Teaching Bio-Transport Courses for Undergraduate and Graduate Students

in ME and BME

Lisa Xuemin Xu, Ph.D.

Med-X Research Institute & School of Biomedical Engineering

Shanghai Jiao Tong University

Teaching Experiences

• 500 Level Graduate Course in ME at Purdue (1997-2002)

• Graduate Course in BME at Shanghai Jiao Tong Univ. (2003-present)

• Undergraduate Course in BME at Shanghai Jiao Tong Univ. (2005-present)

Description:

This course is designed for biomedical engineering undergraduates with

necessary physics and mathematics background. A student achieving a

passing grade in this course shall be able to use the basic bio-heat and

mass transfer theories and method to analyze real biomedical problems,

be familiar with important applications of bio-heat transfer.

Bio-Heat Transfer Course (Undergraduate) 2 Credits, FALL Semester

COURSE TOPICS

• Energy conservation and metabolisms• Basics of conduction, convection, radiation• Convection over body surface, sweating, respiration• Heat transfer to blood vessels• Thermal equilibration length of blood Vessel• Anatomy and description of human vasculature system• Temperature induced dynamic change of blood flow• Bio-heat Equation (Pennes Equation)• Temperature measurement and IR Detection of Breast

Cancer• Application I: Tumor thermal treatment• Application II ： Cryo-preservation

Textbook and References

Text: • Thermal Dosimetry and Treatment Planning, JC Chato, KD Paulsen,

RB Roemer, M. Gautherie (Ed.), Springer-Verlag Berlin Heidelberg New York, London, Paris, Tokyo, Hongkong, 1990

Reference books ：• Heat Transfer in Medicine and Biology, A. Shitzer, Robert C.

Eberhart, Plenum Press, New York and London, 1985• Heat Transfer Essentials, Latif M. Jiji, Begell House Inc. Publishers,

New York, 1998

Advanced Bio-heat and Mass Transfer (Graduate Course)

3 Credits, Spring Semester

Description:

This course is for graduate students of biomedical engineering specialty. The aim of this course is to introduce advanced bio-heat and mass transfer problems and research fields. Upon completion of this course, students are expected to understand mechanisms underlying thermal physics interaction with biological systems, and more importantly, to be able to simulate, analyze and evaluate the transportation of heat and mass problems in this field.

Course Topics • Review of basic concepts• Bio-heat transfer equations ： Pennes, WJ, Chen-

Holmes Equation, different models• Biological responses to thermal stress • Advanced bio-heat and mass transfer modeling

I ： thermal treatmentII : cryobiology

• Micro and nano bio-heat and mass transfer I : modelingII : experimental techniquesIII: applications

• Thermal physics in life sciences: tumor, energy and environment

ReferencesPapers:Modeling 1. Harry H. Pennes (1948)2. Chen-Holmes (1980)3. WJ Model (1984-85)4. Baish (1994) 5. New vascular models (1997-2002)Thermoregulation and PhysiologyAdvanced Thermal Measurement TechniquesLatest Papers Related to Thermal Physics in Life Sciences

Books:1. Avraham Shitzer, Robert C. Eberhart, Heat Transfer in Medicine and

Biology, 1985, Plenum Press, New York and London2.Young I. Cho, Advances in Heat Transfer. Bioengineering Heat

Transfer 1992, Academic Press, INC

Cryosurgery of Cryosurgery of Prostate CancerProstate Cancer

Protein and Gene Protein and Gene ExpressionExpression

Alternated Thermal Alternated Thermal Treatment of Breast Treatment of Breast CancerCancer

Thermally Targeted Thermally Targeted Nano Drug DeliveryNano Drug Delivery

Applications of Thermal Physics

Discussion

• Bio-transport theories and experimental techniques for translational research (molecular diagnosis and treatment, nano-carrier delivery, tissue engineering etc.)

• New comprehensive text book integrating bio-thermal physics, biomechanics, biochemistry, and advanced measurement techniques