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Volume 4 • Issue 3 • 1000e113 J Chromat Separation Techniq ISSN:2157-7064 JCGST, an open access journal Open Access Hassan, J Chromat Separation Techniq 2013, 4:2 DOI: 10.4172/2157-7064.1000e113 Open Access Overview on Hyperlipidemia Bassam Abdul Rasool Hassan* Clinical Pharmacy Discipline, School of Pharmaceutical Sciences, University of Sains Malaysia, 11800, Minden, Penang, Malaysia *Corresponding author: Bassam Abdul Rasool Hassan, Clinical Pharmacy Discipline, School of Pharmaceutical Sciences, University of Sains, Malaysia, 11800, Minden, Penang, Malaysia, Tel: (+6) 016-423-0950; E-mail: [email protected] Received March 15, 2013; Accepted March 17, 2013; Published March 19, 2013 Citation: Hassan BAR (2013) Overview on Hyperlipidemia. J Chromat Separation Techniq 4: e113. doi:10.4172/2157-7064.1000e113 Copyright: © 2013 Hassan BAR, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Introduction It is a medical condition characterized by an elevation of any or all lipid profile and/or lipoproteins in the blood. is medical condition or problem divided into two subtypes which are: primary hyperlipidemia and secondary hyperlipidemia. Primary hyperlipidemia which is usually taken place as a result of genetic problems i.e., mutation within receptor protein, while secondary hyperlipidemia will arises as a result of other underlining diseases like diabetes. Alteration and/ or abnormality in the metabolism of lipid and lipoproteins is a very common condition that taken place within general population, and it consider as one of the main risk factor in the incidence of cardiovascular disease due to their influence on atherosclerosis. Critical Factors that Play Role in Hyperlipidemia Incidence ere are several factors which play significant role in the incidence of this medical problem which are the following: family history, Chronic diseases (diabetes mellitus, renal failure, nephritic syndrome and hypothyroidism), alcoholism and smoking, obesity and un healthy diets intake. Classifications of Hyperlipidemia Besides the above classifications i.e., primary and secondary hyperlipidemia subtypes, hyperlipidemia also classified according to the type of lipid elevated which is hypercholesterolemia, hypertriglyceridemia or both in combined hyperlipidemia. Diagnosis of Hyperlipidemia In this part the patients have to fast for at least 12 hours before taking the blood sample, the main reason for this is that chylomicron clearance required at least 10 hours. e laboratory test for this case mainly focuses on the lipid profile i.e., measure lipid profile which include total plasma cholesterol, HDL, LDL, VLDL and triglycerides levels. e mathematical way to calculate the VLDL is by dividing triglyceride value by 5, while for LDL it can be calculated by subtracting HDL cholesterol and VLDL cholesterol from total plasma cholesterol value. Managements used for Hyperlipidemia e major treatment used for hyperlipidemia divided into three parts which are: • Dietary control: is point focus on reducing intake of foods that contain high amount of saturated fat and cholesterol i.e., foods of animal origin. On the other hand this point will encourage intake of food or supplements that include fish oil or olive oil which include a very low concentration of saturated fat. Or focusing on intake of vegetarian foods which are free of cholesterol. ese types of food will significant play role in reducing elevated triglyceride levels. • Lifestyle change: is will include focusing on daily exercises, since regular exercises will lead to an improvement within lipid concentrations i.e., daily walking will reduce triglyceride level by an average of 10 mg/dL and elevation within HDL level by 5 mg/dL. • Medical treatments: ese treatments will be indicated for those patients who suffer from hyperlipidemia since early childhood i.e., familial hyperlipidemia. ese medications include: HMG CoA reductase inhibitors (first line treatment for elevated LDL levels), Fibrates (first line treatment for triglyceride elevation), Bile acid sequestrants (second line treatment for elevated LDL levels), Nicotinic acid (niacin) (second line treatment for all lipid disorders) and Ezetimibe and colesevelam (second line treatments to reduce absorption of cholesterol through gastrointestinal tract). Conclusion erefore it is a very important point for the open access journals to encourage researchers and clinicians to work hard in order to clarify the main problems associated with hyperlipidemia and the proper treatment used to treat this medical problem. Editorial Journal of Chromatography Separation Techniques J o u r n a l o f C h r o m a t o g r a p h y & S e p a r a t i o n T e c h n i q u es ISSN: 2157-7064
Transcript of t o g r a p h y &Se r o m paratio Journal of ...€¦ · Bassam Abdul Rasool Hassan* Clinical...
Volume 4 • Issue 3 • 1000e113J Chromat Separation TechniqISSN:2157-7064 JCGST, an open access journal
Open Access
Hassan, J Chromat Separation Techniq 2013, 4:2 DOI: 10.4172/2157-7064.1000e113
Open Access
Overview on HyperlipidemiaBassam Abdul Rasool Hassan*
Clinical Pharmacy Discipline, School of Pharmaceutical Sciences, University of Sains Malaysia, 11800, Minden, Penang, Malaysia
*Corresponding author: Bassam Abdul Rasool Hassan, Clinical Pharmacy Discipline, School of Pharmaceutical Sciences, University of Sains, Malaysia, 11800, Minden, Penang, Malaysia, Tel: (+6) 016-423-0950; E-mail: [email protected]
Received March 15, 2013; Accepted March 17, 2013; Published March 19, 2013
Citation: Hassan BAR (2013) Overview on Hyperlipidemia. J Chromat Separation Techniq 4: e113. doi:10.4172/2157-7064.1000e113
Copyright: © 2013 Hassan BAR, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
IntroductionIt is a medical condition characterized by an elevation of any or all
lipid profile and/or lipoproteins in the blood. This medical condition or problem divided into two subtypes which are: primary hyperlipidemia and secondary hyperlipidemia.
Primary hyperlipidemia which is usually taken place as a result of genetic problems i.e., mutation within receptor protein, while secondary hyperlipidemia will arises as a result of other underlining diseases like diabetes.
Alteration and/ or abnormality in the metabolism of lipid and lipoproteins is a very common condition that taken place within general population, and it consider as one of the main risk factor in the incidence of cardiovascular disease due to their influence on atherosclerosis.
Critical Factors that Play Role in Hyperlipidemia Incidence
There are several factors which play significant role in the incidence of this medical problem which are the following: family history, Chronic diseases (diabetes mellitus, renal failure, nephritic syndrome and hypothyroidism), alcoholism and smoking, obesity and un healthy diets intake.
Classifications of Hyperlipidemia Besides the above classifications i.e., primary and secondary
hyperlipidemia subtypes, hyperlipidemia also classified according to the type of lipid elevated which is hypercholesterolemia, hypertriglyceridemia or both in combined hyperlipidemia.
Diagnosis of HyperlipidemiaIn this part the patients have to fast for at least 12 hours before
taking the blood sample, the main reason for this is that chylomicron clearance required at least 10 hours. The laboratory test for this case mainly focuses on the lipid profile i.e., measure lipid profile which include total plasma cholesterol, HDL, LDL, VLDL and triglycerides
levels. The mathematical way to calculate the VLDL is by dividing triglyceride value by 5, while for LDL it can be calculated by subtracting HDL cholesterol and VLDL cholesterol from total plasma cholesterol value.
Managements used for HyperlipidemiaThe major treatment used for hyperlipidemia divided into three
parts which are:
• Dietary control: This point focus on reducing intake of foodsthat contain high amount of saturated fat and cholesterol i.e., foods of animal origin. On the other hand this point will encourage intake of food or supplements that include fish oil or olive oil which include a very low concentration of saturated fat. Or focusing on intake of vegetarian foods which are free of cholesterol. These types of food will significant play role in reducing elevated triglyceride levels.
• Lifestyle change: This will include focusing on daily exercises,since regular exercises will lead to an improvement within lipid concentrations i.e., daily walking will reduce triglyceride level by an average of 10 mg/dL and elevation within HDL level by 5 mg/dL.
• Medical treatments: These treatments will be indicated forthose patients who suffer from hyperlipidemia since early childhood i.e., familial hyperlipidemia. These medications include: HMG CoAreductase inhibitors (first line treatment for elevated LDL levels), Fibrates(first line treatment for triglyceride elevation), Bile acid sequestrants(second line treatment for elevated LDL levels), Nicotinic acid (niacin)(second line treatment for all lipid disorders) and Ezetimibe andcolesevelam (second line treatments to reduce absorption of cholesterolthrough gastrointestinal tract).
ConclusionTherefore it is a very important point for the open access journals
to encourage researchers and clinicians to work hard in order to clarify the main problems associated with hyperlipidemia and the proper treatment used to treat this medical problem.
Editorial
Journal of Chromatography Separation Techniques
Journal o
f Chr
omato
graphy & Separation Techniques
ISSN: 2157-7064
