Supplementaryinformation:

Table1:ProteobacterialandArchaebacterialgenomesusedforpreparationofFig.19,theorderhere(toptobottom)correspondstotheircolumnappearanceinFig.19fromlefttoright.Theproteomeswererandomlypicked(smallgenomesandendosymbiontsexcluded)fromRefSeqversionMarch2011.

Proteobacteria

1.AcidithiobacillusferrooxidansATCC23270(uid57649)2.AcidovoraxcitrulliAAC001(uid58429)3.AeromonashydrophilaATCC7966(uid58617)4.AllochromatiumvinosumDSM180(uid46083)5.AlteromonasmacleodiiDeepecotype(uid58251)6.AromatoleumaromaticumEbN1(uid58231)7.BdellovibriobacteriovorusHD100(uid61595)8.BeijerinckiaindicaATCC9039(uid59057)9.Brucellaabortusbv19941(uid58019)10.Burkholderia383(uid58073)11.Campylobacterconcisus13826(uid58667)12.CaulobactercrescentusCB15(uid57891)13.CupriavidusmetalliduransCH34(uid57815)14.DesulfarculusbaarsiiDSM2075(uid51371)15.DesulfobacteriumautotrophicumHRM2(uid59061)16.DesulfovibrioaespoeensisAspo2(uid42613)17.Enterobacter638(uid58727)18.Escherichiacoli536(uid58531)19.GallionellacapsiferriformansES2(uid51505)20.GeobacterbemidjiensisBem(uid58749)21.KetogulonicigeniumvulgareY25(uid59581)22.LegionellalongbeachaeNSW150(uid46099)23.MarinomonasMWYL1(uid58715)24.MethylobacillusflagellatusKT(uid58049)25.Methylobacterium446(uid58843)26.MethylococcuscapsulatusBath(uid57607)27.MyxococcusxanthusDK1622(uid58003)28.NeisseriagonorrhoeaeFA1090(uid57611)29.NitrosomonaseuropaeaATCC19718(uid57647)30.OchrobactrumanthropiATCC49188(uid58921)31.ParvularculabermudensisHTCC2503(uid51641)32.PasteurellamultocidaPm70(uid57627)33.ProteusmirabilisHI4320(uid61599)34.PseudomonasaeruginosaLESB58(uid59275)35.RalstoniaeutrophaH16(uid62925)36.RhizobiumetliCFN42(uid58377)37.RhodobactercapsulatusSB1003(uid47509)38.RhodoferaxferrireducensT118(uid58353)39.RhodospirillumcentenumSW(uid58805)40.RuegeriapomeroyiDSS3(uid57863)41.Saccharophagusdegradans240(uid57921)42.Salmonellaentericaarizonaeserovar62z4z23RSK2980(uid58191)43.SphingomonaswittichiiRW1(uid58691)44.SyntrophobacterfumaroxidansMPOB(uid58177)45.TeredinibacterturneraeT7901(uid59267)46.ThiobacillusdenitrificansATCC25259(uid58189)47.ThiomicrospiracrunogenaXCL2(uid58183)48.VibriocholeraeM662(uid59355)49.XanthomonasalbilineansGPEPC73(uid43163)50.Yersiniaenterocolitica8081(uid57741)

Archaea

1.Acidilobussaccharovorans34515(uid51395)2.AciduliprofundumbooneiT469(uid43333)3.AeropyrumpernixK1(uid57757)4.ArchaeoglobusfulgidusDSM4304(uid57717)5.CaldivirgamaquilingensisIC167(uid58711)6.CandidatusKorarchaeumcryptofilumOPF8(uid58601)7.CenarchaeumsymbiosumA(uid61411)8.Desulfurococcuskamchatkensis1221n(uid59133)9.FerroglobusplacidusDSM10642(uid40863)10.HalalkalicoccusjeotgaliB3(uid50305)11.HaloarculamarismortuiATCC43049(uid57719)12.HalobacteriumNRC1(uid57769)13.HaloferaxvolcaniiDS2(uid46845)14.HalogeometricumborinquenseDSM11551(uid54919)15.HalomicrobiummukohataeiDSM12286(uid59107)16.HaloquadratumwalsbyiDSM16790(uid58673)17.HalorhabdusutahensisDSM12940(uid59189)18.HalorubrumlacusprofundiATCC49239(uid58807)19.HaloterrigenaturkmenicaDSM5511(uid43501)20.HyperthermusbutylicusDSM5456(uid57755)21.IgnicoccushospitalisKIN4I(uid58365)22.IgnisphaeraaggregansDSM17230(uid51875)23.MetallosphaerasedulaDSM5348(uid58717)24.MethanobacteriumAL21(uid63623)25.MethanobrevibacterruminantiumM1(uid45857)26.MethanocaldococcusfervensAG86(uid59347)27.MethanocellapaludicolaSANAE(uid42887)28.MethanococcoidesburtoniiDSM6242(uid58023)29.MethanocorpusculumlabreanumZ(uid58785)30.MethanoculleusmarisnigriJR1(uid58561)31.MethanohalobiumevestigatumZ7303(uid49857)32.MethanohalophilusmahiiDSM5219(uid47313)33.MethanoplanuspetroleariusDSM11571(uid52695)34.MethanopyruskandleriAV19(uid57883)35.MethanosaetathermophilaPT(uid58469)36.MethanosarcinaacetivoransC2A(uid57879)37.MethanosphaerulapalustrisE19c(uid59193)38.MethanospirillumhungateiJF1(uid58181)39.MethanothermobactermarburgensisMarburg(uid51637)40.NatrialbamagadiiATCC43099(uid46245)41.NatronomonaspharaonisDSM2160(uid58435)42.NitrosopumilusmaritimusSCM1(uid58903)43.PyrobaculumaerophilumIM2(uid57727)44.PyrococcusabyssiGE5(uid62903)45.StaphylothermushellenicusDSM12710(uid45893)46.SulfolobusacidocaldariusDSM639(uid58379)47.ThermococcusbarophilusMP(uid54733)48.ThermofilumpendensHrk5(uid58563)49.ThermoproteusneutrophilusV24Sta(uid58421)50.VulcanisaetadistributaDSM14429(uid52827)

Table2:Sourceofeukaryotegenomesequencedata.

TimeofDownload Organism Data DatabaseJuly2011 Ascarissuum Genome RefSeqJuly2011 Caenorhabditiselegans Genome RefSeqJuly2011 Piromycessp.E2 Proteins,ESTs GenBankJuly2011 Fusariumoxysporum Genome *July2011 Encephalitozooncuniculi Genome RefSeqJuly2011 Enterocytozoonbieneusi Genome RefSeqJuly2011 Entamoebahistolytica Genome RefSeqJuly2011 Giardiaintestinalis Genome RefSeqJuly2011 Trichomonasvaginalis Genome RefSeqJuly2011 Euglenagracilis Proteins,ESTs GenBankJuly2011 Trypanosomabrucei Genome RefSeqJuly2011 Nyctotherusovalis Proteins,ESTs GenBankSeptember2011 Perkinsusmarinus Genome RefSeqSeptember2011 Phytophtorainfestans Genome RefSeqJuly2011 Blastocystishominis Genome GenBankJuly2011 Chlamydomonasreinhardtii Genome RefSeqFebruary2012 Cyanophoraparadoxa Genome +

July2011 Naegleriagruberi Genome RefSeq

*FusariumComparativeSequencingProject,BroadInstituteofHarvardandMIT(http://www.broadinstitute.org/).+Cyanophora GenomeProject(http://cyanophora.rutgers.edu/cyanophora/).

EukaryoticsequencessearchedforFig.19.Completeproteomesweredownloaded,ifavailable.InothercasestheavailableproteinsandESTsweredownloaded.

*FusariumComparativeSequencingProject,BroadInstituteofHarvardandMIT(http://www.broadinstitute.org/).

SupplementaryTable3:EukaryoticsequencessearchedforFig.19.Completeproteomesweredownloaded,ifavailable.InothercasestheavailableproteinsandESTsweredownloaded.

Table3:Fastaformatsearchsequencesusedtopreparefigue19.

ASCTIA

>gi|71754875|ref|XP_828352.1|succinyl‐coA:3‐ketoacid‐coenzymeAtransferasemitochondrialprecursor[TrypanosomabruceiTREU927]MLRRTNFFRIGLDKVMSLSSAVQDIKNGATLAVGGFGTGGMPHAIMQEIKKMGVRDLIIYSDGAGVDGYGIGVLFENKQINKMIVSYVGNNKIFARQYLEGDVELEFCPQGSLAERMRAGGAGIPAFYTPTAVGTVLQTGGQITKYDKNGGVLKESTPRETRFFGGRLYCLENAIKTDFSIVKAWKGDRCGNLVFRGTARNFNVPVGQCGQTVIAEVENLVENGDIDPDEVHLPGVYVDRVVVPERYQTLIEHRTVTRHDGAGNKPTKASTRGEEVRQRIARRAALEFANGMYVNLGIGIPTESSNYIPAGVNVVLQSENGLIGMGPFPTEDKVDADWINAGKQTISHLAGSALFDSATSFAMIRGGHMDLTMLGALEVAANGDLANFMIPGKLVKGPGGAMDLVSCGTRVVVTTTHCSKNGDPKIVERCRLPVTGKHCVCRIITEYAVFDVVDGRLVLKEIAEDTTVDQVKKLTGVGFDADNVITMPLAPLT

ASCTIB

>gi|192807489|gb|ACF06126.1|mitochondrialacetate:succinateCoA‐transferase[Fasciolahepatica]MYQLAFLRCRYASPIVREARRAFHASRKCQYYIDGPQEPFSPMPGRFPKWASNGDETFGFLKDGANVFIHGGAATPSLLIKELYEYVMSKNLKDIKLFHIHTEGPYPFNDAEGHFRSTSLFTGGNCRKAIQEGRADYTPIFLSEIPLLFRRKHVQLDLALINVTPPDKHGFCSLGPSVDVTRAAIQNATHIVAQVNDQLPLTRGDASIHFSNLTVMRAGSQPCHEMSPRPASEVEDKIGQIIAENLVEDGATLQTGIGAIPDAVLSKLTNHKNLGVHTEMFSDGVVQLVQLGAITNAYKKLRPGKVVSSFVVGTRKVFDFLDNNPMVDMCDVAWVNSPVVIAQNPKPVAINSCIEIDITGQVSSDSIGTTIYSGFGGQVDFLRGAAVSLDGQGKPIIAVPSVTKRNETKIVPHLKLGGGVVTTRAHVHYVVTEYGIAYLFGKNLRQRAHALIQIAHPDHRESLEKAAFDRLKVMPSPL

ASCTIC

>gi|123975034|ref|XP_001330176.1|hypotheticalprotein[TrichomonasvaginalisG3]MLSSSSRAIASLKSRCAYEPYLAKVCKAEDTIPIFKNGMSIGWSGFTPVGDPKVVPIALAEYVEKNNLQGKLRFNMFIGASSGAKNEDRWAKNGMIARRYPYQNGANLKKNINSGKTMFADKHLSMFPQDLTWGFYTKQRGGGIDLAIVEATEILADGSIVLGGAVGSAVEFLNAADKIIIELNTAIPSFKGCHDIVAPWKPPGKPYNITSVDSRIGSLSVKIDPSKVVAVVESHAIFPGRPVKGADATAKAIAGHIVDFFQNEVKQGRLPENLYPLQSGVGNIANAVVDGLNDSPFGHLTVYTEVLQEAMLPMFDSGKLKFGSSTSLTLSQWDKLYDNFDFYRNKFVLRPQAISNSPEVIRRLGVIAMNTPIEVDIFGHANSTLINGTKLVNGLGGSGDFLRNGYLSIMHCPSARKTKKDKTGISCVVPMCTHVDHTEHDLDVIVTEQGLADLRGLAPVERARLMIEKTVHPDYKDQMREYLNLAIQATQPKGAGHEPQILSKVFKMQENLKKKGTMHLDSW

acetyl­CoAsynthetase(ADP­forming)

>gi|9502268|gb|AAF88064.1|AF286346_1acetyl‐CoAsynthetase[Entamoebahistolytica]MQFEPLFNPKSVPVIGASDRKESVGYAVMNNMIKGGYKGNLYPVGRKPELFGKKCYAKIGKIEEKVDLAVIAIPAKFVPGVCIECGEAGVKGLIIITAGFAEAGEEGKKMCIEIQATCQKYNMRMIGPNCLGIINPRDGVNASFASVMPEAGGVAFISQSGALCTAILDWAANQHVGFSYFVSIGSSIDTDYADLFEFFAKDPKVTSILMYIESIKDAKKFVLRAREFAADKPIILLKAGKSSEGAAAAMSHTGSLAGNDAVYDAVFDRCGCIRVDSICDLWDCAHVLATQNIPQNNRLCIITNAGGPGVISTDRLVSVHGHLAKLSESTMNELNAFLSPFWSHSNPVDVLGDATAGVYQKTLDIVIKDPQIDGVVVVLTPQAMTDPVAVAKSLVEHGPYQNQSLPHGWVNQKSEAGVKILEEGKIPNFETPERAVTAFGYIMRHPDIAAKLKEIPKYLDVQVDYEGAKKLIADVVADGRTTFTEYEGKMMFSKYGIPIKGMAKASTEDEAVAEAMKIGTPVVMKILSPDIMHKTDVGGVKVKLTTEEEIRKAYRDIMTSVKEKKPEARIHGVLLEKMVGFKYECIIGCKKDPLFGPVIVFGMGGVTVELYKDTNIALPPIGLQEADRLIDGTKISKLLRGYRGMPACDVEGLKKILVQFSKMIMDFPEISEVDINPLAVSYEEFLVLDAKIVLDKNMIGKEVPKYSHLVIQP

acetyl­CoAsynthetase(AMP­forming)

>gi|169853833|ref|XP_001833594.1|acetyl‐CoAsynthetase[Coprinopsiscinereaokayama7#130]MSQTVADYLVTDDLTILLGLIAATVFLVNNLYKPQPLVHPILLGRQSDVGRARNPGESAVYRNYGTGLMGRFPIRPGKDVHILLDLVRAETEGPRTLWGTKLTNRTLQDRAAALGTGLIRLAGLKPNQSTVLLLLNDGFEFLLTDLALASHGIVSYTLSSAKLLSSVLDSHRPSAIVTHAAMLPGILELIYDSDERQNEYTIVVVDELPREVRAGVASNIKLLPFEDVEREGVRVEKILSPVPKPSDVFTISLYEGKNGMIQGAQLTHENFTAGVAAIHALLPASHTFSTLDTIASAHSLSTAFGRAVAYTALYEGTGFATLPSSIIYEGEDDHPSGSADYRDLTRVMGY

PIPFPTVLFLKPEHLRSTTDEILQHARKASLLYRFGWRHKLAGITDGFLTRDSLWDRMLFDSARNRVLGKISATTRAVIVSGGPVDADLMTPARIAFSVPVINTLSHPLVAAPVLASHAFDLQDFSLTGTSSQKPLPAHTGPPGVNVEVKLVGVDDEKVESGGDPVGVMYVRGPPVAKLVNVEGYVEVPSGDDDGWTGLGVRAKVQTNGSFVEMID

succinyl­CoAligasealphachain

>gi|159469923|ref|XP_001693109.1|succinyl‐CoAligase[Chlamydomonasreinhardtii]MWRLFLTAAGSAKSESSALAGFVRGFASQAAHNPAVFVDKNTKVICQGLTGKNGTFHTEQAIAYGTQMVGGVTPKKGGTSHLGLPVFNTVAEAKAATGCHATVIYVPPPFAAKAILEAVEAELELVVCITEGIPQHDMVRVKKAMQGQTKTRLIGPNCPGIIKPGECKIGIMPGYIHTPGKIGIVSRSGTLTYEAVFQTTNQGLGQSTVVGIGGDPFNGTNFVDCLERFVKDPQTEGIIMIGEIGGTAEEEAAEFIRKSGTKKPVVSFIAGLTAPPGRRMGHAGAIISGGKGTATDKIKALEEAGVTVTRSPAQMGVTMMRVMKERGLA

succinyl­CoAligasebetachain

>gi|159466790|ref|XP_001691581.1|succinate‐coaligasebetachain[Chlamydomonasreinhardtii]MLPALTGKLLKQATGSLAALSQCQQLRFFNVHEYQGAQIMSKFGVNVPPGIPATTLDEVKKAVDQMADEKGEVVIKSQILAGGRGLGKFTNGLQGGVHIVPKAKALELAKQMLGATLVTKQTGPAGKPVNTLLISKKMKLKREMYFAILLDRKTAGPMMIGCSEGGTSIEDLAEKFPEKIIKIPIDIRVGITDAQAMQMVEGLRVTGDKAAAAKQIKALYTLFDKSDCTMVEVNPLAEGLDGSLIAADAKLGFDDNAAYRQKPIFDMKDESQIDPREVAASKYDLNYIGLDGSIGCMVNGAGLAMATMDIIKMHGGAPANFLDVGGSANEQQVVEAFKILTGDKQVKAILVNIFGGIMKCDVIASGIVNAAKQVGVQVPLVVRLEGTNVARGKEILATSGMTIITADDLDDAAKKAVASIA

isocitratedehydrogenase(TCAcycle)

>gi|6323203|ref|NP_013275.1|Idp2p[SaccharomycescerevisiaeS288c]MTKIKVANPIVEMDGDEQTRIIWHLIRDKLVLPYLDVDLKYYDLSVEYRDQTNDQVTVDSATATLKYGVAVKCATITPDEARVEEFHLKKMWKSPNGTIRNILGGTVFREPIIIPRIPRLVPQWEKPIIIGRHAFGDQYKATDVIVPEEGELRLVYKSKSGTHDVDLKVFDYPEHGGVAMMMYNTTDSIEGFAKASFELAIERKLPLYSTTKNTILKKYDGKFKDVFEAMYARSYKEKFESLGIWYEHRLIDDMVAQMLKSKGGYIIAMKNYDGDVESDIVAQGFGSLGLMTSVLITPDGKTFESEAAHGTVTRHFRQHQQGKETSTNSIASIFAWTRGIIQRGKLDNTPDVVKFGQILESATVNTVQEDGIMTKDLALILGKSERSAYVTTEEFIDAVESRLKKEFEAAAL

alcoholdehydrogenase(NADH­dependent)

>gi|2492738|sp|Q24857.1|ADH3_ENTHIRecName:Full=Alcoholdehydrogenase3;Short=ADHMTMLNFTYYNPVRLIYGKGSLDEIEKQHLIPEDARIMMTYGGGSIKKNGVYEEVLKHIKPIVEFGGIEPNPSHETCIKAIKIAKENKINFLVAVGGGSIIDATKYIALGMEHTYSDDPYDICLKGGKFKVNPAQAKIGVVLTIPATGSETNCWGVISRHADKLKLPFNNESVFPTWSIVDPCFTMSLPDNQIRNGLVDSFVHCIEQYIGNYHLNPVVEAETEGVMRTIIGVSHKTLENHQDYQARITFCYAATVALNMSLLCGVTLCGGAHAVGVTLCGGAHAVGHELTSYYGLAHGETLAITTPGVMRFNKEKNAKKLIQMGEQVFGIKNSTPEAAIEATEKWFKSIGMKTRLSEWGKGKEEFETIARKFEGNPAGAHKDIDYKGCLQILNDIY

alcoholdehydrogenase(NADPH­dependent)

>gi|27733393|gb|AAO21494.1|AF241248_1alcoholdehydrogenase[Trichomonasvaginalis]MGRFTLPRVLYHGKGALENLKTLKGKRAFVVTGSHAMRKFGFLDKVVNYLKEAKFEVHVFDGVEQDPSVETVFKGAKAMEEFKPDWIVALGGGSPIDAAKAMWAVYEYPEMTFEKLIVPFSFPELRQKAHFCAITSTSGTATEVTAFSVITDYQKGIKYPLADFNITPDVAIVDPDLAETMPKKLVAFTGMDALTHAFEAYVSTLHCDYTDGLALHSIKLIFETLEASFNGCMKARATMHNAQCLAGMAFSNALLGIVHSMAHKTGAAYTSGHIVHGCANAMYLPKVIKYNSKNEEALHRYGDIARFLGMQGKDDVELVDAICQRIRDLCVKIEVPLCIKDYENGMINEQEYLAKLKDVATNAIGDACTGSNPRQPTQEEMEKLLLAVFFDKPIDF

alcoholdehydrogenaseE

>gi|2052472|gb|AAC47539.1|alcoholdehydrogenaseE[Giardiaintestinalis]MSLSDFDYGQELVETPEELNALFEKVEEAAHAFRQLDQAQVDKIFYAAAFAASNQRIPLAKMAYEETNMGVVEDKVIKNMFGSEYVYNKYKNMKTAGIIEEDKAGNTITVADPLGILAGIVPTTNPTSTAIFKCLIALKTRNCIIFSPHHRAVKSTIHGPRIVRDAAVKAGAPPNCIAWITKPSVPLAKALMGHPKTSCVLATGGPGMVTSAYSSGNPSIGVGPGNVPALIDETCDYKTAVNQVINSKSFDNGVVCASEQAIVCVTKEIYDKCIEELKFRGAYVMTEGREAACQQADPALNEATGKHQLNCDIVGRPARDIAANGSVVVPADCKCRCIVGTFTEVRHDEAMSCEKLSPVLGICWAETFEKAVDICGQMIDMAGAGHTAAIHTAPHRRDRIEYFTHHIRAGRIVVNSPSTFGGIGDLYNFAIDPTMTIGCGSYGKNSVSENVGPKHLLNYKKVAIVRRNPLWFKVPQVMHVGEGALAKAAADLISRGLSRAYIITGKVMHDLGFTDKIISPLTAGNVTVKVFTDVLPDPDLGTCYRSLAEVRDFQPDMIIALGGGSAMDLAKMVRLLYEHPKVDFAGLAQRFMDIRKRIYEYPECLDLRTAKTFSVAIPTTSGTGSEVTPF

SVITDEKEHVKYPLADYQLMTHMAVIDPELVLTVPASLASWTGVDALTHAIESYVSVMATEYTMPLSLQAIKTVFENLEKSVVSRCPTARGNVHQAATIAGIAFANAFLGICHSCAHKLGQKYHIPHGLANAIMLPHVIRYNAVDDPVKIATFPQYLYPVALERYAEIADYCGFTNKNDGKSVKEKTEILIKKIYDLYEKVGIDAKISACKEAPVEADFFAEENLDYLAYHAFDDQCTGANPRYPLIEDFKELFRAAW

lactatedehydrogenase

>gi|987693|dbj|BAA04088.1|lactatedehydrogenase[OryzasativaJaponicaGroup]MKKASSLSELGFDAEGASSGFFRPVADGGSTPTSHRRRLTKISVIGAGNVGMAIAQTILTREHGGRDRAGGRGAGQAARGDAGPAARGGVPPPRPPRLRHRPGRHARLRPGHRHGRRAPDPRGEPPEPAAAERGAVPEDRAGAGGALAGGAAADRLQPRRRADVRGVEDVGVPGEPRHRLRHQPRLLLVPLPPRRAPPGQRPGCPVQAYMVGEHGDSSVAIWSSMSVAGMPVLKSLRESHQSFDEEALEGIRRAVVDSAYEVISLKGYTSWAIGYSVASLAASLLRDQHRIHPVSVLASGFHGIPQDHEVFLSLPARLGRAGVLGVAEMELTEEEARRLRRSAKTLWENCQLLDL

malatedehydrogenase

>gi|71746906|ref|XP_822508.1|malatedehydrogenase[TrypanosomabruceiTREU927]MVIFFGRAQTRRVTGKVVVFGATTNVGKHLSLLLTLSPQVKELCCFDPLNDVTLRMTETRVRGIVKDLSHIDTGVVLRAVDDPQQWEPAMRNAQLVLICTGSIPNPSRLQRDLALAECAPEYLVAMELVARAAPHAIVGIASGPVNSLVPLAREVLLRHSAFDPRKLFGITSRDVMRTRVLFAKELHMNPYDVNVHVVGGKGDATVCPLITQTGFQLPHQRMVQLCEEVQRPENFTAGDHNSTGCRVDSQNVQGQEKFTCPTLSTANAAYEWVTSIMKAQRGDRGITECSFVESSIKRETPFFSSRVELGEEGAAQLLPLGALTPYEEELVAAAVPLIVEDVEAGLRLSKTGVDAVS

malicenzyme

>gi|154415099|ref|XP_001580575.1|malicenzyme[TrichomonasvaginalisG3]MSVKKDYASLSVAAHKEWRGKIETVVRCKVEDREDLSLAYTPGVAQPCIEIQKNPDLSYEFTRRWNTVAVVTDGTAVLGLGDIGPEAGTPVMEGKALLFKRFGDVDAIPLCVRSKSVDDIVKVVSLLAGSFGGVNLEDISAPRCFEIEKKLQEICDIPIFHDDQHGTAIVTLAALLNALKIVGKKIEEIKVVTSGAGAAGIAIIKLLIAVGVNPKNVILTDRQGAIYKGRSGLNDIKVEMAEITNSELKQGTLAEVIKGADVFIGVSAPKTLTEDMVKSMADKAIVFPMANPTPEIMPDLAKAAGAAVVGTGRSDFPNQINNVLAFPALFRGALDVRASRITNEMNIAAARAIASLVSDEELNPDYILPNPFDKRIKETVSKAVAQAAIKCGVARINQ

methylmalonyl­CoAmutase

>gi|218775149|dbj|BAH03574.1|methylmalonyl‐CoAmutase[Euglenagracilis]MLRKFRPLCIDLPPKWVEMANKELKGKGTVDKLLWNTPEGITVKPIYTAEDIKEHRSLPGVFPYTRGPHASMYTIRPWTIRQYAGFSTVEESNAFYKKAIAAGQQGLSVAFDLPTHRGYDSDHPRVEGDVGMAGVAVDSVEDMKLLFDGIPLEKMSVSMTMNGAALPILAMYIVAGEEQGADKAKMSGTIQNDILKEFMVRNTYIYPAEISITIIAHIMGYLAKNMPKYNSISISGYHLQEAGAHAALELGFTIADGLEYINAALKAGLTVDEIAPRLSFFFGIGMNFYMEVAKLRAARQLWATKVKELFQPKSAKSLLLRTHCQTSGWSLTEQDPYNNIIRTTVEAMAAVMGGTQSLHTNSFDEAIALPTPFSSRIARNTQLIIQEETGITKVVDPWAGSYAMEKLTDDLIVEATKVIDEVQLLGGMTKAINSGMPKLRIEESAARKQARIDSGADVIVGVNKYTIPQDGESVEVLSIDNTIVRKKQVERLSKIRATRDSAAVEKALDAITECARNGEGNLLDLAVIAARARATVGEISLAIEKVHGRYVAGTNVVSGVYLSEYENNIKDKGGIESIRKKVEAFEAKHGRRPRILVCKMGQDGHDRGAKVVSTGFADMGFDVDVGPLFQTPAEVARHAVEADVHIVGVSTQAAGHKTRVPQLINELKSQNASDILVIVGGVIPQKDYDALYEAGVSLVFGPGTRLPEAAEKVLNKL

methylmalonyl­CoAepimerase

>gi|300121330|emb|CBK21710.2|Methylmalonyl‐CoAepimerase[Blastocystishominis]MLANFARRAFATAKPYRILGIQQIAIGGTSKTALQNLWIDIFGLEKIHSFESTKENVKEDILRCGKGPMAVEVDIMEPYDPAKSPKVNVPPLNHIGLWVDDLPACVKYLQEKGVRFTPGGIRKGAAGYDVTFIHPKGKEPNPLSGEGVLIELVQAPQNVIDYYEKL

propionyl­CoAcarboxylase

>gi|300122043|emb|CBK22617.2|Propionyl‐CoAcarboxylasesubunit?[Blastocystishominis]MFGRSFSGIRGVSKLARSFATEGELPFKKILVANRGEIACRVFKTAKRMGIKTVAVYSDADRNAKHVKMADEAVYIGPSPSAQSYLVADKIVEACRKTGADAVHPGYGFLSENWRFAETLEKEGIIWCGPGKYAIEAMGDKIGSKILAVKAKVNTIPGFNGEINSDEEVLRIANDIGYPVMIKASAGGGGKGMRIAWNDKEALSGFHLSKQEAKSAFGDDRMFIEKYIEEPRHIEIQVLGDKFGNYCAFPERECSIQRRNQKVIEESPSVLLDEETRTAMGKQACMMAKAVNYCSAGTVEFLCDKHKNFYFLEMNTRLQVEHPITEMVTREDIVEQMFWIAAGRKLPDRLINWPLKRYAHAIEARVYAEDPRRNFLPSLGLLTKYIEPRGEFVRCDSGILDGSQISMYYDPMICKLVTWGDDRATAIKRMDEALNTYIIRGLNHNSAFLQDVIRSKRFGSGKITTNFIKEEYPDGWTGSHLTETEAEQLI

AATIAVHQERLAKEATNDQQMESYEPVCEKDLVATVGEKEYKVHMEFEGEAMTLEIDGKKVQYFEPTTEGYSMQYCGGNFDVVLRSARAQELSKFMIPKVQPDTSKFLASPMAGSLVKVHVKEGDRVEAGQPLAVVEAMKMQNELYAQKACVVKKVYFKPGQNLALDDVIMDFDVSA

trans­2­enoyl­CoAreductase

>gi|62287512|sp|Q5EU90.1|TER_EUGGRRecName:Full=Trans‐2‐enoyl‐CoAreductase,mitochondrial;Flags:PrecursorMSCPASPSAAVVSAGALCLCVATVLLATGSNPTALSTASTRSPTSLVRGVDRGLMRPTTAAALTTMREVPQMAEGFSGEATSAWAAAGPQWAAPLVAAASSALALWWWAARRSVRRPLAALAELPTAVTHLAPPMAMFTTTAKVIQPKIRGFICTTTHPIGCEKRVQEEIAYARAHPPTSPGPKRVLVIGCSTGYGLSTRITAAFGYQAATLGVFLAGPPTKGRPAAAGWYNTVAFEKAALEAGLYARSLNGDAFDSTTKARTVEAIKRDLGTVDLVVYSIAAPKRTDPATGVLHKACLKPIGATYTNRTVNTDKAEVTDVSIEPASPEEIADTVKVMGGEDWELWIQALSEAGVLAEGAKTVAYSYIGPEMTWPVYWSGTIGEAKKDVEKAAKRITQQYGCPAYPVVAKALVTQASSAIPVVPLYICLLYRVMKEKGTHEGCIEQMVRLLTTKLYPENGAPIVDEAGRVRVDDWEMAEDVQQAVKDLWSQVSTANLKDISDFAGYQTEFLRLFGFGIDGVDYDQPVDVEADLPSAAQQ

phosphateacetyltransferase

>gi|159472743|ref|XP_001694504.1|phosphateacetyltransferase[Chlamydomonasreinhardtii]MSLNSSTMSRRQAVAGAPAVAPFRHAGLFPRVRLCANRRVARVAPKAAGNGNIAQGEQGFDTLFLSDISLVGQRTPLLLGFFNYFERHLPHVGFFEPIAAEALASSELRIDRHVELVYKVFNLKGDVRAMTGVQDAEAARMIANGQHSELLDKIYSQYASYKEGQDLVLVEGPGPLMGGTELDAQIAAALNAPVLMTMTGQPNATVADYYNRAMVKRQVFLDHHVEVLGLVMNGLPRQSHAILSGQLRDKFAAAGLPFAGAIPTDIMLRNVRLDEVQTAMGAQRLYGDSLLTDVEFDDVVVASQRLEELLEILAERPMGRPLVVTSADRLDIVLGLLAAQLSVSGPGVAGILLTQAGSARSGRNYARDTIDRIFAGLSSSGLYKGSLLPVLVTDMPLRDAIRKLDNLDAAILPSSTRKISQCKRLFEQYVDANAVVARLQNMVRPNRMTPKMFMHTLKSMCNATPQHIVLPESEDKRVLAAAADVVQRGLAKITLLGDPTTILAEAAKLGLDLSGCNIHNPNTSDRFDKYVDMLVEARKKKGMTREVAADTLHGDVNFFATMMIVAGDADGMVSGAVHTTASTVRPALQVLKSPDTPLVSSVFIMCLPDRVVVYGDCAVNVNPSAADLAQIAITSNDTAAAFGIEPRVAMLSYSTLGSGSGPDVQKVSEAVAIVKQRRPDIKVEGPIQYDAAIDPKVAAVKVQGLSEVAGKATVFIFPDLNTGNNTYKAVQQSTGAIAMGPVMQGLLRPVNDLSRGCTVPDIINTICVTSIQASRMSSAARAAAAKAAVAAV

alanineaminotransferase

>gi|76664072|emb|CAI59804.2|putativealanineaminotransferaseprecursor[Nyctotherusovalis]KKASDAGTNVKGDSDNSTRGIPTGQVMTKQNMEDIVKFCHKNSLVILADEVYQKNIYREKPFISFKKVVYGMPAPYNEVELISFHSTSKGVVGECGLRGGYMELDNIDSFVSEQILKLRSISLCSNTVGQVMTELMVNPPKAGVNSPEVVAKHQKEYDIVFGGLKKRSVLLADKLNSIPGLKTNNIEGALYAYPSIFLPERAIKAAKEKGLAPDAMYCVEALEECGLVLVPGSGCGQKEGTYHFRITNLILDTEEFDQALEAFKRFNAKFFAKYSQ

aspartateaminotransferase

>gi|71755339|ref|XP_828584.1|aspartateaminotransferasemitochondrial[TrypanosomabruceiTREU927]MGKPDPILGLGQDFRMDPAKRKVNLSIGVYRDDADQPFVLECVKQATLGTNMDYAPVTGIASFVEEAQKLCFGPTCAALRDGRIASCQTLGGTGALRIGGDLLNRFVANCNRIYGPDVGYPNHESIFAKAGMELTPYSYYDPATKGFNLAGMLECLDKAPEGSVILVHACAHNPTGVDPTHDDWRQVCDVIKRRNHIPFVDMAYQGFATGQLDYDAFVPRHLVDMVPNLIVAQSFSKNFGLYGHRCGALHISTASAEEAKRLVSQLALLIRPMYSNPPLYGAWVVSSILKDPQLTALWKKELKQMSSRIAEVRKRLVSELKACGSVHDWSHIERQVGMMAYTGLTREQVELLRSEYHIYMTLNGRAAVSGLNSTNVEYVSQAIHNVTK

glutamatedehydrogenase

>gi|4106519|gb|AAD02872.1|glutamatedehydrogenase[Trypanosomabrucei]MMRRASYCAGHAFTSLTVVGSRRFFQGERCEAEIVKLTKERGMFSDASVEASVHQLMSRLSDSPYVRHYTDAEVSAHAHGFLCAKARSALGEPFEHFHESDDSAFYICRKDQASQLRAVRQLTKFVSRERETKQSVSVRCYTAGDSDIAVFTAKIRPFVNPNPEKGETDIGQLASSAFLEERSPEMQERYQDLINRFHESVVPVHTVREVDGEVCFSMIMAADRSYYIATLQTVIQEIPGAVVTRCFSETFSNDTHVYTYFVRGATSQQLSDRASLVPFLPTRPRSLITRLHEDMVFDTEQTVYTDAAVIRLLLTPQPTSEDYRHLRSLVSKEPNGLSRLNNLRTTLSLEMMSERYILTLISTYPEFMKEIYEDFQVGTTHERRCAIREKITTRFREDQRSEHDLGIFNAFLQFNEVVLKHNFFKQHKVALCFRLDPSFLRSLGYPRVPHGVFLLAGAQWRGFHVRFTDIARGAVRMIFSKDTMYRRNKRSVFQENYNLALTQLLKNKDIPEGGSKGTILVSSRYLNTFNQPLCERIFLQYADALLDVVIPGEEGIVDRLKTPEIIFLGPDEHTAGTFPSVGSLFSKKRGYSAWKSFTTGKDASLGGIPTTILIAMTTRSVRTMVRGVYEKLGLDEASQTKFLTGGPDGDLGSNEILLSKEKTLAVLDISASLFDPEGLNKEELKRLATARKQLRDFDKSKLSSKGFLVLTGDKNVTLPDGTHVSDGVSFRDEFHLTKYSAADVFVPCGGRPRSVTLANVGRFLNLSAADNDSLLAGGSIQLKTPKYKIIVEGANLFISQDARLAIERCGIVLIKDASANKGGVTSSSLEVYAGVALSDEEHAQHMCVKDPNNVPEFYKKYVLDIIERIESNARREFEAIWREQQVQEGMPKTLIADSLSEKNVRVRASI

LSSDMCENKELVRYVLSNYTPKTLLEVVPLETLMERVPLEYQKAICAMWLASEYVYTTGISGNEFDFFTFMTKHMEQAKHIS

pyruvatecarboxylase

>gi|300122746|emb|CBK23311.2|PyruvateCarboxylase(subunit?)[Blastocystishominis]MFKLGTSSSILSKCGWRLLSKRSFEKVMAANRGEIAVRVMRAARELSLKTVAIYSYEDRYNMHRSKADECYMLSKEKSAIGAYLDIPTIVDIAKKNGVSAIHPGYGFLSENAEFAKAVEDAGIVFIGPTVENLRMMADKTSARKVAIDHGIPVVPGTPDPVATYEQALSFCNEVGYPVIIKAAFGGGGKGMRVVRSEQELKQNFELASREALSAFGNGTIFLERYLEEPRHIEVQVIGDGTGRVVHLYERDCSVQRRHQKVIENAPAVNLDPAIRDGILQSACRLCSLIKYRSAGTVEFLVDKQGRYYFMEVNPRIQVEHTVSEEITGINIVQKQIQLAQGYSFEELGLQQDKITTRGYSIQARITTENPSKNFQPDTGVLSTFEMAAGQGFRLDGIGYQGYEVTPHYDSLLVKMTTRGLTWEEAMDRAYSGLNEFKVDGVKTNIPFLLNVLRNPIYRSGKATTFFIEQNPELLKARDEHENPEKVVNYLANLIVNGHPSELGATGPAPAPTDPTVPPTPPGAIPAGLRDVFLKEGPKGFAKAVRAHKGLLLTDTTWRDGHQSLLATRMRTRDILAIAPATARMLPNLFSLECWGGATFDVAMRFLHECPWDRLAKMRELVPNIPFQMLLRGANAVGYSAYADNVNYKFCEMAVKMGMDVFRVFDSLNYIENMRLGIDCVGAAGGIIEATACYTGDCASPNETKYTVDYYLDYVRKLVDLGIHVLNIKDMAGLLTPQAAKLLVGSIRREFPDLPIHIHTHDTAGTGVYSMIECAKAGADAVDVAIDSMSGMTSQPSMGAVVAALKNTELDTGISLETVQTLNDYWNDVRGVYAPFESGQKSGSSDVYLHEMPGGQYTNLMYQSQQLGLSGQWPLVKRAYEEANELCGDIIKVTPSSKVVGDLANFMVQNKLTKKDVLERAEQLNFPTSVIEYFQGYLGIPEPWGFPEPFRSRVLKGRKLPNGKDRLEGRPGASLPPYDLEGTKKMLAEKYGESRAQDHDVLSYALYPRVFQDWKDFEDRNGDISTLPTRYFLQPMKSDEEITVDVSPSKRMYIRYKGMSEVNKQGQREVNFQIDGRPHTVVVNDIKASASVKRREQAQEGNKAQVGSPMTGAVVEVKVEAGKKVKAGEPICILSAAKMETVVAAPFSGILKRVIVEKGEKLKAGDLLVEIESEKK

pyruvatedecarboxylase

>gi|6323163|ref|NP_013235.1|Pdc5p[SaccharomycescerevisiaeS288c]MSEITLGKYLFERLSQVNCNTVFGLPGDFNLSLLDKLYEVKGMRWAGNANELNAAYAADGYARIKGMSCIITTFGVGELSALNGIAGSYAEHVGVLHVVGVPSISSQAKQLLLHHTLGNGDFTVFHRMSANISETTAMITDIANAPAEIDRCIRTTYTTQRPVYLGLPANLVDLNVPAKLLETPIDLSLKPNDAEAEAEVVRTVVELIKDAKNPVILADACASRHDVKAETKKLMDLTQFPVYVTPMGKGAIDEQHPRYGGVYVGTLSRPEVKKAVESADLILSIGALLSDFNTGSFSYSYKTKNIVEFHSDHIKIRNATFPGVQMKFALQKLLDAIPEVVKDYKPVAVPARVPITKSTPANTPMKQEWMWNHLGNFLREGDIVIAETGTSAFGINQTTFPTDVYAIVQVLWGSIGFTVGALLGATMAAEELDPKKRVILFIGDGSLQLTVQEISTMIRWGLKPYIFVLNNNGYTIEKLIHGPHAEYNEIQGWDHLALLPTFGARNYETHRVATTGEWEKLTQDKDFQDNSKIRMIEVMLPVFDAPQNLVKQAQLTAATNAKQ

pyruvatedehydrogenaseE1alphasubunit

>gi|151944896|gb|EDN63155.1|pyruvatedehydrogenasealphasubunit(E1alpha)[SaccharomycescerevisiaeYJM789]MLAASFKRQPSQLVRGLGAVLRTPTRIGHVRTMATLKTTDKKAPEDIEGSDTVQIELPESSFESYMLEPPDLSYETSKATLLQMYKDMVIIRRMEMACDALYKAKKIRGFCHLSVGQEAIAVGIENAITKLDSIITSYRCHGFTFMRGASVKAVLAELMGRRAGVSYGKGGSMHLYAPGFYGGNGIVGAQVPLGAGLAFAHQYKNEDACSFTLYGDGASNQGQVFESFNMAKLWNLPVVFCCENNKYGMGTAASRSSAMTEYFKRGQYIPGLKVNGMDILAVYQASKFAKDWCLSGKGPLVLEYETYRYGGHSMSDPGTTYRTRDEIQHMRSKNDPIAGLKMHLIDLGIATEAEVKAYDKSARKYVDEQVELADAAPPPEAKLSILFEDVYVKGTETPTLRGRIPEDTWDFKKQGFASRD

pyruvatedehydrogenaseE1betasubunit

>gi|151946607|gb|EDN64829.1|pyruvatedehydrogenasebetasubunit(E1beta)[SaccharomycescerevisiaeYJM789]MFSRLPTSLARNVARRAPTSFVRPSAAAAALRFSSTKTMTVREALNSAMAEELDRDDDVFLIGEEVAQYNGAYKVSKGLLDRFGERRVVDTPITEYGFTGLAVGAALKGLKPIVEFMSFNFSMQAIDHVVNSAAKTHYMSGGTQKCQMVFRGPNGAAVGVGAQHSQDFSPWYGSIPGLKVLVPYSAEDARGLLKAAIRDPNPVVFLENELLYGESFEISEEALSPDFTLPYKAKIEREGTDISIVTYTRNVQFSLEAAEILQKKYGVSAEVINLRSIRPLDTEAIIKTVKKTNHLITVESTFPSFGVGAEIVAQVMESEAFDYLDAPIQRVTGADVPTPYAKELEDFAFPDTPTIVKAVKEVLSIE

pyruvatedehydrogenaseE2

>gi|151944463|gb|EDN62741.1|pyruvatedehydrogenasecomplexdihydrolipoamideacetyltransferasecomponent(E2)[SaccharomycescerevisiaeYJM789]MSAFVRVVPRISRSSVLTRSLRLQLRCYASYPEHTIIGMPALSPTMTQGNLAAWTKKEGDQLSPGEVIAEIETDKAQMDFEFQEDGYLAKILVPEGTKDIPVNKPIAVYVEDKADVPAFKDFKLEDSGSDAKTSTKAQPAEPQAEKKQEAPAEETKTSAPEAKKSDVAAPQGRIFASPLAKTIALEKGISLKDVHGTGPRGRITKADIESYLEKSSKQSSQTSGAAAATPAAATSSTTAGSAPSPSSTASYEDVPISTMRSIIGERLLQSTQGIPSYIVSSKISVSKLLKLRQSLNATANDKYKLSINDLLVKAITVAAKRVPDANAYWLPNENVIRKFKNVDVSVAVAT

PTGLLTPIVKNCEAKGLSQISNEIKELVKRARINKLAPEEFQGGTICISNMGMNNAVNMFTSIINPPQSTILAIATVERVAVEDAAAENGFSFDNQVTITGTFDHRTIDGAKGAEFMKELKTVIENPLEMLL

pyruvatedehydrogenaseE3

>gi|118678|sp|P09624.1|DLDH_YEASTRecName:Full=Dihydrolipoyldehydrogenase,mitochondrial;AltName:Full=Dihydrolipoamidedehydrogenase;AltName:Full=GlycinedecarboxylasecomplexsubunitL;AltName:Full=Lipoamidedehydrogenasecomponentofpyruvatedehydrogenasecomplex;AltName:Full=PyruvatedehydrogenasecomplexE3component;Flags:PrecursorMLRIRSLLNNKRAFSSTVRTLTINKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGALSLKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEVDKRGRLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEMLKTGHGHVNYNNIPSVMYSHPEVAWVGKTEEQLKEAGIDYKIGKFPFAANSRAKTNQDTEGFVKILIDSKTERILGAHIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAFKEANMAAYDKAIHC

pyruvate­formatelyase

>gi|159462978|ref|XP_001689719.1|pyruvate‐formatelyase[Chlamydomonasreinhardtii]MLTPLSYPIINTVSSSLPALHAMSQMLLEKTMRRGLATVSAAASSAVGRPIPMAVRSPMRSMAAASAAAEALPVAPSHSCAADPDKHPHLPDPRPKPAVDAGINVQKYVQDNYTAYAGNSSFLAGPTDNTKKLWSELEKMIATEIEKGVMDVDPSKPSTITAFPPGYIDKDLETVVGLQTDAPLKRAIKPLGGVNMVKAALESYGYTPDPEVARLYSTVRKTHNSGVFDAYTDEMRAARKSGILSGLPDGYGRGRIIGDYRRVALYGVDALIKAKKTDLKHNLLGVMDEEKIRLREEVNEQIRALSELKEMGAAYGFDLSRPAANSREAVQWLYFGYLGAVKEQDGAAMSLGRIDAFLDTYFERDLKAGTITEAEVQELIDHFVMKLRIVRQLRTPEYNALFAGDPTWVTCVLGGTDASGKAMVTKTSFRLLNTLYNLGPAPEPNLTVLWNDNLPAPFKEFCAKVSLDTSSIQYESDNLMSKLFGSDYSIACCVSAMRVGKDMQYFGARANLPKLLLYTLNGGRDEVSGDQVGPKFAPVRSPTAPLDYEEVKAKIEDGMEWLASMYANTMNIIHYMHDKYDYERLQMALHDTHVRRLLAFGISGLSVVTDSLSAIKYAQVTPVIDERGLMTDFKVEGSFPKYGNDDDRVDEIAEWVVSTFSSKLAKQHTYRNSVPTLSVLTITSNVVYGKKTGSTPDGRKKGEPFAPGANPLHGRDAHGALASLNSVAKLPYTMCLDGISNTFSLIPQVLGRGGEHERATNLASILDGYFANGGHHINVNVLNRSMLMDAVEHPEKYPNLTIRVSGYAVHFARLTREQQLEVIARTFHDTM

pyruvateformate­lyaseactivatingenzyme(PFL_AE)

>gi|92084844|emb|CAF04130.1|pyruvateformate‐lyaseactivatingenzyme[Chlamydomonasreinhardtii]MNAASMSCAATGLQRSGPLAMNAATTSRTGPASGLPKHSWGASARRAFVAPATISERLQRKLSTNYSVVLPQYEPTDPSGIPEVFGNVHSTESMSAVDGPGVRFLVFVQGCAMRCLFCSNPGTWTLKGGNKTSSKEIAADIKRVRNYLKPRGGITISGGEAMLQPHFVSTVFQEVHALGLNTTVDTTGQGTKAGNWDVVLPHTDLVLFCIKHIDPIKYEALTGMKQRGASGFADQLAERKIPFYLRYVYIPGYTDGVKDIDKLIEWCKQQPTFQGIELLPYHVLGRNKWEVMGLPYPLDGTNTPPHEQVRAVIKVFNDNDVPVICAE

Pyruvate:NADPoxidoreductase

>gi|9909124|dbj|BAB12024.1|pyruvate:NADP+oxidoreductase[Euglenagracilis]MKQSVRPIISNVLRKEVALYSTIIGQDKGKEPTGRTYTSGPKPASHIEVPHHVTVPATDRTPNPDAQFFQSVDGSQATSHVAYALSDTAFIYPITPSSVMGELADVWMAQGRKNAFGQVVDVREMQSEAGAAGALHGALAAGAIATTFTASQGLLLMIPNMYKIAGELMPSVIHVAARELAGHALSIFGGHADVMAVRQTGWAMLCSHTVQQSHDMALISHVATLKSSIPFVHFFDGFRTSHEVNKIKMLPYAELKKLVPPGTMEQHWARSLNPMHPTIRGTNQSADIYFQNMESANQYYTDLAEVVQETMDEVAPYIGRHYKIFEYVGAPDAEEVTVLMGSGATTVNEAVDLLVKRGKKVGAVLVHLYRPWSTKAFEKVLPKTVKRIAALDRCKEVTALGEPLYLDVSATLNLFPERQNVKVIGGRYGLGSKDFIPEHALAIYANLASENPIQRFTVGITDDVTGTSVPFVNERVDTLPEGTRQCVFWGIGSDGTVGANRSAVRIIGDNSDLMVQAYFQFDAFKSGGVTSSHLRFGPKPITAQYLVTNADYIACHFQEYVKRFDMLDAIREGGTFVLNSRWTTEDMEKEIPADFRRKLAQKKVRFYNVDARKICDSFGLGKRINMLMQACFFKLSGVLPLAEAQRLLNESIVHEYGKKGGKVVEMNQAVVNAVFAGDLPQEVQVPAAWANAVDTSTRTPTGIEFVDKIMRPLMDFKGDQLPVSVMTPGGTFPVGTTQYAKRAIAAFIPQWIPANCTQCNYCSYVCPHATIRPFVLTDQEVQLAPESFVTRKAKGDYQGMNFRIQVAPEDCTGCQVCVETCPDDALEMTDAFTATPVQRTNWEFAIKVPNRGTMTDRYSLKGSQFQQPLLEFSGACEGCGETPYVKLLTQLFGERTVIANATGCSSIWGGTAGLAPYTTNAKGQGPAWGNSLFEDNAEFGFGIAVANAQKRSRVRDCILQAVEKKVADEGLTTLLAQWLQDWNTGDKTLKYQDQIIAGLAQQRSKDPLLEQIYGMKDMLPNISQWIIGGDGWANDIGFGGLDHVLASGQNLNVLVLDTEMYSNTGGQASKSTHMASVAKFALGGKRTNKKNLTEMAMSYGNVYVATVSHGNMAQCVKAFVEAESYDGPSLIVGYAPCIEHGLRAGMARMVQESEAAIATGYWPLYRFDPRLATEGKNPFQLDSKRIKGNLQEYLDRQNRYVNLKKNNPKGADLLKSQMADNITARFNRYRRMLEGPNTKAAAPSGNHVTILYGSETGNSEGLAKELATDFERREYSVAVQALDDIDVADLENMGFVVIAVSTCGQGQFPRNSQLFWRELQRDKPEGWLKNLKYTVFGLGDSTYYFYCHTAKQIDARLAALGAQRVVPIGFGDDGDEDMFHTGFNNWIPSVWNELKTKTPEEALFTPSIAVQLTPNATPQDFHFAKSTPVLSITGAERITPADHTRNFVTIRWKTDLSYQVGDSLGVFPEN

TRSVVEEFLQYYGLNPKDVITIENKGSRELPHCMAVGDLFTKVLDILGKPNNRFYKTLSYFAVDKAEKERLLKIAEMGPEYSNILSETYHYADIFHMFPSARPTLQYLIEMIPNIKPRYYSISSAPIHTPGEVHSLVLIDTWITLSGKHRTGLTCTMLEHLQAGQVVDGCIHPTAMEFPDHEKPVVMCAMGSGLAPFVAFLRDGSTLRKQGKKTGNMALYFGNRYEKTEFLMKEELKGHINDGLLTLRCAFSRDDPKKKVYVQDLIKMDEKMMYDYLVVQKGSMYCCGSRSFIKPVQESLKHCFMKAGGLTAEQAENEVIDMFTTGRYNIEAW

pyruvate:ferredoxinoxidoreductase

>gi|300122846|emb|CBK23853.2|Pyruvate:Ferredoxin(flavodoxin)Oxidoreductase(PFO)[Blastocystishominis]MFSTCAKRAVCGISRFNTAFSSTAPKAFIAQFGTKKRVAIDGNEAAAHAIYQVSDAAMLFPITPSSGMGEHCDAWANKGLKNVFGQKVVITEMQSEAGAAGALHGTLTGGLLGTTFSSSQGLMLMVPSMHKISGELLPGVIHVSSRSVSKMTTCLYCDYGDVFQTRATGFAYLSSHSVQEAHDLALVSHLSAINSSIPFLHFFDGFRTSHEMSSIELISPEDIKSIFPFEKALEHKNRGVNPVHPYSIGVAYGDDVWMQTLQTHQPYYDAVPDKVQAAMDQVASITGRQYHLFDYVGAPDAENVMVLMGASAQTAEETVEYLNQHGEKVGVMKVHLWRPFSLKHFAAALPKTVKQICVLDKVREENAYGEPLYLDVNCAVRDLDRDIKVICGEFGVAGKEFTPNLVKAVFDNMKAEKPKTHFTLGVVDDVCHTSLPIPPPLNTLPDSVTQCILYGLGSDGTVGATQEAVKLIVENTPLYAQANFGFDAHKSGGLTVTDVRFGPEPIKAEYTVQSADYVGCHTTAYVHKYDMLKHIKEGGTFVLNAPWKTVEELDANLPPAIKHQIAEKKVKLYVIDATSVAQKVGLRQRINMVMQAVFFKLSKVLPEDQATKLIADNIRTRYAKKGEEVVNMNITAMEQAGKELVEIDYPSSWIDYKMEPLRTFGPEVPDYFKNLFYPTTLLDGDRFPVSAFTPGGIHPTDTSKYEKRGFAVSVPVWNKDTCTQCNQCSVMCPHAVIRPFLMDAEETKKAPASFVSLPAVGDELKGLNFRIQASPLDCTGCEVCVNVCPTQSLNMEPLGSVKDVEGKNWDFAMTLTNKGDLVDKTTVKGSQFQPPLIQFNGACAGCGETQYVKMLTQLFGSKMILADAMGCSMVWSGTSGLIPFTVDKNGYGPVWCSSLFEDHAEYGFGVNKANQIKRARLESNIQAALADGGVSAELKGCMEKWLSNKNDKAVCDELFEQMKPLLAAEQSKPAVKAVADYQDMLPVITTWLYGGDGWAYDIGFVGLDHVLASGENVKIMILDTEMYANTGGQQSKSTQMSAVAKFAAGGKRLMKKDMGKVAMNYKNVYVASIAIGADARQAIKALTEANSYNGPALIIAYSPCQQHGMPSQLGMSHQADEQRKAVECGYWPLYRYDPRRAEKGENPFQLDFKKLKGKVDDFLEGENRFSILTRQNPEAAKELHKQLQEEVEKRHAERVRMAMSDKQLWKELNKVYGKKK

alpha­ketoglutaratedecarboxylase

>gi|161352467|ref|NP_215764.2|alpha‐ketoglutaratedecarboxylase[MycobacteriumtuberculosisH37Rv]MANISSPFGQNEWLVEEMYRKFRDDPSSVDPSWHEFLVDYSPEPTSQPAAEPTRVTSPLVAERAAAAAPQAPPKPADTAAAGNGVVAALAAKTAVPPPAEGDEVAVLRGAAAAVVKNMSASLEVPTATSVRAVPAKLLIDNRIVINNQLKRTRGGKISFTHLLGYALVQAVKKFPNMNRHYTEVDGKPTAVTPAHTNLGLAIDLQGKDGKRSLVVAGIKRCETMRFAQFVTAYEDIVRRARDGKLTTEDFAGVTISLTNPGTIGTVHSVPRLMPGQGAIIGVGAMEYPAEFQGASEERIAELGIGKLITLTSTYDHRIIQGAESGDFLRTIHELLLSDGFWDEVFRELSIPYLPVRWSTDNPDSIVDKNARVMNLIAAYRNRGHLMADTDPLRLDKARFRSHPDLEVLTHGLTLWDLDRVFKVDGFAGAQYKKLRDVLGLLRDAYCRHIGVEYAHILDPEQKEWLEQRVETKHVKPTVAQQKYILSKLNAAEAFETFLQTKYVGQKRFSLEGAESVIPMMDAAIDQCAEHGLDEVVIGMPHRGRLNVLANIVGKPYSQIFTEFEGNLNPSQAHGSGDVKYHLGATGLYLQMFGDNDIQVSLTANPSHLEAVDPVLEGLVRAKQDLLDHGSIDSDGQRAFSVVPLMLHGDAAFAGQGVVAETLNLANLPGYRVGGTIHIIVNNQIGFTTAPEYSRSSEYCTDVAKMIGAPIFHVNGDDPEACVWVARLAVDFRQRFKKDVVIDMLCYRRRGHNEGDDPSMTNPYVYDVVDTKRGARKSYTEALIGRGDISMKEAEDALRDYQGQLERVFNEVRELEKHGVQPSESVESDQMIPAGLATAVDKSLLARIGDAFLALPNGFTAHPRVQPVLEKRREMAYEGKIDWAFGELLALGSLVAEGKLVRLSGQDSRRGTFSQRHSVLIDRHTGEEFTPLQLLATNSDGSPTGGKFLVYDSPLSEYAAVGFEYGYTVGNPDAVVLWEAQFGDFVNGAQSIIDEFISSGEAKWGQLSNVVLLLPHGHEGQGPDHTSARIERFLQLWAEGSMTIAMPSTPSNYFHLLRRHALDGIQRPLIVFTPKSMLRHKAAVSEIKDFTEIKFRSVLEEPTYEDGIGDRNKVSRILLTSGKLYYELAARKAKDNRNDLAIVRLEQLAPLPRRRLRETLDRYENVKEFFWVQEEPANQGAWPRFGLELPELLPDKLAGIKRISRRAMSAPSSGSSKVHAVEQQEILDEAFG

alpha­ketoglutaratedehydrogenase(TCAcycle)

>gi|171785|gb|AAA34721.1|alpha‐ketoglutaratedehydrogenase[Saccharomycescerevisiae]MLRFVSSQTCRYSSRGLLKTSLLKNASTVKIVGRGLATTGTDNFLSTSNATYIDEMYQAWQKDPSSVHVSWDAYFKNMSNPKIPATKAFQAPPSISNFPQGTEAAPLGTAMTGSVDENVSIHLKVQLLCRAYQVRGHLKAHIDPLGISFGSNKNNPVPPELTLDYYGFSKHDLDKEINLGPGILPRFARDGKSKMSLKEIVDHLEKLYCSSYGVQYTHIPSKQKCDWLRERIEIPEPYQYTVDQKRQILDRLTWATSFESFLSTKFPNDKRFGLEGLESVVPGIKTLVDRSVELGVEDIVLGMAHRGRLNVLSNVVRKPNESIFLNLKGSSARDDIEGSGDVKYHLGMNYQRPTTSGKYVNLSLVANPSHLESQDPVVLGRTRALLHAKNDLKEKTKALGVLLHGDAAFAGQGVVYETMGFLTLPEYSTGGTIHVITNNQIGFTTDPRFARSTPYPSDLAKAIDAPIFHVNANDVEAVTFIFNLAAEWRHKFHTDAIIDVVGWRKHGHNETDRPSFTQPLMYKKIAKQKSVIDVYTEKLISEGTFSKKDIDEHKKWVWNLFEDAFEKTKDYVPSQREWLTAAWEGFKSPKELATEILPHEPTNVPESTLKELGKVLSSWPEGFEVHKNLKRILKNRGKSIETGEGIDWATGEALAFGTLVLDGQNVRVSGEDVERGTFSQRHAVLHDQQSEAIYTPLSTLNNEKADFTIANSSLSEYGVMGFEYGYSLTSPDYLVMWEAQFGDFANTAQVIIDQFIAGGEQKWKQRSGLVLSLPHGYDGQGPEHSSGRLERFLQLANEDPRYFPSEEKLQRQHQDCNFQVVYPTTPANLFHILRRQQHRQFRKPLALFFSKQLLRHPLARSSLSEFTEGGFQWIIEDIEHGKSIGTKEETKRLVLLSGQVYTALHKRRESLGDKTTAFLKIEQLHPFPFAQLRDSLNSYPNLEEIVWCQEEPLNMGSWAYTEPRLHTTLKETDKYKDFKV

RYCGRNPSGAVAAGSKSLHLAEEDAFLKDVFQQS

fumarase

>gi|6324993|ref|NP_015061.1|Fum1p[SaccharomycescerevisiaeS288c]MLRFTNCSCKTFVKSSYKLNIRRMNSSFRTETDAFGEIHVPADKYWGAQTQRSFQNFKIGGARERMPLPLVHAFGVLKKSAAIVNESLGGLDPKISKAIQQAADEVASGKLDDHFPLVVFQTGSGTQSNMNANEVISNRAIEILGGKIGSKQVHPNNHCNQSQSSNDTFPTVMHIAASLQIQNELIPELTNLKNALEAKSKEFDHIVKIGRTHLQDATPLTLGQEFSGYVQQVENGIQRVAHSLKTLSFLAQGGTAVGTGLNTKPGFDVKIAEQISKETGLKFQTAPNKFEALAAHDAIVECSGALNTLACSLFKIAQDIRYLGSGPRCGYHELMLPENEPGSSIMPGKVNPTQNEALTQVCVQVMGNNAAITFAGSQGQFELNVFKPVMIANLLNSIRLITDAAYSFRVHCVEGIKANEPRIHELLTKSLMLVTALNPKIGYDAASKVAKNAHKKGITLKESALELGVLTEKEFDEWVVPEHMLGPK

fumaratereductase

>gi|72388944|ref|XP_844767.1|NADH‐dependentfumaratereductase[TrypanosomabruceiTREU927]MVDGRSSASIVAVDPERAARERDAAARALLQDSPLHTTMQYATSGLELTVPYALKVVASADTFDRAKEVADEVLRCAWQLADTVLNSFNPNSEVSLVGRLPVGQKHQMSAPLKRVMACCQRVYNSSAGCFDPSTAPVAKALREIALGKERNNACLEALTQACTLPNSFVIDFEAGTISRKHEHASLDLGGVSKGYIVDYVIDNINAAGFQNVFFDWGGDCRASGMNARNTPWVVGITRPPSLDMLRNPPKEASYISVISLDNEALATSGDYENLIYTADDKPLTCTYDWKAKELMKPSQSNIAQVSVKCYSAMYADALATACFIKRDPAKVRQLLDGWRYVRDTVRDYRVYVRENERVAKMFEIATEDAEMRKRRISNTLPARVIVVGGGLAGLSAAIEAAGCGAQVVLMEKEAKLGGNSAKATSGINGWGTRAQAKASIVDGGKYFERDTYKSGIGGNTDPALVKTLSMKSADAIGWLTSLGVPLTVLSQLGGHSRKRTHRAPDKKDGTPLPIGFTIMKTLEDHVRGNLSGRITIMENCSVTSLLSETKERPDGTKQIRVTGVEFTQAGSGKTTILADAVILATGGFSNDKTADSLLREHAPHLVNFPTTNGPWATGDGVKLAQRLGAQLVDMDKVQLHPTGLINPKDPANPTKFLGPEALRGSGGVLLNKQGKRFVNELDLRSVVSKAIMEQGAEYPGSGGSMFAYCVLNAAAQKLFGVSSHEFYWKKMGLFVKADTMRDLAALIGCPVESVQQTLEEYERLSTSQRSCPITRKSVYPCVLGTKGPYYVAFVTPSIHYTMGGCLISPSAEIQMKNTSSRAPLSHSNPILGLFGAGEVTGGVHGGNRLGGNSLLECVVFGRIAGDRASTILQRKSSALSFKVWTTVVLREVREGGVYGAGSRVLRFNLPGALQRSGLSLGQFIAIRGDWDGQQLIGYYSPITLPDDLGMIDILARSDKGTLREWISALEPGDAVEMKACGGLVIERRLSDKHFVFMGHIINKLCLIAGGTGVAPMLQIIKAAFMKPFIDTLESVHLIYAAEDVTELTYREVLEERRRESRGKFKKTFVLNRPPPLWTDGVGFIDRGILTNHVQPPSDNLLVAICGPPVMQRIVKATLKTLGYNMNLVRTVDETEPSGSSKI

Flavodiironprotein

>gi|162330011|pdb|2Q9U|AChainA,CrystalStructureOfTheFlavodiironProteinFromGiardiaIntestinalisMSSKPKYVQDQEMIPGVYWVGIVDWMVRIFHGYHTDEGSSYNSYFIDDECPTVIDSVKYPFAEEWLSRIAACCPLDKIKYVVMNHAEGDHASSLKDHYHKFTNATFVCTKKCQEHLKILYGMEKATWLIVDDKYTLKIGKRTLKFIPVPLLHWPDSTFTYCPEDKILFSNDGFGQHYATSRRWADECDVSHVMHLFKEYTANILGLFSAQMRKALEVASTVEIKYILSAHGVSWRGDAMGLAIAEYDRWSKGQHCQKKVTVVLDSMYGTTHRMALALLDGARSTGCETVLLEMTSSDITKVALHTYDSGAVAFASPTLNNTMMPSVAAALNYVRGLTLIKGKPAFAFGAFGWSNRAVPDIVAELRDGCKADVYDEKGITFKFNYTEELLEQAYNAGVDLGKRAIAYCEKNAPKQ

sulfide:quinoneoxidoreductase

>gi|157092622|gb|ABV22505.1|sulfide:quinoneoxidoreductase[Arenicolamarina]MASRKVSLVLTGRVLMCQQLPAQAARAAVAPHVASFSSSAPLETAKKMNYKMVVVGGGTGGCAAAHMFSRKLGKGNVAVIEPADTHYYQPLWTLVGGGLRKLDQSAQPMNKVLPGACDWIKDSAVQFDPDNNTVFTKHGYEVKYDFLVCAMGLQLNYHLIKGLPEAFDVDPSLCSNYWDKTVIKTRPAMEAVTEGNVIFTFPNSPIKCAGAPQKIMYLTEEYLRQSGKRDKTNVIYNTSLGVVFGVKKYAEALTKIVQERNIQVNFRHNLIEVRPDKKEAVFEHLDTKEQKVFDYAMLHVVPPMSTPEALWNSPLVNESGYVTVKRETLQHTKYPNVFGIGDNTDIPTAKTAAAVASQTGILKKNLAAAMNGHEIAGKQYDGYTSCPLVTSKNTVIMAEFDWDGQPLETFPINQAKERRTMFHFKADIFPQMYWHMLIKGYWHGPGLFRKAMHLGMSR

copper­containingnitritereductase(nirK)

>gi|156618572|gb|ABU88100.1|copper‐containingnitritereductase[Fusariumoxysporum]MSRMVTICWTLAPATSQLLPIASRAAASTAFIRNLSLPTRRAPVIGARSFSSNTRSNSRVSHPRLTPALAVSTGLALSYYLYQRGPQPVKLGLAPEKPEKPKCAHCVDEKPEVIQEKAVGCCEDEQTTTYQEKPLSCCVDDEASIAMVPAIGGDHKHKIFETVDDETLLISKLPKEDAILTTAPNVPPSITRDHPALVRVPLVTTTKLAQLTSQYKYEQWTFNGTVPGPFIRAKVGDVVELSLTNKDPAGNPHNIDCHAFTGPGGGAAVTTAEEGETKVGRFKLLYPGLYVYHCAAAPVPVHIANGMYGLMYVQPEGNDLPPVDKEYYVMQSEFYHEPPEVDDDGRRSEIVEFSYPNGLREEPQVVAFNGSESALTRDHPLKAHVGDDVRIFFGNAGPNLTSSFHIIGTHFKNVYRDGGVTSNPSKGIQTVSVPCGGSTIVDLKMAVPGTYTLVDHSIFRLDKGAVGFLNVSGPQNPGVYQSSQPPRPCVGCKLHS

cytochromeP450nor

>gi|117179|sp|P23295.2|NOR_FUSOXRecName:Full=CytochromeP45055A1;AltName:Full=CYPLVA1;AltName:Full=CytochromeP450DNIR;AltName:Full=CytochromeP450nor;AltName:Full=NitricoxidereductaseMASGAPSFPFSRASGPEPPAEFAKLRATNPVSQVKLFDGSLAWLVTKHKDVCFVATSEKLSKVRTRQGFPELSASGKQAAKAKPTFVDMDPPEHMHQRSMVEPTFTPEAVKNLQPYIQRTVDDLLEQMKQKGCANGPVDLVKEFALPVPSYIIYTLLGVPFNDLEYLTQQNAIRTNGSSTAREASAANQELLDYLAILVEQRLVEPKDDIISKLCTEQVKPGNIDKSDAVQIAFLLLVAGNATMVNMIALGVATLAQHPDQLAQLKANPSLAPQFVEELCRYHTASALAIKRTAKEDVMIGDKLVRANEGIIASNQSANRDEEVFENPDEFNMNRKWPPQDPLGFGFGDHRCIAEHLAKAELTTVFSTLYQKFPDLKVAVPLGKINYTPLNRDVGIVDLPVIF

nitratereductase(NADH­nar)

>gi|169990912|dbj|BAG12905.1|nitratereductase[Fusariumoxysporum]METSTTTTLLQQERIPENSEPISTHIHTHSLPPTPPGTAKPSRIGSFHDLQELSSVESPRLDHIKPYPLPPKFSPKSVLKEDLKTPDNFVERDPRLIRLTGVHPFNVEAPLSDLYDEGFLTSENFHYVRNHGHVPRCEDDDILDWEFEISGLVENPIKMNVRDLINDYQQLTYPVTFVCAGNRRKEQNIVRKTKGFSWGAAGLSTALWTGVAIGDLLAAAKPKRGARYVCFWGADRQPNGYYGTSIKLKWCMDPYRGVMVLQMNGKTLHPDHGKPVRIVIPGLIGGRSIKWLKKITVTQEPRDNWYHIYDNRVLPTMISPEESANLPEVWKDEKYAIYDLSTNSAICYPAHEEKVPFTDAPASYKVRGYAYGGGGRRITRVEVTLDKGKSWRLANIRYPEDDYRNAPEGDTLYGGRVDMWWRETSFCWCFWDLDIPLDELKSADDIMMRAMDESMNVQPRDMYWSVLGMMNNPWFRIVIHKEDHALRFEHPTHATLKIKGRMDQVKEAGGNLTNGYWGEKAPGEVQEIVVKKPEKQICMTNPQINRKITIEELKAHSGEKEPWFVVKGEVYDGTPYLSGHPGGAASIFGAAGQDATEEFMAIHSENAKAMLPTYHIGTLNEESRAILSGDATKTNDDANREVFLQSKTWSKAILDKRTSISPDTKIFSFKLNHEGQKIGLPTGQHLMMRLRDPATREAIIRSYTPYSDGSDCGRLDILIKIYYDTPQRKGGVMTQALDALPIGHWVDFKGPTGKFVYHGNGLCTINDRQRRVRRFIMVCGGSGITPIRQVLRAVMHNPKDTTPCLIFNGNRSVDDILCKKELDELEAANPSRCRVVNALSDPPPEWNGLKGFVNQALVPEQMALPKASGEGDELVLVCGPPPMVKAVEASFLGMGFKSDDFVFF

succinatesemialdehydedehydrogenase

>gi|6319478|ref|NP_009560.1|TPA:Uga2p[SaccharomycescerevisiaeS288c]MTLSKYSKPTLNDPNLFRESGYIDGKWVKGTDEVFEVVDPASGEIIARVPEQPVSVVEEAIDVAYETFKTYKNTTPRERAKWLRNMYNLMLENLDDLATIITLENGKALGEAKGEIKYAASYFEWYAEEAPRLYGATIQPLNPHNRVFTIRQPVGVCGIICPWNFPSAMITRKAAAALAVGCTVVIKPDSQTPLSALAMAYLAEKAGFPKGSFNVILSHANTPKLGKTLCESPKVKKVTFTGSTNVGKILMKQSSSTLKKLSFELGGNAPFIVFEDADLDQALEQAMACKFRGLGQTCVCANRLYVHSSIIDKFAKLLAERVKKFVIGHGLDPKTTHGCVINSSAIEKVERHKQDAIDKGAKVVLEGGRLTELGPNFYAPVILSHVPSTAIVSKEETFGPLCPIFSFDTMEEVVGYANDTEFGLAAYVFSKNVNTLYTVSEALETGMVSCNTGVFSDCSIPFGGVKESGFGREGSLYGIEDYTVLKTITIGNLPNSI

opine/strombine/octopinedehydrogenase

>gi|218081329|emb|CAL90921.1|strombinedehydrogenase[Arenicolamarina]MVVALICGGGNGAHVCAGIAASQPGVEARVLTLFADEAERWTKAMACNDFVVTVNSKGKAPTELKAKPTVVSKKAADVMSGVDIIVLMVPAFAHTGYLEELKPLMKPGMVLVGCPGQAGFEFAVRGILGDLARHVSLLSFESLPWACRMLEFGKKSEVLATKGSLTGALQLGDPAPAVDPTAMLQQVLGEAPKLITKGHLLGITLMGTNGYLHPSIMFGFWSHWDGKPLEQSPLFYNGVDRFSAGVLSSVSDEVVAIAKAVMQQRPQVDLNNVTHIVDWYRRCYANDITDPTDLYSCIQTNNAYNGLTHPCEQTSNGRFVPNYRYRYLTEDIPFGLVVMRGIATLAGVATPSMDKVITWAQGCLGKEYLVGDQLTGKDIPATRCPQAYNLPCLDTILGLA

nuoFNADHdehydrogenase51kDasubunit

>gi|51947517|gb|AAU14243.1|hydrogenosomalNADHdehydrogenase51kDasubunit[Nyctotherusovalis]MIARTCKRLGTMARLFSAADSAKKAETVSKNYGNISDQDRIFSNLYKDQDPFIDGALKRGDWYRTKDILACPHDFVIDEIKKSGLRGRGGAGFPSGLKYSFMPKKSDGRPSFLVVNADESEPATCKDREIMRHDPHKLVEGALIVGYAMRARAAYVYIRGEFWDEAMQLERAVAEAYEKGFIGKNACGSGYDFDIYVHRGAGAYICGEETSMLSSIEGVIGKPRMKPPYPAGTGLYGCPTTVTNVETVSTVPTIMRRGGGWFASFGRKNNHGTKLYCLSGHINNPCTVEDEMSISLRELIERHGGGVRGGWDNLLGVIPGGSSTPIISKELCETALMDFDSLIEAGSAFGTAGVIVLDKSTDVIDAILRLSKFYLHESCGQCTPCREGTGWLVDILERMKIGKADYGEIDQLYELTKQIEGHTICALGEAAAWPVQGLIKHYRDVIEDRIDKYHSEHPAAAEEFIISHHPVKGTH

nuoG

>gi|11467055|ref|NP_042531.1|NADHdehydrogenase,subunit11[Acanthamoebacastellanii]MKNISFKVNDFQYTINNKLTLIQACLKNKVDISRFCFHEKLSIAGNCRMCLVEDLKQVKPLASCAINVSN

SMNIYTNTLKVKKARESVLEFLLANHPLDCPICDQGGECDLQDQSVVFGSDRGRFYEFKRSVEDKDCGPLIKTIMNRCIHCTRCVRFSNEVAGVNILGVTGRGSKMEIGFYIENLMRSELSGNVIDLCPVGALTSKPFAFTSRPWELKSYNSIDVLDSLHSNIRVDIRGTKIMRILPRVNSELNEDWITDKIRFSYDSFRRQRLYDPMVKISGSFLKIGWKKAMLFIKKFFCNFLGFNHSSFIPLRGYIGDYLDLETIYTFKKFLLLNGSNFFLPSSSYNDLTALYSFNTPLTRLDEGDFCILLDVNLRVELPIVNSRIKQLVSKKMLPVFVLGFYSNFNYFVKHISNSSKTLLHVLEGSHWLSAKISKKFSSKPIFLIGDSSSLLKGSLIVPLFNFTNVICDNWNGLNIISNDSSYLSTKEFNLSSSHSQNSHLLNFPINFVLNYDKAVLVDSSAFQIYQGHHGDTNAINSNLIFPSTSFIEKNSFYSNSLAIVQKTKKILFSPGNSRDDWKILNALIDNFGFSYFKVRNSFDLVSFLSESTPFILYKRSFSFKCFGFYEQLVYHFFNYFSVNNNYYIYDSITRNSKIMSLCFNKFKMKGYNFF

nuoE

>gi|123446843|ref|XP_001312168.1|Respiratory‐chainNADHdehydrogenase24Kdsubunitfamilyprotein[TrichomonasvaginalisG3]MLASVNTSRFFARLNKKSVLIQKDFKFSDQSKVDAILAKYPKENKRAATIPLLHLGQRENGGYLTTGVLQAISKIVGVTAGRVHETACFYSMFRFQPPNNHIVEVCKGLSCYLTGSDNVKEAIQKATGGTFKEGKSPDGQFTLEEVECLGACANAPVMILDGVYYQNLTAETAKIIIECVKAGKSVKELDAVHTHPPRPLP

ironhydrogenaseassemblyproteinHydEF

>gi|159466536|ref|XP_001691465.1|ironhydrogenaseassemblyprotein[Chlamydomonasreinhardtii]MAHSLSAHSRQAGDRKLGAGAASSRPSCPSRRIVRVAAHASASKATPDVPVDDLPPAHARAAVAAANRRARAMASAEAAAETLGDFLGLGKGGLSPGATANLDREQVLGVLEAVWRRGDLNLERALYSHANAVTNKYCGGGVYYRGLVEFSNICQNDCSYCGIRNNQKEVWRYTMPVEEVVEVAKWALENGIRNIMLQGGELKTEQRLAYLEACVRAIREETTQLDLEMRARAASTTTAEAAASAQADAEAKRGEPELGVVVSLSVGELPMEQYERLFRAGARRYLIRIETSNPDLYAALHPEPMSWHARVECLRNLKKAGYMLGTGVMVGLPGQTLHDLAGDVMFFRDIKADMIGMGPFITQPGTPATDKWTALYPNANKNSHMKSMFDLTTAMNALVRITMGNVNISATTALQAIIPTGREIALERGANVVMPILTPTQYRESYQLYEGKPCITDTAVQCRRCLDMRLHSVGKTSAAGVWGDPASFLHPIVGVPVPHDLSSPALAAAASADFHEVGAGPWNPIRLERLVEVPDRYPDPDNHGRKKAGAGKGGKAHDSHDDGDHDDHHHHHGAAPAGAAAGKGTGAAAIGGGAGASRQRVAGAAAASARLCAGARRAGRVVASPLRPAAACRGVAVKAAAAAAGEDAGAGTSGVGSNIVTSPGIASTTAHGVPRINIGVFGVMNAGKSTLVNALAQQEACIVDSTPGTTADVKTVLLELHALGPAKLLDTAGLDEVGGLGDKKRRKALNTLKECDVAVLVVDTDTAAAAIKSGRLAEALEWESKVMEQAHKYNVSPVLLLNVKSRGLPEAQAASMLEAVAGMLDPSKQIPRMSLDLASTPLHERSTITSAFVKEGAVRSSRYGAPLPGCLPRWSLGRNARLLMVIPMDAETPGGRLLRPQAQVMEEAIRHWATVLSVRLDLDAARGKLGPEACEMERQRFDGVIAMMERNDGPTLVVTDSQAIDVVHPWTLDRSSGRPLVPITTFSIAMAYQQNGGRLDPFVEGLEALETLQDGDRVLISEACNHNRITSACNDIGMVQIPNKLEAALGGKKLQIEHAFGREFPELESGGMDGLKLAIHCGGCMIDAQKMQQRMKDLHEAGVPVTNYGVFFSWAAWPDALRRALEPWGVEPPVGTPATPAAAPATAASGV

hydrogenaseassemblyfactorHydG

>gi|159466244|ref|XP_001691319.1|hydrogenaseassemblyfactor[Chlamydomonasreinhardtii]MSVPLQCNAGRLLAGQRPCGVRARLNRRVCVPVTAHGKASATREYAGDFLPGTTISHAWSVERETHHRYRNPAEWINEAAIHKALETSKADAQDAGRVREILAKAKEKAFVTEHAPVNAESKSEFVQGLTLEECATLINVDSNNVELMNEIFDTALAIKERIYGNRVVLFAPLYIANHCMNTCTYCAFRSANKGMERSILTDDDLREEVAALQRQGHRRILALTGEHPKYTFDNFLHAVNVIASVKTEPEGSIRRINVEIPPLSVSDMRRLKNTDSVGTFVLFQETYHRDTFKVMHPSGPKSDFDFRVLTQDRAMRAGLDDVGIGALFGLYDYRYEVCAMLMHSEHLEREYNAGPHTISVPRMRPADGSELSIAPPYPVNDADFMKLVAVLRIAVPYTGMILSTRESPEMRSALLKCGMSQMSAGSRTDVGAYHKDHTLSTEANLSKLAGQFTLQDERPTNEIVKWLMEEGYVPSWCTACYRQGRTGEDFMNICKAGDIHDFCHPNSLLTLQEYLMDYADPDLRKKGEQVIAREMGPDASEPLSAQSRKRLERKMKQVLEGEHDVYL

hydrogenase

>gi|19548180|gb|AAL90459.1|AF446076_1[Fe]‐hydrogenase[Piromycessp.E2]CLVDVKGSWKPLTACTTEVWEGMEIETDTPAVRETVRSSLAMMREEHPNDCMTCESNGNCEFQDLIYRYQIDAQHPVRTLLRNKFKKTNHSITEPCYSPFDDSTFSISRDMNKCVKCGRCVRACHHFQNINILGFINRAGYERVGTPMDRPMNFTKCVECGQCSQVCPVGAITERNECIEVLRHLDTKRKIVVVSTAPAIRVALAEEFNAEPDFDFTGKMVAGLKKLGFDYIFDTNFSADLTIMEEGTELITRLNEGGKFPMFTSCCPGWINMVEKSYPEIRDNLSSCKSPQQMIGAVIKTYFAKKINAKPEDIIHVSVMPCTAKKGEAKRPEFKRDGVPDIDHVITTRELITLLKLKRINPSELKNEKFDSPLGIGSSAGNLFGVTGGVMEAAVRTAQIITGVENPIPLGELKAIRGLDGIKAASVPLKTKDGKDVNVRAAVVSGGANIQKFLEKLKKKELEFDFVEMMMCPGGCINGGGQPKSADPKVVAKKMERMYTMDDQASLRLSHENPEITQIYKEFLKEPNGHLSHELLHTHYNDRSKAIQDMSLHQK

phosphoenolpyruvatecarboxykinase(Chlamydomonas)

>gi|159473685|ref|XP_001694964.1|phosphoenolpyruvatecarboxykinase,splicevariant[Chlamydomonasreinhardtii]MALLSSRSSANCTGRSVRRATVAPAPVVKPHSSVAMRFTNNTKQDAAVPAPCDMQFVLDSKFTRESGLQPRVVFRNLTTPQLYEMALAHEPGTHITSSGALATLSGEKTGRSPKDKRVVRDPETEKDLWWGPYSPNYVMDDRTFLTNRERAIDYLNTLDRVYVVDAFVNWDPESRLKVRVVTSRAYHALFMSNMLIKPTEEELKTFGEPDFVIYNAGAFPANKYTQFMTSQTSIDLSLKHKEMVILGTMYAGEMKKGVFTLMHYLMPMQGKLSLHSGCNVGADDDVTMFFGLSGTGKTTLSADPKRPLIGDDEHVWSDKGVFNIEGGCYAKCIGLKATTEPEIWNAIKFGTVLENVDYNPVTREVDYESERLTENTRASYPIEFMNNARIPCVGPHPKNVVLLACDAFGALPPVSRLTLEQAMYHFISGYTAKVAGTEMGVTEPTATFSACFGSAFLMLHPYKYATMLAEKMKAHGTTAWLINTGWTGGKYGVGKRISLKHTRAIIDAIHSGELDKAEYVTTPIFGLQVPKAISGVPAEILSPENVWPNKDEFAMCLNSLGHMFIRNFEHFNDGEQFVGKDTAARILTGGPQPIAKEDVEKKGFGAFKTQ

phosphoenolpyruvatecarboxykinase(Giardia)

>gi|159119302|ref|XP_001709869.1|Phosphoenolpyruvatecarboxykinase[GiardialambliaATCC50803]MSLHPVVDERSQTIIDQLNCPAFNELLLDAIELMRPSSLYIQTSSKEEIDYARSNALAQGEEHQLAMPGHTYHFDSPDDQGRDKKNTLILLDDQTGLDADVMTRDRKEGTAHVREIMKGCMEGKQMLIAFYCLGPVNCSFSKTAVQFTDSWYILHSENVLYRNGFAQMVNRHMKETSANRSFYAFYHSVGRTDSANRPVDIDKRRIYINPVEHLVYTINNSYAGNALACKKLALRLAIYDSNHHPEKNNLTEHMFLSTFANPCIPNDKLNVCGAFPSACGKTSTSMAPGSSIIGDDMVYMQIVDDNMGIRRCKAVNIETGMFGIISGVNPSDDPLIYDCLTSERECIFSNVLVGEDGRPYWDGMYYGKSKNDMVNEPGLLPSSGRNYKGTWTKPELPIMHGNARFTLNLKELRNVSPELDNPDGVDVDLILYGGRDSNTCPPVYQAHNWAHGVYIGSSIESETTAATLGTQGVVVSNPMANLDFLIVPVPMYLENHVRFGRLLGSRAPKVFGVNYFLKDPTTGEYLNSKLDKKVWVAWACGRTRGHYRAKCTPIGWIPYYEDLKSLFRSELDTDYTEEQYNIQFTINVENYIQKMVRIMKLYGGKQAPTEWVIMECRVMRALKKLLAEKGSAVSPSAFDDYESQSWFDRAFVEE

acetatekinase

>gi|159472745|ref|XP_001694505.1|acetatekinase[Chlamydomonasreinhardtii]MLAGKVPVGSAVPPRNTAPSGKGSKVLVVNAGSSSIKFKIFTAETLLPGAAGLFDRIGEGDPANCVLKASVPDDGGKPKKFEKKIPAKDHLTAMQDIMSFIDENVSSTFASEVCAVGHRIVHGLDMSQPKLLTPDVIRCIQDASMFAPLHNPPHLQGIYASQKVFGPDVPQVAVFDTAFHQTMPPESYVYGLPYDMYEKHKIRRYGFHGTSHKYLVDQAAAMLGKKVSETNVITCHLGNGSSVAAVRGGQCVDTSMGMTPLEGLLMGTRCGDIDPAVVLHIQNQLGLSASETDTLLNKKSGLLGLTGSNDLRTVIEGAGKGEPRSQLGLDMFVRRVRKYIGAYMAMLDGQVDAVVFSAGIGENSALVRGLICDRMQALGIAVDKDANAAAVGGKQADISGPGARIRALVIPTDEELSIAQQTLQVVRGAALAA

alternativeoxidase

>gi|71747778|ref|XP_822944.1|alternativeoxidase[TrypanosomabruceiTREU927]MFRNHASRITAAAAPWVLRTACRQKSDAKTPVWGHTQLNRLSFLETVPVVPLRVSDESSEDRPTWSLPDIENVAITHKKPNGLVDTLAYRSVRTCRWLFDTFSLYRFGSITESKVISRCLFLETVAGVPGMVGGMLRHLSSLRYMTRDKGWINTLLVEAENERMHLMTFIELRQPGLPLRVSIIITQAIMYLFLLVAYVISPRFVHRFVGYLEEEAVITYTGVMRAIDEGRLRPTKNDVPEVARVYWNLSKNATFRDLINVIRADEAEHRVVNHTFADMHEKRLQNSVNPFVVLKKNPEEMYSNQPSGKTRTDFGSEGAKTASNVNKHV

propionate:succinateCoAtransferase

>gi|16130821|ref|NP_417395.1|propionyl‐CoA:succinate‐CoAtransferase[Escherichiacolistr.K‐12substr.MG1655]METQWTRMTANEAAEIIQHNDMVAFSGFTPAGSPKALPTAIARRANEQHEAKKPYQIRLLTGASISAAADDVLSDADAVSWRAPYQTSSGLRKKINQGAVSFVDLHLSEVAQMVNYGFFGDIDVAVIEASALAPDGRVWLTSGIGNAPTWLLRAKKVIIELNHYHDPRVAELADIVIPGAPPRRNSVSIFHAMDRVGTRYVQIDPKKIVAVVETNLPDAGNMLDKQNPMCQQIADNVVTFLLQEMAHGRIPPEFLPLQSGVGNINNAVMARLGENPVIPPFMMYSEVLQESVVHLLETGKISGASASSLTISADSLRKIYDNMDYFASRIVLRPQEISNNPEIIRRLGVIALNVGLEFDIYGHANSTHVAGVDLMNGIGGSGDFERNAYLSIFMAPSIAKEGKISTVVPMCSHVDHSEHSVKVIITEQGIADLRGLSPLQRARTIIDNCAHPMYRDYLHRYLENAPGGHIHHDLSHVFDLHRNLIATGSMLG

glutamateaminotransferase

>gi|242398987|ref|YP_002994411.1|glutamateaminotransferase[ThermococcussibiricusMM739]MEYPKLVVTPPGPKAKELVEREKRVISQGLGVKLFPVVPERGYGALIEDVDGNVFIDFLAGAAAASTGYAHPKLVKEVQEQVSKIQHSMIGYTYSKRAIEVAEILAEKSPIENPKILFGLSGSDSIDLLMKVARFATRKPWIIAFIGAYHGQTYGATSVAAFQSSQKRGFSPLVPNVVWIPYPNPYRNVWNIDGYEEPDELINAFLDYLENYVFAHVIPPDEVSILLAEPIQGDAGIVVPPDNFFKELKKVLDEREILLAMDEVQTGIGRTGKWFGSEWFEVEPDFISFGKGVASGMGLSGVIGKAHLMEMTSGSALLTPAANPVISAAAYATLRIIEEENLLKNALKVG

EFIKKRLLEMKESYDVIGDVRGKGLMIGAEIVKPNTKVPNPDLTGKICWRAFELGLILPSYGMFGNVIRITPPLVITKKIAEKGLEIMEQALKDALAGKVKHKTITWH

betaketosynthase

>gi|82408974|gb|ABB73268.1|betaketosynthase[Rhodococcussp.SW09]VDPQQRLLLESAWEALEQAGIQPDSPDLTGTGVYIGLMGGDYGFHLMSQRNVDAEGYLMTGTSDSVASGRISYSLGFTGPAVTVDTACSSSLVAMHLAAQALRDGECPLALAGGATVMSTPGVLVEFSRQRGLAPDGRCKPFSDRADGTGLSEGSGMVVLERLSDARRNGHRVLATIRGSAVNQDGASNGLTAPNGPSQERVIRQALANASLGPTDIDAVEAHGTGT

beta­hydroxyacyldehydrogenase

>gi|51473740|ref|YP_067497.1|3‐hydroxyacyl‐CoAdehydrogenase[Rickettsiatyphistr.Wilmington]MQNEIKKVCVIGAGVMGSGIAALIANSSHRVVLLDILDKDSNDPNKIVKNAVKNLHRQKLPPLSYPDKVNFITIGNLEHDLDLIKECNLVIEVIVEKLDIKHQLYNKIIPYLKEDTIIASNTSTLPLKKLKENLPNNIKSRFIITHFFNPPRYMELVELIIDNTIKDEVIEKISVFLTKILGKTIIKCNDTPGFIANRVGCFLLELVAHKAIAQNLDFVTIDQIFSRCLGLPNTGIFGLYDLIGHDVMKLISSSLLSALPKSDDYHRIYFNTKVFDKMIEHNLIGRKGEGGFYRLSVSNGKKIKEVINISDLSYHPVQKVDISFNNLDELLASDSIYSKFFSEIITEFYIYLTSLVPSVTNNIYDIDATMKLGYSWHYGPFELLTIAVKNGWNSIIKNADLMNISLPKYLASKEYQKIDKQKFNSKKDFLQESTIVLANDSANLIHYCENLIFVITTKMNTLNHNVFYLLQEAVSKAENYGKNLYIFPQGNNFSAGADLKLILSYIQDGNFDNLENLLKLGQQTMRYLKYSSVHIISCARGVALGGGCELLLNSSYIVANQELNAGLIEFGVGLIPGWSGVTEMFARSNGDKTKLIRNIKNIIEQNKTSSADYFKADYDVSNMQVNMNKHYILDEALKLNVSNKIVSIPHKIALPKINIVSEIDTSKYNDLQNKVLNKFQNIIDKHNEISEAELLTYEREIFLELAKEPQTIEKLHAIVG

fattyacyl­coenzymeAreductase

>gi|298200319|gb|ADI60057.1|fattyacyl‐coenzymeAreductase[Euglenagracilis]MNDFYAGKGVFLTGVTGFVGKMVVEKILRSLPTVGRLYVLVRPKAGTDPHQRLHSEVWSSAGFDVVREKVGGPAAFDALIREKVVPVPGDMVKDRFGLDDAAYRSLAANVNVIIHMAATIDFTERLDVAVSLNVLGTVRVLTLARRARELGALHSVVHVSTCYVNSNQPPGARLREQLYPLPFDPREMCTRILDMSPREIDLFGPQLLKQYGFPNTYTFTKCMAEQLGAQIAHDLPFAIFRPAIIGAALSEPFPGWCDSASACGAVFLAVGLGVLQELQGNASSVCDLIPVDHVVNMLLVTAAYTASAPPADPSPSSLALSPPQLPLATLPPGTVADVPIYHCGTSAGPNAVNWGRIKVSLVEYWNAHPIAKTKAAIALLPVWRFELSFLLKRRLPATALSLVASLPGASAAVRRQAEQTERLVGKMRKLVDTFQSFVFWAWYFQTESSARLLASLCPEDRETFNWDPRRIGWRAWVENYCYGLVRYVLKQPIGDRPPVAAEELASNRFLRAML

glucokinase

>gi|159113013|ref|XP_001706734.1|Glucokinase[GiardialambliaATCC50803]MPYSLSGDLGGTKCFLAIHDLDVLKTDPRAAPLLEHELLCKDYQSTGDLINDFLKRWDRETPIVGCLGVAGPVTNGRVCITNLDWNESEEELQNTTGVGKMKLINDFAAIGYGLLAIRPDDYLDFDARNGSVSTPTVVPDNSTGIVSYAGAGTGFGVGFVADGVAYAAEGGHTTFSPMEAEDHALAQFIKEKYNTDHVSFERVVSGLGLRNMHDFFWKNLSGLASPVLREHVLSRDHDIDMGFLAKCAETGDKYALKIFKKFFYYYGFYLGNICVLFRPKDYFIAGGILAKDLNLVCGPCREDFCRGLYTKGRMSHLPNGVSFHVVTNQKLGIVGAAYFCTKM

hexokinase

>gi|71746804|ref|XP_822457.1|hexokinase[TrypanosomabruceiTREU927]MSRRLNNILEHISIQGNDGETVRAVKRDVAMAALTNQFTMSVESMRQIMTYLLYEMVEGLEGRESTVRMLPSYVYKADPKRATGVFYALDLGGTNFRVLRVACKEGAVVDSSTSAFKIPKYALEGNATDLFDFIASNVKKTMETRAPEDLNRTVPLGFTFSFPVEQTKVNRGVLIRWTKGFSTKGVQGNDVIALLQAAFGRVSLKVNVVALCNDTVATMISHYFKDPEVQVGVIIGTGSNACYFETASAVTKDPAVAARGSALTPISMESGNFDSKYRFVLPTTKFDLDIDDASLNKGQQALEKMISGMYLGEIARRVIVHLSSINCLPAALQTALGNRGSFESRFAGMISADRMPGLQFTRSTIQKVCGVDVQSIEDLRIIRDVCRLVRGRAAQLSASFCCAPLVKTQTQGRATIAIDGSVFEKIPSFRRVLQDNINRILGPECDVRAVLAKGGSGVGAALISAIVADGK

glucose­6­phosphateisomerase

>gi|120744|sp|P13377.1|G6PI_TRYBBRecName:Full=Glucose‐6‐phosphateisomerase,glycosomal;Short=GPI;AltName:Full=Phosphoglucoseisomerase;Short=PGI;AltName:Full=Phosphohexoseisomerase;Short=PHIMSSYLDDLRIDLAASPASGGSASIAVGSFNIPYEVTRRLKGVGADADTTLTSCASWTQLQKLYEQYGDEPIKKHFEADSERGQRYSVKVSLGSKDENFLFLDYSKSHINDEIKCALLRLAEERGIRQFVQSVFRGERVNTTENRPVLHIALRNRSNRPIYVDGKDVMPAVNKVLDQMRSFSEKVRTGEWKGHTGKAIRHVVNIGIGGSDLGPVMATEALKPFSQRDLSLHFVSNVDGTHIAEVLKSIDIEATLFIVASKTFTTQETITNALSARRALLDYLRSRGIDEKGSVAKHFVALSTNNQKVKEFGIDEENMFQFWDWVGGRYSMWSAIGLPIMISIGYENFVELL

TGAHVIDEHFANAPPEQNVPLLLALVGVWYINFFGAVTHAILPYDQYLWRLPAYLQQLDMESNGKYVTRSGKTVSTLTGPIIFGEAGTNGQHAFYQLIHQGTNLIPCDFIGAIQSQNKIGDHHKIFMSNFFAQTEALMIGKSPSEVRRELEAAGERSAEKINALLPHKTFIGGRPSNTLLIKSLTPRALGAIIAMYEHKVLVQGAIWGIDSYDQWGVELGKVLAKSILPQLRPGMRVNNHDSSTNGLINMFNELSHL

phosphofructokinasePPi

>gi|67482265|ref|XP_656482.1|phosphofructokinase[EntamoebahistolyticaHM‐1:IMSS]MTERRHVHQRNDLLIAKKPEEPLPSLEITSLGECKYENTYASPEPFVNGMKMSMSAIKIDGIPVNECEVDLAGPMEKIFFIPERTKVGIVTCGGLCPGLNNVIRGLVMNLQNRYGVKQIYGLKYGYEGLVPELSEQMKLDTLTVSDIHQRGGTILGTSRGAQDPKIMAQFLIDNNFNILFTLGGDGTLRGANAINKELRRRGSPIAVVGIPKTIDNDICYTDSTFGFDTAVELAQEAINSVHYEAKSAKNGVGIVKLMGRDAGFIALYASVASGDVNLVLIPEVDTPIEEILRMTERRLMSKGHIVIVIAEGACQNLKPKGLDLGSDKSGNIVHWDAVTYIRQEIDKYLENKKIEHTIKFVDPSYMIRSAPCSAADAHFCLCLANAAVHVAMAGKTGLVICHHHNNFVSIPIERACYYLKRVNPEGPMLSMMKSIEMVE

phosphofructokinaseATP

>gi|72386991|ref|XP_843920.1|ATP‐dependentphosphofructokinase[Trypanosomabrucei]MAVESRSRVTSKLVKAHRAMLNSVTQEDLKVDRLPGADYPNPSKKYSSRTEFRDKTDYIMYNPRPRDEPSSENPVSVSPLLCELAAARSRIHFNPTETTIGIVTCGGICPGLNDVIRSITLTGINVYNVKRVIGFRFGYWGLSKKGSQTAIELHRGRVTNIHHYGGTILGSSRGPQDPKEMVDTLERLGVNILFTVGGDGTQRGALVISQEAKRRGVDISVFGVPKTIDNDLSFSHRTFGFQTAVEKAVQAIRAAYAEAVSANYGVGVVKLMGRDSGFIAAQAAVASAQANICLVPENPISEQEVMSLLERRFCHSRSCVIIVAEGFGQDWGRGSGGYDASGNKKLIDIGVILTEKVKAFLKANKSRYPDSTVKYIDPSYMIRACPPSANDALFCATLATLAVHEAMAGATGCIIAMRHNNYILVPIKVATSVRRVLDLRGQLWRQVREITVDLGSDVRLARKLEIRRELEAINRNRDRLHEELAKL

fructose­bisphosphatealdolaseclass1

>gi|161968|gb|AAA30153.1|fructose‐bisphosphatealdolase(ald)(EC4.1.2.13)[Trypanosomabrucei]MSKRVEVLLTQLPAYNRLKTPYEAELIETAKKMTAPGKGLLAADESTGSCSKRFAGIGLSNTAEHRRQYRALMLECEGFEQYISGVILHDETVYQKAKTGETFPQYLRRRGVVPGIKTDCGLEPLVEGAKGEQMTAGLDGYIKRAKKYYAMGCRFCKWRNVYKIQNGTVSEAVVRFNAETLARYAILSQLCGLVPIVEPEVMIDGTHDIETCQRVSQHVWSEVVSALHRHGVVWEGCLLKPNMVVPGAESGLKATAEQVAEYTVKTLARVIPPALPGVTFLSGGLSEVMASEYLNAMNNCPLPRPWKLTFSYARALQSSAIKRWGGKESGVEAGRRAFMHRAKMNSLAQLGKYNRADDDKDSQSLYVAGNTY

fructose­bisphosphatealdolaseclass2

>gi|159119664|ref|XP_001710050.1|Fructose‐bisphosphatealdolase[GiardialambliaATCC50803]MPLCTLRQMLGEARKHKYGVGAFNVNNMEQIQGIMKAVVQLKSPVILQCSRGALKYSDMIYLKKLCEAALEKHPDIPICIHLDHGDTLESVKMAIDLGFSSVMIDASHHPFDENVRITKEVVAYAHARGVSVEAELGTLGGIEEDVQNTVQLTEPQDAKKFVELTGVDALAVAIGTSHGAYKFKSESDIRLAIDRVKTISDLTGIPLVMHGSSSVPKDVKDMINKYGGKMPDAVGVPIESIVHAIGEGVCKINVDSDSRMAMTGAIRKVFVEHPEKFDPRDYLGPGRDAITEMLIPKIKAFGSAGHAGDYKVVSLEEAKAWYK

triosephosphateisomerase

>gi|71755425|ref|XP_828627.1|triosephosphateisomerase[TrypanosomabruceiTREU927]MSKPQPIAAANWKCNGSQQSLSELIDLFNSTSINHDVQCVVASTFVHLAMTKERLSHPKFVIAAQNAIAKSGAFTGEVSLPILKDFGVNWIVLGHSERRAYYGETNEIVADKVAAAVAAGFMVIACIGETLQERESGRTAVVVLTQIAAIAKKLKKADWAKVVIAYEPVWAIGTGKVATPQQAQEAHALIRSWVSSKIGADVAGELRILYGGSVNGKNARTLYQQRDVNGFLVGGASLKPEFVDIIKATQ

glyceraldehyde3­phosphatedehydrogenase

>gi|72390505|ref|XP_845547.1|glyceraldehyde3‐phosphatedehydrogenase,glycosomal[TrypanosomabruceiTREU927]MSVALFFSSFLAVPYFPCICLSFCGAEFIRANQTSKRLTTNLNMTIKVGINGFGRIGRMVFQALCDDGLLGNEIDVVAVVDMNTDARYFAYQMKYDSVHGKFKHSVSTTKSKPSVAKDDTLVVNGHRILCVKAQRNPADLPWGKLGVEYVIESTGLFTVKSAAEGHLRGGARKVVISAPASGGAKTFVMGVNHNDYNPREHHVVSNASCTTNCLAPLVHVLVKEGFGISTGLMTTVHSYTATQKTVDGVSVKDWRGGRAAALNIIPSTTGAAKAVGMVIPSTQGKLTGMAFRVPTADVSVVDLTFIATRDTSIKEIDAALKRASKTYMKNILGYTDEELVSADFISDSRSSIYDSKATLQNNLPNERRFFKIVSWYDNEWGYSHRVVDLVRHMAARDRAAKL

phosphoglyceratekinase

>gi|115503965|ref|XP_001218775.1|phosphoglyceratekinase[Trypanosomabrucei]MSTAPNAKNNISLKKSVGDVWPLTAKRVLMRVDFNVPMQNGHITNDYRIRAAIPTIRRVIDQGGICILLSHLGRPRGVSMVAGVRDIRRRYHEAQFHDNKGKTAFFSVLPGEEKVKILAKSSAREEATHISPEVKSGKTMLFARLPEDEKKSLLMQYLNENKDSALPQMSVSAGYEEQYSLRPVAVRLAELLGQHVYFAHDCLDARVEVSRLKRGNVMLLENVRFYSEENGENAEEREAMAKILASYGDVYISDAFGAAHRDSATMTGIPKILGHGAAGYLMEKEISYFAKVLGNPPRPLVAIVGGAKVSEKIQLLDNMLQRIDYLLIGGAMAYTFLKAQGYSIGKSKCEESKLEFARSLLKKAEDRKVQIILPIDHVCHTEFKAVDSPLITEDQNIPEGHMALDIGPKTIEKYVQTIGKCKSAIWNGPMGVFEMVPYSKGTFAIAKAMGRGTQKRGLMSIIGGGESAGAAELCGEAARISHVSTGGGASLELLEGKTLPGVAVLDDKE

phosphoglyceratemutasetypeI

>gi|71747944|ref|XP_823027.1|2,3‐bisphosphoglycerate‐independentphosphoglyceratemutase[TrypanosomabruceiTREU927]MALTLAAHKTLPRRKLVLVVLDGVGIGPRDEYDAVHVAKTPLMDALFNDPKHFRSICAHGTAVGLPTDADMGNSEVGHNALGAGRVVLQGASLVDDALESGEIFTSEGYRYLHGAFSQPGRTLHLIGLLSDGGVHSRDNQVYQILKHAGANGAKRIRVHALYDGRDVPDKTSFKFTDELEEVLAKLREGGCDARIASGGGRMFVTMDRYEADWSIVERGWRAQVLGEGRAFKSAREALTKFREEDANISDQYYPPFVIAGDDGRPIGTIEDGDAVLCFNFRGDRVIEMSRAFEEEEFDKFNRVRLPKVRYAGMMRYDGDLGIPNNFLVPPPKLTRTSEEYLIGSGCNIFALSETQKFGHVTYFWNGNRSGKLSEERETFCEIPSDRVQFNQKPLMKSKEITDAAVDAIKSGKYDMIRINYPNGDMVGHTGDLKATITSLEAVDQSLQRLKEAVDSVNGVFLITADHGNSDDMVQRDKKGKPVRDAEGNLMPLTSHTLAPVPVFIGGAGLDPRVQMRTDLPRAGLANVTATFINLMGFEAPSDYEPSLIEVA

phosphoglyceratemutasetypeD

>gi|6322697|ref|NP_012770.1|phosphoglyceratemutasetypeD[SaccharomycescerevisiaeS288c]MPKLVLVRHGQSEWNEKNLFTGWVDVKLSAKGQQEAARAGELLKEKKVYPDVLYTSKLSRAIQTANIALEKADRLWIPVNRSWRLNERHYGDLQGKDKAETLKKFGEEKFNTYRRSFDVPPPPIDASSPFSQKGDERYKYVDPNVLPETESLALVIDRLLPYWQDVIAKDLLSGKTVMIAAHGNSLRGLVKHLEGISDADIAKLNIPTGIPLVFELDENLKPSKPSYYLDPEAAAAGAAAVANQGKK

enolase

>gi|71746974|ref|XP_822542.1|enolase[TrypanosomabruceiTREU927]MTIQKVHGREVLDSRGNPTVEVEVTTERGVFRSAVPSGASTGVYEACELRDGDKKRYVGKGCLQAVKNVNEVIGPALIGRDELKQEELDTLMLRLDGTPNKGKLGANAILGCSMAISKAAAAAKGVPLYRYLASLAGTKELRLPVPCFNVINGGKHAGNALPFQEFMIAPVKATSFSEALRMGSEVYHSLRGIIKKKYGQDAVNVGDEGGFAPPIKDINEPLPILMEAIEEAGHRGKFAICMDCAASETYDEKKQQYNLTFKSPEPTWVTAEQLRETYCKWAHDYPIVSIEDPYDQDDFAGFAGITEALKGKTQIVGDDLTVTNTERIKMAIEKKACNSLLLKINQIGTISEAIASSKLCMENGWSVMVSHRSGETEDTYIADLVVALGSGQIKTGAPCRGERTAKLNQLLRIEEELGAHAKFGFPGWS

pyruvatekinase

>gi|159469714|ref|XP_001693008.1|pyruvatekinase[Chlamydomonasreinhardtii]MVSLGLETVLAGTPSNICKTKVVCTLGPKSRSVEVLEELLRAGMSVARFNFSHGSHDYHQETLDNLRQAMANTKVMCAAMLDTKGPEIRTGTLKDGKPVQLTAGQEVTITTDYALPGDEKTIAMSYKKLAQDVKPGSQILCADGSIVLEVVSTDPAAGTVRARCMNSAMLGERKNVNLPGVVVDLPTLTDKDVDDLINWALPNDIDFIAASFVRKGSDIDTIRQVLGERGRSIKIISKVENQEGIQNFDDILAKTDSVMVARGDLGMEIPTEKIFLAQKMMIQKCNYAGKPVITATQMLESMIKNPRPTRAEATDVANAVLDGTDCVMLSGETAAGNFPVEAVKVMTKICREAEASLDYYAMFKNILKQAPMPMSPLESLASSAVRTAHKVHASLIVVLTREGSTARLVAKYRPLVPVLTVAVPVLTTDSLTWTCSGEAPARQCLVTRGLIPVLAEGSARATDSDTTDEILAAAIEHAKRARYCAKGDSIVALHRIGNASVIKIVDIK

pyruvate,orthophosphatedikinase

>gi|397141|emb|CAA52673.1|pyruvate,orthophosphatedikinase[Entamoebahistolytica]MQRVYAFEDGDGTNKKLLGGKGAGLCTMTKIGLPVPQGFVITTEMCKQFIANGNKMPEGLMEEVKKEYQLVEKKSGKVFGGEENPLLVSVRSGAAMSMPGMMDTILNLGLNDKTVVALAKLTNNERFAYDSYRRFVSLFGKIALNACDEVYDKTLENKKVEKGVKLDTELDANDMKELAQVFIKKTEEFTKQPFPVDPYAQLEFAICAVFRSWMGKRAVDYRREFKITPEQADGTAVSVVSMVYGNMGNDSATGVCFTRDPGTGENMFFGEYLKNAQGEDVVAGIRTPQIISKMAEDRDLPGCYEQLLDIRKKLEGYFHEVQDFEFTIERKKLYMLQTRNGKMNATATVRTGVDMVEEGLITKEQAIMRIAPQSVDQLLHKNMPANYAEAPLVKGLPASPGAATGAVVFDADDAVEQAKGKKVLLLREETKPEDIHGFFVAEGILTCRGGKTSHAAVVARGMGKPCVSGAEGIKVDVAKKIAKIGSLEVHEGDILTIDGSTGCVYKGEVPLEEPQVGSGYFGTILKWANEIKKIGVFAAGDLPSAAKKALEFGAEGIGLCRTERMFNAVERLPIVVKMILSNTLEERKKYLNELMPLQKQDFIGLLKTMNGLPVTVRLLDPPLHEFLPTLEELMREIFEMKLSGKTEGLAEKEVVLKKVKELMEVNPMIGHRGIRLGTTNPEIYEMQIRAFLEATREVIK

EGINDHREIMIPNVTEVNELINLRKNVLEPVHEEVEKKYGIKVPFSYGTMVECVRAALTADKIATEASFFSFGTNDLTQGTFSYSREDSENKFIPKYVELKILPANPFEILDRPGVGEVMRIAVTKGRQTRPELLVGICGEHGGEPSSIEWCHMIGLNYVSCSSYRIPVARIAAAQAQIRHPREN

40SribosomalproteinS14­A

>gi|10383793|ref|NP_009960.2|Rps14ap[SaccharomycescerevisiaeS288c]MSNVVQARDNSQVFGVARIYASFNDTFVHVTDLSGKETIARVTGGMKVKADRDESSPYAAMLAAQDVAAKCKEVGITAVHVKIRATGGTRTKTPGPGGQAALRALARSGLRIGRIEDVTPVPSDSTRKKGGRRGRRL

40SribosomalproteinS23

>gi|6321556|ref|NP_011633.1|Rps23ap[SaccharomycescerevisiaeS288c]MGKGKPRGLNSARKLRVHRRNNRWAENNYKKRLLGTAFKSSPFGGSSHAKGIVLEKLGIESKQPNSAIRKCVRVQLIKNGKKVTAFVPNDGCLNFVDENDEVLLAGFGRKGKAKGDIPGVRFKVVKVSGVSLLALWKEKKEKPRS

40SribosomalproteinS2

>gi|6321315|ref|NP_011392.1|Rps2p[SaccharomycescerevisiaeS288c]MSAPEAQQQKRGGFGGRNRGRPNRRGPRNTEEKGWVPVTKLGRLVKAGKITTIEEIFLHSLPVKEFQIIDTLLPGLQDEVMNIKPVQKQTRAGQRTRFKAVVVVGDSNGHVGLGIKTAKEVAGAIRAGIIIAKLSVIPIRRGYWGTNLGQPHSLATKTTGKCGSVTVRLIPAPRGSGIVASPAVKKLLQLAGVEDVYTQSNGKTRTLENTLKAAFVAIGNTYGFLTPNLWAEQPLPVSPLDIYSDEASAQKKRF

eukaryotictranslationinitiationfactor2alphasubunit

>gi|6322466|ref|NP_012540.1|Sui2p[SaccharomycescerevisiaeS288c]MSTSHCRFYENKYPEIDDIVMVNVQQIAEMGAYVKLLEYDNIEGMILLSELSRRRIRSIQKLIRVGKNDVAVVLRVDKEKGYIDLSKRRVSSEDIIKCEEKYQKSKTVHSILRYCAEKFQIPLEELYKTIAWPLSRKFGHAYEAFKLSIIDETVWEGIEPPSKDVLDELKNYISKRLTPQAVKIRADVEVSCFSYEGIDAIKDALKSAEDMSTEQMQVKVKLVAAPLYVLTTQALDKQKGIEQLESAIEKITEVITKYGGVCNITMPPKAVTATEDAELQALLESKELDNRSDSEDDEDESDDE

60SribosomalproteinL2a

>gi|14318555|ref|NP_116688.1|Rpl2ap[SaccharomycescerevisiaeS288c]MGRVIRNQRKGAGSIFTSHTRLRQGAAKLRTLDYAERHGYIRGIVKQIVHDSGRGAPLAKVVFRDPYKYRLREEIFIANEGVHTGQFIYAGKKASLNVGNVLPLGSVPEGTIVSNVEEKPGDRGALARASGNYVIIIGHNPDENKTRVRLPSGAKKVISSDARGVIGVIAGGGRVDKPLLKAGRAFHKYRLKRNSWPKTRGVAMNPVDHPHGGGNHQHIGKASTISRGAVSGQKAGLIAARRTGLLRGSQKTQD

60SribosomalproteinL11­A

>gi|6325359|ref|NP_015427.1|Rpl11ap[SaccharomycescerevisiaeS288c]MSAKAQNPMRDLKIEKLVLNISVGESGDRLTRASKVLEQLSGQTPVQSKARYTVRTFGIRRNEKIAVHVTVRGPKAEEILERGLKVKEYQLRDRNFSATGNFGFGIDEHIDLGIKYDPSIGIFGMDFYVVMNRPGARVTRRKRCKGTVGNSHKTTKEDTVSWFKQKYDADVLDK

60SribosomalproteinL15­A

>gi|6323057|ref|NP_013129.1|Rpl15ap[SaccharomycescerevisiaeS288c]MGAYKYLEELQRKKQSDVLRFLQRVRVWEYRQKNVIHRAARPTRPDKARRLGYKAKQGFVIYRVRVRRGNRKRPVPKGATYGKPTNQGVNELKYQRSLRATAEERVGRRAANLRVLNSYWVNQDSTYKYFEVILVDPQHKAIRRDARYNWICDPVHKHREARGLTATGKKSRGINKGHKFNNTKAGRRKTWKRQNTLSLWRYRK

40SribosomalproteinS5

>gi|6322583|ref|NP_012657.1|Rps5p[SaccharomycescerevisiaeS288c]MSDTEAPVEVQEDFEVVEEFTPVVLATPIPEEVQQAQTEIKLFNKWSFEEVEVKDASLVDYVQVRQPIFVAHTAGRYANKRFRKAQCPIIERLTNSLMMNGRNNGKKLKAVRIIKHTLDIINVLTDQNPIQVVVDAITNTGPREDTTRVGGGGAARRQAVDVSPLRRVNQAIALLTIGAREAAFRNIKTIAETLAEELINAAKGSSTSYAIKKKDELERVAKSNR

ProteasomecomponentPRE6

>gi|6324535|ref|NP_014604.1|Pre6p[SaccharomycescerevisiaeS288c]

MSGYDRALSIFSPDGHIFQVEYALEAVKRGTCAVGVKGKNCVVLGCERRSTLKLQDTRITPSKVSKIDSHVVLSFSGLNADSRILIEKARVEAQSHRLTLEDPVTVEYLTRYVAGVQQRYTQSGGVRPFGVSTLIAGFDPRDDEPKLYQTEPSGIYSSWSAQTIGRNSKTVREFLEKNYDRKEPPATVEECVKLTVRSLLEVVQTGAKNIEITVVKPDSDIVALSSEEINQYVTQIEQEKQEQQEQDKKKKSNH

MeioticrecombinationproteinDMC1

>gi|6321027|ref|NP_011106.1|Dmc1p[SaccharomycescerevisiaeS288c]MSVTGTEIDSDTAKNILSVDELQNYGINASDLQKLKSGGIYTVNTVLSTTRRHLCKIKGLSEVKVEKIKEAAGKIIQVGFIPATVQLDIRQRVYSLSTGSKQLDSILGGGIMTMSITEVFGEFRCGKTQMSHTLCVTTQLPREMGGGEGKVAYIDTEGTFRPERIKQIAEGYELDPESCLANVSYARALNSEHQMELVEQLGEELSSGDYRLIVVDSIMANFRVDYCGRGELSERQQKLNQHLFKLNRLAEEFNVAVFLTNQVQSDPGASALFASADGRKPIGGHVLAHASATRILLRKGRGDERVAKLQDSPDMPEKECVYVIGEKGITDSSD

ProteasomecomponentPUP2

>gi|6321692|ref|NP_011769.1|Pup2p[SaccharomycescerevisiaeS288c]MFLTRSEYDRGVSTFSPEGRLFQVEYSLEAIKLGSTAIGIATKEGVVLGVEKRATSPLLESDSIEKIVEIDRHIGCAMSGLTADARSMIEHARTAAVTHNLYYDEDINVESLTQSVCDLALRFGEGASGEERLMSRPFGVALLIAGHDADDGYQLFHAEPSGTFYRYNAKAIGSGSEGAQAELLNEWHSSLTLKEAELLVLKILKQVMEEKLDENNAQLSCITKQDGFKIYDNEKTAELIKELKEKEAAESPEEADVEMS

ProteasomecomponentY13

>gi|6321574|ref|NP_011651.1|Pre9p[SaccharomycescerevisiaeS288c]MGSRRYDSRTTIFSPEGRLYQVEYALESISHAGTAIGIMASDGIVLAAERKVTSTLLEQDTSTEKLYKLNDKIAVAVAGLTADAEILINTARIHAQNYLKTYNEDIPVEILVRRLSDIKQGYTQHGGLRPFGVSFIYAGYDDRYGYQLYTSNPSGNYTGWKAISVGANTSAAQTLLQMDYKDDMKVDDAIELALKTLSKTTDSSALTYDRLEFATIRKGANDGEVYQKIFKPQEIKDILVKTGITKKDEDEEADEDMK

DNA­directedRNApolymeraseIIlargestsubunit

>gi|6320061|ref|NP_010141.1|Rpo21p[SaccharomycescerevisiaeS288c]MVGQQYSSAPLRTVKEVQFGLFSPEEVRAISVAKIRFPETMDETQTRAKIGGLNDPRLGSIDRNLKCQTCQEGMNECPGHFGHIDLAKPVFHVGFIAKIKKVCECVCMHCGKLLLDEHNELMRQALAIKDSKKRFAAIWTLCKTKMVCETDVPSEDDPTQLVSRGGCGNTQPTIRKDGLKLVGSWKKDRATGDADEPELRVLSTEEILNIFKHISVKDFTSLGFNEVFSRPEWMILTCLPVPPPPVRPSISFNESQRGEDDLTFKLADILKANISLETLEHNGAPHHAIEEAESLLQFHVATYMDNDIAGQPQALQKSGRPVKSIRARLKGKEGRIRGNLMGKRVDFSARTVISGDPNLELDQVGVPKSIAKTLTYPEVVTPYNIDRLTQLVRNGPNEHPGAKYVIRDSGDRIDLRYSKRAGDIQLQYGWKVERHIMDNDPVLFNRQPSLHKMSMMAHRVKVIPYSTFRLNLSVTSPYNADFDGDEMNLHVPQSEETRAELSQLCAVPLQIVSPQSNKPCMGIVQDTLCGIRKLTLRDTFIELDQVLNMLYWVPDWDGVIPTPAIIKPKPLWSGKQILSVAIPNGIHLQRFDEGTTLLSPKDNGMLIIDGQIIFGVVEKKTVGSSNGGLIHVVTREKGPQVCAKLFGNIQKVVNFWLLHNGFSTGIGDTIADGPTMREITETIAEAKKKVLDVTKEAQANLLTAKHGMTLRESFEDNVVRFLNEARDKAGRLAEVNLKDLNNVKQMVMAGSKGSFINIAQMSACVGQQSVEGKRIAFGFVDRTLPHFSKDDYSPESKGFVENSYLRGLTPQEFFFHAMGGREGLIDTAVKTAETGYIQRRLVKALEDIMVHYDNTTRNSLGNVIQFIYGEDGMDAAHIEKQSLDTIGGSDAAFEKRYRVDLLNTDHTLDPSLLESGSEILGDLKLQVLLDEEYKQLVKDRKFLREVFVDGEANWPLPVNIRRIIQNAQQTFHIDHTKPSDLTIKDIVLGVKDLQENLLVLRGKNEIIQNAQRDAVTLFCCLLRSRLATRRVLQEYRLTKQAFDWVLSNIEAQFLRSVVHPGEMVGVLAAQSIGEPATQMTLNTFHFAGVASKKVTSGVPRLKEILNVAKNMKTPSLTVYLEPGHAADQEQAKLIRSAIEHTTLKSVTIASEIYYDPDPRSTVIPEDEEIIQLHFSLLDEEAEQSFDQQSPWLLRLELDRAAMNDKDLTMGQVGERIKQTFKNDLFVIWSEDNDEKLIIRCRVVRPKSLDAETEAEEDHMLKKIENTMLENITLRGVENIERVVMMKYDRKVPSPTGEYVKEPEWVLETDGVNLSEVMTVPGIDPTRIYTNSFIDIMEVLGIEAGRAALYKEVYNVIASDGSYVNYRHMALLVDVMTTQGGLTSVTRHGFNRSNTGALMRCSFEETVEILFEAGASAELDDCRGVSENVILGQMAPIGTGAFDVMIDEESLVKYMPEQKITEIEDGQDGGVTPYSNESGLVNADLDVKDELMFSPLVDSGSNDAMAGGFTAYGGADYGEATSPFGAYGEAPTSPGFGVSSPGFSPTSPTYSPTSPAYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPAYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPNYSPTSPSYSPTSPGYSPGSPAYSPKQDEQKHNENENSR

T­complexprotein1subunitgamma

>gi|6322446|ref|NP_012520.1|Cct3p[SaccharomycescerevisiaeS288c]MQAPVVFMNASQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTNDGHAILREIDVAHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVIIIQALKKALTDALEVIKQVSKPVDVENDAAMKKLIQASIGTKYVIHWSEKMCELALDAVKTVRKDLGQTVEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHPKMSRHIENPRVVLLDCPLEYKKGESQTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRPTLVITEKGVSDLAQHYLLKGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGT

NCGLFKVEMIGDEYFSFLDNCKEPKACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPSLSPGGGATEMAVSVKLAEKAKQLEGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLRAKHAQGNFTTGIDGDKGKIVDMVSYGIWEPEVIKQQSVKTAIESACLLLRVDDIVSGVRKQE

centromere/microtubulebindingfactor5

>gi|6323204|ref|NP_013276.1|Cbf5p[SaccharomycescerevisiaeS288c]MSKEDFVIKPEAAGASTDTSEWPLLLKNFDKLLVRSGHYTPIPAGSSPLKRDLKSYISSGVINLDKPSNPSSHEVVAWIKRILRCEKTGHSGTLDPKVTGCLIVCIDRATRLVKSQQGAGKEYVCIVRLHDALKDEKDLGRSLENLTGALFQRPPLISAVKRQLRVRTIYESNLIEFDNKRNLGVFWASCEAGTYMRTLCVHLGMLLGVGGHMQELRRVRSGALSENDNMVTLHDVMDAQWVYDNTRDESYLRSIIQPLETLLVGYKRIVVKDSAVNAVCYGAKLMIPGLLRYEEGIELYDEIVLITTKGEAIAVAIAQMSTVDLASCDHGVVASVKRCIMERDLYPRRWGLGPVAQKKKQMKADGKLDKYGRVNENTPEQWKKEYVPLDNAEQSTSSSQETKETEEEPKKAKEDSLIKEVETEKEEVKEDDSKKEKKEKKDKKEKKEKKEKKDKKEKKEKKEKKRKSEDGDSEEKKSKKSKK

ProteasomecomponentY7

>gi|6323547|ref|NP_013618.1|Pre8p[SaccharomycescerevisiaeS288c]MTDRYSFSLTTFSPSGKLGQIDYALTAVKQGVTSLGIKATNGVVIATEKKSSSPLAMSETLSKVSLLTPDIGAVYSGMGPDYRVLVDKSRKVAHTSYKRIYGEYPPTKLLVSEVAKIMQEATQSGGVRPFGVSLLIAGHDEFNGFSLYQVDPSGSYFPWKATAIGKGSVAAKTFLEKRWNDELELEDAIHIALLTLKESVEGEFNGDTIELAIIGDENPDLLGYTGIPTDKGPRFRKLTSQEINDRLEAL

T­complexprotein1subunitepsilon

>gi|6322524|ref|NP_012598.1|Cct5p[SaccharomycescerevisiaeS288c]MAARPQQPPMEMPDLSNAIVAQDEMGRPFIIVKDQGNKKRQHGLEAKKSHILAARSVASIIKTSLGPRGLDKILISPDGEITITNDGATILSQMELDNEIAKLLVQLSKSQDDEIGDGTTGVVVLASALLDQALELIQKGIHPIKIANGFDEAAKLAISKLEETCDDISASNDELFRDFLLRAAKTSLGSKIVSKDHDRFAEMAVEAVINVMDKDRKDVDFDLIKMQGRVGGSISDSKLINGVILDKDFSHPQMPKCVLPKEGSDGVKLAILTCPFEPPKPKTKHKLDISSVEEYQKLQTYEQDKFKEMIDDVKKAGADVVICQWGFDDEANHLLLQNDLPAVRWVGGQELEHIAISTNGRIVPRFQDLSKDKLGTCSRIYEQEFGTTKDRMLIIEQSKETKTVTCFVRGSNKMIVDEAERALHDSLCVVRNLVKDSRVVYGGGAAEVTMSLAVSEEADKQRGIDQYAFRGFAQALDTIPMTLAENSGLDPIGTLSTLKSKQLKEKISNIGVDCLGYGSNDMKELFVVDPFIGKKQQILLATQLCRMILKIDNVIISGKDEY

T­complexprotein1subunitdelta

>gi|6320058|ref|NP_010138.1|Cct4p[SaccharomycescerevisiaeS288c]MSAKVPSNATFKNKEKPQEVRKANIIAARSVADAIRTSLGPKGMDKMIKTSRGEIIISNDGHTILKQMAILHPVARMLVEVSAAQDSEAGDGTTSVVILTGALLGAAERLLNKGIHPTIIADSFQSAAKRSVDILLEMCHKVSLSDREQLVRAASTSLSSKIVSQYSSFLAPLAVDSVLKISDENSKNVDLNDIRLVKKVGGTIDDTEMIDGVVLTQTAIKSAGGPTRKEKAKIGLIQFQISPPKPDTENNIIVNDYRQMDKILKEERAYLLNICKKIKKAKCNVLLIQKSILRDAVNDLALHFLSKLNIMVVKDIEREEIEFLSKGLGCKPIADIELFTEDRLGSADLVEEIDSDGSKIVRVTGIRNNNARPTVSVVIRGANNMIIDETERSLHDALCVIRCLVKERGLIAGGGAPEIEISRRLSKEARSMEGVQAFIWQEFASALEVIPTTLAENAGLNSIKVVTELRSKHENGELNDGISVRRSGTTNTYEEHILQPVLVSTSAITLASECVKSILRIDDIAFSR

60SribosomalproteinL4­A

>gi|6320215|ref|NP_010295.1|Rpl4bp[SaccharomycescerevisiaeS288c]MSRPQVTVHSLTGEATANALPLPAVFSAPIRPDIVHTVFTSVNKNKRQAYAVSEKAGHQTSAESWGTGRAVARIPRVGGGGTGRSGQGAFGNMCRGGRMFAPTKTWRKWNVKVNHNEKRYATASAIAATAVASLVLARGHRVEKIPEIPLVVSTDLESIQKTKEAVAALKAVGAHSDLLKVLKSKKLRAGKGKYRNRRWTQRRGPLVVYAEDNGIVKALRNVPGVETANVASLNLLQLAPGAHLGRFVIWTEAAFTKLDQVWGSETVASSKVGYTLPSHIISTSDVTRIINSSEIQSAIRPAGQATQKRTHVLKKNPLKNKQVLLRLNPYAKVFAAEKLGSKKAEKTGTKPAAVFAETLKHD

T­complexprotein1subuniteta

>gi|6322350|ref|NP_012424.1|Cct7p[SaccharomycescerevisiaeS288c]MNFGSQTPTIVVLKEGTDASQGKGQIISNINACVAVQEALKPTLGPLGSDILIVTSNQKTTISNDGATILKLLDVVHPAAKTLVDISRAQDAEVGDGTTSVTILAGELMKEAKPFLEEGISSHLIMKGYRKAVSLAVEKINELAVDITSEKSSGRELLERCARTAMSSKLIHNNADFFVKMCVDAVLSLDRNDLDDKLIGIKKIPGGAMEESLFINGVAFKKTFSYAGFEQQPKKFNNPKILSLNVELELKAEKDNAEVRVEHVEDYQAIVDAEWQLIFEKLRQVEETGANIVLSKLPIGDLATQFFADRNIFCAGRVSADDMNRVIQAVGGSIQSTTSDIKPEHLGTCALFEEMQIGSERYNLFQGCPQAKTCTLLLRGGAEQVIAEVERSLHDAIMIVKRALQNKLIVAGGGATEMEV

SKCLRDYSKTIAGKQQMIINAFAKALEVIPRQLCENAGFDAIEILNKLRLAHSKGEKWYGVVFETENIGDNFAKFVWEPALVKINALNSATEATNLILSVDETITNKGSESANAGMMPPQGAGRGRGMPM

SupplementaryTable##:TemplateproteinsequencestosearchforhomologsinFig.19.SequencesweredownloadedfromNCBIJulytoOctober2011.