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HbA1c: hoe goed waren we en zijn we geworden?

Jaar Afwijking Intralab Interlab Target CV CV

1993 ---- 5.2% 22.0%

1999 +0.3% 4.9% 11.2%

2002 -0.1% 3.4% 8.5%

2003 -0.2% 2.9% 6.9%

2004 +0.1% 2.6% 4.8%

Compliment aan de Labs en ManufacturersBron: C.W Weykamp

Glucose (Combi Algemene Chemie) mol/LGlucose (Combi Algemene Chemie) mol/L Ronde 2008.1Ronde 2008.1Gebruikte methodesGebruikte methodes AantalAantal   

GDHGDH 1414   

GODGOD 4040   

HKHK 140140   

   OverallOverall GDHGDH GODGOD HKHK

Concentratie monster 2Concentratie monster 2 3,93,9 4,04,0 3,93,9 3,93,9

Tussenlab CV in %Tussenlab CV in % 3,03,0 4,04,0 2,72,7 3,13,1

     

Concentratie monster 1Concentratie monster 1 10,410,4 10,610,6 10,410,4 10,410,4

Tussenlab CV in %Tussenlab CV in % 2,92,9 2,62,6 2,52,5 2,92,9

     

Concentratie monster 4Concentratie monster 4 16,916,9 17,217,2 16,916,9 16,816,8

Tussenlab CV in %Tussenlab CV in %    2,72,7 3,33,3 2,62,6 2,72,7

Microalbumine (Combi Urine) mg/LMicroalbumine (Combi Urine) mg/L Ronde 2008.1Ronde 2008.1

Gebruikte methodesGebruikte methodes AantalAantal   

INAINA 1919   

ITAITA 128128   

   OverallOverall INAINA ITAITA

Concentratie monster FConcentratie monster F 3,53,5 3,83,8 3,43,4

Tussenlab CV in %Tussenlab CV in % 34,334,3 21,121,1 35,335,3

Concentratie monster BConcentratie monster B 10,910,9 12,112,1 10,710,7

Tussenlab CV in %Tussenlab CV in %    20,220,2 9,19,1 21,521,5

Concentratie monster EConcentratie monster E 2525 25,325,3 2525

Tussenlab CV in %Tussenlab CV in % 8,88,8 7,97,9 8,88,8

  

Standardization in Standardization in Laboratory Medicine:Laboratory Medicine:

are the times changing?are the times changing?

EQA provider / SKML EQA provider / SKML chemistry section:chemistry section:post-market vigilance of post-market vigilance of analytical performanceanalytical performancetools:tools: harmonizers /harmonizers / trueness controls trueness controls

Clinical chemistClinical chemistin case of excessive bias: in case of excessive bias: temporary (re)calibrationtemporary (re)calibrationtools:tools: matrix-based matrix-based reference materials reference materials

ManufacturerManufacturer& directive 98/79/EC& directive 98/79/ECon IVD-MD & JCTLMon IVD-MD & JCTLM

Traceability Traceability chainchain

CLUE =

commutability

Standardization Standardization in Laboratory in Laboratory

Medicine:Medicine:

the times have the times have changed!changed!

En wat Bokito lukte,zal ons ook lukken….……eens

En wat Bokito lukte,zal ons ook lukken….……eens