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The IMPACT StudyHow old is atherosclerosis?

Randall C. Thompson, MDProfessor of MedicineUniversity of Missouri Kansas CityAttending CardiologistMid America Heart Institute

The IMPACT StudyHow old is atherosclerosis?

Randall C. Thompson, MDProfessor of MedicineUniversity of Missouri Kansas CityAttending CardiologistMid America Heart Institute

Thompson et al: The Lancet, March 10, 2013

Randall C. ThompsonAdel H. AllamGuido P. LombardiL. Samuel WannM. Linda SutherlandJames D. SutherlandMuhammad Al TohamySoliman,Bruno Frohlich,David T. Mininberg Janet M. Monge Clide M. Vallodolid Samantha L. Cox Gomaa el-Maksoud Ibrahim Badr Michael I. Miyamoto Abd el-Halim Nur el-din Jagat Narula Caleb E. Finch Gregory S. Thomas

Thompson et al: The Lancet, March10 , 2013

BackgroundAtherosclerosis is commonly considered to be a disease of modern times and related to modern lifestyles.Butis it? Maybe this statement isnt completely true.Was it present in ancient people?

Coronary Calcium Scoring

Consensus interpretation

Unangan F 47-51y Ahmose-Meritamun Egyptian M 40-50 yThompson et al: The Lancet, March10 , 2013

Unangan F 47-51y Ahmose-Meritamun Egyptian M 40-50 yThompson et al: The Lancet, March10 , 2013

Unangan F 47-51yEgyptian F 45-50yAncestral Puebloan F 46-51yPeru F 41-44y

Unangan F 47-51yEgyptian F 45-50yAncestral Puebloan F 46-51yPeru F 41-44y

DietEgyptPeruAncestral PuebloansAleutianDietFarmers, domesticated animalsFarmers, domesticed animalsForager-farmersHunter gatherersFood examplesWheat, barley, dates, figs, olives, beans, radishes, onions, cucumber, lettuce, cabbageCorn, potato, sweet potato, manioc, beans, bananas, hot pepperCorn, squash pine nuts, seeds, grassesMarine, berries, no agricultureProtein sourcesDomesticated cattle, sheep, goats, pigs, hyenas, ducks, geese, birds, fishDomesticated alpaca, guinea pigs, ducks, deer, birds, fishRabbit, mice, big horn sheep, mule deer, fishSeal, sea otter, whales, shellfish, sea urchins, birds, eggs, fishHousingEgyptPeruAncestral PuebloansAleutianHousingAbove ground mud brick housesAbove ground mud homesSubterranean single family homes (pithouses) Subterranean single & multi-family homes (barabaras)Smoke exposureCooked with wood or coal in yard or on roofCooked with wood or alpaca dung outsideUsed fire for warmth and cookingUsed fire for warmth and cooking in barabaras; used seal oil lamps for lightSummary Because of the large number of CT scans accumulated for this study, we were able to demonstrate that atherosclerosis was present in humans in numerous cultures, across a very wide geographic distribution, and dating back at least 4000 years. Atherosclerosis, including coronary artery disease, was also found in a population not known to have atherosclerosis, hunter gatherers.

IMPACT Numerous questions remain and The IMPACT Study is continuing.

Thank YouRandall C. ThompsonAdel H. AllamGuido P. LombardiL. Samuel WannM. Linda SutherlandJames D. SutherlandMuhammad Al TohamySoliman,Bruno Frohlich,David T. Mininberg Janet M. Monge Clide M. Vallodolid Samantha L. Cox Gomaa el-Maksoud Ibrahim Badr Michael I. Miyamoto Abd el-Halim Nur el-din Jagat Narula Caleb E. Finch Gregory S. Thomas