The Identification, Synthesis, Protein Crystal Structure and in vitro Biochemical Evaluation of a...
1
2005 Pyrazole derivatives R 0180 The Identification, Synthesis, Protein Crystal Structure and in vitro Biochemical Evaluation of a New 3,4-Diarylpyrazole Class of Hsp90 Inhibitors. — High-throughput screening of a library of 50,000 compounds identified 3,4-diarylpyra- zole CCT018159 (I) as a novel and potent inhibitor of Hsp90 ATPase. The synthesis of (I) and a number of close analogues is described and some structure—activity relation- ships are discussed. — (MCDONALD*, E.; et al.; Bioorg. Med. Chem. Lett. 15 (2005) 14, 3338-3343; Cancer Res. UK Cent. Cancer Therap., Inst. Cancer Res., Sutton, Surrey SM2 5NG, UK; Eng.) — C. Hettrich 43- 136
-
Upload
edward-mcdonald -
Category
Documents
-
view
212 -
download
0
Transcript of The Identification, Synthesis, Protein Crystal Structure and in vitro Biochemical Evaluation of a...
2005
Pyrazole derivativesR 0180 The Identification, Synthesis, Protein Crystal Structure and in vitro Biochemical
Evaluation of a New 3,4-Diarylpyrazole Class of Hsp90 Inhibitors. — High-throughput screening of a library of 50,000 compounds identified 3,4-diarylpyra-zole CCT018159 (I) as a novel and potent inhibitor of Hsp90 ATPase. The synthesis of (I) and a number of close analogues is described and some structure—activity relation-ships are discussed. — (MCDONALD*, E.; et al.; Bioorg. Med. Chem. Lett. 15 (2005) 14, 3338-3343; Cancer Res. UK Cent. Cancer Therap., Inst. Cancer Res., Sutton, Surrey SM2 5NG, UK; Eng.) — C. Hettrich
43- 136