Tell it straight: How Selenium helps prevent Cancer
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Transcript of Tell it straight: How Selenium helps prevent Cancer
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Overview1. What is Selenium?2. A model for cancer in the lab3. ‘The big experiment’
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N a t i o n a l I n s t i t u t e Fo r C e l l u l a r B i o t e c h n o l o g yN a t i o n a l I n s t i t u t e Fo r C e l l u l a r B i o t e c h n o l o g y National Institute for Cellular Biotechnology
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Selenium in the diet
http://www.teagasc.ie/soil/trace/grassland/selenium.asp
http://www.microfeeder.com/news/en_selen.asp (modified after Hasselberger, 2006)
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Bene
fitRi
sk
Narrow range for protective effects
‘Just right.’ One key function of
selenium-containing proteins is anti-oxidant protection
Too little Se- oxidative damage
Too much Se- oxidative damage
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Selenium and cancer• Selenium's role as a protector against oxidative
damage has gained interest in cancer research
Image from http://www.bluemountainorganics.com/_blog/Health_and_Nutrition
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Selenium and cancer• Studies in various
populations worldwide have found a link between low selenium levels and certain types of cancer
• Results inconclusive-
back to the drawing board
Skin
Lung
Colon and prostate
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Cell culture• We can grow cells in the lab from
virtually any organ in the body to study what’s happening at the level of the cell
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The big experiment
Cell will die CellCells will repair
Attempt repair- ineffective, causing the incorporation of mistakes, can lead to cancer
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The big experiment
Cell will die CellCells will repair
Attempt repair- ineffective, causing the incorporation of mistakes, can lead to cancer
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• Understand more about the role selenium is playing in cancer prevention
• How much selenium should we be getting from our diets to maximise protection
Potential impact of this research
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Quest i ons?N a t i o n a l I n s t i t u t e f o r C e l l u l a r B i o t e c h n o l o g y
D u b l i n C i t y U n i v e r s i t y , G l a s n e v i n , D u b l i n 9 , I r e l a n d .
+ 3 5 3 1 7 0 0 5 7 0 0
w w w. n i c b . i e
n i c b @ d c u . i e
T h a n k y o u !