Survival of the weakest: is evolution on our side?

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IS EVOLUTION ON OUR SIDE? SURVIVAL OF THE WEAKEST

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The 1%. Jeremy Cohen examines what makes us unique. Are there observable genetic traits that will determine how we respond to severe illness and can we measure them?

Transcript of Survival of the weakest: is evolution on our side?

Page 1: Survival of the weakest: is evolution on our side?

I S E V O L U T I O N O N O U R S I D E ?

S U R V I VA L O F T H E W E A K E S T

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R I C H A R D D A W K I N S

“A chicken is simply an egg’s way of making more eggs”

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S O R E N S O N E T A L N E J M 1 9 8 8

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T H E I N T E R N A T I O N A L H A P M A P P R O J E C T

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G W A S

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T I T L E

April

May

June

July

0 35000 70000 105000 140000

129,096Mb

63,178Mb

8,215Mb

3,423Mb

C O M PA R A T I V E G E N O M E S I Z E

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S C H I S T O C E R C A A M E R I C A N A S C H I S T O C E R C A G R E G A R I A

F. A C R I D I D A E

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E X A M I N I N G E X P R E S S I O N

R N A E X T R A C T I O N , R E V E R S E T R A N S C R I P T I O N A N D L A B E L L I N G

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E X A M I N I N G E X P R E S S I O N

H Y B R I D I S AT I O N

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E X A M I N I N G E X P R E S S I O N

M E A S U R E M E N T

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P E TA B Y T E

E N T I R E D N A O F T H E U N I T E D S TAT E S ( T W I C E )

2 0 0 0 Y E A R S W O R T H O F F O U R M I N U T E S O N G S

S T O R A G E C A PA C I T Y O F T H E W O R L D O F WA R C R A F T

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G E N E E X P R E S S I O N P R O F I L I N G I N S E P T I C

S H O C K

• S U B S T U D Y O F A D R E N A L

• A L L A D R E N A L PAT I E N T S

W I T H I N 2 4 H O U R S

E N R O L M E N T

• B L O O D F O R D N A / R N A

E X T R A C T I O N

• M A I L E D T O U Q C C G R W I T H I N

7 2 H O U R S C O L L E C T I O N

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G E N E E X P R E S S I O N P R O F I L I N G I N S E P T I C

S H O C K

• E S T I M AT E D 1 8 0 0 PAT I E N T

S A M P L E S

• 1 4 0 0 PAT I E N T D I S C O V E R Y

S A M P L E / 4 0 0 PAT I E N T

VA L I D AT I O N S A M P L E

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G E N E E X P R E S S I O N P R O F I L I N G I N S E P T I C

S H O C K

• D I F F E R E N T I A L

E X P R E S S I O N L E V E L S I N

S U R V I V O R S / N O N

S U R V I V O R S

• B I O L O G I C A L

E X P L O R AT I O N C L A S S I F I E R