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![Page 1: Survival Analysis using R - Western Universityrdc.uwo.ca/events/docs/presentation_slides/2009-10/Jones-SurvivalR... · Survival Analysis using R Bruce L. Jones Department of Statistical](https://reader031.fdocuments.in/reader031/viewer/2022021617/5b45cfd97f8b9ad1138bfb10/html5/thumbnails/1.jpg)
Survival Analysisusing R
Bruce L. Jones
Department of Statistical and Actuarial SciencesThe University of Western Ontario
March 24, 2010
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Outline
• What is R?
• Why use R?
• A bit about R
• What is Survival Analysis?
• The survival package in R
• Example
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What is R?
• R is a free software environment for statistical computing and graphics.
• It compiles and runs on a wide variety of UNIX platforms, Windowsand MacOS.
• R is very popular among researchers in statistics.
• R is similar in appearance to S.
• R was initially written by Ross Ihaka and Robert Gentleman
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Why use R?
• It contains advanced statistical routines not yet available in otherpackages.
• It provides an unparalleled platform for programming new statisticalmethods in an easy and straightforward manner.
• It has state-of-the-art graphics capabilities.
• It’s free. Just go to http://www.r-project.org
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Assignment, Vectors and Arrays
> 1+2*3
[1] 7
> x=3
> y<-2
> x+y
[1] 5
> z=c(2,3,4,5)
> z
[1] 2 3 4 5
> 2*z
[1] 4 6 8 10
>
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Assignment, Vectors and Arrays
> 1+2*3
[1] 7
> x=3
> y<-2
> x+y
[1] 5
> z=c(2,3,4,5)
> z
[1] 2 3 4 5
> 2*z
[1] 4 6 8 10
>
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Assignment, Vectors and Arrays
> z=2:5
> z
[1] 2 3 4 5
> z=seq(2,5,1)
> z
[1] 2 3 4 5
> zz=seq(10,300,3)
> zz
[1] 10 13 16 19 22 25 28 31 34 37 40 43 46 49 52 55 58 61 64[20] 67 70 73 76 79 82 85 88 91 94 97 100 103 106 109 112 115 118 121[39] 124 127 130 133 136 139 142 145 148 151 154 157 160 163 166 169 172 175 178[58] 181 184 187 190 193 196 199 202 205 208 211 214 217 220 223 226 229 232 235[77] 238 241 244 247 250 253 256 259 262 265 268 271 274 277 280 283 286 289 292[96] 295 298
>
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Assignment, Vectors and Arrays
> z=2:5
> z
[1] 2 3 4 5
> z=seq(2,5,1)
> z
[1] 2 3 4 5
> zz=seq(10,300,3)
> zz
[1] 10 13 16 19 22 25 28 31 34 37 40 43 46 49 52 55 58 61 64[20] 67 70 73 76 79 82 85 88 91 94 97 100 103 106 109 112 115 118 121[39] 124 127 130 133 136 139 142 145 148 151 154 157 160 163 166 169 172 175 178[58] 181 184 187 190 193 196 199 202 205 208 211 214 217 220 223 226 229 232 235[77] 238 241 244 247 250 253 256 259 262 265 268 271 274 277 280 283 286 289 292[96] 295 298
>
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Assignment, Vectors and Arrays
> mat=array(1:12,c(3,4))
> mat
[,1] [,2] [,3] [,4]
[1,] 1 4 7 10
[2,] 2 5 8 11
[3,] 3 6 9 12
> mat=matrix(1:12,3,4)
> mat
[,1] [,2] [,3] [,4]
[1,] 1 4 7 10
[2,] 2 5 8 11
[3,] 3 6 9 12
>
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Assignment, Vectors and Arrays
> mat=array(1:12,c(3,4))
> mat
[,1] [,2] [,3] [,4]
[1,] 1 4 7 10
[2,] 2 5 8 11
[3,] 3 6 9 12
> mat=matrix(1:12,3,4)
> mat
[,1] [,2] [,3] [,4]
[1,] 1 4 7 10
[2,] 2 5 8 11
[3,] 3 6 9 12
>
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Functions
> plus=function(a,b) a+b> plus(3,4)[1] 7> plus(3)
Error in plus(3) : element 2 is empty;the part of the args list of ’+’ being evaluated was:(a, b)
> plus=function(a,b=0) a+b> plus(3,4)[1] 7> plus(3)[1] 3> plus(1:3,4:5)
[1] 5 7 7Warning message:In a + b : longer object length is not a multiple of shorter object length
>
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Functions
> plus=function(a,b) a+b> plus(3,4)[1] 7> plus(3)
Error in plus(3) : element 2 is empty;the part of the args list of ’+’ being evaluated was:(a, b)
> plus=function(a,b=0) a+b> plus(3,4)[1] 7> plus(3)[1] 3> plus(1:3,4:5)
[1] 5 7 7Warning message:In a + b : longer object length is not a multiple of shorter object length
>
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What is Survival Analysis?
Survival Analysis is the study of lifetimes and their distributions. It usuallyinvolves one or more of the following objectives:
• to explore the behaviour of the distribution of a lifetime.
• to model the distribution of a lifetime.
• to test for differences between the distributions of two or more lifetimes.
• to model the impact of one or more explanatory variables on a lifetimedistribution.
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The Nature of Lifetime Data
• It’s almost always incomplete.
– It often involves right-censoring.
– It sometimes involves left-truncation.
• The methods of survival analysis allow for this incompleteness.
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The survival Package in R
> install.packages("survival") # first time only
--- Please select a CRAN mirror for use in this session ---trying URL ’http://probability.ca/cran/bin/windows/contrib/2.10/survival_2.35-8.zip’Content type ’application/zip’ length 2445387 bytes (2.3 Mb)opened URLdownloaded 2.3 Mb
package ’survival’ successfully unpacked and MD5 sums checked
The downloaded packages are inC:\Documents and Settings\jones\Local Settings\Temp\RtmpEQ5ZaF\downloaded_packages
> library(survival)
Loading required package: splines
>
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Creating a Survival Object
Example 1. Complete data lifetimes: 26, 42, 71, 85, 92.
> ex1.times=c(26,42,71,85,92)
> ex1.surv=Surv(ex1.times)
> ex1.surv
[1] 26 42 71 85 92
> class(ex1.surv)
[1] "Surv"
> class(ex1.times)
[1] "numeric"
>
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Creating a Survival Object
Example 2. Right-censored lifetimes: 26, 42, 71, 80+, 80+.
> ex2.times=c(26,42,71,80,80)
> ex2.events=c(1,1,1,0,0)
> ex2.surv=Surv(ex2.times,ex2.events)
> ex2.surv
[1] 26 42 71 80+ 80+
>
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Creating a Survival Object
Example 3. Left-truncated and right-censored lifetimes:Left-truncation time is 40 for all individuals;Event/right-censoring times are 42, 71, 80+, 80+.
> ex3.lttimes=rep(40,4)
> ex3.times=c(42,71,80,80)
> ex3.events=c(1,1,0,0)
> ex3.surv=Surv(ex3.lttimes,ex3.times,ex3.events)
> ex3.surv
[1] (40,42 ] (40,71 ] (40,80+] (40,80+]
>
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Real Data Example
Lifetimes: Times until death of 26 psychiatric patients
Number of deaths: 14
Number of censored observations: 12
Covariates: patient age and sex (15 females, 11 males)
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Real Data Example
The Data
patient sex age time death patient sex age time death
1 2 51 1 1 14 2 30 37 02 2 58 1 1 15 2 33 35 03 2 55 2 1 16 1 36 25 14 2 28 22 1 17 1 30 31 05 1 21 30 0 18 1 41 22 16 1 19 28 1 19 2 43 26 17 2 25 32 1 20 2 45 24 18 2 48 11 1 21 2 35 35 09 2 47 14 1 22 1 29 34 010 2 25 36 0 23 1 35 30 011 2 31 31 0 24 1 32 35 112 1 24 33 0 25 2 36 40 113 1 25 33 0 26 1 32 39 0
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Real Data Example
Questions
• Does the lifetime distribution behave the way we expect?
• Are the lifetimes different for females and males?
• Do the lifetimes depend on age?
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Estimating the Survival Function
We can explore the lifetime distribution by examining nonparametricestimates of the survival function.
The R function survfit allow us to do this.
> library(KMsurv) # get the data> data(psych)> attach(psych)> names(psych)
[1] "sex" "age" "time" "death"
> psych.surv=Surv(age,age+time,death) # create a survival object
> psych.fit1=survfit(psych.surv˜1) # obtain the estimates
> plot(psych.fit1,xlim=c(40,80),xlab="age",ylab="probability",+ main="Survival Function Estimates") # plot the estimates>
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Estimating the Survival Function
40 50 60 70 80
0.0
0.2
0.4
0.6
0.8
1.0
Survival Function Estimates
age
prob
abili
ty
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Estimating the Survival Function
Now let’s consider females and males separately.
> psych.fit2=survfit(psych.surv˜sex) # separate by sex
> plot(psych.fit2,xlim=c(40,80),xlab="age",ylab="probability",+ main="Survival Function Estimates for Males (red) and Females",+ col=c("red","blue"))
> plot(psych.fit2,xlim=c(40,80),xlab="age",ylab="probability",+ main="Survival Function Estimates for Males (red) and Females",+ col=c("red","blue"), conf.int=T)>
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Estimating the Survival Function
40 50 60 70 80
0.0
0.2
0.4
0.6
0.8
1.0
Survival Function Estimates for Females (blue) and Males
age
prob
abili
ty
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Estimating the Survival Function
40 50 60 70 80
0.0
0.2
0.4
0.6
0.8
1.0
Survival Function Estimates for Females (blue) and Males
age
prob
abili
ty
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Testing for Differences
The R function survdiff allow us to test for differences between lifetimedistributions.
> survdiff(psych.surv˜sex)
Error in survdiff(psych.surv ˜ sex) : Right censored data only
> psych.surv2=Surv(time,death) # create new survival object> survdiff(psych.surv2˜sex)
Call:survdiff(formula = psych.surv2 ˜ sex)
N Observed Expected (O-E)ˆ2/E (O-E)ˆ2/Vsex=1 11 4 6.24 0.807 1.61sex=2 15 10 7.76 0.650 1.61
Chisq= 1.6 on 1 degrees of freedom, p= 0.205
>
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Testing for Differences
The R function survdiff allow us to test for differences between lifetimedistributions.
> survdiff(psych.surv˜sex)
Error in survdiff(psych.surv ˜ sex) : Right censored data only
> psych.surv2=Surv(time,death) # create new survival object> survdiff(psych.surv2˜sex)
Call:survdiff(formula = psych.surv2 ˜ sex)
N Observed Expected (O-E)ˆ2/E (O-E)ˆ2/Vsex=1 11 4 6.24 0.807 1.61sex=2 15 10 7.76 0.650 1.61
Chisq= 1.6 on 1 degrees of freedom, p= 0.205
>
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Fitting a Proportional Hazards Model
The model: h(t|x1, . . . , xp) = h0(t) exp(β1x1 + · · · + βpxp)
• The PH model is often used when we are interested in the impact ofthe covariates, x1, . . . , xp, but not the lifetime distributions themselves.
• We can estimate and make inferences about β1, . . . , βp without esti-mating h0.
• The R function coxph allows us to do this.
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Fitting a Proportional Hazards Model
> psych.coxph1=coxph(psych.surv˜sex)> summary(psych.coxph1)
Call:coxph(formula = psych.surv ˜ sex)
n= 26
coef exp(coef) se(coef) z Pr(>|z|)sex 0.3900 1.4770 0.6102 0.639 0.523
exp(coef) exp(-coef) lower .95 upper .95sex 1.477 0.677 0.4466 4.884
Rsquare= 0.016 (max possible= 0.926 )Likelihood ratio test= 0.43 on 1 df, p=0.5141Wald test = 0.41 on 1 df, p=0.5227Score (logrank) test = 0.41 on 1 df, p=0.5203
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Fitting a Proportional Hazards Model
Next we use our survival object psych.surv2, which does not involve left-truncation.
> psych.coxph2=coxph(psych.surv2˜sex)> summary(psych.coxph2)
Call:coxph(formula = psych.surv2 ˜ sex)
n= 26
coef exp(coef) se(coef) z Pr(>|z|)sex 0.7511 2.1194 0.6055 1.241 0.215
exp(coef) exp(-coef) lower .95 upper .95sex 2.119 0.4718 0.6469 6.944
Rsquare= 0.062 (max possible= 0.945 )Likelihood ratio test= 1.66 on 1 df, p=0.1981Wald test = 1.54 on 1 df, p=0.2148Score (logrank) test = 1.61 on 1 df, p=0.2046
Note that the last test is exactly that performed using survdiff.
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Fitting a Proportional Hazards Model
Finally, consider
> psych.coxph3=coxph(psych.surv2˜age+sex)> summary(psych.coxph3)
Call:coxph(formula = psych.surv2 ˜ age + sex)
n= 26
coef exp(coef) se(coef) z Pr(>|z|)age 0.20753 1.23063 0.05828 3.561 0.00037 ***sex -0.52374 0.59230 0.73753 -0.710 0.47762---Signif. codes: 0 *** 0.001 ** 0.01 * 0.05 . 0.1 1
exp(coef) exp(-coef) lower .95 upper .95age 1.2306 0.8126 1.0978 1.380sex 0.5923 1.6883 0.1396 2.514
Rsquare= 0.553 (max possible= 0.945 )Likelihood ratio test= 20.91 on 2 df, p=2.879e-05Wald test = 14.3 on 2 df, p=0.0007866Score (logrank) test = 21.27 on 2 df, p=2.409e-05
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Conclusions about this Example
• There is great uncertainty due to the small number of observations.
• Times until death depend on age at first admission to the hospital.
• We cannot conclude that the lifetimes are different for females andmales.
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Fitting an Accelerated Failure Time Model
• This is a popular fully parametric model for which the lifetime distrib-ution is the same for different covariate values, except that the timescale is multiplied by a different constant.
• The R function survreg can be used to fit an AFT model.
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Summary
• R is a flexible and free software environment for statistical computingand graphics.
• The survival package contains functions for survival analysis.
– Surv creates a survival object.
– survfit estimates (nonparametrically) the survival function.
– survdiff performs tests for differences in lifetime distributions.
– coxph fits the proportional hazards model.
– survreg fits the accelerated failure time model.
These slides are here:
http://www.stats.uwo.ca/faculty/jones/survival_talk.pdf
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