavivirusvirulenceattenuation

• themoleculareventsleadingtoflavivirus

morphogenesisbybuddingatintracellular

membranes

• theroleofcellularandhumoralimmuneresponses

inrecoveryfromorexacerbationofflavivirus

infection

• therisksandbenefitsassociatedwiththeuse

ofJapaneseencephalitisvirusvaccinesinthe

Australiancontext.

Molecular Virology Laboratory

Dr Mario Lobigs

Prevention & control of Flavivirus infectionhttp://jcsmr.anu.edu.au/org/dig/vi-mv/molecular.php


Weemploymousemodelsofviralinfectiontostudy

immuneresponsestoviralinfectionwhichapply

tohumandisease.Theoutcomeofaninfectionis

dependentnotonlyonthetypeofresponsemounted

bythehost,butalsobytheevasionmechanisms

viruseshaveevolvedtosubverttheseresponses.

Wefoundthatmiceinfectedwithinfluenzavirus

havemassiveamountsofinflammatorycytokines

presentintheirlungs,andthatblockingthese

preventsthedevelopment

ofpneumonia.Wehad

previouslyidentifiednitric

oxide(NO)asacritical

mediatorofpneumonia,

asinhibitionofNO

allowedmicethatwould

havenormallydiedfrom

infectiontorecover.

Interestingly,inhibition

ofNOalsosignificantly

Dr Guna Karupiah

Understanding host-virus interactionshttp://jcsmr.anu.edu.au/org/dig/infimm/index.php

Infection & Immunity Group

reducedtheproductionofinflammatorycytokines

indicatingthatNOactsupstreamofthesecytokines

andisinvolvedintheirinduction.

Poxviruses,includingectromeliavirus(whichcauses

mousepox),encodeproteinsthatinactivatethe

cytokinestumournecrosisfactor(TNF)andgamma

interferon(IFN-γ).WefoundthatviralTNFreceptor

(vTNFR)bindstomembraneTNFtosendasignalin

thereversedirection(reversesignaling)intotheTNF-

bearingcell,whichresultsinswitchingofforonof

specificgenesinvolvedininflammation.Thisindicates

thatvTNFRmodulatesthehostimmuneresponse

throughreversesignaling.Inaddition,usingamutant

ectromeliaviruslackingIFN-γbindingprotein(vIFN-

γbp),wehaveshownthatvIFN-γbpdampensboth

innateandadaptiveimmuneresponses.Henceitmay

bepossibletousebothpurifiedvTNFRandvIFN-γbp

astherapeuticagentsintreatingunrelatedchronic

inflammatoryconditionswhereTNFandIFN-γare

overproduced.

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TheCancerandVascularBiologyGroupisparticularly

interestedinunderstandinghowbloodvesselshelp

solidcancersgrowandspreadtootherorgans.

Whenprimarycancersarisetheycannotgrowbeyond

1-2millimetresindiameterunlesstheyinducethe

growthofnewbloodvesselsthatsupplythemwith

oxygenandnutrientsandremovetoxicby-products

ofmetabolism.

Similarly,bloodvesselsplayanimportantroleinthe

spreadofcancercellstootherorgans,thecancer

cellshavingtousearangeofdegradativeenzymes

todigesttheirwaythroughbloodvesselwalls,

particularlywhentheylodgeindistantorgans.

TheCancerandVascularBiologyGrouphasbeenable

todeveloprelativelysimplesugar-baseddrugsthat

inhibitbloodvesselgrowthintumoursandblockakey

enzyme,calledheparanase,thataidscancerspread.

Oneofthesedrugs,PI-88,hasreachedPhaseIII

clinicaltrialsincancerpatients.

Thesedrugsarealsobeinginvestigatedaspotential

newanti-inflammatoryagents.

InparallelstudiestheGroupisinvestigatinga

numberofwaysofstimulatingtheimmunesystem

torecognisecancercellsasforeignandeliminate

them.Oneofthesevaccinationapproachesinvolves

inducinganimmunereactiontotumoursresembling

thatwhichoccursinthelungsofpatientssuffering

fromchronicasthma.

Itishopedthatthecombinationofthesenovel

immunologicalanddrug-basedapproachescanbe

usedtoeffectivelycontrolmanycancertypes.

Controlling cancerhttp://jcsmr.anu.edu.au/org/dig/canc-vascbiol/index.php

Professor Chris Parish

Cancer & Vascular Biology Group Division of Immunology & Genetics

The general aims of the group are:

• togeneratenewknowledgerelevanttoour

understandingofthefundamentalpropertiesof

immuneresponsesatthemolecular,cellularand

wholesystemlevel,withparticularemphasison

immuneresponsesagainstviruses;

• tostudyvirus/hostinteractionsatthecellularand

molecularlevelandthroughthisdevisestrategies

forthepreventionofviraldisease;

•toexploretheuseofgammaray

inactivatedviruspreparationsas

inducersofcytotoxicTcellmemoryand

theirefficacyasvaccinesforcontrolof

influenzaandFlavivirusencephalitis.

Inordertounderstandthecomplex

natureofviraldisease,ourinvestigations

focuson:thedifferentfunctionsof

cytolyticeffectormolecules,MHCclass

Iantigenpresentation,Tlymphocyte

Professor Arno Müllbacher

Viral Immunology Group

responsesagainstinfectionwithviruses,bacteriaand

fungi,thecytotoxicTmemoryresponse,virus/host

interactionsinflavivirusinfections,andviralimmune

evasionstrategies.

Weemployalargenumberofvirusmodelsincluding

flaviviruses,poxviruses,influenzaandparainfluenza

viruses,alphavirusesandadenovirusesinthesestudies.

Theavailabilityandestablishmentbyourlaboratories

ofgene-targetedmicedefectiveinimmuneeffector

moleculeshasallowedustolearnimportanthost/

parasiterelationshipsinthecontextofthehost

immuneresponse.

Inaddition,weareexploringtheinterfacebetween

innateandadaptiveimmuneresponses,and

particularlytheroleoftype-Iinterferoninregardsto

sequentialviralandbacterialinfections.

Furthermore,weareemployingourexpertisein

cytotoxicTcellresponsesandinvirus-inactivationto

formulateacross-reactiveandcross-protectiveanti-

influenzavaccine.

Fighting viral diseasehttp://jcsmr.anu.edu.au/org/dig/vi-mv/viral.php

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Apotentialtherapy

thatinhibitstheonset

ofType1diabetesis

beingexploredbythe

Diabetes/Transplantation

ImmunobiologyGroup,

incollaborationwith

ProfessorChrisParishand

theCancerandVascular

BiologyGroup.

Thegrouphasdiscovered

thattheenzymeheparanaseplaysanovelandcritical

roleininitiatingtheautoimmuneresponsethatleads

toType1diabetes.

Inthisformofdiabetesthebordersurroundingtheinsulin-

producingpancreaticisletsisbrokendownbyimmune

cells(insulitis)andtheisletisinvaded,damagedand

preventedfromproducinginsulin.

Collaborativeresearchhasshownthatperlecan–a

heparansulfate(HS)-containingproteoglycan–is

presentintheoutercapsuleorbasementmembrane

surroundingisletsandprotectstheisletfrom

infiltrationbyinsulitisleukocytes.Heparanaseisthe

onlyenzymeknowntobreakdownheparansulfate.

Thegroup’sresearchhasshownthatheparanase

expressionisincreasedseven-foldintheisletsof

pre-diabeticnon-obesediabetic(NOD)miceandat

diabetesonset–normallybetween100and200days

ofageinmice.

In vivotreatmentwithPI-88,apotentinhibitorof

heparananse,protectstheNODmicefromtheonset

ofclinicaldiabetesbysignificantlydelayingthe

progressionofinsulitisintotheislets.

ThesefindingsstronglysuggestthatHSisessentialforthesurvivalofinsulin-producingisletbetacellsandtheconversionfromnon-destructiveinsulitistodestructiveinsulitisinNODmiceisduetotheproductionofheparanasebyinsulitisleukocytes(MNCs).

TheMNC-derivedheparanaseinducesclinicaldiabetesbydegradingtheisletbasementmembraneHSandintra-isletHS,therebyinducingbetacelldemise.OurfurtherstudieswillassessthepotentialforheparanaseinhibitorsasanovelinterventiontherapyintheclinicforrescuingbetacellfunctioninpatientswithnewlydiagnosedT1D.

Diabetes / Transplantation Immunobiology Group

Dr Charmaine Simeonovic

Intervention therapy for Type 1 diabeteshttp://jcsmr.anu.edu.au/org/dig/tranimm/index.php


NaturalKiller(NK)cells,asmallpopulationofwhite

bloodcells,areessentialcellsforimmunitytoviral

infectionsandcancer.

NKcellssenseaberrantcellsbyrecognisingthelossof

selfproteinsand,throughvariousactivationreceptors,

areabletokillthosecellsdirectly.

Asaconsequenceoftheirinteractionwithvirally

infectedorcancerouscellsNKcellscommunicate

withantigenpresentingcellsthroughtheproduction

ofcytokines.Thisresultsinthesubsequentantigen

specificimmunitybeingbiasedtowardsa

cellularresponse.

Althoughtherehavebeensignificantadvancesin

recentyearsinidentifyingNKcellactivationreceptors,

themoleculestheyinteractwithremainlargely

unknown.Additionally,NKcellsubsetscanbedefined

bytheirexpressionofvariousreceptorsimplying

selectivebiologicalfunctions.

During2006wehavecontinuedourfocusonhuman

NKcells.Inparticularwehavestudiedtheactivation

receptor

NKp30.

Wehave

analysed

expression

ofthe

differentformsofNKp30inNKcellswiththeaim

ofdefiningtheirroleinNKcellfunction.Ifwe

understandthefunctionoftheseproteinsitmay

bepossible,inthefuture,tomanipulatethem.The

moleculesthatthedifferentNKp30proteinsinteract

withremaintobeidentified,andwehavebegunthis

investigationbyproductionofrecombinantformsof

theseproteins.Otherstudieshaveinvestigatedsubsets

ofNKcellsthathaveaco-receptorrepertoiresimilar

tosubsetsofTcells,implyingthattheseNKcellsmay

haveaspecialisedfunction.

Futurestudieswillcontinuetheseandother

investigationsaimedatunderstandingthebiologyof

humanNKcells.

Division of Immunology & GeneticsCancer & Human Immunology Group

Dr Hilary Warren

Natural killer cellshttp://jcsmr.anu.edu.au/org/dig/canc-humimm/index.php

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s Division of Molecular BioscienceHead of Division Professor Frances Shannon

Asthma and Allergy Group

Biomolecular Structure Laboratory

Cancer and Molecular Immunology Group

Chromatin and Transcriptional Regulation Laboratory

Computational Genomics

Computational Proteomics and Therapy Design Group

Cytokine Gene Expression Laboratory

Cytokine Molecular Biology and Signalling Group

Gene Targeting Laboratory

Medical Genetics

Membrane Physiology and Biophysics Group

Molecular Genetics Group

Muscle Research Group

Predictive Medicine Group

Ubiquitin Laboratory

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Division of Molecular BioscienceBiomolecular Structure Laboratory

Dr Marco Casarotto

Designing drugshttp://jcsmr.anu.edu.au/org/dmb/biostruct/index.php

Mostprescribeddrugsareaimedattreatingthe

averageindivudual.However,drugdosesthat

areeffectiveinsomeindividualscanbetoxicor

ineffectiveinothers.Ithasbeenreportedthatadverse

drugreactionsarethefifthmostfrequentcauseof

death.Drugsthatareeffectiveinmostpeoplebut

areextremelytoxicinasmallnumberofindividuals

cannotbeusedunlessthepatientsinwhomtoxicityis

likelytooccurcanbeidentified.

TheMolecularGeneticsGroupstudiesthegenetic

differencesbetweenindividualsintheirabilityto

breakdownanddetoxifytherapeuticdrugs.Our

ultimateaimistoprovideteststhatallowthe

personalisedprescriptionofdrugsatsafeeffective

levels.Thedetoxificationofforeignchemicals

involvessimilarprocessestothoseinvolvedinthe

metabolismofmedicines.Ourstudiesarerelevant

totheidentificationofindividualsusceptibilityto

toxicchemicalswithintheenvironment.Theworkis

particularlyfocusedontheinvestigationofenzymes

calledglutathionetransferases(GSTs).Theseenzymes

exhibitawiderangeofgeneticvariabilitythathas

beenshowntoimpactdirectlyonthemetabolism

ofanti-cancerdrugsandtoinfluencetheonsetof

Parkinson’sandAlzheimer’sdiseases.

Division of Molecular BioscienceMolecular Genetics Group

Dr Phil Board

Medication for the individual patienthttp://jcsmr.anu.edu.au/org/dmb/molgen/index.php

Thestructureof

biomoleculeslikeproteins,

DNAanddrugsplaya

vitalroleinallbiological

processes.Byexploring

thestructuresofthese

moleculesweaimto

tacklemanyofthe

diseasesthatconfront

oursociety.

TheworkoftheBiomolecularStructureLaboratory

focusesonawiderangeofbiologicalmolecules

associatedwithvariousdiseases.Oneclassofprotein

underinvestigationformsviralionchannelsandtheir

actionshavebeenimplicatedinAIDS,hepatitisCand

RossRiverfever.

Thelaboratoryteamisendeavouringtomapthe

structureofthesemembraneproteinsanddesign

drugstoblocktheiraction.Membraneproteinsare

relatedtomusclefunctionandplayanintegralrole

inskeletalandcardiacmusclefunction.Structural

elementsoftwoproteins,thedihydropyridineand

ryanodinereceptorsarebeingexploitedtodesign

drugsthattargetheartdiseaseandcorrectskeletal

muscleassociatedconditions.

Thewaytherapeuticdrugsmaketheirwayintocells

posesoneofthemoderndaychallengesofdrug

design.Weareexploringthedeliveryofbiological

cargoessuchaspeptides/proteins,DNA,RNAand

drugcompoundsintoavarietyofcells.Theenzyme

glutathionetransferase(GST)hasbeenshowntobean

effectivevehicleforthedeliveryofthesemolecules.

Thelaboratoryisinvolvedinthedeliveryofmolecules

thatmayholdthekeyintheeffectivetreatmentof

diabetes,cancerandsexuallytransmitteddiseases.

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Division of Molecular BioscienceComputational Proteomics & Therapy Design

Division of Molecular BioscienceMuscle Research Group

Thefocusofourresearchistounderstandhow

proteinscarryouttheirfunctionsinthecell,in

termsoftheirmolecularstructure,interactionsand

energetics,andalsohowthegeneshaveevolvedto

enabletheproteinstoworkinthisway.Apartfrom

answeringfundamentalquestions,ourfindingshelp

tounderstandtheproteins’normalfunctionsand

theirdysfunctionsindisease.Ourstudyapproach

isunusualasweemployinnovativecouplings

ofcomputationandexperimentwhichcantake

advantageofexistingknowledgeandthepowerof

computationalsimulation

andbioinformatics,

andalsocomparative

genomicswhichcan

exploitpubliclyavailable

genomesequenceand

otherdataformodel

organisms,suchasmouse,

chicken,frogandfish,

totrackevolutionary

changesintheproteins.

Professor Jill Gready

A conceptual biology approach to understanding protein function in cellshttp://jcsmr.anu.edu.au/org/dmb/cptd/index.php

Usingthisapproachwehavedeveloped,testedandpatentednewtechnologyforthedesignofmutantswithimprovedcatalyticefficiencyandsubstratespecificityofthemaincarbon-dioxidefixingplantenzyme,Rubisco.Combiningourcomputationalinsightswithstructuralandsequencebioinformatics,andphylogeneticanalyses,wedevelopedanovelstrategy,calledphylogeneticgrafting,formakingpredictionsofmultiplemutationstoincreaseRubisco’sefficiency.Furtherresearchisnowintrainforengineeringcropplantsforgreaterproductivityandspecificfeaturessuchasdroughttolerance,andforbiomassandbiofuelproduction.

Usingasimilarlywiderangeofmethodsinaprojectsystematicallymappingthefunctionalevolutionofthethreeprionprotein(PrP)familygenes(PrP;Doppel,Dpl;andShadoo),werecentlydefinedamechanismforregulatingco-ordinatedtranscriptionofthePrPandDplgenes.Thiscanexplainhowtherelativelevelsofthetwoproteinsarecontrolled,andcanbe“tipped”undercertainconditionsintoastateinducingapoptosisandcelldeathinAlzheimer’sdisease.

TheMuscleResearchGroupisinvestigatingthe

molecularmechanismsthatunderliedefectsin

skeletalandcardiacmusclethatleadtodebilitating

myopathiesandcardiacarrest.

Ouraimistounderstandthemolecularmachinerywithin

theryanodinereceptorcalciumreleasechannelatthe

coreoftheproteincomplexthatdeterminesmuscle

contraction.Theryanodinereceptoristheionchannel

inthemembraneoftheintracellularcalciumstore.

Thechannelreleasescalciumfromthestoreregulating

calciumsignallinginmuscleandtheforceofcontraction.

Defectivesignallingleadstopoormusclefunctionandto

fatalmyopathiesincludingmalignanthyperthermiaand

centralcorediseaseinskeletalmuscleandpolymorphic

ventriculartachycardiaintheheart.

Wearealsoinvestigatingmolecularinteractionsbetween

keyproteinsthatregulatetheamountofcalciuminthe

intracellularcalciumstore.Ourfocusisonthecalcium

bindingproteinwithinthestore,calsequestrin,andits

molecularcommunicationswiththeryanodinereceptor

viatwoanchoringproteins,triadinandjunctin.

Thesignificanceofthisresearchisthatmovement,

respirationandheartfunctionalldependoncalcium

signalling.Thereforetheresultswillfacilitatethe

useofcalciumsignallinginmuscleasaplatform

foravarietyofpurposes.Theseincludereducingthe

debilitatingeffectsofchangesincalciumsignalling

andmuscleperformanceinageingandingenetically-

ordrug-induceddisorders.Theworkwillfacilitate

thedesignofnovelcompoundsfortreatingmuscle

disorders.

Professor Angela Dulhunty

How calcium affects muscle contractionhttp://jcsmr.anu.edu.au/org/dmb/muscle/index.php

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TheComputationalGenomicsGroupundertakes

researchinbioinformaticsaimedatgenome

decryption-identifyingregionsofthegenomewhich

encodefunctionsthatinfluencediseasesusceptibility.

Ourapproachtothischallengeseekstoexploitthe

effectofnaturalselectiononincreasingordecreasing

theamountofgeneticvariationatfunctionally

importantgenomiclocations.

Oneaspectofourresearchinvolvescharacterising

thebackgrounddistributionofgeneticvariationand

theprocessesresponsibleforit.Wehavebeenable

toshowthattheinfluenceoflocalDNAsequence

onlevelsofvariationchangessubstantiallyacross

thegenomeofmammals.Wehaveshownthat

nucleotidesflankedbyaC-Gbasepairmutatemore

rapidlyinregionsofthegenomewheretherearefew

CandGnucleotides.Wesuggestthiseffectmostlikely

originatesfromaninfluenceonproofreadingbythe

DNApolymerasesresponsibleforreplication.

Anotheraspectofourresearchinvolvesexplicitly

evaluatingtheinfluenceofadaptiveevolution

arisingfrominteractionsbetweensequenceresidues.

Illustratingtheseisaclassofmutationsthatcause

humandisease,yetareobservedinotherspecies.Itis

presumedthatthesevariantsoccurinotherspecies

duetocompensatorychangesthatamelioratethe

effectofthemutation.Thisyearwehavedeveloped

newstatisticaltechniquesformeasuringtheseeffects.

Wehaveappliedthetechniquetodatasetsofhuman

disease-causingmutationsandidentifiedthemost

likelycompensatorychanges.Thistechniquehasalso

beenshowntodetectthegeneralinfluenceofprotein

secondarystructureonlevelsofvariation.

Dr Gavin Huttley

Susceptibility to diseasehttp://jcsmr.anu.edu.au/org/dmb/compgen/index.php

Division of Molecular BioscienceThe Computational Genomics Group

Division of Molecular BioscienceCytokine Gene Expression Laboratory

Howgeneexpressioniscontrolledinthecontextof

DNApackagedintothecellnucleusisafundamental

unansweredquestioninbiology.

Itisessentialforthedevelopmentofanorganism

tocontrolgeneexpression.Itisalsocriticalto

controlgeneexpressiontriggeredbyenvironmental

signals–sincegeneexpressioniskeytothecorrect

responseofcellstotheirenvironment,likeanimmune

response.Aberrantgeneexpressionunderliesmuch

humandisease–forexampleautoimmunity,chronic

inflammationandTcellleukaemia.

Weuseimmunesystem

cellstostudythe

molecularmechanisms

ofgeneexpressionin

responsetoenvironmental

signals.Tlymphocytecells

rapidlyandpreciselyalter

theirgeneexpressionin

responsetoinfection.

Professor Frances Shannon

Gene expression & diseasehttp://jcsmr.anu.edu.au/org/dmb/cytogene/index.php

Thisyear,wehavefocusedourresearchontwo

proteinswhichmaytriggerthecellresponse–c-Rel

andZeb.Theseproteinshavebeenselectedbecause

deletingthegenesthatmaketheseproteinshas

severeconsequencesforTcelldevelopmentor

functioninmice.

Wehavediscoveredthatc-Relisanimportant

modulatorofglobalgeneexpressionintheTcell

responsetoimmunesignals.Wehavealsodiscovered

anovelroleforc-RelinTcelldevelopmentthatwill

bethesubjectoffurtherinvestigation.Wehave

shownZebtobespecificandpreciselytimedrepressor

ofgeneexpressioninTcells.

Inotherresearchontherelationshipofgenestructure

(chromatin)togeneexpression,wehaveidentified

novelchromatinsignaturesthatappeartodictatethe

timingofthegeneresponsetoimmuneactivation.

Weareextendingthesefindingstoagenome-wide

investigationofchromatinstructureacrossinducible

genesinTlymphocytes.

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Division of Molecular BioscienceMembrane Physiology & Biophysics Group

Chromatin & Transcriptional Regulation Laboratory Division of Molecular Bioscience

Oneofthemostamazingengineeringachievements

innatureishowovertwometresofgeneticmaterial

(DNA)canbecompactedandsqueezednearlya

milliontimestofitintoahumancell.Theremarkable

structurethatachievesthisisthechromosome.

ThisastonishingpackagingofDNAthatproduces

achromosomeisachievedbyacomplexschemeof

folding.DNAisfirstwrappedaroundamixtureof

proteins(calledhistones)toformacompleteunit

knownasanucleosome.About30millionofthem

arerequiredineveryhumancelltocompactour

DNA.Achromosomeisahighlyvariedstructure

consistingofalineararrayofnucleosomesfoldedto

differentextentstoformdistinctdomains.Compacted

domainspreventunwantedgenesfrombeingused

whilemoreopendomainsallowtherightgenestobe

utilised.Specificdomainsalsokeeptheendsofthe

chromosomesstableandenableachromosometo

copyitselfeverytimeourcellsdivideandgrow.

Howachromosomeisdividedintothesedifferent

compartmentsremainsamystery,buttoworkout

thisbasicprocessisnecessarytofullyunderstand

developmentaldisordersanddiseasestateslikecancer.

Byexaminingthestructureofchromosomesinliving

cellscombinedwiththedevelopmentofasystem

whereitispossibletoassembleaverysmallpartof

chromosomeinatesttube,ourgrouphasprovided

newinformationonhowchromosomesareput

togetherbyshowingthatalteringthebiochemical

makeupofanucleosomewithvariantformsofthe

histonesplaysakeyroleinestablishingfunctionally

specialisedchromosomaldomains.

Chromosomes – the fundamental units of lifehttp://jcsmr.anu.edu.au/org/dmb/chromatin/index.php

Dr David Tremethick

Ourbraincommunicatesusingelectricalsignalswhosebalanceiscriticalinnormalbrainfunction.Theseelectricalsignalsaregeneratedthroughtheactivationofspecificionchannelsinthecellmembrane.

Thedynamiccontrolofionchannelnumbersandtheirsubcellulardistributionisfundamentaltonervoussystemdevelopment,circuitformationandrefinement,andpathologicalprocesses – likedepression,anxiety,insomniaandepilepsies.

Ourresearchisdirectedatunderstandingtherelationshipbetweentheinfluenceofreceptor

cellularlocalisationandtheeffectofdrugsonGABAAreceptors,themajorinhibitoryneurotransmitterreceptorinthebrain.

GABAAreceptorsareused,forexample,whenwesleeporarerelaxed,bycalmingbrainactivityandarethetarget

ofanarrayofprescribeddrugs.ByidentifyingthecomponentsthatinfluenceionmovementthroughGABAAreceptorswewillbetterunderstandthedrugs’impactonGABAAreceptors.

OurlatestworkhashelpedtoidentifyapreviouslyunknownmechanismwherecontrollingthelocaldensityofspecificGABAAreceptorsinthemembraneenablesthesizeoftheinhibitorysignaltobemodulatedbothbyagonistanddrugs.

Theunderlyingmolecularmechanismweproposeinvolvestheco-ordinatedopeningofadjacentreceptors,challengingtheclassicalviewofionchannelgating.

ItmayemergethatthenatureanddegreeofreceptorclusteringisawayinwhichaneuronisabletomodulatetonicGABAergicinhibition,byprovidingastrongandco-ordinatedresponsetoinhibitoryneurotransmittersandneuromodulators.Thismayunderlietheprincipaleffectsofdrugssuchas

benzodiazepinesandgeneralanaesthetics.

Dr Louise Tierney

Receptors in the control of brain functionhttp://jcsmr.anu.edu.au/org/dmb/membrane/index.php

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Asthmaiscausedbyabnormalimmuneresponsesto

allergenssuchaspollensanddustmites.However,

asthmaisalsorelatedtothegeneticmakeupofan

individual,sothatparentswhohaveasthmaare

morelikelytohavechildrenwhoalsohaveasthma.

ThegenesinourDNAencodeproteinsthathavevery

diversefunctions.Forexample,someproteinsare

receptorsthatdirectcellularresponsestoexternal

stimuli.Otherproteinsfunctionasenzymes,which

areabletomodifyothermolecules.Theaimofour

researchistounderstandhowgeneticvariation

changesthefunctionof

proteinsandenhances

theriskofdeveloping

asthma.

TheIL-4Rαreceptoris

foundoninflammatory

cells.However,asthmatics

aremorelikelytohave

aformofIL-4Rαthat

stimulatesanexaggerated

immuneresponse.Wehaveshownthatchangesin

thisreceptorintensifiesinflammationintheallergic

lungandthewayinwhichallergensstimulate

immunecellstoreleasefactorsthatdamage

theairways.

Comparedtonon-asthmatics,cellsliningthelung

inasthmaticsaremoresusceptibletodamageby

toxinssuchasthosefoundinairpollutantsand

cigarettesmoke.GlutathionetransferasePi(GSTP)is

anenzymethatinactivatestoxicmetabolitesanda

geneticvariantofGSTPisknowntoenhancetherisk

ofdevelopingasthma.Ourstudieshaveshownthat

GSTPplaysacriticalroleininhibitingthedevelopment

ofallergicinflammationandabnormalrespiratory

functioninthelung.

Collectively,ourstudiesareconstructinganintegrated

pictureofhowchangesinourgeneticmakeupenhance

thelikelihoodofasthma.Inthefuture,thisinformation

willenablebettertargetingofmedicationsthatprevent

oralleviatethesymptomsofasthma.

Dr Dianne Webb

Genes & asthmahttp://jcsmr.anu.edu.au/org/dmb/allergy/index.php

Asthma & Allergy Group Division of Molecular Bioscience

How cytokines influence the immune systemhttp://jcsmr.anu.edu.au/org/dmb/cytomol/index.php

Professor Ian Young

TheresearchofourGroupcentresonthreecytokines

(IL-3,IL-5andGM-CSF)whichregulateimmune

responsestoinfections.

Thesehormonelike-proteinsstimulatetheformation

andactivationofwhitebloodcellsinvolvedinhost

defenceagainstparasitesandinallergicinflammation

indiseasessuchasasthma.Wewishtounderstand

howthecytokinesmodifythegrowth,maturation

andactivationofbloodcellsbybindingtotheircell

surfacereceptors.Tothisendwehavedetermined

the3Dstructureofthemainsignallingreceptor(hβc)

sharedbythesecytokinesusingX-raycrystallography.

Guidedbythenewstructure,wehavemadechanges

topotentiallyimportantaminoacidsinthereceptor

todeterminetheirrole.

Ourrecentstudiesofreceptorhβcandtheclosely

relatedβIL-3receptorhaveindicatedtherearetwo

modesofreceptoractivationwhichinfluencewhether

bloodcell-formingstemcellsundergomaturation

orself-renewalinresponsetoIL-3.Excessiveself-

renewalanddefectivematurationarethehallmarksof

leukemiaanditisthereforeimportanttounderstand

howtheseprocessesareregulated.

Ofrelevancetoourresearchisthefindingthatthe

specificreceptorrequiredforIL-3signalling(IL-3Rβ)

ispresentinabnormallyhighlevelsonthesurfaceof

leukemicstemcells.Ourfuturestudieswillinvestigate

thepossibleinvolvementoftheIL-3receptorsystem

inmyeloidleukemia.

Division of Molecular BioscienceCytokine Molecular Biology & Signalling Group

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Autonomic Neuroeffector Transmission Laboratory

Blood Vessel Laboratory

Brain Modelling Laboratory

Cerebral Cortex Laboratory

Developmental Neurobiology Laboratory

Movement and Memory Laboratory

Neuronal Network Laboratory

Neuronal Signalling Laboratory

Synapse and Hearing Laboratory

Visual Neuroscience Laboratory

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Theolfactorycortexisarelativelysimplebrainregion

thatdoesacomplexjob–ithelpsustorecogniseand

rememberthemanyodoursweencounterindailylife.

TheCerebralCortexLaboratoryaimstounderstand

howtheolfactorycortexmakessenseofodours,

whichinturnmayleadtoabetterunderstandingof

brainfunction.

Thelaboratorystudiesthepropertiesofnervecells(or

neurons)intheolfactorycortexofmice.Neuronsare

thebuildingblocksofthebrain,sobyunderstanding

neuronsweareseveralstepsclosertounderstanding

howthebrainworks.

Theadvantageofstudyingtheolfactorycortexis

thatitsstructureissimplerthanotherbrainregions.

Wehopethiswillmakethesenseofsmelleasierto

explain,leadingtonewinsightsintobothnormaland

pathologicalbrainactivity.

In2006westudiedtheneuronsthatreceivemostof

theinputtotheolfactorycortex.Wehavediscovered

anunexpecteddiversityinthepropertiesofthese

Division of NeuroscienceCerebral Cortex Laboratory

Dr John Bekkers

Nerve cells underlying the sense of smellhttp://jcsmr.anu.edu.au/org/dns/cortex/index.php

neurons,allowingustomakepredictionsabouttheir

likelyrolesinolfactoryprocessing.

Wealsomadesomeexcitingdiscoveriesaboutanother

classofneuron,theinhibitoryinterneurons,which

mayactas“pacemakers”ofelectricalsignallinginthe

olfactorycortex.Weidentifiedatleastfivedifferent

typesofinterneuron,basedonshape,location,

molecularmarkersandelectricalproperties.

Futureworkwilltestthehypothesisthateach

interneuronclassisspecialisedtoperformaparticular

taskwhendecodingsmells.

TheBloodVesselLaboratoryaimstodeterminetheroleofionchannelsandcellularcouplinginvascularfunctionundernormalconditions,sowecanthenbegintounderstandwhatchangesoccurduringvasculardisease.

Invascularfunctionionchannelsaffectbloodvesseldiameterandbloodflowbyallowingtheflowofpositiveandnegativeionsthroughtheplasmamembraneofcells.

Specialisedionchannels–gapjunctions–mediatecellularcouplingbyconnectingthecytoplasmofadjacentcellsallowingthecoordinationofcellular

responses.Thecoordinatedbehaviourofsmallarteriesisfundamentaltotheregulationofbloodflow,bloodpressureandadequatetissueperfusion.

Arteriolartoneisdeterminedbyabalancebetweenstimuliwhichpromoteconstrictionofbloodvessels(vasoconstriction)orrelaxationofbloodcells(vasodilation).Disruption

ofthisbalanceinfavourofvasoconstrictionoccursduringhypertensionanddiabetes,oftenresultingfromdysfunctionofcellsinthevascularwall.

Wehavedemonstratedthatcellcouplinglinksthemusclecellsofcerebralarterieswiththeinnerendothelium.Thiscouplingisessentialforcoordinatedoscillationsinvasculardiameter,whichmayprotectthebrainagainstinjuryfrombloodpressurefluctuations.Wehavealsoidentifiedanovelionchannelwhichplaysanimportantroleindeterminingvasculartoneundernormalconditions.Wehavefoundthatupregulationofanotherionchannelinspecificarteriescontributestothecellulardysfunctionfoundinhypertension.

Finally,wehaveshownthatchangesincellcouplingoccurinrenalarteriolesduringdiabetesandthesemayresultfromchangesinanenzymeessentialfortheformationofapotentvasodilator.Upregulationofthisenzymeoffersprotectionagainstchemically-induceddiabetes.

Ourstudiesprovideevidencethatcellcouplingandionchannelsareimportantinsettingvasculartoneandcontributingtovasculardysfunctionduringdisease.

Blood Vessel Laboratory

Professor Caryl Hill

Division of Neuroscience

How blood flow regulation controls blood pressurehttp://jcsmr.anu.edu.au/org/dns/bloodvessel/index.php

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ResearchintheVisualNeuroscienceLaboratoryaims

toexplainthecellularandmolecularmechanismsof

vision,sowecanbegintounderstandwhyitfalters.

Humanscanseeoveranenormousrangeoflight

intensities.Ourrodphotoreceptorsareusedunder

twilightandmoon-lightlevels,whereasourconesare

usedinbrighterlightandmediatecolourvision.

Wehaveinvestigatedrecoveryafterintenselight

exposures,byrecordingelectricalactivityfromthe

livinghumaneye.We

haveshownthatthe

slownessofrecoveryis

presentevenatthefirst

processingstageinthe

retina(theretinal

bipolarcells).

Byrecordingtheelectrical

activityofsinglerod

photoreceptorcellstaken

fromtheeyesofmiceandzebrafish,ourresearchers

arelearningaboutthemolecularmechanismsthat

permitthesecellstorecoverrapidlywhenlight

isextinguished.

Throughcollaborationswithoverseascolleagues

wehaveprovidedamathematicalmodelofthe

time-courseoftheelectricalresponseofcone

photoreceptorsinthelivinghumaneye,showinghow

humanconesareabletocontinuefunctioning,even

atextremelyhighlightintensities.

IncollaborationwithcolleaguesinPerth,anew

scanninglaserophthalmoscopehasbeendeveloped

thatcanmeasurethelevelofvisualpigment

rhodopsininthelivingeye.

Thisresearchhasadvancedunderstandingofhowcells

atthebeginningofthevisualsystemrespondtolight,

howtheyrecoverfromlight,andhowtheyprocess

visualinformation.

Visual Neuroscience Laboratory Division of Neuroscience


Theworkofthislaboratoryisaimedatunderstanding

thebiologicalbasisoflearningandmemory.

Transmissionattheconnections(synapses)between

braincells(neurons)canbeenhancedbyintense

activity.Thisenhancement,knownaslong-term

potentiation(LTP),isbelievedtounderlielearningand

memoryinthebrain.LTPcanlastfordifferentperiods

oftime,justlikememories.

AllformsofLTPrequireanelevationofcalciuminside

theneuron.Wehaveshownthatelevationofcalcium

indifferentpartsoftheneurondeterminehowlong

LTPcanlast.

Morerecentlywehaveinvestigatedtherelationships

betweentheelectricalactivitiesatthesynaptic

connectionversuscell-wideactivity(actionpotentials)

thatarerequiredtotriggerLTP.

Whileshort-lastingLTPdoesnotrequireaction

potentials,longer-lastingformsdo.Infact,short-

lastingLTPcanbeconvertedintoalong-lastingform

byactionpotentials.

Thistypeofresearchintothemechanismsunderlying

LTPwilleventuallyhelpourunderstandingofhow

differentformsofmemoryaremaintainedby

thebrain.

Professor Trevor Lamb

Movement & Memory Laboratory

Exploring visionhttp://jcsmr.anu.edu.au/org/dns/visual/index.php

Brain mechanisms of learning & memoryhttp://jcsmr.anu.edu.au/org/dns/movememory/index.php

Dr Clarke Raymond

Professor Steve Redman

��



Hirschsprung’sdiseaseisacongenitalcondition

affectingthebowel,causedbytheabsenceofnerve

cellsinthedistalbowelandischaracterisedbythe

failureofrelaxationandobstruction.

Hirschsprung’sdiseaseismostlycausedbythe

mutationofagene(theendothelinreceptorBgene,

ERTB).Inadditiontobowelobstruction,neurological

symptomsareoftenassociatedwithHirschsprung’s

disease,includingmentalretardation,nervedeafness

andseizures.However,littleisknownaboutthebrain

changesatcellularand

molecularlevelsin

thiscondition.

Toaddressthisquestion,

theBrainDevelopment

Laboratorystudiedthe

brainsofaratwith

Hirschsprung’sdisease.

Usingthein vivo cell

labellingtechnique

wediscoveredathree-to-fivefolddecreaseincell

proliferationinthecerebellumandhippocampus

ofthediseasedrat,comparedwithnon-diseased

littermates.Thefunctionalsignificanceofthiscell

reductionisyettobedetermined.

Therewasalsoatwo-foldincreaseinthenumbers

ofprogrammedcelldeathinthecerebellumand

hippocampusoftherat.Weanalysedthelevelsof

severalneuronalgrowthfactorsbutdidnotdetectany

changesintheHirschsprung’srats.

Thisstudyrevealscellularchangesinthebrains

ofdiseasedratsandhasdirectrelevancetoour

understandingoftheneurologicaldeficitsof

Hirschsprung’sdiseasepatientswiththe

ERTBmutation.

Ourfutureresearchwillinvestigatethemechanism

ofdecreasedcellbirthandincreasedcelldeathinthe

brainandthefunctionalconsequencesof

thesechanges.

Dr Zan-Min Song

Brain Development Laboratory

Understanding the effects of Hirschsprung’s diseasehttp://jcsmr.anu.edu.au/org/dns/braindev/index.php

Theinternalmechanismsusedbythespinalcordto

produceeverydaymovement–walkingandrunning

–arenotwellunderstood.

IncollaborationwithProfessorRobBrownstoneand

DrJenniferWilsonatDalhousieUniversityinCanada,

wehaveinvestigatedthepropertiesandnetwork

behaviourofaclusterofinterneurons(Hb9+)that

maybeinvolvedinthecontrolofthis

rhythmicmovement.

Thisclusterofinterneuronscanfireactionpotentials

simultaneously.Thissynchronousandrhythmic

activitydependsonelectricalcouplingbetweenthe

Hb9+interneuronsandotherneighbouringneurons.

Theinterneuronsalsoreceivecommonsynapticinput

whichmodulatesactivity.

Importantly,theoutputofthespinalcordcontrolling

movementrelatedmuscleactivitycanalsooccurat

thesametimeasactivityintheseinterneurons.It

suggestsHb9+interneuronsworkinawaythatwould

Professor Steve Redman

Dr Anna Cowan

Movement & Memory Laboratory

Spinal cord cells which control movementhttp://jcsmr.anu.edu.au/org/dns/movememory/index.php

berequiredofneuronsinvolvedinnetworksthat

producelocomotoractivity–ormovement.

Wehopetodiscoverwhetherthereisaconnection

betweenthelocomotoractivityandthisclusterof

interneuronsandunderstandhownetworksofneurons

inthespinalcordenableustowalkandrun.

��

Researchintheneuralnetworklaboratoryis

discoveringthebuildingblocksofbrainfunctionthat

couldonedayleadtothedevelopmentofcuresfor

illnesseslikeAlzheimer’sdisease.

Ourworkhasledtoabetterunderstandingofhow

informationisprocessedinthebrainandgiven

insightsintothemakeupofthecellswhichdothis

importantwork.

Communicationbetweencellsinthebrainoccursin

areascalledsynapses.We

havemadesignificant

progresstogaininsight

intohowtheelementsof

thesynapsesarechanged

ondemandandhow

thesechangesaffectthe

informationtransfer.

Wehavediscoveredthere

aretwokindsofsynapse,

simpleandcomplex.Simplesynapsestakelonger

toregeneratesowhenstimulatedtheywillquickly

diminishtheirresponse.Complexsynapses,however,

areabletoaccesscalciumstorestoregeneratefaster

andcanmaintainareactiontostimulusforlonger.

ItispredictedthatintheAlzheimer’sbrainthereare

moresimplesynapsesthancomplexones,thoughthis

isresearchforthefutureinthelaboratory.

Theresearchatthelaboratoryhasalsouncovereda

waytopharmacologicallyconvertsimplesynapsesto

complexsynapsesandviceversa,whichmay,ifthe

predictionsabouttheAlzheimer’sbrainarecorrect,be

abuildingblocktoadvancesinthisarea.

Thenextstepforthisresearchistoinvestigatethe

molecularmechanismsinvolvedandwhatdetermines

thedynamicsinalivingbrain.



Neural Network Laboratory

Associate Professor Christian Stricker

Simple & complex brain processeshttp://jcsmr.anu.edu.au/org/dns/neuronetwork/index.php

TheNeuronalSignallingLaboratoryconductsbasic

researchonhownervecellsinthebrainprocess

information.Thisworkinvolvesrecordingactivity

fromsinglenervecellsusingbothelectricaland

opticaltechniques.Duringthepastyearwehavebeen

investigatingthefollowingissues:

Electrical properties of dendritic spines

Communicationbetweennervecellsinthebrain

occursatspecialisedregionscalledsynapses.Inthe

cortex,themajorityofsynapsesaremadeontosmall

(onethousandthofamillimetre)

processescalleddendriticspines.Due

totheirsmallsizetechnologyhas

notallowedthefunctionofdendritic

spinestobeinvestigateddirectly

before.However,wearenowableto

studythemusingopticaltechniques

byrecordingchangesinmembrane

potentialinsinglespinesusing

confocalmicroscopy.

Cellular mechanisms underlying absence epilepsy

Oneofthemostcommonformsofepilepsyin

childrenisabsenceepilepsy.Wehavebeenstudying

thecellularmechanismsunderlyingthisdiseaseinan

animalmodel.Wehavefoundthatthereisa50per

centreductioninaparticularproteincalledHCN1in

thecortexoftheseanimals.Importantly,wefindthat

thisreductionofHCN1leadstoincreasedexcitability

ofthecortex,andthereforemayplayaroleincausing

absenceseizures.

Cortical micro-architecture

Thecerebralcortexiscriticalforconsciousperception

ofsensoryinformation–howwerecogniseaglassas

aglassorapersonfromthesoundoftheirvoice.But

howthecerebralcortexdoesthisisnotunderstood.

Wehaverecentlydiscoveredthattheinteraction

oftwosetsofsub-networkswithinthecortexmay

enablethemainoutputofthecortextocombine

differentfeaturesofasensorystimuluswhichresults

intheperceptionofsensoryinformation.

Associate Professor Greg Stuart

Neuronal Signalling Laboratory

Information processing in the brainhttp://jcsmr.anu.edu.au/org/dns/neurosignal/index.php

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Cochlea-relateddeafnesscausessignificantchangesin

auditorycentersofthebrain.Revealingthesechangesis

importanttoourunderstandingoftheauditorysystem,

andthecontinueddevelopmentofcochlearimplantsand

othertherapiestoovercomedeafness.

Hearingisahighlydevelopedsense,requiring

extremelyrapidandcomplexprocessingofsignals

transmittedtothebrainviatheauditorynerve.

Connectionsbetweenauditoryneuronsinvolvedin

thelocalisationofsoundsrepresentsomeofthemost

powerfulandfastestsynapsesinthemammalian

brain.Itisgenerallyassumedthatsensoryinputto

thedevelopingbrainshapesthestrengthofsynaptic

connectionsandthemembranepropertiesofneurons.

Insightintotheroleofactivityinregulatingsynaptic

transmissionandneuronalmembranepropertiescan

begainedbystudyingtheeffectsofeliminatingor

reducingauditorynerveactivityie.deafness.Weare

studyinganaturallyoccurringstrainofmice,dn/dn,

withamutationinatransmembraneproteinin

cochlearhaircellswhichrenderstheseanimalsdeaf

frombirth.

Ourexperimentshaverevealedthatthesynapse

betweenauditorynervefibersandneuronsinthe

brainstemismuchstrongerindeafmice,andthatthe

postsynapticneuronsaremuchmoreexcitableindeaf

mice.Recently,wehaveshownthattheexcitability

ofauditoryneuronscanbesignificantlymodifiedin

normalhearingmiceinresponsetosoundstimuli.

Ourfutureexperimentsareaimedatunderstanding

themechanismsunderlyingthisplasticityinthe

centralpathwaysoftheauditorysystem.

Division of NeuroscienceThe Synapse & Hearing Laboratory

Professor Bruce Walmsley

Congenital deafnesshttp://jcsmr.anu.edu.au/org/dns/synapse/index.php

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Globallyhypertension(highbloodpressure)is

theleadingcauseofdeath,causingheartattack,

stroke,kidneyfailure,andothercomplications

suchasblindnessandprematurity.TheHighBlood

PressureResearchUnit(HBPRU)undertakesbasic

andclinicresearchintohypertension,inparticular

thedevelopmentofhypertensioncausedbyadrenal

glucocorticoidhormones.

Wehavefoundglucocorticoid(steroidhormone)-

inducedhypertensionrelatestoalterednitricoxide

(NO)productionandfunctionandisassociatedwith

elevatedreactiveoxygenspecies(ROS),whichact

bymoppingupvasodilatorNO.Ourstudiessuggest

animbalanceofNO(deficiency)andROS(excess)

isimportantinthecausationofglucocorticoid

hypertensionduebothtonaturallyoccurringand

syntheticsteroids.Weareinvestigatingarangeof

strategiesrelevanttotheapparentimbalancebetween

NOandROS.

WehavedemonstratedthatL-arginine,aprecursor

fortheNOproducingenzymeNOsynthaseand

theantioxidantstempol,apocynin,folateandN-

acetylcysteinepreventandreversesteroid-induced

hypertensionwhileallopurinolandvitaminsCandE

hadnoeffect.Weareidentifyingagentsthatprevent

and/orreverseglucocorticoid-hypertensionintherat

whichareappropriateforuseinclinicaltrials.

OurcollaborationwithAssociateProfessorKevin

CroftandDrTrevorMoriattheUniversityofWestern

Australiahasenabledustomeasuremarkersof

systemicoxidativestressandinvestigatetheroleof

20-hydroxyeicosatetraenoicacid(20-HETE),apotent

constrictorinsmallarteries,inglucocorticoid-induced

hypertension.Wearealsostudyingthegenetic

modificationsinducedbyglucocorticoidusingmicro-

arrayandRT-PCRincollaborationwithProfessor

FrancesShannonandDrRubyLin(TheUniversityof

NewSouthWales).

InanongoingcollaborationwithDrGeorgeMangos

andAssociateProfessorJohnKelly(StGeorgeHospital,

Sydney),clinicalstudiesarebeingconductedinto

cortisol-inducedhypertensionandtheeffectof

syntheticsteroidsonbloodvesselfunction.

Theresultsofourstudieswillhelpunderstanding

ofthemechanismsbywhichglucocorticoidsinduce

hypertensionandhavemajorimplicationsfor

treatmentofsteroid-inducedhypertension,and

possiblybroaderimplicationsforourunderstanding

andtreatmentofso-calledessentialhypertension.

Head of Unit Professor Judith A Whitworth

Professor Judith Whitworth

Dr Yi Zhang

Steroid hormones & high blood pressurehttp://jcsmr.anu.edu.au/org/hbpru/index.php

High Blood Pressure Research Unit

Staff & Student Achievements Degrees, Prizes & Awards

AmajorstrategicgoalofJCSMRistoprovideoutstanding

trainingandmentoringformedicalresearchersofthefuture.

Manyofouracademicstaffsupervisepost-graduatescholars

throughtheirstudiesleadingtoHonours,MastersandPhD

degrees.

JCSMRstaffandstudentscontinuetobehonouredand

acknowledgedthroughawardsandprizespresentedbylocal,

nationalandinternationalorganisations.

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Congratulations to our students who have successfully completed their study during 2006

Degrees

PhD degrees awarded in 2006YA AbdellatifModulation of the skeletal muscle ryanodine receptor by GSTM2-2

H AlonsoComputer modelling and simulations of enzymes and their mechanisms

AM De MestreRegulation of heparanase transcription

JM HarrisonModulation of vaccine responses by genetic adjuvants

MY HyunCharacterisation of novel ligand binding affinity for murine macrophage C-type lectin and dendritic cell immunoreceptor

R KhouryPersistent sodium channels and hypoxia

CEL LimMurine glutathione transferase zeta deficiency

TL LuuFactors influencing the single-channel properties of recombinant GABAA receptors

KE PetersInvestigation of a second inflammatory bowel disease susceptibility locus (IBD8) on chromosome 16

BJ ScottEvolution of the Gerbich native allele of glycophorin C: Co-evolution of malaria and its human hosts

MC TaylorFunctional characterisation of the mammalian deubiquitylating enzyme, USP14

JP WoodallThe ontogeny of interferon-gamma responses in the fetal lamb

O ZeidCalcium buffering in spinal motoneurones

J ZhangConnexin expression in the renal vasculature: Role of endothelial nitric oxide in normal and diabetic conditions

J ZhouThe molecular mechanism of H2A.Bbd in chromatin transcriptional regulation

Honours degrees awarded in 2006

J Altin

N Botelho

G Chua

K Couchman

C Gyngell

Y Ho

B Kong

K Lam

J Ng

N Schultz

B Sivakumar

I Sivalingam

A Subramaniam

EJ Tan

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Awards 2006

RT BakerAusBiotech Canberra and Region Biotech Summit : Second Prize for High-level expression and purification of authentic recombinant proteins

S DayTravel Grant to attend the AIDS Vaccine 2006 Conference, Amsterdam, The Netherlands

J EllisonANU Environmental Achievement award

J EllyardAustralasian Society for Immunology (ACT Branch) Student Travel Bursary to attend the Annual Conference of the Society, Auckland, New Zealand

C GoodnowAustralian Research Council Federation Fellowship

T LambThe 2006 Proctor Medal of the Association for Research in Vision and Ophthalmology for outstanding research in the basic or clinical sciences as applied to ophthalmology

A ListonFrank Fenner Medal: Most outstanding thesis submitted in JCSMR during 2005

S OngJacquot Research Entry Scholarship for 2007

L PalmerAmerican Society for Neuroscience Graduate Student Travel Award to attend the Society for Neuroscience 36th Annual meeting in Atlanta, GA, USA

I PoonAustralasian Society for Immunology (ACT Branch) Student Travel Bursary to attend the Annual Conference of the Society, Auckland, New Zealand

I SakalaAustralasian Society for Immunology (ACT Branch) Student Travel Bursary to attend the Annual Conference of the Society, Auckland, New Zealand

L SimsonAusBiotech Canberra and Region Biotech Summit : First Prize for Enhancing Adult Stem Cell Mobilisation Using Small Anionic Glycan Mimetics (AGMs)

E Sutcliffe2006 Ruth Gani Memorial Travelling Fellowship for Human Genetics Australian Society of Medical Research Domestic Travel Award

D YuAustralasian Society for Immunology (ACT Branch) Student Travel Bursary to attend the Annual Conference of the Society, Auckland, New Zealand Australasian Society for Immunology New Investigator Award: Annual Scientific Meeting, Auckland, New Zealand

Professor Frank Fenner awards Dr Adrian Liston the Fenner Medal for the most outstanding thesis presented in The John Curtin School of Medical Research in 2005.

Professor Ed Pugh (left) and Professor Trevor Lamb (right) following the award of the Proctor Medal of the Association for Research in Vision and Ophthalmology (ARVO).

Prizes and Awards 2006Prizes and Awards presented to JCSMR staff and students during 2006

Prizes and Awards

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Stage 1 of the new JCSMR building,

completed in July 2006, has won a

number of building awards. Melbourne

architects Lyons designed the

building with state of the art research

laboratories and facilities and included

design elements to represent the

biomedical nature of the

building’s purpose.

Project managers Hindmarsh were

awarded the 2006 ACT Master Builders

Project of the Year, and subsequently the

MBA National President’s Award.

Building Awards

Top: From the foyer, the view out the front entrance of the new building takes in the campus across South Oval.

Bottom: The wide sweeping staircase and front façade of the award winning Stage 1 of the new JCSMR Building.

The twisted blades are an architectural representation of the DNA helix.

Research Collaborations & Visitors to JCSMR

StaffandstudentsofTheJohnCurtinSchoolofMedical

Researchcontinuetoenjoyclosecollaborativetieswith

colleaguesacrossDivisionswithintheSchool,andwithother

scientistsatTheAustralianNationalUniversity.

JCSMRresearchersalsoenjoyclosescientificassociationand

collaborationwithcolleaguesthroughoutAustraliaandthe

world.Someofthesecollaborativeresearchventuresarelisted

here.

Inaddition,wehavethepleasureofwelcomingvisitorsfrom

local,nationalandinternationaluniversitiesandresearch

instituteswhocometoJCSMRtopresentseminarsorworkon

collaborativeresearchprojectswithinourlaboratories.


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06 Research Collaborations 2006

Dr RT BakerZinc fingers in deubiquitylating enzymesDr J Mackay School of Molecular and Microbial Biosciences, The University of Sydney, Sydney, NSW

Dr JM BekkersInfluence of the dendritic tree on the firing properties of neuronsProfessor M Häusser Wolfson Institute for Biomedical Research, University College, London, UKSynaptic transmission in neuronal cultures from GAD67-GFP transgenic miceDr Y Yanagawa and Professor K Obata Gunma University, Maebashi City, Gunma, Japan, and RIKEN BSI, Wako, Saitama, JapanRole of Septin-3 in the synaptic vesicle cycleProfessor P Robinson Children’s Medical Research Institute, Sydney, NSW

Dr E BertramRole of T cell costimulation in generation of TCR diversity and cytokine production following influenza virus infectionDr S Turner and Professor P Doherty Department of Microbiology and Immunology, The University of Melbourne, Melbourne, VICRole of TNF members LIGHT and 4-1BBL in T cell costimulationProfessor TH Watts Department of Immunology, University of Toronto, Toronto, CanadaRole of STAT-1 in EAEDr D Willenborg Neurosciences Research Unit, The Canberra Hospital, Canberra, ACT

Dr E Bertram and Dr P ManaRole of TNF family member LIGHT in EACDr D Linares and Dr D Willenborg Neurosciences Research Unit, The Canberra Hospital, Canberra, ACT

Dr E Bertram and Professor C Goodnow Role of CARMA-1 in T cell regulation and allergyDr M Cook The Canberra Hospital, Canberra, ACT and Phenomix Australia, Canberra, ACT

Professor PG BoardDetermination of glutathione transferase structuresProfessor M Parker St Vincent’s Medical Research Institute, Melbourne, VICFunction of Zeta class GSTsProfessor MW Anders Department of Pharmacology and Physiology, University of Rochester Medical Centre, Rochester, NY, USA

Studies of GST knock out miceDr J Dahlstrom Department of Anatomical Pathology, The Canberra Hospital, Canberra, ACT

Dr MG CasarottoStructural studies into the mechanism of dihydrofolate reductaseProfessor G Roberts Centre for Mechanisms of Human Toxicity, University of Leicester, Leicester, UKDr J Basran Department of Biochemistry, University of Leicester, Leicester, UKChitinase and chitin binding proteinsDr C Vorgias Biology Department, Athens University, Athens, GreecePeptide activators of the ryanodine receptorProfessor I Toth Pharmacy Department, The University of Queensland, Brisbane, QLD Effects of drugs that block Vpu ion channels studied with NMR techniquesProfessor T Watts and Dr W Fischer Biomembrane Structure Unit, University of Oxford, Oxford, UK

Dr P CooperAdjuvant activity of microparticulate inulinProfessor N Petrovsky Department of Diabetes and Endocrinology, Flinders Medical Centre, Adelaide, SAProfessor M Korbelik British Columbia Cancer Agency, Vancouver, BC, CanadaDr L Wang Medical School, Monash University, Melbourne, VIC

Dr WB CowdenThe role of nitric oxide in infectious and autoimmune diseaseDr K Rockett Institute of Molecular Medicine, University of Oxford, Oxford, UKThe role of NO in regulation of EAEDr D Willenborg Neurosciences Research Unit, The Canberra Hospital, Canberra, ACTThe activity and mechanism of action of novel glycoprotein processing inhibitor anti-rejection agentsProfessor A Hibberd Hunter Valley Hospital Transplant Unit, Newcastle, NSW

Professor AF DulhuntyVarious aspects of ryanodine receptor physiologyDr D Laver Hunter Medical Research Institute, The University of Newcastle, Newcastle, NSWIdentification of novel RyR specific compoundsProfessor DG Lamb Department of Zoology, La Trobe University, Melbourne, VIC

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Collaborations 2006

Research Collaborations

Role of triadin and calsequestrin in regulating calcium release from intracellular stores and Contribution of splicing defects in ryanodine receptors to myotonic dystrophyProfessor R Dirksen Department of Pharmacology and Physiology, University of Rochester Medical Centre, Rochester, NY, USARegulatory and pore forming domains of calcium release channelsProfessor F Zorzato Department of Experimental and Diagnostic Medicine, General Pathology Section, University of Ferrara Medical School, Ferrara, ItalyActions of CLIC and GST family proteins on the heartDr M Diaz School of Veterinary Studies, The University of Edinburgh, Edinburgh, UKRole of the Beta subunit of the dihydropyridine receptor in excitation-contraction couplingProfessor J Abramson Department of Physics, Portland State University, Portland, OR, USAContribution of splicing defects to myotonic dystrophyProfessor M Takahashi Department of Neurology, Osaka University Graduate School of Medicine, Osaka, JapanStudies of the molecular nature of calsequestrinProfessor M Varsanyi Institut für Physiologische Chemie, Ruhr Universität, Bochum, GermanyStructure of ion channel domain peptidesProfessor N Ikemoto Boston Biomedical Research Institute, Boston, MA, USARegulation of ion channels by CRISP proteinsDr M O’Brien and Dr G Gibbs Monash Institute of Medical Research, Melbourne, VIC

Professor S EastealGenetic epidemiology of high prevalence mental disordersProfessor A Jorm ORYGEN Research Centre, The University of Melbourne, Melbourne, VICGenetic epidemiology of neuroanatomical correlates of high prevalence mental disordersProfessor P Sachdev School of Psychiatry, The University of New South Wales, Sydney, NSWIdentifying genes that modify athletic performanceProfessor K North Neurogenetics Research Unit, The Children’s Hospital at Westmead, Sydney, NSW

Dr C FreemanRoles of VEGF and heparanase in diabetic retinopathy and the use of HS-mimetics to inhibit their actionsDr J Hu Zhongshan University, Guangzhou, China

Design of novel HS-mimetics to inhibit uptake, replication and cell-to-cell spread of HSV, HIV and RSVDr E Trybala Department of Clinical Virology, Goteborg University, Goteborg, SwedenExpression of heparanase in ischemic lesions of rat brainProfessor H Takahashi Department of Molecular and Cellular Physiology, Graduate School of Medicine, Ehime University, Toon, Ehime, JapanIdentification of patients lacking heparanase activityDr H Yang Jiangsu Institute of Hematology, The First Affliated Hospital of Soochow University, Suzhou, ChinaInhibition of Plasmodium falciparum growth and cell adhesion by heparan sulfate mimeticsDr K Andrews Queensland Institute of Medical Research and Australian Centre for International and Tropical Health and Nutrition, Brisbane, QLDUse of HS-mimetics for Alzheimer’s diseaseProfessor D Small and Dr M Beckman Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VICNovel HS-mimetics that inhibit smooth muscle cell proliferationProfessor L Khachigian and Dr F Santiago Centre for Vascular Research, Department of Pathology, The University of New South Wales, Sydney, NSWInhibition of C1s protease activity of the classical complement pathwayAssociate Professor R Pike Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VICThe role of heparanase in rheumatoid arthritisDr R Li and Dr P Smith The Canberra Hospital, Canberra, ACT

Dr C Freeman and Dr L SimsonUse of novel HS-mimetics to mobilise haemopoietic progenator and stem cells into the circulationProfessor J-P Levesque Haematopoietic Stem Cell Laboratory, Cancer Biotherapies Program, Mater Medical Research Institute, Brisbane, QLD

Professor C GoodnowMechanisms regulating islet beta cells in diabetesDr C Nolan The Canberra Hospital, Canberra, ACTMucin gene functionsDr M McGuckin Mater Medical Research Institute, Brisbane, QLDDr M Cook Phenomix Aust Pty Ltd, Canberra, ACT

Professor Levon Khachigian, Centre for Vascular Research, Department of Pathology, The University of New South Wales

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Professor C Goodnow and Dr E BertramMutations affecting male fertilityDr M O’Bryan and Professor D de Kretser Monash Institute of Reproduction and Research, Melbourne, VICMutations affecting the mammary glandDr C Ormandy The Garvan Institute of Medical Research, Sydney, NSW

Professor C Goodnow, Dr E Bertram, Dr C Vinuesa and Dr L TzeIdentifying genes for immunity and toleranceDr J Cyster, Professor L Lanier and Professor A Weiss University of California, San Francisco, CA, USA

Professor C Goodnow, Dr E Bertram and B WhittleHearing mutationsDr H Dahl Murdoch Children’s Research Institute, Melbourne, VIC

Professor C Goodnow and Dr G HoyneRole of cbl genes in B and T cell toleranceAssociate Professor W Langdon and Dr C Thien The University of Western Australia, Perth, WA

Professor C Goodnow and Dr A ListonThymic defects in aire-deficiencyProfessor R Boyd and D Gray Monash University, Melbourne, VICEffects of Foxp3 deficiency on islet-specific toleranceProfessor A Rudensky Department of Immunology, University of Washington, Seattle, WA, USA

Professor C Goodnow and Dr C VinuesaA programme of screening for ENU-mutations affecting lymphocyte response to antigenDr R Cornall and Professor J Bell University of Oxford, Oxford, UK

Professor JE GreadyComputational studies of disulfide bridges in proteinsDr M Wouters Victor Chang Cardiac Research Institute, Sydney, NSW

Professor JE Gready, Mr H Alonso and Dr PL CumminsComputational simulation of the mechanism of the enzyme methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr)Professor S Ragsdale University of Nebraska, Lincoln, NB, USA

Professor JE Gready and Mr N ChakkaAssessment of gene dysfunction in human male infertilityDr M O’Bryan Monash Institute of Reproduction and Research, Melbourne, VIC

Professor JE Gready, Mr N Chakka and Ms T VassilievaEvolution of prion protein and its homologues in vertebratesDr T Simonic and Dr L Sangiorgio Department of Animal Pathology, University of Milan, Milan, ItalyProfessor SV Edwards and Dr D Janes Department of Organismic and Evolutionary Biology and Museum of Comparative Zoology, Harvard University, Cambridge, MA, USA

Professor JE Gready, Dr PL Cummins and Dr IV RostovApplication of the ONIOM QM/MM method to simulation of enzyme reactionsDr T Vrevren and Dr MJ Frisch GAUSSIAN Inc, New Haven, CT, USA

Professor JE Gready and Ms T VassilievaRegulation of prion protein and doppel by FAC1Professor K Jordan-Sciutto Penn State University, Philadelphia, PA, USA

Professor IA HendryTesting behaviour of Gz knockout mice using pre-pulse inhibitionDr M van den Buuse Mental Health Research Institute of Victoria, Melbourne, VICPupillary constriction in Gz knockout miceProfessor KW Yau Johns Hopkins University School of Medicine, Baltimore, MD, USAGz coupling to dopamine D2-like receptors in vivoDr CD Blaha Macquarie University, Sydney, NSWNeuromuscular growth factors role of TGF-beta and GDNF in motoneurone survival and deathDr I McLennan University of Otago, Dunedin, NZ Increase of IGFBP1 following hypoxia in the piglet. Protein 14-3-3 in the CSF of newborn rats following hypoxia-ischaemiaDr Z Kecskes The Canberra Hospital, Canberra, ACTHypoxia alters GABAA-subunit compositionDr P Dodd School of Molecular and Microbial Sciences, The University of Queensland, Brisbane, QLD

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Collaborations 2006


Professor CE HillIdentification of IP3 receptor subtypes in arteries and astrocytes Dr RJH Wojcikiewicz Department of Pharmacology, SUNY Upstate Medical University, Syracuse, NY, USAModelling of vasomotion in cerebral arteriesProfessor T Griffith and Dr D Parthemos University of Cardiff, Cardiff, UKRole of T-type calcium channels in control of cerebrovascular tone Dr LL Cribbs Cardiovascular Institute, Loyola University Medical Center, Loyola, IL, USARole of eNOS in connexin expression in renal microvasculature and induction of diabetes Professor S Kawashima and M Yokoyama The First Department of Internal Medicine, Kobe University School of Medicine, Kobe, Japan Professor PL Huang Harvard Medical School, Cardiovascular Research Centre, Massachusetts General Hospital, Charlestown, MA, USARole of gap junctions in renal autoregulation and blood pressureDr T Takenaka and Professor H Suzuki Department of Nephrology, Saitama Medical College, Saitama, JapanRole of the endothelium and gap junctions in cerebral vasomotion Dr RE Haddock and Dr SL Sandow Department of Physiology and Pharmacology, The University of New South Wales, Sydney, NSW

Professor GDS HirstProperties of interstitial cells of Cajal in the gastrointestinal tractProfessor H Suzuki and Dr H Hashitani Department of Physiology, Nagoya City University Medical School, Nagoya, JapanProperties of ion selective channels in gastric smooth muscle cellsDr N Teramoto Kyushu University, Fukuoka, Japan

Dr G HoyneDelta3-Notch signalling in T cell development and functionDr S Dunwoodie and Dr G Chapman The Victor Chang Cardiac Research Institute, Sydney, NSWEffects of Lunatic Fringe a modulator of Notch signalling in T cell development and toleranceDr C Guidos University of Toronto, Toronto, Canada

A novel immunotheraphy for type 1 diabetes based on targeting of the Notch signalling pathway in autoantigen-specific cellsDr B Champion Celldex Therapeutics Limited, Cambridge, UK

Dr G Hoyne and Dr E BertramRole of CD45 splicing and susceptibility to autoimmune disease in miceDr D Willenborg The Canberra Hospital, Canberra, ACT

Dr G Hoyne and Professor MF ShannonRole of c-rel in regulatory T cell differentiation and homeostasisProfessor S Gerondakis The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC

Dr M HulettRole of EGR1 and YY1 in tumour progressionProfessor LM Khachigian The University of New South Wales, Sydney, NSWGeneration of heparanase and HRG knockout miceDr R Brink Centenary Institute of Cancer Medicine and Cell Biology, Sydney, NSWHeparanase expression in EAEAssociate Professor D Willenborg and Dr M Staykova The Canberra Hospital, Canberra, ACTHeparanase expression in hypoxiaProfessor M Whitelaw and D Peet The University of Adelaide, Adelaide, SADr B Roberts The University of South Australia, Adelaide, SACharacterisation of the interaction of histidine-rich glycoprotein with leukocyte Fc receptorsProfessor M Hogarth and Dr B Wines Austin Research Institute, Melbourne, VICMigration of eosinophils in inflammatory diseaseDr S Hogan Cincinnati Children’s Hospital Medical Centre, Cincinnati, OH, USA

Dr G HuttleyEvolution of triplet-repeat containing proteinsMr N Faux and Professor J Whisstock Monash University, Melbourne, VICBRCA1 evolution in mammalsDr M Wakefield The Walter and Eliza Hall Institute of Medical Research, Melbourne, VICEvolution of mammalsDr M Wakefield The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC

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Analytical tools for comparative genomics Professor R Knight Colorado State University, Boulder, CO, USA Dr M Wakefield The Walter and Eliza Hall Institute of Medical Research, Melbourne, VICAlignment of biological sequencesMr A Isaev Cray Pty Ltd, Canberrra, ACT

Dr T JuelichElucidation of transcriptional mechanisms for the establishment and maintenance of CD8 T cell effector gene function in a mouse influenza A modelDr S Turner The University of Melbourne, Melbourne, VIC

Dr G Karupiah and Dr G ChaudhriPathophysiological significance of reverse signalling through membrane TNFDr J Sedgwick Bone and Inflammation Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USAModulation of the immune response by poxvirusencoded cytokine homologsProfessor M Buller Department of Molecular Microbiology and Immunology, St Louis University, St Louis, MO, USADr A Alcami Department of Molecular and Cellular Biology, Centro Nacional De Biotecnologia, Madrid, SpainMapping of orthopoxvirus CD8 T cell determinantsDr D Tscharke Queensland Institute for Medical Research, CBCRC, Brisbane, QLDDr J Yewdell and Dr J Bennink National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USAChemokine receptors in infectious diseasesDr W Kuziel Department of Molecular Genetics and Microbiology, Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, TX, USAProfessor M Mack Klinikum der Universität Regensburg, Innere Medizin II, Abt für Nephrologie, Regensburg, GermanyPathogenesis of influenza pneumonia and flavivirus encephalitisDr A Scalzo The Lions Eye Institute, Perth, WA Dr W Yokoyama Washington University School of Medicine, St Louis, MO, USAInvestigating the role of dendritic cell subsets in anti-poxviral immunityDr G Belz The Walter and Eliza Hall Institute for Medical Research, Melbourne, VIC

Tracking virus-specific B cells using Blimp-1 transgenic miceDr S Nutt The Walter and Eliza Hall Institute for Medical Research, Melbourne, VIC

Professor TD LambTransduction and adaptation in photoreceptorsProfessor EN Pugh Jr Department of Ophthalmology, University of Pennsylvania, Philadelphia, PA, USAPhototransduction in conesDr S Kawamura Graduate School of Frontier Bioscience, Osaka University, Osaka, Japan,Dr Y Fukada Department of Biophysics and Biochemistry, Graduate School of Science, JapanHuman electroretinogramDr OAR Mahroo Physiological Laboratory, University of Cambridge, Cambridge, UKMolecular mechanisms of vertebrate phototransductionDr RD Hamer Smith-Kettlewell Eye Research Institute, San Francisco, CA, USADevelopment of a scanning laser ophthalmoscopeDr FN Reinholz and Dr BA Patterson Lions Eye Institute, Perth, WAResponses of human cone photoreceptorsDr H van Hateren Department of Neurobiophysics, University of Groningen, Groningen, The Netherlands

Dr M LobigsFlavivirus virulence and vaccinationDr RA Hall Department of Microbiology and Parasitology, The University of Queensland, Brisbane, QLDFlavivirus interferon escapeDr A Khromykh School of Molecular and Microbial Sciences, The University of Queensland, Brisbane, QLDDengue virus virulence, pathogenesis and tropisDr PJ Wright Department of Microbiology, Monash University, Melbourne, VIC Dr A Davidson University of Bristol, Bristol, UKCytomegalovirus US6 glycoprotein interactions with TAPDr H Hengel Institute for Virology, Heinrich-Heine Universität Düsseldorf, Düsseldorf, GermanyCross-protective value of Chimerivax-JEV against Australian flavivirusesProfessor T Monath ACAMBIS INC, Cambridge, MA, USA

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Collaborations 2006


Dr M Lobigs and Dr P CooperFlavivirus vaccines based on inulin adjuvantsProfessor N Petrovsky Flinders Medical Centre, Adelaide, SA

Dr KI MatthaeiThe role of IL-5 and eosinophils in gut allergyDr S Hogan Division of Allergy and Immunology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USAThe role of IL-5 and eosinophils in allergyDr M Rothenberg Division of Pulmonary Medicine, Allergy & Immunology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USAThe role of “Flightless I” in wound healingDr A Cowin Skin Biology Laboratory, Child Health Research Institute, Adelaide, SAParasite infection in gene deficient miceDr L Dent Eosinophil Biology Laboratory, Microbiology and Immunology, School of Molecular and Biomedical Science, Adelaide University, Adelaide, SAThe role of the ryanodine receptor in vivoProfessor P Allen Department of Anesthesia, Brigham and Womens Hospital, Harvard Medical School, Boston, MA, USA

Professor A MüllbacherOral induced T cell toleranceDr J Chin Elizabeth MacArthur AG Institute, NSW Department of Agriculture, Camden, NSWThe role of granzyme A in fungal infectionDr R Ashman Oral Biology and Pathology, The University of Queensland, Brisbane, QLDThe role of granzymes in viral infectionProfessor M Smyth Peter MacCallum Cancer Centre, Melbourne, VICGliotoxin as virulence factor in AspergillosisDr J Pardo and Dr M Simon Max Planck Institute fur Immunbiologie, Freiburg, Germany

Professor A Müllbacher and Dr M RegnerThe granzymes in early defence against viral infectionDr J Trapani and Dr V Sutton Peter MacCallum Cancer Centre, Melbourne, VICRole of granzymes in cytolytic leukocyte-mediated killing and viral-induced immunopathologyDr M Simonand Dr J PardoMaxPlanckInstitutefurImmunbiologie,Freiburg-Zahringen,Germany

The role of poxvirus encoded serpins in cytotoxic T cell induced apoptosisDr R Wallich Department of Immunology, University of Heidelberg, Heidelberg, GermanyGamma irradiated influenza virus as a vaccine against bird fluDr D Boyle and Dr T Bowden CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, VIC

Professor C ParishRole of platelets in tumour metastasisDr M Berndt The Baker Medical Research Institute, Melbourne, VICProfessor C Chesterman and Professor B Chong School of Pathology, The University of New South Wales, Sydney, NSWCarbohydrate-based inhibitors of leukocyte extravasationDr M Hickey Department of Medicine, Monash University, Melbourne, VICDevelopment of dendritic cell targeting vaccinesAssociate Professor D Jackson Department of Microbiology and Immunology, The University of Melbourne, Melbourne, VICDevelopment of a liposome-based TB vaccineDr W Britton Centenary Institute of Cancer Medicine and Cell Biology, Sydney, NSW

Professor C Parish and Dr L SimsonDevelopment of a liposome-based tumor vaccineAssociate Professor P Hogg School of Pathology, The University of New South Wales, Sydney, NSWImmunosurveillance of MCA-induced sarcomas in TH2-immune deficient miceProfessor M Smyth Peter MacCallum Cancer Centre, Melbourne, VIC

Professor IA RamshawEvaluation of HIV prophylactic and therapeutic vaccinesDr S Kent The University of Melbourne, Melbourne, VICDesign of HIV-1 vaccinesDr D Boyle CSIRO Australian Animal Health Laboratory, Geelong, VICDevelopment of vaccines against genetically modified virusesProfessor A Ramsay Louisiana State University Health Sciences Center, New Orleans, LA, USA

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Development of a novel TB vaccineDr W Britton Centenary Institute of Cancer Medicine and Cell Biology, Sydney, NSWEvaluation of a nasopharyngeal cancer therapeutic vaccineProfessor D Moss Queensland Institute of Medical Research, Brisbane, QLDDevelopment of enhanced immune responses to HIV vaccinesProfessor P Doherty and Dr S Turner The University of Melbourne, Melbourne, VIC

Dr C RanasingheHIV pox-virus vaccines and CD8 T cell avidityDr S Turner The University of Melbourne, Melbourne, VICMucosal vaccines and immunityProfessor A Ramsay Louisiana State University Health Sciences Center, New Orleans, LA, USA

Dr S RaoMicroarray functional analysisDr G Denyer The University of Sydney, Sydney, NSWComputational promoter analysisDr T Werner Genomatix, Munich, GermanyHIV and RNAi strategiesAssociate Professor A Kelleher National Centre in HIV Epidemiology and Clinical Research, The University of New South Wales, Sydney, NSW Regulatory T-cells and transcriptional regulationDr N Seddiki Centre for Immunology, Sydney, NSWEffector function gene analysisDr S Turner The University of Melbourne, Melbourne, VIC

Dr C RaymondThe persistence of spike timing-dependent plasticityProfessor WC Abraham Department of Psychology, University of Otago, Dunedin, NZ

Professor SJ RedmanThreshold excitation in dendritic neuronsProfessor J Jack University College, London, UKRadial redistribution of calcium in pyramidal cell somas and regulation of slow after-hyperpolarisationDr W Spain University of Washington, Seattle, WA, USADr R Foehring University of Tennessee, Memphis, TN, USAElectrotonic coupling and rythmogenesis in the spinal cordProfessor R Brownstone Faculty of Medicine, Dalhousie University, Halifax, NS, Canada

Professor MF ShannonControl of GM-CSF gene transcription in T cellsDr A Holloway Discipline of Biochemistry, University of Tasmania, Hobart, TASThe role of c-Rel in CD28 signaling and regulatory networks in T cellsDr S Gerondakis The Walter and Eliza Hall Institute of Medical Research, Melbourne, VICIL-2 gene regulation in T cells Professor R Schwartz Laboratory of Cellular and Molecular Immunology, National Institutes of Health, Bethesda, MD, USATranscriptional networks in T cellsDr K Gardener National Cancer Institute, National Institutes of Health, Bethesda, MD, USAThe role of Foxp3 in regulatory T cellsDr S Barry Department of Paediatrics, The University of Adelaide, Adelaide, SAMicro RNAs and control of transcriptionDr Greg Goodall Hanson Institute, Adelaide, SA

Dr CJ Simeonovic Transient transmission of porcine endogenous retrovirus (PERV) to fetal lambs after pig islet tissue xenotransplantation Dr RR Tönjes Division of Medical Biotechnology, Paul-Ehrlich-Institute, Langen, GermanyClinical Associate Professor JD Wilson Department of Endocrinology, The Canberra Hospital, Canberra, ACTDr P McCullagh Faculty of Veterinary Science, The University of Sydney, Sydney, NSWRole of matrix metalloproteinases in the development of destructive autoimmunity and clinical diabetes in NOD miceDr R Rodgers Department of Obstetrics and Gynaecology, The University of Adelaide, Adelaide, SA

Dr L SimsonEosinophils in respiratory syncytial virus InfectionAssociate Professor S Mahalingam Centre for Virus Research, University of Canberra, Canberra, ACT

Associate Professor C StrickerQuantal analysis of cell pairs in the subplate during developmentDr J Torres and Professor MJ Friedlander Department of Neurobiology, University of Alabama, Birmingham, AL, USA

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Collaborations 2006


Dr GJ StuartInteraction of action potentials with inhibitory synaptic eventsProfessor M Häusser Wolfson Institute for Biomedical Research, University College, London, UKRole of HCN Channels in absence epilepsyDr S Petrou, Professor S Berkovic and Associate Professor T O’Brien The University of Melbourne, Melbourne, VICDr L Dibbins Women’s and Children’s Hospital, Adelaide, SACharacterisation of synaptic plasticity following motor learning in the ratDr T Aumann The University of Melbourne, Melbourne, VIC

Dr ML TierneyEffects of mutations in M2 on the conductance of GABAA receptors.Dr B Cromer St Vincent’s Institute of Medical Research, Melbourne, VICA universal approach towards the design, expression and characterisation of soluble ligand binding domains of ligand-gated ion channelsDr N Unwin Medical Research Council Laboratory of Molecular Biology, Cambridge, UK

Dr DJ TremethickThe role of histone variants in modulating chromatin fibre dynamicsDr K Luger Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO, USAThe structure and function of histone variants during spermatogenesisDr C Caron Institut Albert Bonniot, Grenoble, FranceImprinted X inactivation in MammalsDr J Lee Massachusetts General Hospital, Boston, MA, USAChromatin remodelling during X inactivationDr E Heard Curie Institute, Paris, France

Dr CG VinuesaRole of SAP in follicular helper T cell (TFH) differentiationDr J Cannons and P Schwartzberg National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USARegulation of ICOS expression by RoquinDr KP Lam Laboratory of Molecular and Cellular Immunology, Biomedical Sciences Institute, Agency for Science, Technology and Research, (A*STAR), Singapore

Memory formation in germinal centresProfessor I MacLennan MRC Centre for Immune Regulation, The University of Birmingham, Birmingham, UKIdentification of ROQUIN allelic variants in patients with familial SLEDr J Harley Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma, OK, USARole of ICOS in systemic and organ-specific autoimmunityDr A Hutloff Robert Koch Institute, Berlin, Germany

Dr CG Vinuesa and Dr M CookAPOSLE study- Identification of susceptibility alleles in Australian SLE patientsDr S Addlestein Royal Prince Alfred Hospital, Sydney, NSWDr S Riminton Repatriation General Hospital, Sydney, NSWDr D Fulcher Westmead Hospital, Sydney, NSWDr S Alexander Children’s Hospital, Sydney, NSWDr P Pavli The Canberra Hospital, Canberra, ACT

Professor B WalmsleyElectrical stimulation of the cochlea in congenitally deaf miceProfessor R Shepherd Bionic Ear Institute, Melbourne, VICMechanisms of central neuronal integrationProfessor REW Fyffe Center for Brain Research, Wright State University, Dayton, OH, USAMembrane properties of auditory neuronsProfessor ID Forsythe The University of Leicester, Leicester, UKIn vivo recordings of auditory neurons in congenitally deaf miceDr AG Paolini La Trobe University, Melbourne, VIC

Dr HS WarrenNatural Killer cell subsets in cord bloodDr D Knight Department of Obstetrics and Gynaecology, The Canberra Hospital, Canberra, ACT

Dr DC WebbComparative roles of IL-4 and IL-13 in regulating dendritic cell function Professor P Foster Discipline of Immunology and Microbiology, The University of Newcastle, Newcastle, NSW

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The development of allergic inflammation in the lungs of GSTP-/- miceProfessor R Wolf and Dr C Henderson Ninewells Hospital and Medical School, Dundee, UKExpression of the Ym2 protein in a chronic murine model of allergic pulmonary diseaseAssociate Professor R Kumar Department of Pathology, The University of New South Wales, Sydney, NSWIdentification of Ym-homologous human proteins and their relationship to disease severity in asthmaticsProfessor F Chung Imperial College London, London, UKCiliated cell specific expression of GSTPDr L Ostrowski University of North Carolina, Chapel Hill, NC, USA

Professor JA Whitworth and Dr Y ZhangGlucocorticoid receptors in knockout miceDr TJ Cole Department of Biochemistry and Molecular Biology, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, VICMechanism(s) by which glucocorticoids induce hypertension in humansDr J Kelly and Dr G Mangos St George Hospital, Sydney, NSWEffects of antioxidants and glucocorticoids on plasma F2-isoprostane concentrationsAssociate Professor K Croft and Dr T Mori School of Medicine and Pharmacology, Royal Perth Hospital Unit, The University of Western Australia, Perth, WA

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Optimising microarray in experimental hypertensionProfessor W Anderson Department of Physiology, School of Biochemical Sciences, Monash University, Melbourne, VICPlamsa BH4 analysisDr J Earl Department of Clinical Biochemistry, The Children’s Hospital at Westmead, Sydney, NSWGene expression in glucocorticoid induced hypertension in ratsDr R Lin School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, NSW

Professor IG YoungRole of IL-3 receptor in myeloid leukaemia Dr K F Bradstock Department of Haematology, Westmead Hospital, Sydney, NSWProfessor Y Chen Fujian Medical University, Fuzhou, ChinaSubcellular targeting of photosensitizers and other locally acting drugs with application in cancer therapyDr AS Sobolev Department of Biophysics, Moscow State University, Moscow, Russia

Professor Sam Berkovic The University of Melbourne

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Visitors 2006

Visitors to JCSMR 2006We have welcomed colleagues from Australia and overseas into The John Curtin School of Medical Research throughout 2006, to share their research findings or to carry out research projects in JCSMR laboratories in collaboration with JCSMR staff and students.

Professor WC AbrahamDepartment of Psychology, University of Otago, Dunedin, New Zealand

Professor P BartlettQueensland Brain Institute, The University of Queensland, Brisbane, QLD

Professor T BlankensteinMax-Delbrueck Center for Molecular Medicine and Institute of Immunology of the Charite, Berlin, Germany

Professor D BowtellPeter MacCallum Cancer Centre, Melbourne, VIC

Professor G Chevenix-TrenchQueensland Institute of Medical Research, Brisbane, QLD

Dr A de MestreBaker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA

Professor J EliasYale University School of Medicine, New Haven, CT, USA

Dr C EngwerdaImmunology and Infection Laboratory, Queensland Institute of Medical Research, Brisbane, QLD

Professor B Fazekas de St GrothCentenary Institute of Cancer Medicine and Cell Biology, Sydney, NSW

Professor M FeldmannImperial College, London, UK

Dr C FineCentre for Applied Philosophy and Public Ethics, The University of Melbourne, Melbourne, VIC

Dr E FinkelCosmos, Melbourne, VIC

Dr R FoehringUniversity of Tennessee, Memphis, TN, USA

Professor B FrenchDepartment of Physiology & Biophysics, The University of Calgary, Calgary, Alberta, Canada

Dr M FreseVirus Research Group, Biomedical Sciences; Health, Design and Science, The University of Canberra, Canberra, ACT

Professor J HarleyRheumatology, Immunology & Allergy Division, University of Oklahoma Health Sciences Center, OK, USA

Dr K HeinzelMax-Planck-Institute for Immunobiology, Freiburg, Germany

Mr J HendersonCray Australia, Pty Ltd, Canberra, ACT

Dr P HodgkinImmunology Division, The Walter and Eliza Hall Institute of Medical Reserarch, Melbourne, VIC

Professor M HogarthBurnet Institute, Melbourne, VIC

Professor D JansDepartment of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC

Dr L JermiinThe University of Sydney, Sydney, NSW

Professor L KhachigianCentre for Vascular Research, The University of New South Wales, Sydney, NSW

Professor P KoopmanInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD

Professor KP LamSigN - Singapore Immunology Network, Agency for Science Technology and Research (A*Star), Biopolis, Singapore

Dr S LesageHospital Masisonneuve-Rosemont, Centre de Recherche Guy-Bernier, Montreal, Quebec, Canada

Professor G MannWestmead Millennium Institute for Medical Research, Sydney, NSW

Dr A MansellCentre for Functional Genomics and Human Disease, Monash Institute of Medical Research, Melbourne, VIC

Dr M McConvilleThe Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, VIC

Professor David Bowtell, Peter MacCallum Cancer Centre, Melbourne.

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Professor G McFaddenBotany School, The University of Melbourne, Melbourne, VIC

Professor R MoqbelUniversity of Alberta, Edmonton, AB, Canada

Mr B BuckleyEssys Pty Ltd, Canberra, ACT

Dr C NorburyDepartment of Microbiology and Immunology, Hershey Medical Center, Penn State University, Hershey, PA, USA

Dr R OlsenMolecular & Medical Pharmacology, UCLA, Los Angeles, CA, USA

Dr P PapathanasiouStanford University School of Medicine, Stanford, CA, USA

Dr W PattersonThe University of Western Australia, Perth, WA

Dr W PaulNational Institute of Allergy & Infectious Diseases, National Institutes of Health, Bethesda, MD, USA

Dr F ReinholzLions Eye Institute, Perth, WA

Associate Professor M RyanDepartment of Biochemistry, La Trobe University, Melbourne, VIC

Dr A ScalzoDepartment of Microbiology, University of Western Australia, Perth, WA

Dr M SelgelidCentre for Value, Ethics and the Law in Medicine, University of Sydney, Sydney, NSW

Dr W SpainUniversity of Washington, Seattle, WA, USA

Professor T SpeedThe Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC

Professor J SprentGarvan Institute of Medical Research, Sydney, NSW

Professor R StockerFaculty of Medicine, The University of Sydney, Sydney, NSW

Dr H TangCentre for Infection and Immunity, The Institute of Biophysics, Chinese Academy of Sciences

Professor E WhitelawQueensland Institute of Medical Research, Brisbane, QLD

Dr R WilliamsSchool of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, NSW

Dr J WilsonEditor, Nature Immunology, New York, NY, USA

Dr S WoodStem Cell Laboratory, Child Health Research Institute, Adelaide, SA

Mr R WylieApple Computer Australia Pty Ltd

Visi

tors

200

6

Visitors

Dr Cordelia Fine, Centre for Applied Philosophy and Public Ethics, The University of Melbourne.

Staff, Students & Invited Presentations

Thefollowingsectionprovidesadirectoryofstaffandstudents

ofTheJohnCurtinSchoolofMedicalResearchduring2006,

undertheirDivisionalgroupings.

Includedisalistofscientificpresentationsourstaffand

studentshavebeeninvitedtopresentatconferencesandat

otherresearchinstitutionsbothnationallyandinternationally

throughouttheyear.


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Staff 2006


Professor and HeadParishCR,BAgrSc(UMelb),PhD(UMelb)

School Technical Support OfficersWoltringD,AssDipBiol(CIT),AssDipPath(CIT),BSc(fromApril)WoodhamsCE,BAppSc(CCAE),GradDipInfSyst(UC)(untilAugust)

Divisional AdministratorWeilETF

Cancer and Human Immunology Group Fellow and LeaderWarrenHS,BSc(Hons),PhD(Qld),NHMRCSeniorResearchFellow

Research FellowBettadapuraJ,MSc,PhD(Bangalore)(untilMay)

Senior Technical OfficerJacksonRJ,BSc(Hons)(Monash),PhD(Edin)(fromJuly)(part-time)

Cancer and Vascular Biology Group Professor and LeaderParishCR,BAgrSc(UMelb),PhD(UMelb)

FellowFreemanC,BSc(Hons)(Adel),PhD(Adel)

Viertel Senior Medical Research FellowHulettM,BSc(Hons)(UMelb),PhD(UMelb)(transferred to Division of Molecular Biosciences from July)

Research FellowsHindmarshEJ,BSc(Hons)(USyd),PhDRaoS,BSc(Hons)(Keele),PhD(KingsCollegeLond)

NHMRC Peter Doherty Postdoctoral FellowsQuahB,BSc,PhDSimsonL,BSc(UC),PhD

Postdoctoral FellowEichnerD,BSc(Hons)(transferred to Division of Molecular Biosciences from July)

Visiting FellowsAbdul-MajidAMS,PhD(UNSW)(September-October)AdaGL,DSc(USyd),FAAAltinJ,BSc,GradDipSci,PhDBurchWM,BSc(UMelb),MSc(UMelb),PhD(Lond)ChestermanC,MBBS(USyd),DPhil(Oxon),FRACP,FRCPACooperPD,DSc,PhD(ULond)(untilMay)FangY-Y,BMed(ShanghaiSecondMedicalUniversity),PhD(Adel)LiR,MD(ChinaMedicalUniversity),PhD(SouthernCross)(fromApril)

MimsC,BSc,MD(ULond)PriceJ,BSc(Hons)(UMelb),PhD(UMelb)(fromDecember)StaykovaM,PhD(USofia)

School AssociateNOzarac,BSc(UNSW),PhD(UNSW)

Senior Technical OfficersBezosA,BSc(USyd),MSc(USyd)HornbyJ,BSc(Hons)(Queens,Belfast)(transferred to Division of Molecular Biosciences from July)

Technical OfficersBrowneA,BAPaglerE,BSc(SantoTomas)(transferred to Division of Molecular Biosciences from July)

Technical Officer Vavrina-KunA,BMedSci(part-time)

Visiting Technical OfficersGomersallT,BAppSc(UC)(untilJuly)WaringS,BSc(Hons)(UNSW)(August-December)

Laboratory Technician JianP(part-time)

Editorial/Administrative Assistant ParishB,BSc(Madras),BSc,MSc,GradDipCompStudies(UC)(part-time)

Cellular Microbiology Group (from September)Professor and LeaderHirstT,BSc(Hons)(Kent),DPhil(York)

Computational Genomics Laboratory (transferred to Division of Molecular Bioscience from July)

Diabetes/Transplantation Immunobiology Laboratory Fellow and Leader SimeonovicCJ,BSc(Hons),PhD

Visiting Fellows McCullaghP,MBBS(UMelb),DPhil(Oxon),MRCP(Lond),MD(UMelb)WilsonJD,BSc(Hons),MBBCh,BAO(Hons),MD(Queens,Belfast),MRCP(UK),FRACP

Technical OfficersBrownD,AsDipAppPath(CIT)(part-time)HamiltonP,CertificateIIinAnimalTechnology(CIT)PoppSK,BSc,AssDipAppSci,Biol(CIT)

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Staff 2006


The Immunogenomics Laboratory Professor and Laboratory HeadGoodnowCC,BVSc(Hons)(USyd),BScVet(Hons)(USyd),PhD(USyd),FAA

Executive Assistant to Professor GoodnowVitlerL

Laboratory ManagerTownsendM,PathTechCert(TAFE),AssDipAppPath(TAFE)

Immune Tolerance and Signalling Genomics GroupProfessor and LeaderGoodnowCC,BVSc(Hons)(USyd),BScVet(Hons)(USyd),PhD(USyd),FAA

Research FellowBertramE,BSc(Hons)(Adel),PhD(Adel)

Postdoctoral FellowsDaleyS,BVSc(UQ),DPhil(Oxon)(fromMay)HorikawaK,MD(Chiba),PhD(Tokyo)ListonA,BSc(Hons)(Adel),PhD(untilFebruary)ManaP,PharmD,MPharm,PhD(SantiagodeCompostela)

DFG, German Research Foundation PD FellowEndersA,MD(Freiburg)

NHMRC Peter Doherty Postdoctoral FellowTzeL,BSc(Beloit),PhD(Minnesota)

Visiting FellowsAthanasopoulosV,PhD(UMelb)CornallR,PhDFahrerA,BSc(Hons)(UMelb),PhD(UMelb)JenneC,BSc(Hons)(Guelph),PhD(Calgary)(fromFebruary)WatsonS,BSc(Hons)(Edin),PhD(ULond)(February-March)

Laboratory Technical Staff

In charge of pre-immune serologyDomaschenzH,PathTechCert(TAFE)

In charge of immune serologyKucharskaE,BSc,MSc(Warsaw)

Research TechniciansEmmettS,BSc(Hons)(Monash)HowardD,BScPulsfordK,DipAppSci(CIT)RootsC,BAppSci(UC)SjollemaG,BSc(Hons)WilsonJ,AssocDipAnimalSci(CIT)(March–December)

Research Assistants SiggsOM,BSc(Adel),DipLang(Adel)(January-June)WilsonA,BSc(Hons)(UC),RN(part-time)

Laboratory AssistantsHoyneR(casual)HuX,BSc(BeijingInstituteofTechnology)

Humoral Immunity and Autoimmunity GroupSenior Research Fellow and Program LeaderVinuesaCG,LMS(MBBS)(Madrid),DRCOG(ULond),MSc,PhD(Birmingham)

Postdoctoral FellowsAthanasopoulos,Vicki(part-time)(untilJune)RigbyR,BSc(SheffieldHallam),PhD(ImperialCollegeLond)(fromSeptember)SilvaD,MBBS(Colombia),PhD

Visiting FellowWalterG,BA(Cantab),MBChB(Edin),MRCP(UK),MD(fromSeptember)

Laboratory Technical StaffAngelucciC,BSc(Hons)(Deakin),PhDHoganJ,BMedSci,GradDipGenCouns(Newcastle)

Laboratory AssistantHuX,BSc(BeijingInstituteofTechnology)

Research Assistant WilsonA,BSc(Hons)(UC),RN(part-time)

T Cell Development and Regulation Genomics GroupSenior Research Fellow and Program Leader HoyneG,BSc(Hons)(UWA),PhD(UWA)

Laboratory Technical StaffKofflerJ,BAppSc(UC)

Immunopathology Group Fellow and LeaderCowdenWB,BS(TroyState),PhD(UQ)(untilNovember)

Visiting Fellows EschlerB,BSc(Hons)(USyd),DipEd(USyd),MSc(USyd),PhD(Woll)(untilDecember)MarchD,BSc(Hons)(Adel),PhD(UQ)(untilDecember)

Technical OfficersBartellG,BSc(Hons)(USyd),MSc(untilAugust)GapellaJP,AnimalTechCert(TAFE)(untilDecember)

Laboratory TechnicianHigginsD,DipApplSci(CIT)(untilSeptember)

Visiting Technical OfficersMartinL,BSc(Newcastle)(untilDecember)PavlinovicL(untilMarch)

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06


Infection and Immunity Group Senior Research Fellow and LeaderKarupiahG,BSc(Hons),MSc(Malaya),PhDInternationalResearchScholaroftheHowardHughesMedicalInstitute

Research FellowChaudhriG,BSc(Hons),PhD

CJ Martin FellowWangY,MB(BeijingMedical),MM(USyd),PhD

Postdoctoral FellowPanchanathanV,MBBS,MPhil(Malaya)

Visiting FellowsBelzG,BVBiol(UQ),BVSc(Hons)(UQ),PhD(UQ)FoxwellR,BSc(UWA),BSc(Hons)(UMelb),MSc(Lond),PhD(UC),GradCertHigherEducation(UC)ScalzoA,BSc(Hons)(UMelb),PhD(UMelb)

Senior Technical OfficersThaHlaR,BRTC(TAFE)ZhouJ,BMed,(BeijingMedicalUniversity),MMed(USyd)(untilMarch)

Technical OfficerTanA,BBioTech(Hons)(fromApril)

Laboratory Technician JianP(part-time)

Predictive Medicine Group (transferred to Division of Molecular Bioscience from July)

Vaccine Immunology GroupProfessor and LeaderRamshawIA,MSc(Brunel),PhD

FellowThomsonS,BSc(USyd),PhD(UQ)(untilOctober)

Research FellowRanasingheC,BSc(Rouen),MPhil(Colombo),PhD(UWA)

NHMRC Peter Doherty Postdoctoral FellowAmyesE,DPhil(Oxon)

Postdoctoral FellowJuelichT,BSc(Hons)(Stuttgart),PhD

Visiting FellowsJacksonRJ,BSc(Hons)(Monash),PhD(Edin)RamsayAJ,BSc,PhD(Otago)

Research AssistantHarrisonJ,BSc(Hons)(Adel)(untilJuly)

Laboratory ManagerMedveczkyCJ,AssocDipTechBiol(TAFE)

Senior Technical Officers McArthurC,BSc(Flinders),MSc(untilFebruary)ShoobridgeM,BSc(Hons)(untilSeptember)

Technical Officers GaoK,BSc(ShanDong),MPhilNolanL,BAppSci(UC)WoltringD,AssDipBiol(CIT),AssDipPath(CIT),BSc(untilMarch)

Visiting Technical OfficerBeaton,S,HNC(Scotland)

Viral Immunology and Molecular Virology Group Professor and Joint LeaderMüllbacherA,BSc,MSc(Auck),PhD

Fellow and Joint LeaderLobigsM,BSc(Hons),PhD

Research FellowsLeeE,BSc(Hons),PhDRegnerM,PhD

Postdoctoral FellowAlsharifiM,BBioMedSci(Hons)(Monash),PhD

Visiting FellowsAllevaLM,BSc(Hons),PhDBettadapuraJ,MSc,PhD(Bangalore)(fromJune)BlandenRV,MDS(Adel),PhD,FAABuddAC,BSc(USyd),BSc(Hons),PhDChinJ,MSc(Hons)(UQ),PhD(UQ)CooperPD,DSc,PhD(ULond)(fromMay)WaringP,BSc(Hons)(UQ),MSc,PhD

Senior Technical OfficersKoskinenA,AssocDipMedSciPavyM,AssocDipAppSc(CIT)(fromAugust)

Technical OfficersLobigsP,AssocDipMedSci(fromOctober)PavlinovicL(fromApril)PavyM,AssocDipAppSc(CIT)(untilAugust)SmythV(fromMay)

Visiting ScholarLauerN(fromSeptember)

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Presentations 2006


Presentations 2006

Dr EM BertramLarge scale ENU variation of the mammalian genome: linking causal relationships between genes and immunityNational Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA

Large scale ENU variation of the mammalian genome: linking causal relationships between genes and immunityNational Human Genome Research Center, National Institutes of Health, Bethesda, MD, USA

Large scale ENU variation of the mammalian genome: linking causal relationships between genes and immunityInstitute of Systems Biology, Seattle, WA, USA

Large scale ENU variation of the mammalian genome: linking causal relationships between genes and immunityKings College, London, UK

Large scale ENU variation of the mammalian genome: discovery of a novel gene variant Thunder with reduced T cells in the peripheryImmunology Group of Victoria, Beechworth, VIC

Molecular and Cellular Analysis of the ENU-induced Mouse gene variant, Face, with a point mutation in STAT-1 responsible for spontaneous T cell hyperactivity1st Joint Meeting of European National Societies of Immunology - 16th European Congress of Immunology, Palais des Congrès, Paris, France

LIGHT deficient mice show enhanced recruitment of antigen specific CD8+ T cells into the lung following intranasal influenza virus infection1st Joint Meeting of European National Societies of Immunology - 16th European Congress of Immunology, Palais des Congrès, Paris, France

Professor CC GoodnowMouse models as the rosetta stone for human genome-phenome research, Future of Genetics ForumAustralian Genome Alliance, Parliament House, Canberra, ACT

Alternative approaches to find novel pathways in immunologyEURAPS Meeting, Uppsala, Sweden

The genetics of autoimmunityThe Dunn School of Pathology, Oxford, UK

Genes and mechanisms that prevent autoimmune diseaseMcGill University, Montreal, QC,Canada

Immunological tolerance: how many mechanisms and how many genes?Dan H Campbell Memorial Lecture, The 2006 Midwinter Conference of Immunologists at Asilomar, Pacific Grove, CA, USA

Genes and mechanisms that prevent autoimmune disease,The Scripps Research Institute, San Diego, CA, USA

Genome-wide approaches to discover immune regulators11th International Conference on Lymphocyte Activation and Immune Regulation, Newport Beach, CA , USA

Genes and mechanisms for immunological self-tolerance: how many and which ones fail in autoimmune disease?King’s College Medical School, Guy’s Hospital, London, UK

Animal and plant genomics and post-genomicsThe University of Sydney-The Australian National University Co-operation Agreement Planning and Review Workshop, Sydney, NSW

Opening and Closing RemarksDecoding the Genomic Control of Immune Reactions, Novartis Symposium, Canberra, ACT

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Autoimmunity and allergy due to inherited genes causing quantitative variation in the TCR signalosome: differential effects on thymic positive, negative and Foxp3 cell selectionThymOz V - An International Workshop on T Lymphocytes, Heron Island, QLD

Ubiquitin ligases: critical inhibitors for immunological self-toleranceGarvan Institute Symposium on Ubiquitin, Sydney, NSW

Mechanisms and genes inhibiting autoimmunity: many movings parts prone to failureDistinguished Lecture, American Association of Immunologists, Boston, MA, USA

The Laboratory mouse: the rosetta stone for translating genes into healthAustralian and New Zealand Society for Animal Laboratory Science, Conference, Canberra, ACT

Genes and mechanisms preventing autoimmunityBernard Halpern Symposium of Immunology, Paris, France.

Genetic analysis of t-cell regulationPeter MacCallum Cancer Centre, Melbourne, VIC.

Translating the genome sequence into health: how many genes protect us from autoimmune disease and which are they?Edwards Orator, 3rd Australian Health & Medical Research Congress, Melbourne, VIC

Dr C FreemanHeparan sulphate mimetics14th Symposium on Glycosaminoglycans, Villa Vigoni, Loveno di Menaggio, Como, Italy

Roles of heparan sulfate in inflammationManchester Institute of Nephrology and Transplantation, Manchester Royal Infirmary, Manchester, UK

Development of HS mimetics as anti-cancer drugsDepartment of Medical Oncology, Cancer Research UK and the University of Manchester, Christie Hospital NHS Trust, Manchester, UK

Dr G HoyneCurrent Symposia on Regulatory T cells and NK CellsAustralian Society of Immunology, Melbourne, VIC

The role of the novel splicing silencer hnRNPL in T cell homeostasis and functionJCSMR Retreat, Canberra, ACT

Identifying genes that oppose Type 1 diabetesJDRF Workshop for Centre and PPG holders, San Francisco, CA, USA

Dr G KarupiahRole of antibody responses in 1o and 2o poxviral infectionsBiodefense Clinical Research Workshops, National Institutes of Health, Bethesda, MD, USA

Immune response to viral infection8th Federation of Immunological Societies of Asia-Oceania (FIMSA)/IIS Advanced Immunology Course in Immunology, New Delhi, India

Genes and mechanisms of viral immunityNovartis Foundation Symposium - Decoding the Genomic Control of Immune Reactions, Canberra, ACT

Genetic resistance to smallpox: Lessons from mousepoxNovartis Foundation The Australian National University and Australian Phenomics Facility - Decoding the Genomic Control of Immune Reactions, Canberra, ACT

The Mousepox Model: a powerful tool to study immunity to poxvirusesFASEB Summer Research Conference on Poxviruses, Indian Wells, CA, USA

Dr P ManaLIGHT deficient mice show enhanced recruitment of antigen specific CD8+ T cells into the lung following intranasal influenza virus infection.Keystone Symposia: Advances in Influenza Research, Steamboat Springs, CO, USA

Professor C ParishVaccines and immunotherapeutics: Current trends and future developmentsAustralasian Vaccine and Immunotherapeutics Development (AVID) Conference, Melbourne, VIC

Targeting liposomes to dendritic cells: A new approach to vaccine development8th Annual Mater Medical Research Institute Dendritic Cell Symposium, Brisbane, QLD

From angiogenesis to platelets and eosinophils: a multifaceted approach to cancer control16th St Vincent’s and Mater Health Research Symposium, Sydney, NSW


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Presentations 2006

Heparan sulfate and platelets: Two important components of the tumour microenvironment that regulate tumour growth and metastasisHunter Medical Research Institute Conference on Translational Cancer Research, Newcastle, NSW

Heparanase and heparan sulfate: Key regulators of angiogenesis and tumour metastasis8th International Symposium, Victor Chang Cardiac Research Institute, Sydney, NSW

Heparan sulfate mimetics: A new class of therapeutic agentsHeart Research Institute, Sydney, NSW

Heparan sulfate: A key regulator of inflammatory responses36th Annual Scientific Meeting of the Australasian Society for Immunology, Auckland, New Zealand

Dr CG VinuesaThe zinc-finger protein Roquin in autoimmune disease36th Annual Meeting of the Japanese Society for Immunologists, Osaka, Japan

Genetic and cellular mechanisms regulating autoimmunity and self toleranceSymposium on Immunogenetics, Hospital de Valdecillas, Santander, Spain

The Roquin pathway in autoimmunity1st International MUGEN Conference - Animal Models of Human Immunological Diseases, Athens, Greece

Genetic control of autoimmunity and memoryDecoding the Genomic Control of Immune Reactions. Novartis Symposium, Canberra, ACT

Roquin maintains tolerance in germinal centres 1st Joint Meeting of European National Societies of Immunology - 16th European Congress of Immunology, Palais des Congrès, Paris, France

Roquin acts in stress granules to maintain tolerance in follicular helper T cells Annual Brisbane Immunology Group (BIG) Scientific Retreat, Gold Coast, QLD


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006 Division of Molecular Bioscience

Professor and Head of DivisionShannonMF,BSc(Hons),PhD(NationalUniversityofIreland)

Divisional AdministratorMastorisR

Allergy and Inflammation Research GroupProfessor and Group LeaderFosterP,BSc(Hons)(UWA),PhD

Laboratory TechnicianCaiY,BMed(BeijingMed)

Asthma and Allergy GroupFellow and LeaderWebbDC,DipMedLabSc(RMIT),BAppSc(UC),PhD(UC)

Postdoctoral FellowZhouJ,BMed(GuangxiMed),MMed(GuangxiMed),PhD

Laboratory TechnicianCaiY,BMed(BeijingMed)

Biomolecular Structure LaboratoryFellow and LeaderCasarottoMG,BSc(Hons)(UMelb),PhD(UMelb)

Research FellowHarveyP,BSc(Hons)(Griffith),PhD(Griffith)

Postdoctoral Fellows CuiY,MA(CentralChina),PhD(ChineseAcademyofScience)CraigS,BSc(Hons)(UNSW),PhD(UNSW)

Technical OfficersHekimianL,DipLabTech(CIT)KarunasekaraY,MD(USSR)

Cancer and Molecular Immunology Group(transferred from Division of Immunology and Genetics from July)

Fellow and LeaderHulettM,BSc(Hons)(UMelb),PhD(UMelb)

Senior Technical OfficerHornbyJ,BSc(Hons)(Queens,Belfast)

Technical OfficerEichnerD,BSc(Hons)(untilAugust)PaglerE,BSc(SantoTomas)

Chromatin and Transcriptional Regulation LaboratorySenior Fellow and LeaderTremethickDJ,BSc(Hons)(USyd),PhD(MacqU)

Research FellowsRidgwayP,BSc(McMaster),MSc(Queens,Canada),PhDFanJ,BSc(Fudan),MSc(Fudan),PhD(Auckland)RangasamyD,BSc,MTech(India),PhD(Hull)

Postdoctoral FellowGreavesI,PhDSobolevaT,MSc(MSU),PhD(fromMay)

Technical OfficerDevoyM,BSc(Hons)

Laboratory TechnicianYoungS(casual)

Computational Genomics Laboratory (transferred from Division of Immunology and Genetics from July)

Fellow and LeaderHuttleyG,BSc(Hons)(MacqU),PhD(UCRiverside)

Scientific ProgrammerMaxwellP,MSc,DipCompSci(Auckland)

Research ScholarsSammutR,BAppSc(Monash),BEc(Monash)LindsayH,BMathSci(Newcastle),BSc(Hons)(fromFebruary)

Research FellowSchranz,H,BSc(Hons)(USyd),PhD(USyd)

Computational Proteomics and Therapy Design GroupProfessor and LeaderGreadyJE,BSc(Hons),PhD(USyd)FRACI

Research OfficersCumminsPL,BSc(Hons),PhD(USyd)RostovIV,BSc(Kazan),PhD(KarpovInstitute)(part-time)

Postdoctoral FellowKannappanB,BSc(Madras),MSc,PhD(Pune)

Research AssistantAlonsoH,MSc(Cordoba)(fromSeptember)

Visiting FellowsArmaregoWLF,PhD,DSc(ULond),FRSC,FRACIBliznyukA,BSc,PhD(Novosibirsk)GravesJAM,BSc,MSc(Adel),PhD(UCBerkeley)

Visiting International Postdoctoral FellowSangiorgioL,Laurea(VetBiotech),PhD(Milan)

Cytokine Gene Expression LaboratoryProfessor and LeaderShannonMF,BSc(Hons),PhD(NationalUniversityofIreland)

Staff 2006

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Staff 2006

Division of Molecular Bioscence

Postdoctoral FellowsWilkinsonN,PhD(Texas)(untilSeptember)WangJ,BSc(Xinjiang),MSc(WeizmannInstitute),PhDHardyK,BSc(Hons)(USyd),PhD(USyd),Masters(EScience)BuntingK,BSc(Hons)(Adel)PhD(fromAugust)

Senior Technical Officer and Laboratory ManagerPalmerS,BSc(Hons),GradDip(TechManagement)(Monash)

Technical OfficerMaL,MAppSci(Horticulture)(NZ)

Cytokine Molecular Biology and Signalling GroupProfessor and Group LeaderYoungIG,MSc(UMelb),PhD

Postdoctoral FellowsSobolevaT,MSc(MSU),PhD(untilMay)ChenJ,BSc(China),MMed(China),PhD(Flinders)

Research AssistantFordS,BA,MSc(UQ)

Technical OfficersOlsenJ,BScWalkerA,BSc(Hons)(fromFebruary)

Gene Targeting LaboratoryAssociate Professor and HeadKIMatthaei,BSc(Hons)(UNSW),PhD

Visiting FellowsHopkinsonK,DipAppSc(UC),BScApp(UC),DipAPMA(Monash)FreseM,BSc(Osnabrück),PhD(Freiburg)(fromJuly)MegirianD,PhD(Rochester)(fromDecember)

Visiting ScholarMatthaeiNK,BA(Hons)(QUT)

Laboratory TechniciansDamcevskiVW,AssocDipAppSci(CIT)TaylorHIKugathasK,DipMedLabSci(CIT)(untilFebruary)WardJ,BSc(Hons)(fromFebruary)GibsonP(part-time)

Membrane Physiology and BiophysicsResearch Fellow and LeaderTierneyML,BSc,MSc(Otago),PhD

Postdoctoral FellowsPremkumarA,BSc,MSc,PhDLuT,BSc(Hons),PhD

Visiting FellowsCromerB,BSc(Hons),PhD

EwartG,BSc(Hons),PhDOzsaracN,BSc(Hons),PhD

Technical OfficersCurmiJ,BOptom(Hons)WeiB,BMed(China)

Molecular Genetics GroupProfessor and LeaderBoardP,BSc(Hons),PhD(UNE)

Research FellowBlackburnA,BSc(Hons)(UNSW),PhD

Postdoctoral FellowsShieldA,BBiotech(Hons)(Flinders),PhD(Flinders)CraigS,BSc(Hons)(UNSW),PhD(UNSW)LiuD,PhD(USyd)

Visiting FellowDahlstromJ,MBBS(Hons),FPAC,PhD,FRCPA,GradCertEdSt

Senior Technical OfficerCogganM,BSc(Hons)

Laboratory TechniciansCappelloJ,BSc(UC),ADAppSciAnSci(CIT)KarunasekaraY,MD(Vinnitsa)MurrayT,BSc(Hons),BMedSci(USyd)RookeM,BMedSci(PharmSci)(CSU)

Muscle Research GroupProfessor and Group LeaderDulhuntyAF,BSc(USyd),PhD,DSc(UNSW)

Postdoctoral FellowBeardN,BAppSci(Hons)(LaTrobe),PhDKimuraT,BSc(Hons)(Osaka),PhD

Research FellowPouliquinP,BSc(Hons)(Ferrara)

Visiting FellowLaverD,BSc(Hons),PhD(UNSW)

Technical OfficerCurtisS,BSc,PLTC(halftime)

Senior Technical OfficersPaceS,BSc(UTS)GallantE,PhD(Minnesota)

Laboratory TechniciansStivalaJCulleyD,BSc

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Presentations 2006

Predictive Medicine Group (transferred from Division of Immunology and Genetics from July)

Professor and LeaderEastealS,BSc(StAndrews),MBA,PhD(Griffith)

Visiting FellowMackH,BSc,PhD(PennState)

Senior Technical OfficerTanX,BSc,(Shandong),MSc(ChinaPharmaceutical)

Visiting ScholarMatherK,BSc(Hons)(LaTrobe),BSc(Hons),GradDipPsy(CSU)

Ubiquitin LaboratoryFellow and LeaderBakerRT,BSc(Hons)(UNSW),PhD

Technical OfficerMcIntyreM,BSc(Hons)(UWA),GradDipEd(UC)

Laboratory TechnicianBrewJM,BSc(Hons)(March-June)

Divisional Visiting FellowsBarlinG,PhD,DSc(USyd),FRANCCoxG,BSc,PhD(UMelb),FAADenboroughM,MD,ChB(CapeTown),MD(UMelb),DPhil(Oxon),DSc(UMelb),FRCPGibsonFEW,BSc,DSc(UMelb),MA,DPhil(Oxon),FAA,FRSMorrisonJE,BSc(USyd),MSc(UQ),DPhil(Oxon),DScSpinnerE,MScTech,PhD,DSc(Manchester),FRACI

Dr RT BakerRegulation of ubiquitin-dependent functions by deubiquitylationInternational Fellow’s Symposium, Garvan Institute of Medical Research, Sydney, NSW

Ubiquitin: getting it on and getting it offCentre for Vascular Research, The University of New South Wales, Sydney, NSW

Professor P BoardDeficiency of glutathione transferase Zeta causes oxidative stress and sensitivity to acetaminophen ISSX 1st Asia Pacific Symposium, Juju Island, South Korea

Professor A DulhuntyA variably spliced region of the RyR is implicated in myotonic dystrophy and EC couplingDepartment of Physiology and Pharmacology, The University of New South Wales, Sydney, NSW

A variably spliced region of the RyR is implicated in myotonic dystrophy and EC couplingDepartment of Cell Biology, University of Philadelphia, Philadelphia, PA, USA

Ryanodine Receptor Regulation by PeptidesHerzelya, Israel

Novel regulators of RyR Ca2+ release channels: Molecular changes in genetically linked myopathiesSpecial Session of the European Muscle Conference, Heidelberg, Germany

The muscle model for intracellular calcium signalling: cross-talk between the calcium release channel and the calcium buffer in the intracellular calcium storeComBio2006, Brisbane, QLD

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Professor S EastealH+; The future of human evolutionDefence Science and Technology Organisation Conference Human Performance, Melbourne, VIC

Dr M HulettThe heparan sulphate degrading enzyme heparanase: molecular characterisation and targeting with drug inhibitors to treat cancer and inflammatory disease Department of Biochemistry, La Trobe University, Melbourne, VIC

The heparan sulphate degrading enzyme heparanase: molecular characterisation and targeting with drug inhibitors to treat cancer and inflammatory diseaseLudwig Institute for Cancer Research, Melbourne, VIC

Regulation and Function of the heparan sulphate degrading enzyme heparanase in cancer and inflammation The Australian Health and Medical Research Congress, Melbourne, VIC

The heparan sulphate degrading enzyme is induced in T cells upon activation and promotes infiltration of CD4+ T cell in EAE 36th Annual Scientific Meeting of The Australian Society for Immunology, Auckland, New Zealand

The heparan sulphate degrading enzyme heparanase: Molecular characterisation and targeting with drug inhibitors to treat cancer and inflammatory diseaseMenzies Research Institute, Hobart, TAS

Dr G HuttleyApplication of the COmparative GENomics Toolkit (COGENT) to examining the evolution of DNA’s 5th base, 5-methyl-cytosineInternational Human Genetics Congress, Genetics Society of Australia, Brisbane, QLD

Dr K MatthaeiPlenary Lecture: Gene targeting and transgenics: Providing all the answers or just more problems2nd International Congress on Stem Cell Biology & Technology, Tehran, Iran

Tissue and temporal control of gene expression in vivo2nd International Congress on Stem Cell Biology & Technology, Tehran, Iran

Professor MF ShannonGene transcription in the post-genomic era Keynote speaker - Functional Genomics Workshop, Canberra, ACT

The role of the NF-kB transcription factor c-Rel in T cell gene transcription ComBio2006, Brisbane, QLD

Gene transcription in the immune system: single gene and genome-wide approachesSchool of Molecular Bioscience, The University of Adelaide, Adelaide, SA

Dr ML TierneyTrafficking by GABARAP produces “super” GABA-A channels ComBio2006, Brisbane, QLD

The conductance of recombinant GABA-A receptors with GABARAP American Biophysics Society, Salt Lake City, Utah, USA

Trafficking by GABARAP turns GABA-A receptors into “super channels”Gordon Conference on Ion Channels, Tilton, New Hampshire, USA

Dr D TremethickH2A variants: modulators of higher-order chromatin structure The Gordon Conference on Chromatin Structure and Function, Ciocco, Italy

Partitioning the genome into distinct and dynamic functional domains by modulating chromatin structureGene Expression and Chromatin Symposium, Massey University, Auckland, New Zealand

Dr D WebbThe roles of IL-4, IL-13 and IL-4Rα in modulating pulmonary dendritic cells and their functional interaction with CD4+ T cellsAustralasian Society for Immunology, Auckland, New Zealand

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Head of DivisionStuartGJ,BSc(Hons)(Monash)PhD

Divisional AdministratorElugaM

Autonomic Neuroeffector Transmission LaboratoryProfessor and LeaderHirstGDS,BSc,PhD(Leeds),FAA

FellowsEdwardsFR,BE,PhD(Monash)YanagidaH,MD,PhD(Nevada)

Laboratory TechnicianGarcia-LondonoAP,BVSc(Caldas)

Blood Vessel LaboratoryProfessor and LeaderHillCE,BSc,PhD,DSc(UMelb)

Postdoctoral FellowEllisA,BSc(Monash),BApplSc(RMIT),PhD(RMIT)(fromSeptember)

Visiting FellowGraysonTH,BSc(UTas),MSc,PhD(Plymouth)

Visiting Technical OfficerBrackenburyT,BSc(Hons),BSc(Natal),MSc,PhD(untilSeptember)

Research OfficerBelfrageKR,BSc(Hons)(LaTrobe)

Cerebral Cortex LaboratoryFellow and LeaderBekkersJM,BSc(Griffith),MSc(Manchester),PhD(Cambridge)

Postdoctoral FellowSuzukiN,BSc(Tsukuba),MMedSc(Tsukuba),PhD(Tokyo)

Research AssistantChenMM,MSc(Liaoning),PhD(Shanghai)(fromSeptember)(part-time)

Developmental Neurobiology LaboratoryProfessor and LeaderHendryIA,BSc(Med),MBBS(USyd),PhD(Cambridge),DSc(USyd)

Laboratory TechnicianHolgateJ,BAppSc(UC)

Postdoctoral FellowKaasinenSK,MSc,PhD(Kuopio)

Visiting FellowMegirianD,MS,PhD(Rochester)

Movement & Memory LaboratoryProfessor and LeaderRedmanSJ,ME(UNSW),PhD(Monash),DSc(Monash),FAA

University Fellow and Emeritus ProfessorCurtisDR,AC,MBBS(UMelb),PhD,FRACP,FAA,FRS

Research FellowsCowanAI,BSc(Hons),PhD(untilSeptember)RaymondC,BSc(Hons)(Otago),PhD(Otago)

Senior Technical OfficerRoddaGR,PTC

Neuronal Network LaboratoryAssociate Professor and LeaderStrickerC,MD(Zurich),PhD(Bern)

Neuronal Signalling LaboratoryLeaderStuartGJ,BSc(Hons)(Monash),PhD

Postdoctoral FellowsKoleMHP,MSc,PhD(Groningen)IlschnerS,MD,PhD(Erlangen)(fromAugust)BretonJ-D,MSc,PhD(Strasbourg)(fromDecember)

Synapse & Hearing LaboratoryProfessor and LeaderWalmsleyB,BE,PhD(Monash),DSc(UNSW)

Postdoctoral FellowsBerntsonA,BA(Minnesota),PhDLeaoR,BSc,MD(UFU),PhD

Visual Neuroscience LaboratoryProfessor and LeaderLambTD,BE(UMelb),ScD(Cambridge),FRS,FAA

Postdoctoral FellowsCameronAM,BPsych(Hons)(JCU),PhD(UQ)JärvinenJLP,MSc(Helsinki),PhD(Cambridge)RuseckaiteR,BSc(VytautasMagnus),MSc(VytautasMagnus),PhD(fromSeptember)VogalisF,PhD(Monash)(fromNovember)

Research OfficerMiaoL,BEng(Tongii),MEng


Staff 2006

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Presentations 2006

Professor T LambPhototransduction, dark adaptation and rhodopsin regenerationThe Proctor Lecture 2006, Annual Meeting of the Association for Research in Vision and Ophthalmology, Fort Lauderdale, Florida, USA

Functional differences between rods and cones: Kinetics, sensitivity, noise, operating range, and recovery from bleachesECVP2006, European Conference on Visual Perception, St Petersburg, Russia

Phototransduction, dark adaptation and rhodopsin regenerationPlenary Lecture, Australian Ophthalmic and Visual Sciences Meeting, Canberra, ACT

Son of a bleach: Recovery of visual sensitivity in human retinal bipolar cells following intense illumination“Seeing Connections” satellite meeting of the Australian Neuroscience Society, The University of Sydney, Sydney, NSW

Dark adaptation of human retinal rod bipolar cellsSchool of Biomedical Science, University of Queensland, Brisbane, QLD

Dark adaptation of human rod bipolar cellsCraik Club seminar, University of Cambridge, Cambridge, UK

Professor C HillEndothelial derived hyperpolarizing factor, gap junctions and hypertensionCardiovascular Research Centre, University of Virginia School of Medicine, Charlottesville, VA, USA

Endothelial derived hyperpolarizing factor, gap junctions and hypertensionDepartment of Diagnostic Radiology, Wales Heart Research Institute, Cardiff University, Cardiff, Wales

Endothelial derived hyperpolarizing factor, gap junctions and hypertensionDepartment of Pharmacology, Oxford University, UK

Endothelial derived hyperpolarizing factor, gap junctions and hypertensionPrince of Wales Medical Research Institute, Sydney, NSW

Dr GJ StuartIntegration of synaptic input in somatosensory cortex 5th Annual Satellite on Motor Control, Sydney, NSW

Investigating synaptic integration with voltage-sensitive dyes 25 Years of Giga-Seal Patch Clamping, Heidelberg, Germany

Dendrites and synaptic plasticityUniversity of Newcastle, Newcastle, NSW

The cerebral hardware of mammalian and human brainsStars to Brains meeting, Canberra, ACT

Learning rules for spike timing-dependent plasticity depend on dendritic synapse location ComBio2006, Brisbane, QLD

Dendrites and synaptic plasticityAnderson Stuart Seminar Series, The University of Sydney, Sydney, NSW

Methods for dendritic patch-clampingDendritic Patch-Clamp Workshop, London, UK

Dr C RaymondLocation, location: Spatial segregation of neuronal calcium signals encodes different forms of LTPQueensland Brain Institute, University of Queensland, Brisbane, QLD

Professor SJ RedmanAdventures with synaptic plasticity: calcium and quanta Australasian Winter Conference on Brain Research, Queenstown, New Zealand

Professor B WalmsleyCentral brainstem processing of auditory signalsWinter Conference on Brain Research, Steamboat Springs, CO, USA

Endbulbs and calyces of Held, and neuronal firing properties in congenitally deaf miceSymposium on the Calyx of Held, Leipzig University, Leipzig, Germany

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Staff 2006

High Blood Pressure Research Unit

Presentations 2006

Professor and HeadWhitworthJA,AC,DSc,MD,PhD,BS(UMelb),MD(Honoriscausa)(USyd),MD(Honoriscausa)(UNSW),FRACP,FAICD

Research FellowZhangY,BMed(Beijing),PhD(Adel)

Clinical Research AssistantWilliamsonPM,SRN(secondedtoStGeorgeHospital,Sydney,NSW)

Laboratory ManagerMcKenzieKUS,AssDipAppSci,ITCertIII(CIT)(untilJune)

Senior Technical OfficerLangtonLK,BSc

Technical OfficerVickersJJ,BSc(UC),RN,RM

Visiting FellowKellyJJ,MBBS(Hons),MD(UNSW)

Professor JA WhitworthImportance of government support and legislation at a national levelInternational Society of Hypertension CVD Prevention meeting, Istanbul, Turkey

Glucocorticoids, hypertension and cardiovascular riskThe 21st Annual Scientific Meeting of The International Society of Hypertension, State of the Art Lecture, Fukuoka, Japan

Medical research in AustraliaEngineers Australia (Canberra Division), Canberra, ACT

Global communication and global healthWomen in Information and Communication, Canberra, ACT

Opening addressCardiac Society of Australia and New Zealand, 54th Annual Scientific Meeting, Canberra, ACT

Hypertension: a global health problem14th Annual Scientific Meeting, Australian Vascular Biology Society, Gold Coast, QLD

Great public service debateAustralian Public Service Commission, Sydney, NSW

Designer babies: a threat to mankindRotary Great Debate, Canberra, ACT

Health research: The best investmentUnion Club, Sydney, NSW

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Students at JCSMR 2006

PhD ScholarsAbrahamM,BSc(UTas),MPhil

AlonsoH,MSc(Cordoba)

ArsovT,MD(StCirilusandMethodius),MS(StCirilusandMethodius)(untilAugust)

AzmanovD,MD(Thracian)

BrewJ,BMedSci(Hons)

BrownK,BSc(Hons)(Murdoch)(untilSeptember)

BuntingK,BSc(Hons)

ChakkaN,BDS(Bangalore)MSc(Bioinformatics)(EastAnglia)

ChenX,BSc(Hons)

CheungS,BSc(fromMarch)

CorleyS,BLaw(UQ),MLaw,BSc(Hons)(USyd)

CorrechaM,MBBS(Cauca)

CouplandL,BSc(Hons),RN(fromMarch)

DayS,BBioTech(Hons)

DixonC

EllisL,BAppSci(UC)

EllyardJ,BAs,BSc(Hons)

EverittA,BSc(untilNovember)

FarnsworthM,BSc(Wollongong),BSc(Hons)

FleningE,BSc(Hons)(UNSW)(untilJanuary)

ForbesE,BSc

FrenchH,BSc(Hons)

HarleyN,BSc(Hons)

HeY-Q,MSc(SunYat-Sen)

HoranC,BMedSci(Hons)

IkedaK,BA(UCBoulder)

KuoI,BSc(BioMed)(UWA),BSc(Hons)

LeangL,BSc(Hons)(Monash)(fromMarch)

LeaoK(neeSvahn),BSc,MSc(Gothenburg)

LeeS-H

LefflerM,BMedSci(Hons)(MacqU)

LetzkusJ,DipBiol(Mainz)

LindsayH, BMathSci(Newcastle),BSc(Hons)(fromFebruary)

LintermanM,BBMEDS(Victoria,Wellington)(fromJanuary)

McCuaigR,BSc(UC),GradDipSciMolBiol,BSc(Hons)(UTas)

McNaughtonE,BSc(Hons)(Otago)(fromFebruary)

MdNorN,MSc(Nottingham)(fromDecember)

MirzaS

MooreA,BSc(Massey)

MorrisM,BMedSci(Hons)(JCU)

MuraseT,BSc(Hons)(untilNovember)

Navarro-GonzalesM,BVSc(Caldas)

NgE,BMedSc(Hons)

O’CallaghanN

OngS,BSc(Med)MBBSFRACP

PalmerL,BSc(UMelb),BA(UMelb),MSc(Minnesota)

PenaJ

PoonI,BBioMedSci(Hons)(Monash)(fromFebruary)

PrescottV(neeSmart),BSc(Hons)

PrichardZ,BSc(Hons)

RandallK,MB(UNSW),BS(UNSW),BSc(UNSW),FRACP,FRCPA(fromFebruary)

RosenbergM,BSc(Hons)(Canterbury)

SakalaI,BMedSc(Zambia)

SammutR,BAppSc(Monash),BEc(Monash)

ScottB,BSc,PGDip(UQ)

SeymourV,BSc(Hons)(Otago)

SheahanD,BSc(Hons)

SimpsonN,MBBS(USyd),MPH(UNSW)

SinghalS,BSc(Hons)(Delhi),MSc(BioTech)(Punjab)

SjollemaG,BSc(untilJuly)

SochaLH,MD(ColombianNational),GradCertClinicalTrialsManagement(UC)

SontaniY,BSc(Murdoch)

StorerJ,BBioTech(Hons)(Wollongong)

SutcliffeE,BSc(NTU),BSc(Hons)

SutherlandD,BMedSi(Hons)(fromJune)

TaeHS,BSc(Hons)(Malaysia)

TaylorM,BSc,MPhil

TranT

VassilievaT

WangZ,MSc(Wollongong)

WeiL

WeissSB,BAppSc,PhD,MFinMgt

WenB

WoodR,BSc(Hons)(JCU)

WuZ,MSc(UNSW),BM(ZhongShan)

YoussoufianM,BSc(California),BSc(Hons)

YuD,BSc(Wuhan)

ZeidO,MD(Cairo)(untilOctober)

ZhangJ,BMSc(Hunan)(untilOctober)

ZiolkowskiA,BSc(Hons)

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Students

Stud

ents

200

6

MPhil ScholarsBrownK,BSc(Hons)(Murdoch)(fromSeptember)

HuX,BSc(BeijingInstituteofTechnology)(fromMay)

KwokA,BSc(Hons)

YingH,BBiolPharmEngineering(Nanjing),MSBiochemMolBiol(Nanjing)

Honours StudentsAltinJ

BotelhoN

CheungBKW

ChuaG

GyngellC

HoY

LamK

NgJ

SchultzN

SivakumarB

SivalingamI(untilJune)

SubramanianA(untilJune)

TanEJ

International ScholarsNanyakkaraB

PauloS

SalomäkiM

SpillmanN

VäisänenM

Research StudentsTehC

LuMC

EvansE

RamanayakeN

ArnettS

KumarS

GunaratnaK

SlaterJ

AltinJ

JainG

Rese

arch

Pro

gram

s

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School Administration & Services

School Administration School Services

School AdministrationHoward Florey Professor of Medical Research and

DirectorWhitworthJA,AC,DSc,MD,PhD,BS(UMelb),MD(Honoriscausa)(USyd),MD(Honoriscausa)(UNSW),FRACP,FAICD

Deputy DirectorRedmanSJ,ME(UNSW),PhD(Monash),DSc(Monash)FAA

Business ManagerWebbB,BRTC(CIT),AdvDipBusMan(CIT)

School VisitorFennerEmeritusProfessorF,AC,CMG,MBE,FRS,FAA,MD,DTM,HonMd,Drhonoriscausa(Liege),FRACP,FRCP(ULond)

Convenor, Graduate Program in Medical Sciences (transferred to ANU College of Medicine and Health Sciences from September) CowanA,BSc(Hons),PhD,GradCertHE

Public Affairs Officer (transferred to ANU College of Medicine and Health Sciences from July) NicolMJ,BSc(Wollongong),BSc(Hons),PhD

Safety & Training Officer CreganA,BSc(untilApril)

Executive Assistant to DirectorJacobsenAJ,CertFrontlineManagement

Administrative AssistantsMoralesDPriestK(untilJune)

Functions AssistantRathboneGK(fromSeptember)

School ServicesAnimal ServicesHeadReidA,MIAT(UK)HNCBiologicalSciences

Deputy HeadMcMathH,MIAT(UK)HNCBiology(fromSeptember)MetcalfeC,CertVetNursing,CertFrontlineManagement(untilSeptember)

Office AdministrationHargraveT

Divisional VeterinarianBainSAF,BVSc(USyd),MACVSc(part-time)

Senior Technical OfficersGoodingDRichardsonJWilsonJ(fromSeptember)

Technical OfficersBurkeHComansCFaucettTPorrittTSuttonM

Animal TechniciansBowditchKBowesVBurkeBCoxSEarlMFigueroaSFookNO’SullivanEPeileM(fromSeptember)SpencerC(fromSeptember)WalkerK(fromSeptember)WilliamsN

Material Support TechniciansCoverGForgieIFowlieC(fromSeptember)HamiltonRHoganPJarvisLSantracCSparrowMViolanteOYoungS(part-time)

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Biomolecular Resource Facility (BRF)ManagerEdwardsK,BSc(Natal),BSc(Hons)(CapeTown),PhD(UniversityCollegeLondon),GradCertTertiaryTeaching(JCU),MEnvMng(UNE)(untilNovember)PalmerS,BSc(Hons),GradDip(TechManagement)(Monash)(fromNovember)(part-time)

Technical SpecialistMilburnP,BSc(Hons),PhD(Sheffield)

Microarray CoordinatorPengK,PhD(Wuhan)

Bioinformatics AnalystOhmsS,MBChB,ME,PhD(Auckland)

DNA sequencingMcCraeC,BiolTechCert(CIT)

Peptide SynthesisMcAndrewK,AssDipAppSci(UC)

Tetramer SynthesisSutherland,TBAppSci(CSU)(untilFebruay)ZhangK,MSc(Fudan),PhD(fromJuly)

Administrative AssistantMooreS

Finance and Research Support(Transferred to ANU College of Medicine and Health Sciences from July)

Finance Manager SawyerV

Senior Finance Officer SinnottT

Finance OfficersCousinsMTalbotM

Senior Purchasing OfficersHicksG(untilMarch)PradoL

Purchasing OfficersAllanN(untilApril)WrightN(fromJune)

Senior StorepersonClementsR (Transferred to JCSMR General Services from July)

StorepersonTalbotA (Transferred to JCSMR General Services from July)

General ServicesHeadElsburyS,BAppSc,GradDipMedLabTech

Operations ManagerMetcalfeC,CertVetNursing,CertFrontlineManagement,DipBus(fromOctober)

Operations AssistantCiuffetelliL(fromFebruary)

Senior StorepersonClementsR(fromJuly)

StorepersonTalbotA(fromJuly)

SecurityBarancewiczD(untilJanuary)(casual)BlinksellP(untilJanuary)CiuffetelliL(untilJanuary)LazarovZ(untilJanuary)SimpkinW(untilJanuary)WilliamsF(untilJanuary)(casual)

CleanersBellingN(untilJanuary)BourkeP(untilJanuary)BourkeR(untilJanuary)(casual)GrantDHattonM(untilJanuary)(casual)McVeyS(untilJanuary)WhiteN(untilJanuary)WilliamsF(untilJanuary)(casual)WilliamsJ(untilJanuary)(casual)

Human Resources (transferred to ANU College of Medicine and Health Sciences from July)

Manager BrowningKO

HR OfficersJonesED(May–August)MurphyMMSmithBATalbotJA

HR Assistant OfficerBurkettSN

School Services

Staf

f 20

06

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Staff 2006

School Services

Information Technology & Communications Unit (ITCU)(transferred to ANU College of Medicine and Health Sciences from July)

HeadCollisA,BIT,BE(Hons)

Network ManagerZhangQ,BComputerSci(Beijing),MBA

ProgrammerColeP(untilFebruary)

Client Support Team LeaderHendersonS,TeachCert(ULond)

Client SupportFisherDHodgkinsDMcCullochASimeD,ElectronicsCert(untilAugust)

Multimedia (transferred to ANU College of Medicine and Health Sciences Outreach Group from July)EdwardsK,PhotCertFenningM,PhotCert,AAIPP(untilAugust)

Media/Wash-Up Section ManagerWoodhamsCE,(untilSeptember)MetcalfeC,CertVetNursing,CertFrontlineManagement,DipBus(fromOctober)

TechniciansGilmartinL,LabSkillCert3(CIT)MundayKThileebhanSBorrettD(fromNovember)(casual)

Microscopy and Cytometry Resource Facility (MCRF)HeadGillespieCM

Histology UnitPrinsAS,BAppSci(RMIT)

Flow Cytomtery UnitVohraH,MSc(Hons)(Punjab),PhD(PGIMER)DawsonS,BAppSci(UC)

Technical ServicesHeadCoombesD

Deputy HeadEmansP

Technical OfficersBestNChampionGCommonsRCremerPEllisonJGairLJakubaszekRJordanTKellyDKeysB(onsecondment)LangPPercivalMRhallGRobertsonASymonsC(untilNovember)TempraD

Administrative AssistantMcGannJ

ApprenticeBackhouseB

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Publications


Afulllistofpublications,includingpeerreviewedjournal

articles,invitedreviewsandbookchaptersauthoredbyJCSMR

staffandstudentsin2006appearsonthefollowingpages.

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JCSMR Publications

Abbey, JL, Hulett, M, and O’Neill, HC (2006) Cell surface expression of a peptide encoded by the unrearranged TCR-V beta 8.2 gene. Molecular Immunology 43(9): 1408-1417.

Adams, Y, Freeman, C, Schwartz-Albiez, R, Ferro, V, Parish, CR, and Andrews, KT (2006) Inhibition of Plasmodium falciparum growth in vitro and adhesion to chondroitin-4-sulfate by the heparan sulfate mimetic PI-88 and other sulfated oligosaccharides. Antimicrobial Agents and Chemotherapy 50(8): 2850-2852.

Alexander, WS, Viney, EM, Zhang, JG, Metcalf, D, Kauppi, M, Hyland, CD, Carpinelli, MR, Stevenson, W, Croker, BA, Hilton, AA, Ellis, S, Selan, C, Nandurkar, HH, Goodnow, CC, Kile, BT, Nicola, NA, Roberts, AW, and Hilton, DJ (2006) Thrombocytopenia and kidney disease in mice with a mutation in the C1galt1 gene. Proceedings of the National Academy of Sciences of the United States of America 103(44): 16442-16447.

Alonso, H, Bliznyuk, AA, and Gready, JE (2006) Combining docking and molecular dynamic simulations in drug design. Medicinal Research Reviews 26(5): 531-568.

Alonso, H and Gready, JE (2006) Integron-sequestered dihydrofolate reductase: a recently redeployed enzyme. Trends in Microbiology 14(5): 236-242.

Alsharifi, M, Lobigs, M, Simon, MM, Kersten, A, Muller, K, Koskinen, A, Lee, E, and Mullbacher, A (2006) NK cell-mediated immunopathology during an acute viral infection of the CNS. European Journal of Immunology 36(4): 887-896.

Alsharifi, M, Regner, M, Blanden, R, Lobigs, M, Lee, E, Koskinen, A, and Mullbacher, A (2006) Exhaustion of type I interferon response following an acute viral infection. The Journal of Immunology 177(5): 3235-3241.

Altin, JG and Parish, CR (2006) Liposomal vaccines - targeting the delivery of antigen. Methods 40(1): 39-52.

Arita, I, Nakane, M, and Fenner, F (2006) Public health - Is polio eradication realistic? Science 312(5775): 852-854.

Arsov, T, Larter, CZ, Nolan, CJ, Petrovsky, N, Goodnow, CC, Teoh, NC, Yeh, MM, and Farrell, GC (2006) Adaptive failure to high-fat diet characterizes steatohepatitis in Alms1 mutant mice. Biomedical and Biophysical Research Communications 342(4): 1152-1159.

Arsov, T, Silva, DG, O’Bryan, MK, Sainsbury, A, Lee, NJ, Kennedy, C, Manji, SSM, Nelms, K, Liu, CN, Vinuesa, CG, and de Kretser, DM (2006) Fat Aussie - A new Alstrom syndrome mouse showing a critical role for ALMS1 in obesity, diabetes, and spermatogenesis. Molecular Endocrinology 20(7): 1610-1622.

Attia, R, D’Este C, Schofield, PW, Brown, AM, Gibson, R, Tavener, M, Horsley, K, Harrex, W, Ross, J, and Team, S (2006) Mental health in F-111 maintenance workers: The study of health outcomes in aircraft maintenance personnel (SHOAMP) general health and medical study. (Ross, J on behalf of the SHOAMP team- JA Whitworth - Chair Advisory Committee). Journal of Occupational and Environmental Medicine 48(7): 682-691.

Baker, RT, (2006) Deubiquitinating enzymes, cell proliferation and cancer. Protein Degradation. Vol 3: Cell Biology of the Ubiquitin-Proteasome System. eds. RJ Mayer, A Ciechanover and M Rechsteiner. Wiley-Vch Weinheim pp.212 - 223

Banwell, MG, Bezos, A, Burns, C, Kruszelnicki, I, Parish, CR, Su, S, and Sydnes, MO (2006) C8c-C15 monoseco-analogues of the phenanthroquinolizidine alkaloids julandine and cryptopleurine exhibiting potent anti-angiogenic properties. Bioorganic and Medicinal Chemistry Letters 16(1): 181-185.

Blackburn, AC, Matthaei, KI, Lim, C, Taylor, MC, Cappello, JY, Hayes, JD, Anders, MW, and Board, PG (2006) Deficiency of glutathione transferase zeta causes oxidative stress and activation of antioxidant response pathways. Molecular Pharmacology 69(2): 650-657.

Blery, M, Tze, L, Miosge, LA, Jun, JE, and Goodnow, CC (2006) Essential role of membrane cholesterol in accelerated BCR internalization and uncoupling from NF-kappa B in B cell clonal anergy. Journal of Experimental Medicine 203(7): 1773-1783.

Board, PG (2006) A class act - The discovery of the Theta class glutathione transferases. The Biochemist 28(5): 35-38.

Bulynko, YA, Hsing, LC, Mason, RW, Tremethick, DJ, and Grigoryev, SA (2006) Cathepsin L stabilizes the histone modification landscape on the y chromosome and pericentromeric heterochromatin. Molecular and Cellular Biology 26(11): 4172-84.

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Publications 2006JCSMR Publications

Bunting, K, Wang, J, and Shannon, MF (2006) Control of interleukin-2 gene transcription: a paradigm for inducible, tissue-specific gene expression. Interleukins. ed. G Litwack. Elsevier Academic Press Inc. Vol 74:105-145.

Burden, CJ, Pittelkow, Y, and Wilson, SR (2006) Adsorption models of hybridization and post-hybridization behaviour on oligonucleotide microarrays. Journal of Physics-Condensed Matter 18(23): 5545-5565.

Bystrom, J, Dyer, KD, Ravin, SS, Naumann, N, Stephany, DA, Foster, PS, Wynn, TA, and Rosenberg, HF (2006) Interleukin-5 does not influence differential transcription of transmembrane and soluble isoforms of IL-5Ralpha in vivo. European Journal of Haematology 77(3): 181-90.

Cameron, AM, Mahroo, OAR, and Lamb, TD (2006) Dark adaptation of human rod bipolar cells measured from the b wave of the scotopic electroretinogram. Journal of Physiology 575(2): 507-526.

Carr, PD, Conlan, F, Ford, S, Ollis, DL, and Young, IG (2006) An improved resolution structure of the human beta common receptor involved in IL-3, IL-5 and GM-CSF signalling which gives better definition of the high-affinity binding epitope. Acta Crystallographica. Section F- structural biology and crystallization communications. 62(6): 509-513.

Casarotto, MG, Cui, YF, Karunasekara, Y, Harvey, PJ, Norris, N, Board, PG, and Dulhunty, AF (2006) Structural and functional characterization of interactions between the dihydropyridine receptor II-III loop and the ryanodine receptor. Clinical and Experimental Pharmacology and Physiology 33(11): 1114-1117.

Chaudhri, G, Panchanathan, V, Bluethmann, H, and Karupiah, G (2006) Obligatory requirement for antibody in recovery from a primary poxvirus infection. Journal of Virology 80(17): 8844.

Clark, IA, Budd, AC, Alleva, LM, and Cowden, WB (2006) Human malarial disease: a consequence of inflammatory cytokine release. Malaria Journal 5: 85-85.

Cook, MC, Vinuesa, CG, and Goodnow, CC (2006) ENU-mutagenesis: insight into immune function and pathology. Current Opinion in Immunology 18(5): 627-633.

Coupar, BEH, Purcell, DFJ, Thomson, SA, Ramshaw, IA, Kent, SJ, and Boyle, DB (2006) Fowlpox virus vaccines for HIV and SHIV clinical and pre-clinical trials. Vaccine 24(99): 1378-1388.

Dahlke, MH, Loi, R, Warren, A, Holz, L, Popp, FC, Weiss, DJ, Piso, P, Bowen, DG, McCaughan, GW, Schlitt, HJ, and Bertolino, P (2006) Immune-mediated hepatitis drives low-level fusion between hepatocytes and adult bone marrow cells. Journal of Hepatology 44(2): 334-341.

Dale, CJ, Thomson, S, De Rose, R, Ranasinghe, C, Medveczky, CJ, Pamungkas, J, Boyle, DB, Ramshaw, IA, and Kent, SJ (2006) Prime-boost strategies in DNA vaccines. DNA Vaccines - Methods and Protocols. Ed. WM Saltzman, Totowa, New Jersey, USA: Humana Press Inc. pp. 171-198.

Davie, JT, Kole, MH, Letzkus, JJ, Rancz, EA, Spruston, N, Stuart, GJ, and Hausser, M (2006) Dendritic patch-clamp recording. Nature Protocols 1: 1235-1247.

De Rose, R, Sullivan, MT, Dale, CJ, Kelleher, AD, Emery, S, Cooper, DA, Ramshaw, IA, Boyle, D, and Kent, SJ (2006) Dose-response relationship of DNA and recombinant fowlpox virus prime-boost HIV vaccines: Implications for future trials. Human Vaccines 2(3): 134-136.

Dixon, C, Christie, J, Milburn, P, Matthaei , KI, Foster, PS, and Webb, DC (2006) Proteomic analysis of bronchoalveolar lavage fluid from allergic mice reveals a potential therapeutic protein. 16th European Congress of Immunology. pp.

Dulhunty, AF (2006) Excitation-contraction coupling from the 1950s into the new millennium. Clinical and Experimental Pharmacology and Physiology 33(9): 763-772.

Dulhunty, AF, Beard, NA, Pouliquin, P, and Kimura, T (2006) Novel regulators of RyR Ca2+ release channels: insight into molecular changes in genetically-linked myopathies. Journal of Muscle Research and Cell Motility 27(5-7): 351-365.

Edwards, FR and Hirst, GDS (2006) An electrical analysis of slow wave propagation in the guinea-pig gastric antrum. Journal of Physiology-London 571: 179-189.

Faber, ESL, Sedlak, P, Vidovic, M, and Sah, P (2006) Synaptic activation of transient receptor potential channels by metabotropic glutamate receptors in the lateral amygdala. Neuroscience 137(3): 781-794.

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JCSMR Publications

Fang, YY, Kashkarov, U, Anders, MW, and Board, PG (2006) Polymorphisms in the human glutathione transferase zeta promoter. Pharmacogenetics and Genomics 16(4): 307-13.

Forbes, E, Hulett, M, Ahrens, R, Wagner, N, Smart, V, Matthaei, KI, Brandt, EB, Dent, LA, Rothenberg, ME, Tang, M, Foster, PS, and Hogan, SP (2006) ICAM-1-dependent pathways regulate colonic eosinophilic inflammation. Journal of Leukocyte Biology 80(2): 330-341.

Franklin, A and Blanden, RV (2006) A/T-targeted somatic hypermutation: critique of the mainstream model. Trends in Biochemical Sciences 31(5): 252-258.

Gibbs, GM, Scanlon, MJ, Swarbrick, J, Curtis, S, Gallant, E, Dulhunty, AF, and O’Bryan, MK (2006) The cysteine-rich secretory protein domain of Tpx-1 is related to ion channel toxins and regulates ryanodine receptor Ca2+ signaling. Journal of Biological Chemistry 281(7): 4156-4163.

Goffin, L, Vodala, S, Fraser, C, Ryan, J, Timms, M, Meusburger, S, Catimel, B, Nice, EC, Silver, PA, Xiao, CY, Jans, DA, and Gething, MJH (2006) The unfolded protein response transducer Ire1p contains a nuclear localization sequence recognized by multiple beta importins. Molecular Biology of the Cell 17(12): 5309-5323.

Goodnow, CC (2006) Discriminating microbe from self suffers a double toll. Science 312(5780): 1606-1608.

Gopinath, B, Musselman, R, Adams, CL, Tani, J, Beard, N, and Wall, JR (2006) Study of serum antibodies against three eye muscle antigens and the connective tissue antigen collagen XIII in patients with Graves’ disease with and without ophthalmopathy: Correlation with clinical features. Thyroid 16(10): 967-974.

Gopinath, B, Musselman, R, Beard, N, El-Kaissi, S, Tani, J, Adams, CL, and Wall, JR (2006) Antibodies targeting the calcium binding skeletal muscle protein calsequestrin are specific markers of ophthalmopathy and sensitive indicators of ocular myopathy in patients with Graves’ disease. Clinical and Experimental Immunology 145(1): 56-62.

Gray, DHD, Seach, N, Ueno, T, Milton, MK, Liston, A, Lew, AM, Goodnow, CC, and Boyd, RL (2006) Developmental kinetics, turnover, and stimulatory capacity of thymic epithelial cells. Blood 108(12): 3777-3785.

Grayson, TH (2006) Is Cx40 a marker for hypertension? Journal of Hypertension 24(2): 279-280.

Gready, JE, Rostov, I and Cummins, PL (2006) Simulations of enzyme reaction mechanisms in active sites: accounting for an environment which is much more than a solvent perturbation. Modelling Molecular Structure and Reactivity in Biological Systems. eds. K.J. Naidoo, M. Hann, J. Gao, M. Field and J, Brady, Eds., Royal Society of Chemistry, London. pp. 101-118

Greaves, IK, Rangasamy, D, Devoy, M, Graves, JAM, and Tremethick, DJ (2006) The X and Y chromosomes assemble into H2A.Z, containing facultative heterochromatin, following meiosis. Molecular and Cellular Biology 26(19): 7343-7343.

Haddock, RE, Grayson, TH, Brackenbury, TD, Meaney, KR, Neylon, CB, Sandow, SL, and Hill, CE (2006) Endothelial coordination of cerebral vasomotion via myoendothelial gap junctions containing connexins 37 and 40. American Journal of Physiology - Heart and Circulatory Physiology. 291: H2047-H2056.

Halenius, A, Momburg, F, Reinhard, H, Bauer, D, Lobigs, M, and Hengel, H (2006) Physical and functional interactions of the cytomegalovirus US6 glycoprotein with the transporter associated with antigen processing (TAP). Journal of Biological Chemistry 281: 5383-5390.

Harrison, JM, Bertram, EM, Boyle, DB, Coupar, BEH, Ranasinghe, C, and Ramshaw, I (2006) 4-1BBL coexpression enhances HIV-specific CD8 T cell memory in a poxvirus prime-boost vaccine. Vaccine 24(47-48): 6867-6874.

Harrison, JM, Bertram, EM, and Ramshaw, IA (2006) Exploiting 4-1BB costimulation for enhancing antiviral vaccination. Viral Immunology 19(4): 593-601.

Harrison, JM and Ramshaw, IA (2006) Cytokines, skin, and smallpox - A new link to an antimicrobial peptide. Immunity 24(3): 245-247.

Hirst, GDS and Edwards, FR (2006) Electrical events underlying organized myogenic contractions of the guinea pig stomach. Journal of Physiology-London 576(3): 659-665.

Hirst, GDS, Garcia-Londono, AP, and Edwards, FR (2006) Propagation of slow waves in the guinea-pig gastric antrum. Journal of Physiology-London 571(1): 165-177.

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Hirst, GDS and Suzuki, H (2006) Involvement of interstitial cells of Cajal in the control of smooth muscle excitability. Journal of Physiology-London 576(3): 651-652.

Ho, JW, Adams, CE, Lew, JB, Matthews, TJ, Ng, CC, Shahabi-Sirjani, A, Tan, LH, Zhao, Y, Easteal, S, Wilson, SR, and Jermiin, LS (2006) SeqVis: visualization of compositional heterogeneity in large alignments of nucleotides. Bioinformatics 22(17): 2162-2163.

Hoyne, GF and Goodnow, CC (2006) The use of genomewide ENU mutagenesis screens to unravel complex mammalian traits: identifying genes that regulate organ-specific and systemic autoimmunity. Immunological Reviews 210: 27-39.

Hu, L, Zhang, Y, Lim, PS, Miao, Y, Tan, C, McKenzie, KUS, Schyvens, CG, and Whitworth, JA (2006) Apocynin but not l-Arginine prevents and reverses dexamethasone-induced hypertension in the rat. American Journal of Hypertension 19(4): 413-418.

Ikeda, K and Bekkers, JM (2006) Autapses. Current Biology 16(9): R308.

Jayasekera, JP, Vinuesa, CG, Karupiah, G, and King, NJC (2006) Enhanced antiviral antibody secretion and attenuated immunopathology during influenza virus infection in nitric oxide synthase-2-deficient mice. Journal of General Virology 87: 3361-3371.

Kampa, BM, Letzkus, JJ, and Stuart, GJ (2006) Requirement of dendritic calcium spikes for induction of spike-timing-dependent synaptic plasticity. Journal of Physiology 574(1): 283-290.

Kampa, BM, Letzkus, JJ, and Stuart, GJ (2006) Cortical feed-forward networks for binding different streams of sensory information. Nature Neuroscience 9(12): 1472-1473.

Kampa, BM and Stuart, GJ (2006) Calcium spikes in basal dendrites of layer 5 pyramidal neurons during action potential bursts. Journal of Neuroscience 26(28): 7424-32.

Kelleher, AD, Puls, RL, Bebbington, M, Boyle, D, Ffrench, R, Kent, SJ, Kippax, S, Purcell, DFJ, Thomson, S, Wand, H, Cooper, DA, and Emery, S (2006) A randomized, placebo-controlled phase I trial of DNA prime, recombinant fowlpox virus boost prophylactic vaccine for HIV-1. AIDS Research and Human Retroviruses 20(2): 294-297.

Kennedy, CL, O’Connor, AEO, Sanchez-Partida, LG, Holland, MK, Goodnow, CC, de Kretser, DM, and O’Bryan, MK (2006) A repository of ENU mutant mouse lines and their potential for male fertility research. Molecular Human Reproduction 11(12): 871-880.

Kole, MH, Hallermann, S, and Stuart, GJ (2006) Single Ih channels in pyramidal neuron dendrites: properties, distribution, and impact on action potential output. Journal of Neuroscience 26(6): 1677-87.

Kumar, RK, Webb, DC, Herbert, C, and Foster, PS (2006) Interferon-gamma as a Possible Target in Chronic Asthma. Inflammation and Allergy Drug Targets 5(4): 253-6.

Lamb, TD and Pugh, EN Jr (2006) Phototransduction, dark adaptation, and rhodopsin regeneration - The Proctor Lecture. Investigative Ophthalmology and Visual Science 47(12): 5138-5152.

Leao, KE, Leao, RN, Sun, H, Fyffe, REW, and Walmsley, B (2006) Hyperpolarization-activated currents are differentially expressed in mice brainstem auditory nuclei. Journal of Physiology 576(3): 849-864.

Leao, RN, Naves, MM, Leao, KE, and Walmsley, B (2006) Altered sodium currents in auditory neurons of congenitally deaf mice. European Journal of Neuroscience 24(4): 1137-1146.

Leao, RN, Sun, H, Svahn, K, Berntson, A, Youssoufian, M, Paolini, AG, Fyffe, REW, and Walmsley, B (2006) Topographic organization in the auditory brainstem of juvenile mice is disrupted in congenital deafness. Journal of Physiology 571(3): 563-78.

Leck, KJ, Blaha, CD, Matthaei, KI, Forster, GL, Holgate, J, and Hendry, IA (2006) G(z) proteins are functionally coupled to dopamine D2-like receptors in vivo. Neuropharmacology 51(3): 597-605.

Lee, E, Pavy, M, Young, N, Freeman, C, and Lobigs, M (2006) Antiviral effect of the heparan sulfate mimetic, PI-88, against dengue and encephalitic flaviviruses. Antiviral Research 69(31-38).

Lee, E, Wright, PJ, Davidson, A, and Lobigs, M (2006) Virulence attenuation of Dengue virus due to augmented glycosaminoglycan-binding affinity and restriction in extraneural dissemination. Journal of General Virology 87: 2791-2801.

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Letzkus, JJ, Kampa, BM, and Stuart, GJ (2006) Learning rules for spike timing-dependent plasticity depend on dendritic synapse location. Journal of Neuroscience 26(41): 10420-10429.

Linares, D, Taconis, M, Mana, P, Correcha, M, Fordham, S, Staykova, M, and Willenborg, DO (2006) Neuronal nitric oxide synthase plays a key role in CNS demyelination. Journal of Neuroscience 26(49): 12672-12681.

Liu, SM, Xavier, R, Good, KL, Chtanova, T, Newton, R, Sisavanh, M, Zimmer, S, Deng, CY, Silva, DG, Frost, MJ, Tangye, SG, Rolph, MS, and Mackay, CR (2006) Immune cell transcriptome datasets reveal novel leukocyte subset-specific genes and genes associated with allergic processes. Journal of Allergy and Clinical Immunology 118(2): 496-503.

Liu, WJ, Wang, XJ, Clark, DC, Lobigs, M, Hall, RA, and Khromykh, AA (2006) A single amino acid substitution in the West Nile virus nonstructural protein NS2A disables its ability to inhibit interferon alpha/beta induction and attenuates virus virulence in mice. Journal of Virology 80: 2396-2404.

Luu, T, Gage, PW, and Tierney, ML (2006) GABA increases both the conductance and mean open time of recombinant GABAA channels co-expressed with GABARAP. Journal of Biological Chemistry 281(47): 35699-35708.

Maddess, T, James, AC, Ruseckaite, R, and Bowman, EA (2006) Hierarchical decomposition of dichoptic multifocal visual evoked potentials. Visual Neuroscience 23(5): 703-712.

Manderson, AP, Quah, B, Botto, M, Goodnow, CC, Walport, MJ, and Parish, CR (2006) A novel mechanism for complement activation at the surface of B cells following antigen binding. Journal of Immunology 177(8): 5155-5162.

Mangos, GJ, Walker, BR, Williamson, PA, Whitworth, JA, and Kelly, JJ (2006) Effect of synthetic corticosteroids on vascular reactivity in the human forearm. Clinical and Experimental Hypertension 28(8): 707-718.

May, F, Lobigs, M, Lee, E, Gendle, Mackenzie, JS, Broom, AK, Conlan, JV, and Hall, RA (2006) Biological, antigenic and phylogenetic characterisation of the flavivirus Alfuy. Journal of General Virology 87: 329-337.

McColl, CD, Jacoby, AS, Shine, J, Iismaa, TP, and Bekkers, JM (2006) Galanin receptor-1 knockout mice exhibit spontaneous epilepsy, abnormal EEGs and altered inhibition in the hippocampus. Neuropharmacology 50(2): 209-218.

Mondo, CK, Zhang, Y, Possamai, VD, Miao, YC, Schyvens, CG, McKenzie, KUS, Hu, LX, Guo, ZJ, and Whitworth, JA (2006) N-acetylcysteine antagonizes the development but does not reverse ACTH-induced hypertension in the rat. Clinical and Experimental Hypertension 28(2): 73-84.

Mullbacher, A, Lobigs, M, Alsharifi, M, and Regner, M (2006) Cytotoxic T-cell immunity as a target for influenza vaccines. Lancet Infectious Diseases 6(5): 255-256.

Murphy, JM and Young, IG (2006) IL-3, IL-5, and GM-CSF signalling: Crystal structure of the human beta-common receptor. Interleukins. ed. G Litwack. Elsevier Academic Press Inc. Vol 74:1-32.

Ng, CH, Easteal, S, Tan, S, Schweitzer, I, Ho, BKW, and Aziz, S (2006) Serotonin transporter polymorphisms and clinical response to sertraline across ethnicities. Progress in Neuro-psychopharmacology and Biological Psychiatry 30(5): 953-957.

Nijnik, A, Ferry, H, Lewis, G, Rapsomaniki, E, Leung, JCH, Daser, A, Lambe, T, Goodnow, CC, and Cornall, RJ (2006) Spontaneous B cell hyperactivity in autoimmune-prone MRL mice. International Immunology 18(7): 1127-1137.

Palmer, LM and Stuart, GJ (2006) Site of action potential initiation in layer 5 pyramidal neurons. Journal of Neuroscience 26(6): 1854-63.

Panchanathan, V, Chaudhri, G, and Karupiah, G (2006) Protective immunity against secondary poxvirus infection is dependent on antibody but not on CD4 or CD8 T-cell function. Journal of Virology 80(13): 63333-6338.

Pardo, J, Urban, C, Galvez, EM, Ekert, PG, Muller, U, Kwon-Chung, J, Lobigs, M, Mullbacher, A, Wallich, R, Borner, C, and Simon, MM (2006) The mitochondrial protein Bak is pivotal for gliotoxin-induced apoptosis and a critical host factor of Aspergillus fumigatus virulence in mice. The Journal of Cell Biology 174(4): 509-519.

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Parish, CR (2006) The role of heparan sulphate in inflammation. Nature Reviews Immunology 6(9): 633-643.

Patterson J, Chandrasekara, A, Bao, S, Hegedus, E, Caterson, I, Denyer G, Turner, B, Mullbacher, A and Chin, J (2006) Prebiotic supplementation with resistant starch alters health indices associated with metabolic changes and intestinal dysbiosis. International Journal of Probiotics and Prebiotics 1:181-192.

Pouliquin, P, Pace, SM, Curtis, SM, Harvey, PJ, Gallant, EM, Zorzato, F, Casarotto, MG, and Dulhunty, AE (2006) Effects of an alpha-helical ryanodine receptor C-terminal tail peptide on ryanodine receptor activity: Modulation by Homer. International Journal of Biochemistry and Cell Biology 38(10): 1700-1715.

Premkumar, A, Dong, XB, Haqshenas, G, Gage, PW, and Gowans, EJ (2006) Amantadine inhibits the function of an ion channel encoded by GB virus B, but fails to inhibit virus replication. Antiviral Therapy 11(3): 289-295.

Prescott, VE, Forbes, E, Foster, PS, Matthaei, K, and Hogan, SP (2006) Mechanistic analysis of experimental food allergen-induced cutaneous reactions. Journal of Leukocyte Biology 80(2): 258-266.

Prescott, VE and Hogan, SP (2006) Genetically modified plants and food hypersensitivity diseases: Usage and implications of experimental models for risk assessment. Pharmacology and Therapeutics 111(2): 374-383.

Prichard, Z and Easteal, S (2006) Characterization of simple sequence repeat variants linked to candidate genes for behavioral phenotypes. Human Mutation 27(1): 120.

Ranasinghe, C, Medveczky, JC, Woltring, D, Gao, K, Thomson, S, Coupar, BEH, Boyle, DB, Ramsay, AJ, and Ramshaw, IA (2006) Evaluation of fowlpox-vaccinia virus prime-boost vaccine strategies for high-level mucosal and systemic immunity against HIV-1. Vaccine 24(31-32): 5881-5895.

Rao, S, Bunting, K, Sutcliffe, EL, and Shannon, F (2006) Deciphering regulatory networks controlled by the NF-kB transcription factor c-Rel in T cells. Microarrays and Transcription Networks, eds. MF Shannon and S Rao. Landes Bioscience, Georgetown, Texas. pp. 75-89.

Raymond, CR and Redman, SJ (2006) Spatial segregation of neuronal calcium signals encodes different forms of LTP in rat hippocampus. Journal of Physiology-London 570(1): 97-111.

Rolph, M, S, Young, T, R, Shum, BOV, Gorgun, CZ, Schmitz-Peiffer, C, Ramshaw, IA, Hotamisligil, GS, and Mackay, CR (2006) Regulation of dendritic cell function and T cell priming by the fatty acid-binding protein aP2. Journal of Immunology 177(11): 7794-7801.

Rui, LX and Goodnow, CC (2006) Lymphoma and the control of B cell growth and differentiation. Current Molecular Medicine 6(3): 291-308.

Rui, LX, Healy, JI, Blasioli, J, and Goodnow, CC (2006) ERK signalling is a molecular switch integrating opposing inputs from B cell receptor and T cell cytokines to control TLR4-Driven plasma cell differentiation. Journal of Immunology 177(8): 5337-5346.

Rummery, N and Hill, C, (2006) The Role of Gap Junctions in the Regulation of Arteriolar Tone. Microvascular Research: Biology and Pathology. ed. D Shepro. Elsevier BV. Vol1: pp. 275-280.

Ruseckaite, R, Maddess, T, Danta, G, and James, AC (2007) Frequency doubling illusion VEPs and automated perimetry in multiple sclerosis. Documenta Ophthalmologica 113(1): 29-41.

Ryu, KY, Baker, RT, and Kopito, RR (2006) Ubiquitin-specific protease 2 as a tool for quantification of total ubiquitin levels in biological specimens. Analytical Biochemistry 353(1): 153-5.

Schofield, PW, Gibson, R, Tavener, M, Attia, R, D’Este C, Guest, M, Brown, AM, Lee, SJ, Horsley, K, Harrex, W, and Ross, J (2006) Neurophysiological health in F-111 aircraft maintenance workers. (Schofield, P W on behalf of the SHOAMP study team and scientific advisory committee, Chair: JA Whitworth) Neurotoxicology 27(5): 852-60.

Shannon, MF, Chen, X, Brettingham-Moore, K, and Holloway, A (2006) Chromatin remodelling: Distinct molecular events during differentiation and activation of T cells. Current Immunology Reviews 2: 273-289.

Sharkhuu, T, Matthaei, K, Forbes, E, Mahalingam, S, Hogan, SP, Hansbro, PM, and Foster, PS (2006) Mechanism of interleukin-25 (IL-17E)-induced pulmonary inflammation and airways hyper-reactivity. Clinical and Experimental Allergy 36:1575-1583.

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JCSMR Publications

Shield, AJ, Murray, TP, and Board, PG (2006) Functional characterisation of ganglioside-induced differentiation-associated protein 1 as a glutathione transferase. Biochemical and Biophysical Research Communications 347(4): 859-866.

Siegle, JS, Hansbro, N, Herbert, C, Yang, M, Foster, PS, and Kumar, RK (2006) Airway hyperreactivity in exacerbation of chronic asthma is independent of eosinophilic inflammation. American Journal of Respiratory Cell and Molecular Biology 35(5): 565-570.

Siggs, OM, Makaroff, LE, and Liston, A (2006) The why and how of thymocyte negative selection. Current Opinion in Immunology 18(2): 175-83.

Socha, LA, Gowardman, J, Silva, D, Correcha, M, and Petrosky, N (2006) Elevation in interleukin 13 levels in patients diagnosed with systemic inflammatory response syndrome. Intensive Care Medicine 32(2): 244-250.

Song, ZM, Hu, J, Rudy, B, and Redman, SJ (2006) Developmental changes in the expression of calbindin and potassium-channel subunits Kv3.1b and Kv3.2 in mouse Renshaw cells. Neuroscience 141(1): 543-543.

Staykova, M, Fordham, S, Bartell, G, Cowden, W, and Willenborg, D (2006) Nitric oxide contributes to the resistance of young SJL/J mice to experimental autoimmune encephalomyelitis. Journal of Neuroimmunology 176(1-2): 1-8.

Strumbo, B, Sangiorgio, L, Ronchi, S, Gready, J, and Simonic, T (2006) Cloning and analysis of transcripts and genes encoding fish-specific proteins related to PrP. Fish Physiology and Biochemistry 32(4): 339-353.

Stuart, G and Palmer, L (2006) Imaging membrane potential in dendrites and axons of single neurons. Pflugers Archiv-Euopean Journal of Physiology 453(3): 403-410.

Suzuki, N and Bekkers, JM (2006) Neural coding by two classes of principal cells in the mouse piriform cortex. Journal of Neuroscience 26(46): 1 1938-11947.

Swartz, JM, Dyer, KD, Cheever, AW, Ramalingam, T, Pesnicak, L, Domachowske, JB, Lee, JJ, Lee, NA, Foster, PS, Wynn, TA, and Rosenberg, HF (2006) Schistosoma mansoni infection in eosinophil lineage-ablated mice. Blood 108(7): 2420-2427.

Tremethick, D (2006) Chromatin: the dynamic link between structure and function. Chromosome Research 14(1): 1-4.

Tscharke, DC, Woo, W-P, Sakala, IG, Sidney, J, Sette, A, Moss, DJ, Bennick, JR, Karupiah, G, and Yewdell, JW (2006) Poxvirus CD8+ T-Cell Determinants and Cross-Reactivity in BALB/c Mice. Journal of Virology 80(13): 6318-6323.

van Hateren, JH and Lamb, TD (2006) The photocurrent response of human cones is fast and monophasic. BMC Neuroscience 7(34).

Wakefield, MJ and Alsop, AE (2006) Assignment of breast cancer associated 1 (BRCA1) to tammar wallaby (Macropus eugenii) chromosome 2q3 in situ hybridization. Cytogenetic and Genome Research 112:180C.

Walker, EJ, Riddell, J, Rodgers, HJ, Bassett, ML, Wilson, SR, and Cavanaugh, JA (2006) IL1RN genotype as a risk factor for joint pain in hereditary haemochromatosis? Annals of the Rheumatic Diseases 65(2): 271-272.

Walmsley, B, Berntson, A, Leao, RN, and Fyffe, REW (2006) Activity-dependent regulation of synaptic strength and neuronal excitability in central auditory pathways. Journal of Physiology 572(2): 313-321.

Wang, J, Shannon, MF, and Young, IG (2006) A role for Ets1, synergizing with AP-1 and GATA-3 in the regulation of IL-5 transcription in mouse Th-2 lymphocytes. International Immunology 18(20): 313-323.

Wang, Y, Lobigs, M, Lee, E, Koskinen, A, and Mullbacher, A (2006) CD8+ T cell-mediated immune responses in West Nile virus (Sarafend strain) encephalitis are independent of gamma interferon. Journal of General Virology 87: 3599-3609.

Warren, HS, Rana, PM, Rieger, DT, Hewitt, KA, Dahlstrom, JE, and Kent, AL (2006) CD8 T cells expressing killer Ig-like receptors and NKG2A are present in cord blood and express a more naive phenotype than their counterparts in adult blood. Journal of Leukocyte Biology 79: 1252-1259.

Wei, L, Varsanyi, M, Dulhunty, AF, and Beard, NA (2006) The conformation of calsequestrin determines its ability to regulate skeletal ryanodine receptors. Biophysical Journal 91(4): 1288-1301.

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Publications 2006

Whitworth, JA (2006) Best practices in use of research evidence to inform health decisions. Health Research Policy and Systems 4:11

Whitworth, JA, Zhang, Y, Mangos, G, and Kelly, JJ (2006) Species variability in cardiovascular research: The example of adrenocorticotrophin-induced hypertension. Clinical and Experimental Pharmacology and Physiology 33(9): 887-891.

Wilson, L, Gage, P, and Ewart, G (2006) Hexamethylene amiloride blocks E protein ion channels and inhibits coronavirus replication. Virology 353(2): 294-306.

Wilson, L, Gage, P, and Ewart, G, 2006, Validation of coronavirus e proteins ion channels as targets for antiviral drugs. The Nidoviruses: Toward Control of SARS and other Nidovirus Diseases, eds. S Perlman and KV Holmes. Springer. pp 573-578.

Yang, M, Rangasamy, D, Matthaei, KI, Frew, AJ, Zimmmermann, N, Mahalingam, S, Webb, DC, Tremethick, DJ, Thompson, PJ, Hogan, SP, Rothenberg, ME, Cowden, WB, and Foster, PS (2006) Inhibition of arginase I activity by RNA interference attenuates IL-13-induced airways hyperresponsiveness. Journal of Immunology 177(8): 5595-5603.

Yang, TZ, Riehl, J, Esteve, E, Matthaei, KI, Goth, S, Allen, PD, Pessah, IN, and Lopez, JR (2006) Pharmacologic and functional characterization of malignant hyperthermia in the R163C RyR1 knock-in mouse. Anesthesiology 105(6): 1164-1175.

Zaunders, JJ, Dyer, WB, Munier, ML, Ip, S, Liu, J, Amyes, E, Rawlinson, W, De Rose, R, Kent, SJ, Sullivan, JS, Cooper, DA, and Kelleher, AD (2006) CD127+CCR5+CD38+++CD4+ Th1 effector cells are an early component of the primary immune response to vaccinia virus and precede development of interleukin-2+ memory CD4+ T cells. Journal of Virology 80(20): 10151-10161.

Zhang, JH, Kawashima, S, Yokoyama, M, Huang, P, and Hill, CE (2006) Increased eNOS accounts for changes in connexin expression in renal arterioles during diabetes. The Anatomical Record Part A- Discoveries in Molecular Cellular and Evolutionary Biology 288A(9): 1000-1008.

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TheJohnCurtinSchoolofMedicalResearchiscommittedto

maintainingcontactwithourpaststaffandstudentsthrough

ourAlumniandFriendsnetwork.Westrivetostrengthenour

tieswithourlocalCanberracommunitythroughvisitsand

speakingengagements.

Forinformationaboutjoiningthisgrowingnetworkoffriends

andsupporters,pleasecontactourPublicAffairsManager:

Dr Madeleine Nicol E:[email protected]

T:+61261252577 F:+61261252337

Our Community


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Com

mun

ity

Cont

act

2006

New facility takes major step in cancer fightMrTomDery,ChairmanofTheAustralian

CancerResearchFoundation(ARCF),with

ProfessorFrancesShannon,ProfessorJudith

WhitworthandProfessorIanChubbatthe

officialopeningoftheACRFBiomolecular

ResourceFacilitylocatedinthenewJohn

CurtinSchoolofMedicalResearchbuilding.

TheACRFhasdonated$1.3Mtowardsset

upandequipmentforthisfacility.Thiswill

provideamuchneededresourcetoscientists

carryingoutresearchintocancerinthe

ACTregion.

Our Community 2006

Opening of the Finkel Lecture TheatreDrsAlanandElizabethFinkelofficiallyopenedtheFinkelLectureTheatreinthenewJCSMRbuildingduringOctober.

DrAlanFinkel,neuroscientistandentrepreneurhaslongbeenassociatedwithJCSMR,sincehispostdoctoralfellowship

inneuroscienceintheearly1980’s.DrElizabethFinkelisanotedsciencecommunicator.Theeventwasalsoattendedby

MrsVeraFinkel,andAlexFinkel.

Nobel Laureate visits JCSMRNobelLaureateEmeritusProfessorJRobin

WarrenvisitedTheJohnCurtinSchoolof

MedicalResearchtospeakinformallywith

studentsatafternoontea.ProfessorWarren,

picturedwithMaryWarren,wasawarded

TheNobelPrizeinPhysiologyorMedicine

2005conjointlywithProfessorBarry

Marshallfor“theirdiscoveryofthebacterium

‘Helicobacterpylori’anditsroleingastritis

andpepticulcerdisease”.

phot

oby

Stu

artH

ay

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Comm

unity Contact 2006

Contact with our Community

Telstra Businesswomen’s Breakfast at JCSMRProfessor Judith Whitworth hosted the Telstra Businesswomen’s network breakfast in the new Board Room in September.

Drs Carola de Vinuesa, Luby Simson, Anneke Blackburn and Monique Youssoufian discussed the expected outcomes of their research.

JCSMR RetreatStaff and students of the JCSMR attended a one day scientific Retreat ‘At Home’ this year, hearing presentations about research and future plans for all areas of the school. As part of the day, staff and students were invited to be a part of an all-school photo, celebrating the move into Stage 1 of our new building.

The Hon. Tony Abbot and JDRF representative Lara sign the card • Mr Robert de Castella, Lara, and The Hon. Tony Abbott • Professor Warwick Anderson (Chief Executive Office National Health & Medical Research Council) Mr Robert de Castella, Ms Rebecca James (Chief Executive Officer Research Australia) and The Hon. Tony Abbott cut a cake at the Research Australia Thank You day celebrations.

Thank You DayResearch Australia hosted the Canberra launch of the 4th Annual Thank You Day celebrations in the JCSMR foyer during October. The Thank You Day card was signed by sporting personalities, medical researchers and health consumers from the Canberra region, including Mr Robert de Castella, former marathon champion. The Federal Minister for Health and Ageing, The Hon. Tony Abbott attended the launch.

Town & GownTown and Gown Christmas

drinks were held at The

John Curtin School of

Medical Research early

in December. The annual

Town and Gown event

celebrates successful

research and endeavour

by bringing together

members of the University

and business communities

from Canberra and the

surrounding region.

Top: Ms Mary-Anne Waldren (Executive Director, Australian Science Festival Ltd) and Dr Susan Stocklmayer (Director, Centre for the Public Awareness of Science, ANU) at the JCSMR Town and Gown event.

Bottom: Professor Helen Christensen (Director Centre for Mental Health Research, ANU) The Hon. Margaret Reid and Mr Robert Wells (Executive Director, ANU College of Medicine and Health Sciences) attend the JCSMR Town and Gown event.

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Com

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Cont

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2006

Join us on Open Day 2007Bookings essential for school groups only

Please contact Dr Madeleine Nicol on

T: 6125 2577 or

E: [email protected]

Open Day 2006

NextOpenDayFriday17August2007,10am–5pm

OnOpenDay,theSchoolisopentoallmembersofthepublic.•Studentsinterestedinmedicalresearchareparticularlyinvited

toattend.•Researchersinfieldsasdiverseasasthma,diabetes,hearing,HIVandcanceropenthedoorsoftheirlaboratoriesto

demonstratetheirworkandanswerquestions.

TheSchoolisopenduringNationalScienceWeekaspartoftheAustralianScienceFestival.•TheJohnCurtinSchoolofMedicalResearchannualOpenDaygivesyoutheopportunitytotalktoscientistsintheirworkinglaboratories.

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Voluntary Service 2006

Commitment to Serving our Community

StaffandstudentsoftheJCSMRareinvolvedinmanyactivitieswhichrelatetotheirresearchbutextendbeyondtheirlaboratorywork.

Inadditiontotheactivitieslistedbelow,JCSMRstaffandstudentsspeakwithcommunitygroupsandinterestedmembersofthepublicthroughsuchactivitiesasNationalYouthScienceForumandJCSMROpenDay,actasrefereesformanyscientificpublicationsandactasexpertassessorsforawiderangeofnationalandinternationalgrantingbodies.

Someothervoluntaryactivitiesarelistedbelow.

Professor GL AdaMember: Australian Influenza Vaccine CommitteeScientific Patron: Burnet Institute, Melbourne, VICPresenter and Participant: National Youth Science Forum at JCSMR, Canberra, ACTCourse Presenter: ACT Senior Colleges: The Importance of Vaccination

Dr RT BakerPresident and Executive Director: Genome Conference IncExecutive Council Member and Honorary Secretary: The Australian Society for Biochemistry andMolecular BiologyExpert Consultant: Human Gene Nomenclature Committee, LondonOrganising Committee Member: International Congress on Yeast Genetics and Molecular Biology,Melbourne, VIC (2007)

Dr JM BekkersDirector and Board Member: The Australian Advanced Neuroscience Research Initiative (AANRI), Moreton Bay Research Station, Stradbroke Island, QLDPanel Member: NHMRC - Neuroscience

Dr EM BertramTreasurer: Australasian Society of Immunology - ACT Branch

Dr A BlackburnCoordinator and Chair: Cancer Biology Workshop, JCSMR, Canberra, ACT

Professor PG BoardMember: Pharmaceutical subcommittee of Australian Drug Evaluation CommitteeAdvisor: Parkinson’s NSW Inc

Dr A CowanInstructor and presenter: The Australian Advanced Neuroscience Research Initiative (AANRI), MoretonBay Research Station, Stradbroke Island, QLD

Professor AF DulhuntyMember: International Union of Physiological Sciences (IUPS) Commission VI: Molecular and Cellular PhysiologyBoard of Directors: ACT Orthopaedic FoundationVice President and President Elect: Australian Society for BiophysicsPanel Member: NHMRC - Molecular Neuroscience

Professor S EastealHead: Research Committee, JDRLegal Pty LtdAdvisory Board: ARC Bioinformatics Centre of Excellence, The University of Queensland, Brisbane, QLD

Dr C FreemanACT convenor: Australian Society for Medical Research (ASMR)Forum Planning Committee Member: ASMR Young Investigator Advisor: ACT cancer website: http://www.hotkey.net.au/~string/listingACT representative: Matrix Biology Society of Australia and New Zealand

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Voluntary Service to Organisations Outside JCSMR

Professor CC GoodnowDeputy Chair: NHMRC Project Grants Review Panel 2aScientific Advisory Committee: Australian Genome Research FacilityMember: Australian Academy of Science, Chair of Sectional CommitteeMember: Australian Academy of Science Special Elections CommitteeMedical Science Review Board Member, Juvenile Diabetes Research FoundationCommunicating Editor: International ImmunologyMember: Infection and Immunity Strategic Advisory Committee, The Wellcome Trust, UKEditorial Board member: Immunity, The Journal of Experimental Medicine, Mammalian Genome, Genome Biology, Journal of Autoimmunity, BMC BiologyMember: Australian Society of ImmunologyMember: American Association of ImmunologistsMember: American Association for the Advancement of Science

Professor JE GreadyConvenor: Australian Society for Biochemistry and Molecular Biology Bioinformatics Special InterestGroupSpecialist Editor: Computer Physics Communications (Biophysics)Advisory Board Member: APAC Grid Program “Grid Resource Management System for Computational Molecular Science Applications”Scientific Adviser: Impact of the proposed Mary River on the survival of Australian lungfish

Professor IA HendryScience Advisor: Board of the Wenkart Foundation

Professor CE HillPanel Member: NHMRC - NeuroscienceACT Representative: ANZ Microcirculation Society

Dr M HulettNational Executive Director: Australian Society for Medical Research (until November)President-Elect and Honorary Treasurer: The Australian Society for Medical Research (from November)Mentor: ANU Distinguished Scholars ProgramPresenter and Participant: National Youth Science Forum at JCSMR, Canberra, ACTPresenter: Australian Medical Students Association Leadership Forum

Dr G HuttleyProgram committee member: Asia Pacific Bioinformatics Consortium

Dr G KarupiahACT Councillor: The Australasian Society for Immunology IncCouncillor: The Federation of Immunological Societies of Asia-Oceania

Professor TD LambAdvisory Editor: Journal of General Physiology

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Voluntary Service 2006

Dr KI MatthaeiConsultant: Australian Quarantine Inspection Service. Member: Stem Cell Ethics Australia Advisory Committee. Panel Member: NHMRC - InflammationMember: ANU Equity Diversity Consultative GroupMember: ANU Institutional Recombinant DNA Biosafety CommitteeAffiliate Member: Centre for the Molecular Genetics of DevelopmentMember: ARC Centre for Network in Genes and Environment in Development

Professor C ParishEditor-in-Chief: Immunology and Cell BiologyMedical Research Advisory Committee Member: The Australian Cancer Research FoundationANU representative: Program Management Committee of the Australian HIV Vaccine ConsortiumCouncil Member: The International Union of Immunological Societies (IUIS)

Professor IA RamshawScientific Advisory Panel Member: Westmead Institute for Cancer Research

Professor SJ RedmanTreasurer: International Brain Research OrganizationBoard Member: Neurosciences Australia LtdResearch Advisory Board Member: Prince of Wales Medical Research InstituteDirector: The Australian Advanced Neuroscience Research Initiative (AANRI), Moreton Bay ResearchStation, Stradbroke Island, QLDMember: NHMRC Program Grants Committee

Professor MF ShannonEditor: FEBS Letters (The Journal of the Federation of European Biochemical Societies)ACT Council Representative: Australian Society for Biochemistry and Molecular BiologyManagement Committee Member: Centre for Vascular Research, The University of New South Wales, Sydney, NSWBoard Member: Lorne Genome Inc

Associate Professor C StrickerInstructor and presenter: The Australian Advanced Neuroscience Research Initiative (AANRI), MoretonBay Research Station, Stradbroke Island, QLD

Dr GJ StuartInstructor and presenter: The Australian Advanced Neuroscience Research Initiative (AANRI), MoretonBay Research Station, Stradbroke Island, QLDChair: ACT “Brain Bee” committeeEditor: Journal of Physiology (London)

Dr ML TierneyOrganising Committee Member: Joint Australian Physiological Society & Australian Society for Biophysics

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Dr DJ TremethickInvited analyst: ChemtractBoard Member: Lorne Genome Inc.ACT representative: Australian Society for Medical Research

Dr CG VinuesaAssociate Editor: News and Commentary, Immunology and Cell BiologyMember: Australasian Society of Immunology

Dr HS WarrenCareer Development Award Committee Member: National Health and Medical Research Council of Australia

Professor JA WhitworthPatron: TADACT, Technical Aid to the Disabled ACTPatron: Wesley Institute, QLDHonorary Ambassador for WomenAmbassador for CanberraTrustee: High Blood Pressure Research Council of AustraliaDirector: Research AustraliaBoard Member: Menzies Research InstituteChair: Research and Development Advisory Committee, The George Institute, Sydney, NSWMember: National Health and Medical Research CouncilChair: Global Advisory Committee on Health Research, WHOMember: WHO Expert Advisory Panel on Health Science and Technology PolicyMember: WHO/ISH Liaison CommitteeMember: ISH International Scientific Program CommitteeWriting Committee Co-Chair: WHO/ISH GuidelinesChair: Selection Panel for the Commonwealth Health Minister’s Award for Excellence in Health andMedical ResearchDirector: Australian Science Festival Ltd (ASF)Ambassador: Heart Foundation (ACT Division)Member: The General Sir John Monash Awards Selection Committee

Professor IG YoungMember: Biological Defence Advisory Committee, (Department of Defence)Member: Awards Committee - Australian Society for Biochemistry and Molecular Biology


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Support to the School 2006

• Grants

• Statistics

• Donors


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Gra

mts

200

5 Grants 2006

ACT Knowledge Fund GrantDr E Bertram, Dr M C Cook, Dr K Nelms and Dr J CherringtonA new approach for the rapid discovery and validation of target genes for drug development$200,000

ANU Major Equipment GrantDr JM Bekkers, Dr G Stuart, Professor B Walmsley, Dr C Raymond and Dr C StrickerPulsed long-wavelength laser for two photon microscopy$192,000Professor CE Hill, Professor AF Dulhunty, Professor B Walmsley, Professor PG Board, Professor C Parish, Dr M Hulett , Dr RT Baker, Professor I Hendry, Dr G Karupiah, Dr ML Tierney and Dr KI MatthaeiHigh resolution digital camera for ultrastructural

studies of biological systems$116,640

Australian Research Council Centre of ExcellenceProfessor P Gresshoff, Professor C Beveridge, Dr B Carroll, Professor B Rolfe, Professor C Parish, Dr M Djordjevic, Dr G Weiller, Dr U Mathesius, Dr R Rose,Professor M Singh and Dr P BhallaIntegrative Legume Research$2,000,000

Australian Research Council Centre of Excellence in Vision ScienceProfessor TD LambResearch Director$2,200,000

Australian Research Council Discovery GrantsDr RT BakerRole of a novel zinc-binding motif in the structure-function of deubiquitinating enzymes$75,000Professor PG Board and Dr M CasarottoCellular uptake of glutathione transferases and their development as cell transfection agents$90,000

Professor AF Dulhunty, Dr DR Laver and Dr MG CasarottoIntrinsic properties of the pore forming domain of the ryanodine receptor calcium channel$105,000Professor S Easteal, Dr R Trent, Dr K North, Dr B Yu, Dr J Gulbin, Dr AG Hahn and Dr N YangIdentifying genes that modify athletic performance$75,000Professor S Easteal, Dr GA Huttley, Dr AV Isaev and Dr MJ WakefieldAdaptive evolution of BRCA1 in ancestral mammals$75,000Professor JE Gready and Dr PL CumminsImportance of conformational and electrostatic contributions in simulations of enzyme reaction mechanisms$93,300Professor CE HillInvolvement of cell coupling in vascular function: Development of a computational modelTotal $105,000Professor T Pogge and Professor JA WhitworthJust rules for incentivising pharmaceutical research for disseminating its benefits.$116,000Professor MF Shannon and Dr P GeorgelNew models for the role of chromatin in controlling inducible gene expression$105,000Dr D TremethickThe Dynamic Control of Chromatin Structure$90,000

Australian Research Council Federation FellowshipProfessor C GoodnowDiscovering genes and mechanisms regulating immune responses$158,111Professor TD LambThe first stage of vision: Transduction and adaptation in retinal photoreceptors$300,000

The amounts shown are for the calendar year 2006

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Grants 2006

Grants

Australian Research Council Linkage GrantsDr MG CasarottoMolecular Interactions of chemical agents with ion channel proteins$70,000Professor AF DulhuntyRefinement and delivery of synthetic compounds that specifically alter muscle contraction$50,000Professor AF Dulhunty, Dr CJ Easton and Dr MG CasarottoSynthetic compounds to specifically activate or inhibit ryanodine receptor calcium ion channels$45,000Professor JE Gready and Professor G OttingWhy is the photosynthetic CO2-fixing enzyme, Rubisco, so inefficient? Dissection of the catalytic chemistry by computational simulation and experimental testing$215,000Dr GA Huttley, Dr A Isaev and Cray Australia P/LNovel bioinformatics approaches for biological inference from comparative genomics data$30,000

The Canberra Hospital Private Practice FundDr HS Warren and Dr D KnightCharacterising a CD8ab Natural Killer cell subset enriched in cord blood$34,687

Diabetes AustraliaDr C Simeonovic, Professor C Parish, Dr P Milburn, Dr W Cowden, Clinical Associate Professor JD Wilson and Dr R RodgersThe role of matrix metalloproteinases in the development of destructive autoimmunity and clinical diabetes in NOD mice$45,000

European Commission GrantProfessor C GoodnowEURAPS: Autoimmune polyendocrine syndrome type 1 – a rare disorder of childhood as a model for autoimmunity EUR 15,000(Combined grant with National Health and Medical Research Council)

Howard Hughes Medical Institute, USADr G KarupiahImmune response to viral infection$50,000

Juvenile Diabetes Research FoundationProfessor C GoodnowMolecular analysis of pathways in diabetes$660,000Professor C Goodnow and Dr GF HoyneIdentifying genes that oppose type 1 diabetes$330,000Dr C Vinuesa and Dr Diego SilvaRoquin prevents autoimmune diabetes through a novel tolerance pathway$206,840

Multiple Sclerosis SocietyDr C Vinuesa, Dr D Silva and Dr D LinaresElucidating the role of the autoimmune modulator Roquin and follicular helper T cells in the prevention of experimental autoimmune encephalitis$55,000

National Health & Medical Research Council Capacity Building GrantProfessor T Dwyer, Dr G Jones, Dr A Venn, Dr L Blizzard, Professor S Easteal, Dr A-L Ponsonby and Professor P ZimmettBuilding Australia’s capacity to study preventable causes of common diseases through epidemiological research. $500,000

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Gra

mts

200

5

Grants

National Health & Medical Research Council Equipment GrantProfessor S Easteal-70 C Freezer for storage of human DNA and tissue samples for genetic analysis.$11,000Professor C HillFunctional Studies of vascular reactivity in health and disease$21,530Associate Professor G Stuart, Professor B Walmsley, Dr JM Bekkers, Dr FR Edwards and Professor SJ RedmanIn vivo study of neuronal networksDr DJ TremethickFluorescence resonance energy transfer imaging and analysis system$42,710Dr D WebbBuxco System for measuring respiratory function$37,804

National Health & Medical Research Council Health Services Research Program GrantProfessor S Leeder, Associate Professor R Colagiuri, Dr J Gillespie, Professor Nicholas Glasgow, Dr Stephen Jan, Mr Robert Wells and Professor JA WhitworthOptimising prevention and Management and care for Australians with, or at risk of serious and continuing chronic illness$703,000

National Health & Medical Research Council Peter Doherty FellowshipsDr ER Amyes$67,250Dr BJ Quah$67,250Dr L Simson$67,250Dr LE Tze$67,250Dr D Webb$57,500

National Health & Medical Research Council Program GrantsProfessor AF Jorm, Professor H Christensen, Dr B Rodgers, Professor S Easteal, Dr K AnsteyEpidemiology of high prevalence mental disorders: Aetiology, course and public health intervention$1,500,000Professor PS Foster, Dr SP Hogan, Dr KI Matthaei, Dr PI Thompson and Professor IG YoungMolecular Mechanisms in the Regulation of Allergy and Inflammation$970,000Professor C Chesterman, Dr R Andrews, Dr M Berndt, Professor B Chong, Professor P Hogg, Dr M Hulett, Associate Professor L Khachigian and Professor C ParishVascular Biology$2,000,000Professor P Doherty, Professor IA Ramshaw, Professor D Cooper and Associate Professor S KentStudies of HIV-1 infection and vaccination$350,000

National Health & Medical Research Council Project GrantsDr JM BekkersSynaptic integration and plasticity in the rat piriform cortex$80,000Dr E BertramCostimulatory mechanisms for enhancing CD8 T cell responses during an acute respiratory infection$144,250Professor P Board, Dr RT Baker and Dr A OakleyInvestigation of the Omega class of glutathione transferases.$160,000Dr G Chaudhri and Dr G KarupiahCritical role of TNF in host-virus interactions and outcome of infection: Involvement of reverse signalling through mTNF$165,000Professor AF DulhuntyCharacteristics of splice variants of the skeletal muscle ryanodine receptor: implications for myotonic dystrophy $85,000

��

Grants 2006

Grants

Professor C GoodnowGenetic and biochemical mechanisms dysregulating CD4 T cell tolerance$145,000Professor C GoodnowEURAPS: Autoimmune polyendocrine syndrome type 1 – a rare disorder of childhood as a model for autoimmunity$169,000 (Combined grant with European Commission)Professor C Goodnow and Dr C VinuesaDefining the immunoregulatory function of Roqin: a novel gene essential for preventing autoimmunity$270,250Professor C Goodnow, Dr C Vinuesa, Dr M Cook and Dr GA HuttleyTranslational study of the genetics of systemic autoimmunity based on mouse mutagenesis$110,600Professor IA HendryThe proteins associated with the neurotrophin retrograde transport signalling endosome$95,000Professor GDS Hirst and Dr FR EdwardsIntramuscular interstitial cells of Cajal; Channels and their modulation by calcium ions and neurotransmitters$171,000Dr GA Huttley and Professor S EastealExploiting sexual differences in germline biology to resole the causes of germline mutation.$105,000Dr G KarupiahRole of plasmacytoid dendritic cells and neutrophils in the generation of antiviral immunity$154,000Professor TD LambElectroretinogram recordings of human scotopic dark adaptation following intense bleaching exposures$75,750Professor TD Lamb, BA Patterson and FN ReinholzProperties of human cone photoreceptors measured using a scanning laser ophthalmoscope to illuminate and image the retina$135,800

Dr M Lobigs and Dr E LeeRole of cell surface glycosaminoglycans in flavivirus biology$161,974Professor A Müllbacher and Dr M RegnerRole of granzymes in innate immunity$175,000Dr SC Barry, Professor MF Shannon, Dr H Zola H and Dr R D’AndreaMolecular Identification of FoxP3 +ve regulatory T cells$472,750Professor MF ShannonThe role of NF-kB transcription factors in regulating T cell transcription networks.$175,500Dr GJ StuartDendritic mechanisms underlying synaptic plasticity$95,000Dr A Gulledge and Dr GJ StuartMechanisms and consequences of cholinergicsignaling in neocortical pyramidal neurons$84,750Dr D Tremethick and Professor D JansEngineered histones as DNA carriers with application in therapeutic$136,000Dr D Tremethick and Dr P RidgwayThe role of heterochromatin in regulating cellular proliferation and development $166,000 Dr Tremethick and Dr D RangasamyMechanisms that underpin chromosome stability$164,000Dr D Webb, Professor R Kumar and Dr MG CasarottoFunctional analysis of the Ym2 chitinase-like lectins in allergic airways disease$92,250

National Health & Medical Research Council R Douglas Wright Biomedical Career Development AwardDr A Blackburn$87,250

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Gra

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200

5

Grants

National Health & Medical Research Council Senior Research FellowshipsDr G Karupiah$114,500Dr HS Warren$114,500

National Health & Medical Research Council Senior Principal Research FellowshipsProfessor GDS Hirst$144,250

National Health & Medical Research Council Urgent Research GrantsProfessor I Clark and Professor A MüllbacherScreening of anti-inflamatory compounds in influenza infections$238,000Professor A Müllbacher and Dr M LobigsGamma-ray inactivated influenza virus vaccine for cross-protective T cell immunity$240,000

National Institutes of Health, USAProfessor C GoodnowGenes for Tolerance and Immunity Consortium$718,553Professor REW Fyffe and Professor B WalmsleyIntegrative Mechanisms in the Central Nervous System$US80,000Drs D Tscharke, Dr G Karupiah and Dr R BullerCD8+ T cell responses in mouse models of smallpox vaccination and challenge$337,000

Viertel Senior Medical Research FellowshipDr MD HulettRegulators of cell invasion and angiogenesis$165,000

�9

Statistics 2006

Income

BaseAllocation $14,072,000

IGS,RTS,RIBG $4,438,000

Adjustments $427,000

OtherIncome $2,670,000

SpecialPurposeFunds(SPF) $9,424,000

TOTAL INCOME $31,031,000

Expenditure

StaffCosts $12,853,000

Scholarships $992,000

Equipment $1,378,000

Travel $470,000

ExpendableResearchMaterial(ERM) $2,216,000

Other $3,685,000

SpecialPurposeFunds(SPF) $9,424,000

TOTAL EXPENDITURE $31,018,000

Special Purpose Funds

GovernmentGrants $8,723,000

Other $701,000

TOTAL $9,424,000

Statistics 2006

Staff Numbers 2006 2005 2004

Academicstaff 91 95.9 96

GeneralStaff—administration,technical&support 195 219 212

Postgraduatestudents 88 84 76

In July 2006, a number of JCSMR administrative staff members were transferred into the newly formed ANU College of Medicine and Health Sciences Administration Group (CAG).

90

Don

ors

2006 Donors 2006

The Director, staff and students of The John Curtin School of Medical Research are extremely grateful for the continued generosity of our friends and donors.

Wewouldliketothankthefollowingdonorsfortheirgeneroussupportin2006

GAda

AustralianDefenceForceAcademy,UniversityCollege

FamilyandfriendsofCharlesBartholomew

JandHBateup

PBischoff

KBos

LBoyle

PandSBunyan

JBurns

MCampbell

Carter

JChan

DConnell

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SDaw

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FFenner

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WGray

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GGrylls

RGrylls

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GHendrie

JandCHill

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JKelly

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9�

Donors 2006

The John Curtin School of Medical Research Needs Your Support

GiftsandbequeststotheSchoolareusedtofundvitalresearchprojectsinareassuchasasthma,cancer,

diabetes,highbloodpressure,hearinglossandvision,aswellasprovidingscholarshipsandpurchasing

specialisedequipment.Yoursupportcanbeprovidedinanumberofwaysincludingagiftorbequestthat

mayassistinfundingaparticularareaofresearch,orascholarshiporprize.

IfyouwouldliketodiscussoptionsforsupportingTheJohnCurtinSchoolofMedicalResearch,please

contact:

DrMadeleineNicol

T:+61261252577F:+61261252337M:0407278913

E:[email protected]

PKriedemann

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Published in Australia by:


ANU College of Medicine and Health Sciences

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Editors: Madeleine Nicol and Frith Rayner

Design and Layout: Sue Henderson

Photography: Karen Edwards

Back cover photograph: Rohan Baker


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Annual Review 2006

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