TAVR: Echo Measurements Pre, Post And Intra Procedure · Saric M, Williams MR. Transthoracic...
Transcript of TAVR: Echo Measurements Pre, Post And Intra Procedure · Saric M, Williams MR. Transthoracic...
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Muhamed Sarić MD, PhD, MPADirector of Noninvasive Cardiology | Echo LabAssociate Professor of Medicine
TAVR: Echo Measurements Pre, Post And Intra Procedure
2017 ASE Florida, Orlando, FL
October 10, 2017 | 8:00 – 8:25 AM | 25 min
Disclosures
Speakers Bureau (Philips, Medtronic)Advisory Board (Siemens)
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PRIMARY INDICATIONS FOR SURGICAL OR PERCUTANEOUS
TREATMENT OF AORTIC STENOSIS
SEVEREAortic Stenosis
SYMPTOMSDyspnea, angina, syncope
LV FUNCTIONDiminished LVEF
Severe symptomatic ASirrespective of LVEF
Severe AS with diminished LVEF irrespective of symptoms
TAVR Indications Based on STS Risk Score
INTERMEDIATE
(4 – 8 %)HIGH RISK
(> 8 %)LOW RISK
(< 4 %)
TAVR is a safe and effective alternativeto surgical AVR
TAVR vs. surgical AVR trials in
progress
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TAVR Prostheses Used in United States
Edwards
Sapien Valves---------------------------------------------
Balloon-expandable bovine pericardial aortic valve prosthesis
Medtronic
CoreValves---------------------------------------------
Self-expandable porcine pericardial aortic valve prosthesis
TAVR Prostheses Used in United States
Edwards
Sapien Valve---------------------------------------------
Balloon Expandable
Medtronic
CoreValve---------------------------------------------
Self Expanding
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Sapien Valve Implantation
CoreValve Implantation
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IMAGING IN PATIENTS UNDERGOING TAVR
Role of various imaging modalities before, during and after
TAVR procedure
Echo
FluoroscopyCT
Role of echocardiography relative to other imaging modalities
in TAVR cases
BEFORE
TAVR Procedure
DURING
TAVR Procedure
AFTER
TAVRProcedure
ECHOCARDIOGRAPHY
: Primary means of establishing diagnosis, severity and subtype of aortic stenosis: Secondary means of TAVR valve sizing
CHEST CT: Primary means of TAVR valve sizing
ECHOCARDIOGRAPHY
: Primary means of assessing for paravalvular leak, overall valve function and possible complications.
Saric M, Williams MR. Transthoracic echocardiography guidance for TAVR.J Am Coll Cardiol Img. 2015;8(3):363-67.
FLUOROSCOPY / CINE
: Primary means of AVR valve implantation guidance
ECHOCARDIOGRAPHY
: Primary means of assessing for prosthetic and overall cardiac function.
IMAGING IN PATIENTS UNDERGOING TAVR
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EchocardiographyPrior to TAVR
ROLE OF ECHO PRIOR TO TAVR• Establish whether indications for TAVR are present
• Severity of aortic stenosis• Subtype of aortic stenosis (high vs. low-gradient)
• Asses LV ejection fraction
• Assist in TAVR valve sizing
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Types of Aortic Stenosis
Classic High-Gradient AS
65-85%
Low-Gradient ASwith Preserved EF
10-25%
Low-Gradient ASwith Diminished EF
5-10%
Severe Aortic Stenosis | TTE Apical 3-Chamber
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Severe Aortic Stenosis | TTE Apical 3-Chamber
Severe Aortic Stenosis | TTE Apical 4-Chamber
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Severe Aortic Stenosis | TTE Apical 5-Chamber
SEVERE AORTIC STENOSISContinuous Wave (CW) Doppler Pulsed Wave (PW) Doppler
AORTIC VALVE
VTI = 134 cmVmax = 4.3 m/sec
Peak/Mean Gradient 74/43 mm Hg
LVOT
VTI = 24 cmVmax = 0.8 m/sec
Area 3.14 cm2
Dimensionless Index = 24 / 134 = 0.18 | Aortic Valve Area = 0.6 cm2
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SEVERE SENILE CALCIFIC AORTIC STENOSIS
OF A TRILEAFLET AORTIC VALVE
Severe Aortic Stenosis
Peak velocity (Vmax) > 4 m/sec
Mean gradient (ΔPmean) > 40 mm Hg
Dimensionless Index < 0.25
Aortic valve area (AVA) < 1.0 cm2
AVA Index < 0.6 cm2/m2
ASE/EAE Guidelines on Valvular StenosisJ Am Soc Echocardiogr. 2009 May;22(5):442.
Our Patient
4.3 m/sec
43 mm Hg
0.18
0.6 cm2
0.3 cm2/m2
TTE STUDY CONCLUSIONS
• Severe senile calcific high-gradient aortic stenosis of a trileaflet native aortic valve with preserved LVEF
• If symptoms attributable to aortic stenosis are:
• Present >>> Refer for TAVR evaluation
• Absent >>> Consider stress testing
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SEVERE SENILE CALCIFIC AORTIC STENOSIS
OF A TRILEAFLET AORTIC VALVE
Severe Aortic Stenosis
Peak velocity (Vmax) > 4 m/sec
Mean gradient (ΔPmean) > 40 mm Hg
Dimensionless Index < 0.25
Aortic valve area (AVA) < 1.0 cm2
AVA Index < 0.6 cm2/m2
ASE/EAE Guidelines on Valvular StenosisJ Am Soc Echocardiogr. 2009 May;22(5):442.
Our Patient
4.3 m/sec
43 mm Hg
0.18
0.6 cm2
0.3 cm2/m2
Our Patient
3.1 m/sec
26 mm Hg
0.26
0.6 cm2
0.3 cm2/m2
AORTIC STENOSIS
2014 ACC/AHA Valvular Heart Disease Guidelines
Low LVEF
Low Gradient
AS Normal LVEF
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AORTIC STENOSIS
2014 ACC/AHA Valvular Heart Disease Guidelines
Low LVEF
Low Gradient
AS Normal LVEF
DOBUTAMINE
STRESS ECHO
(LV Contractile Reserve)
EXERCISE
STRESS TESTING
(Symptoms)
Echocardiography During TAVR Procedure
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Question | Echo Type
Should I use transesophageal echo (TEE) or transthoracic echo (TTE) during TAVR procedures?
These recommendations support the use of TEE for TAVR.
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J Am Coll Cardiol Img. 2015;8(3):363-67.
Evolution of Anesthesia & Echo Imaging for TAVR
INITIAL TAVR EXPERIENCE
General anesthesia
Endotracheal intubation
TEE guidance
SUBSEQUNTTAVR EXPERIENCE
Moderate sedation
No endotracheal intubation
TTE guidance
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Semin Cardiothorac Vasc Anesth. 2016;20(2):147-57.
NYU TAVR Program | TEE vs. TTESep 1, 2011 – Nov 30, 2016
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What to Look For During TAVR on Echo?
• TAVR Valve Function• Paravalvular Leak• Complications
TAVR | Intraprocedural Echo Evaluation
When..
• Proper preprocedural TAVR valve sizing is done, and • When newer generation TAVR valves are used, • By a an experienced TAVR team
… TAVR procedure is typically uneventful… Complications are relatively rare
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TAVR Valve Function
TAVR: Markers of Good Implantation
Valve Shape & Location◦ Short axis: Circular rather than ovoid
◦ Long axis: Proximal end just a few millimeters in the LVOT
Valve Gradient◦ Vmax typically < 2.0 m/sec
Valve Regurgitation◦ No significant paravalvular or transvalvular aortic regurgitation
If one or more suboptimal, consider:
◦ Repositioning TAVR valve (for self-expanding valves)
◦ Post-dilatation of TAVR valve with a balloon
◦ Implantation of another TAVR valve (valve-in-valve procedure)
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TAVR Valve Shape
TAVR Valve Shape
OPTIMAL SHAPE
Circular
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TAVR Valve Shape
SUBOPTIMAL SHAPE
Ovoid
TAVR Valve Location
OPTIMAL LOCATION
No excessive protrusioninto LVOT
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TAVR Valve Location
SUBOPTIMAL LOCATION
Too deepinto LVOT
SELF-EXPANDING
CoreValve Evolut Pro
Most Common TAVR Valves at Present
BALLOON EXPANDABLE
Sapien 3SELF-EXPANDING
CoreValve Evolut R
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TAVR Valve Gradients
Aortic Valve Gradients | Pre & Post TAVR
Before TAVR(Severe native valve stenosis)
After TAVR(Minimal aortic valve gradients)
Vmax = 4.3 m/secPeak/Mean Gradient 74/43 mm Hg
Time to peak gradient 140 msec (late peaking)
Vmax = 1.4 m/secPeak/Mean Gradient 9/3 mm Hg
Time to peak gradient95 msec (early peaking)
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TAVR Valve GradientsOPTIMAL GRADIENT
Vmax < 2.0 m/sec
Vmax = 1.4 m/secPeak/Mean Gradient 9/3 mm Hg
Time to peak gradient95 msec (early peaking)
SUBOPTIMAL GRADIENT
Vmax > 2.0 m/sec
Vmax = 2.6 m/secPeak/Mean Gradient 27/17 mm Hg
Time to peak gradient> 100 msec (late peaking)
Paravalvular Leak Evaluation
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Older TAVR Designs Newer TAVR Designs
JACC Cardiovasc Imaging. 2015 Mar;8(3):340-60.
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TAVR PROCEDURE | TRANSTHORACIC ECHO
Annulus
CoreValve inserted too deep into LVOT
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TAVR PROCEDURE | TRANSTHORACIC ECHO
Significant Paravalvular Aortic Regurgitation
TAVR PROCEDURE | TRANSTHORACIC ECHO
Significant Paravalvular Aortic Regurgitation
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TAVR PROCEDURE | TRANSTHORACIC ECHO
Significant Paravalvular Aortic Regurgitation
10/10/2017NYU LEON H. CHARNEY DIVISION OF CARDIOLOGY
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POST TAVR | TRANSESOPHAGEAL ECHO
Significant Paravalvular Aortic Regurgitation
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PARAVALVULAR AORTIC REGURGITATION POST TAVR
No easy way to grade it
VARC II CriteriaAn expert consensus
without empiric validation
POST TAVR | TRANSESOPHAGEAL ECHO
AR occupies > 30% of prosthetic circumference
Consistent with severe aortic regurgitation
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TAVR PROCEDURE | TRANSTHORACIC ECHO
Pressure Half-time = 63 msec
Consistent with acute aortic regurgitation
POST TAVR | TRANSESOPHAGEAL ECHO
Holodiastolic Flow Reversal in Descending Aorta
Consistent with severe aortic regurgitation
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Echocardiography Post TAVR Procedure
What to Look For Post TAVR on Echo?
Assess for TAVR complications
• Pericardial effusion• LV rupture [LV wire related]• RV rupture [Pacing wire related]
• Annular rupture
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New York University Langone Medical Center
Thank you!
Case #1Pericardial Effusion Post LV Wire Removal
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Prior to CoreValve Insertion
6:49:59 PMNo pericardial effusion
Post CoreValve Insertion But Wire Still in LV
7:23:03 PMFirst TEE image of CoreValve
7:26:036 PMStill no effusion
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Post TAVR Insertion, LV Wire Removed
7:31:06 PMFirst appearance of effusion
7:39:01 PMMassive effusion
Case #2Pericardial Effusion Post RV Wire Removal
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Day 0 | Uneventfully implantation of a TAVR valve
No pericardial effusion
Day 1 | Hypotension minutes post removal of temporary RV pacing wire
New hemorrhagic pericardial effusion
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Day 1 Hypotension minutes post removal of temporary RV pacing wire
Mitral Inflow-----------------------Marked respiratory variations indicative
of tamponade
Day 1 | Post Pericardiocentesis
Resolution of pericardial effusion
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Case #3Annular Rupture After CoreValve Post Dilation
CASE 2017;1(2):70-74
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ANNULAR RUPTURE POST TAVR
Balloon Expandable TAVR Self-expanding TAVR
Several Weeks Post CoreValve | Severe new-onset heart failure with normal LVEF
Bilateral pleural effusions
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Several Weeks Post CoreValve | Severe new-onset heart failure with normal LVEF
Abnormal color Doppler jet at caudal end of CoreValve
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Several Weeks Post CoreValve | Severe new-onset heart failure with normal LVEF
Abnormal color Doppler jet from CoreValve region to RVOT
Several Weeks Post CoreValve | Severe new-onset heart failure with normal LVEF
Systolic AND diastolic flow
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TTE Study Conclusions
Peri-annular rupture with ascending aorta to RVOT communication
CONTRAST CT CONFIRMS ANNULAR RUPTURE
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CONTRAST CT CONFIRMS ANNULAR RUPTURE
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TEE & Fluoroscopy Guided Closure
Aorta-to-RV communication closed using an 8-mm Amplatzer Vascular Plug (AVP)
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NYU TAVR TEAM
New York University Langone Medical Center
Thank You!