HSP90 (Heat-Shock Protein 90 kDa).

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HSP90 (H eat-S hock P rotein 90 kDa)

TAGS:

Transcript of HSP90 (Heat-Shock Protein 90 kDa).

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Proteasoma

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• Attivazione dell’ubiquitinaadenilazionetrasferimento a E2

• Coniugazione• Riconoscimento della catena di poliubiquitina da

parte delle subunità regolatrici del proteasoma

• Rimozione della catena di poliubiquitina• Degradazione enzimatica del substrato

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BORTEZOMIB (VELCADE®)

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MalattiaSito di sviluppo del

tumoreRischio relativo

Forme ereditarie

   Emocromatosi Fegato 219

   Malattia di Crohn Colon 3

   Colite ulcerosa Colon 6

Forme acquisite

Virali

   Hepatite B Fegato 88

   Hepatite C Fegato 30

Batteriche

   Helicobacter pylori Stomaco 11

   PID (pelvic inflammatory disease) Ovaio 3

Parassitarie

   S. hematobium Vescica 2-14

   S. japonicum Colon 2-6

   Fasciola epatica Fegato 14

Da cause chimiche/fisiche/metaboliche

   Riflusso acido Esofago 50-100

   Amianto Pleure >10

   Obesità Molteplici siti 1.3-6.5

ESEMPI DI INFIAMMAZIONI/INFEZIONI CRONICHE LEGATE A UN AUMENTO DEL RISCHIO DI SVILUPPO DI TUMORI

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Characterisation of the Plasmodium falciparum Hsp90 ... · Hsp70 and Hsp90 proteins are functionally linked by an essential adaptor protein known as the Hsp70–Hsp90 organising protein

Characterisation of the Plasmodium falciparum Hsp90 ... · Hsp70 and Hsp90 proteins are functionally linked by an essential adaptor protein known as the Hsp70–Hsp90 organising protein

HSP-90 Inhibition as an Emerging Target - Imedeximedex.com/.../2012/assets/presentations/saturday/Paz-Ares_HSP-90.pdf · Heat shock protein 90 (HSP – 90) Hsp90 83 KDa 166 KDa dimer

HSP-90 Inhibition as an Emerging Target - Imedeximedex.com/.../2012/assets/presentations/saturday/Paz-Ares_HSP-90.pdf · Heat shock protein 90 (HSP – 90) Hsp90 83 KDa 166 KDa dimer

Binding-affinity predictions of HSP90 in the D3R Grand ...lup.lub.lu.se/search/ws/files/20966856/hsp90.pdf · Binding-affinity predictions of HSP90 in the D3R Grand Challenge 2015

Binding-affinity predictions of HSP90 in the D3R Grand ...lup.lub.lu.se/search/ws/files/20966856/hsp90.pdf · Binding-affinity predictions of HSP90 in the D3R Grand Challenge 2015

Tissue-specific expression patterns of heat shock rote ... · The heat shock protein of 90 kDa (Hsp90) has been found to be highly conserved and highly expressed cellular protein

Tissue-specific expression patterns of heat shock rote ... · The heat shock protein of 90 kDa (Hsp90) has been found to be highly conserved and highly expressed cellular protein

KDA Amplifiers - DSP Menu Manualassets.klipsch.com/files/KDA-Amplifiers-DSP-Menu-Manual.pdfThe Klipsch KDA DSP Menu will open in the browser window. OR Design Detail KDA amplifier

KDA Amplifiers - DSP Menu Manualassets.klipsch.com/files/KDA-Amplifiers-DSP-Menu-Manual.pdfThe Klipsch KDA DSP Menu will open in the browser window. OR Design Detail KDA amplifier

Review article Role of hsp90 and the hsp90-binding ... · PDF fileprotein hsp90 complexes also contain one of several TPR domain immunophilins or immunophilin ... movement through

Review article Role of hsp90 and the hsp90-binding ... · PDF fileprotein hsp90 complexes also contain one of several TPR domain immunophilins or immunophilin ... movement through

JOURNAL OF Vol. 268, No. Issue of 15. 1993 in U.S.A. Hsp90 ... · families of heat shock proteins, the 60 kDa class (i.e. prokar- yotic GroEL and eukaryotic hsp60), the 70 kDa class

JOURNAL OF Vol. 268, No. Issue of 15. 1993 in U.S.A. Hsp90 ... · families of heat shock proteins, the 60 kDa class (i.e. prokar- yotic GroEL and eukaryotic hsp60), the 70 kDa class

Refolding activity of bacterial Hsp90 in vivo reveals ancient … · Morán Luengo et al. 1 Ancient function of Hsp90 in vivo | BioRxiv Refolding activity of bacterial Hsp90 in vivo

Refolding activity of bacterial Hsp90 in vivo reveals ancient … · Morán Luengo et al. 1 Ancient function of Hsp90 in vivo | BioRxiv Refolding activity of bacterial Hsp90 in vivo

Localization of the 90-kDa Heat Shock Protein-binding Site within ...

Localization of the 90-kDa Heat Shock Protein-binding Site within ...

Hsp90-Targeted Library - Chemdiv · HtpG (high-temperature protein G), whereas Archaebacteria lack a Hsp90 representative [24]. All eukaryotes possess cytosolic members, called Hsp90

Hsp90-Targeted Library - Chemdiv · HtpG (high-temperature protein G), whereas Archaebacteria lack a Hsp90 representative [24]. All eukaryotes possess cytosolic members, called Hsp90

Inhibition of HSP90 in Trypanosoma cruzi Induces a Stress ... · The 90-kDa heat shock proteins (HSP90) are important in the regulation of numerous intracellular pro-cesses in eukaryotic

Inhibition of HSP90 in Trypanosoma cruzi Induces a Stress ... · The 90-kDa heat shock proteins (HSP90) are important in the regulation of numerous intracellular pro-cesses in eukaryotic

Thermoresistance - downloads.hindawi.comdownloads.hindawi.com/journals/omcl/2019/4606219.f1.pdf · KDa heat shock protein is associated with thermoresistance and chemoresistance but

Thermoresistance - downloads.hindawi.comdownloads.hindawi.com/journals/omcl/2019/4606219.f1.pdf · KDa heat shock protein is associated with thermoresistance and chemoresistance but

Alexzander˜A.˜A.˜Asea Punit˜Kaur Editors Heat Shock ... · The ninety-kilo Dalton heat-shock protein (HSP90) regulates the stability, activa-tion, and degradation of a diverse

Alexzander˜A.˜A.˜Asea Punit˜Kaur Editors Heat Shock ... · The ninety-kilo Dalton heat-shock protein (HSP90) regulates the stability, activa-tion, and degradation of a diverse

ln Wvo Evidence for the Generation of a Glucocorticoid ... · with the 90-kDa heat shock protein (hsp90). In the present study, we have generated a novel form of the GR, in which

ln Wvo Evidence for the Generation of a Glucocorticoid ... · with the 90-kDa heat shock protein (hsp90). In the present study, we have generated a novel form of the GR, in which

Role of the Heat-Shock Response in the Life and Death of ...groups.molbiosci.northwestern.edu/morimoto/research/Publications... · both Hsp90 and Hsp70 immunoprecipitates upon ATP

Role of the Heat-Shock Response in the Life and Death of ...groups.molbiosci.northwestern.edu/morimoto/research/Publications... · both Hsp90 and Hsp70 immunoprecipitates upon ATP

Hsp70 and Hsp90 of E. coli Directly Interact for Collaboration ...biophys.w3.kanazawa-u.ac.jp/References/Chaperonin/HSP90...Hsp70 and Hsp90 of E. coli Directly Interact for Collaboration

Hsp70 and Hsp90 of E. coli Directly Interact for Collaboration ...biophys.w3.kanazawa-u.ac.jp/References/Chaperonin/HSP90...Hsp70 and Hsp90 of E. coli Directly Interact for Collaboration

Treated with a Combination of Heat Shock Protein 90 Inhibitor … · shock protein 90 (HSP90) inhibitor agents including 17-allyloamino-17-demethoxy-geldanamycin (17-AAG), a geldanamycin

Treated with a Combination of Heat Shock Protein 90 Inhibitor … · shock protein 90 (HSP90) inhibitor agents including 17-allyloamino-17-demethoxy-geldanamycin (17-AAG), a geldanamycin

From a Ratchet Mechanism to Random Fluctuations Evolution ... · The 90‐kDa heat shock proteins [heat shock protein 90 (Hsp90)] are a highly conserved ATP-dependent protein family,

From a Ratchet Mechanism to Random Fluctuations Evolution ... · The 90‐kDa heat shock proteins [heat shock protein 90 (Hsp90)] are a highly conserved ATP-dependent protein family,

The Hsp90 Chaperone Machine · PDF fileThe Hsp90 Chaperone Machine September 29th to October 3rd, ... Interaction of Hsp90 with co-factors and substrates by NMR ... for FKBP51 and

The Hsp90 Chaperone Machine · PDF fileThe Hsp90 Chaperone Machine September 29th to October 3rd, ... Interaction of Hsp90 with co-factors and substrates by NMR ... for FKBP51 and

Identification of HSP90 as a new GABARAPL1 (GEC1 ... of... · Heat shock protein 90 (HSP90) Michigan cancer foundation-7 (MCF-7) Proteasome inhibitors abstract GABARAPL1 belongs to

Identification of HSP90 as a new GABARAPL1 (GEC1 ... of... · Heat shock protein 90 (HSP90) Michigan cancer foundation-7 (MCF-7) Proteasome inhibitors abstract GABARAPL1 belongs to