Activeingredients

SUPEROX-C™SUPEROX-C™ AF

Illuminate Your Skin!

Extracted from Kakadu plum, the world’s highest source of vitamin C-Stimulates the expression of SVCT-I, the vitamin C transporter of the skin-Improves skin luminosity

Free radicals are an inevitable actor of tissular aging process. Daily aggressions (sun

exposure, pollution, cigarette smoke, stress, etc.) are able to generate such a huge

amount of free radicals that normal cell antioxidant defenses become overwhelmed,

inducing an oxidative stress that leaves tissue vulnerable to damage. Oxidative stress

induces collagen and hyaluronic acid breakage and leads to a loss of skin consistency

and firmness responsible for the appearance of wrinkles and a dull complexion.

Superox-C™ is a botanical active ingredient extracted from native Australian Kakadu plum specially designed to provide a topical supply of antioxidants necessary to fight free radical-induced skin damages.

THE WORLD’S NATURAL RICHEST SOURCE OF VITAMIN C

Origin of Kakadu plum

Kakadu plum (Terminalia ferdinandiana) is endemic to tropical northern regions of

Australia around the Aborigines territory of the UNESCO World Heritage-listed Kakadu

National Park. The small to medium-sized tree produces fruits about two centimeters

long and a centimeter wide with a single seed.

History and traditional usage

Aborigines have lived in the Kakadu park area for tens of thousands of years. As

nutrient-rich fruits, Kakadu plums have been a traditional source of bush tucker for this

people and were eaten during long treks or hunting trips. In mouth, this bushfood has

a sweet taste and leaving a pleasant bitterness end. It was also traditionally pound and

used as an antiseptic and a soothing balm for aching limbs.

Composition

Kakadu plum is annually exposed to an extremely high sun index (up to 12) with

harmful rays. The fruits have consequently developed a highly efficient self-defense

system composed of a cocktail of various powerful antioxidant molecules to protect to

sun-induced free radicals attack.

Kakadu plum has been identified as the fruit with the world’s highest vitamin C content, up to about 100 times more than an orange! It also contains large amount

of polyphenols (mainly gallic and ellagic acids). Due to its extraordinary antioxidant

composition, Kakadu plum is classified as a superfruit.

Superox-C™ is a Kakadu plum extract, a unique superfruit known

as the world’s richest source of vitamin c. It reinforces cell

antioxidant defenses to better protect against oxidative stress.

DARWIN

PERTH

CANBERRA

ADELAIDE

BRISBANE

SYDNEY

HOBART

MELBOURNE

Kakadu plum harvest region

LOCATION JAN FEB MAR APR MAY JUNEJULY AUG SEPT OCT NOV DEC

Darwin 11 12 11 6 8 7 7 9 11 11 11 10

Brisbane 11 10 9 6 4 3 3 5 7 8 10 11

Sydney 10 9 7 5 3 2 2 3 5 7 8 8

Melbourne 9 9 6 4 2 1 1 2 4 6 8 9

0-2: Low danger

UV INDEX: 3-5: Moderate risk

6-7: High risk

8-10: Very high risk

11+: Extreme risk

Sourc

e: G

ies

et

al.

PLANT SOURCEAMOUNT VIT. C

(mg/100g)

Kakadu plum 5300

Camu-camu 2800

Acerola 1677

Giji berry 150

Orange 53

Acai berry 20

100 X more in vitamin C content

=

STIMULATION OF SVCT-I SYNTHESISSuperox-C™ dose-dependently stimulates the synthesis of SVCT-I in keratinocytes.

Following 24 hours of incubation in presence of Superox-C™, SVCT-I expression is

increased by + 38% at 0.1% and + 106% at 0.2%.

By inducing the SVCT-I channel expression, Superox-C™ contributes to improve the penetration of vitamin C into the skin.

0

50

100

150

200

250

+106%

+38%

+9%

+225%

SV

CT

-I e

xp

ress

ion

(%

)

0.2%0.05% 0.1%FeCI3

10 mMSuperox-C™

Stimulation of Svct-i SyntheSiS

The perfect multifunctional plant-derived ingredient which combines unique

marketing claims & innovative sciences.

Boosts skin luminosity

Helps strengthen skin matrix

Induces skin brightening

Antioxidant protection

Improves skin tone evenness

Reduces the appearance of skin redness

Mul

tif

untional active ingredient

SUPEROX-C™

Svct-i channel

Keratinocyte

SVCT-I Channel

Vitamin C

THE VITAMIN C TRANSPORTER SVCT-IVitamin C plays an essential role in preserving the skin young and healthy. This potent

active molecule is well-known for its multiple actions. It is a strong antioxidant agent

which protects the skin from oxidative stress by neutralizing free radicals-induced

skin damage. Vitamin C also induces collagen biosynthesis in both young and aged

skin. Moreover, vitamin C is an anti-inflammatory agent known to prevent post-

inflammatory hyperpigmentation and exert brightening effect by interrupting the key

steps of melanogenesis.

All these remarkable effects rely on the skin capacity to transport vitamin C through

the skin layers. Sodium-dependant Vitamin C Transporter Type-I (SVCT-I) mainly

expressed on the cell membrane of keratinocytes, plays a crucial role in the vitamin C

distribution.

Technical solution to enhance the sought after effect of vitamin C.

ANTIOXIDANT EFFECTSuperox-C™ (0.2%) has a strong antioxidant activity +54% after 30 min and +79% at

24h.

By supplementing the skin with a topical dose of natural antioxidants, cells boost their defenses against free radicals. Oxidative stress is then reduced.

STIMULATION OF PRO-COLLAGEN IPro-collagen I is the precursor molecule of the collagen which is synthetized by the

fibroblasts. Defective stimulation signal in aged skin contributes to reduce the collagen

synthesis and therefore, weakens the skin structure.

Superox-C™ induces the synthesis of pro-collagen I by +144% at 0.4%.

INDUCTION OF HYALURONIC ACID SYNTHESISHyaluronic acid contributes to maintain skin’s hydration and viscoelastic properties.

Hyaluronic acid synthesis tends to decrease with chronological age.

Superox-C™ induces the synthesis of hyaluronic acid by +59% at 0.2%.

STIMULATION OF SYNDECAN-I SYNTHESISSuperox-C™ induces the expression of syndecan-I by +104% at 0.4% which will help

stimulate the epidermal renewal, a property affected by age.

Superox-C™ protects and reinforces the dermis to improve the skin aspect.

Hyalu

ron

ic a

cid

p

rod

ucti

on

(%

)

0

20

40

60

80

+59%

+40%+41%

0.2%0.05%TGF-β1 ng/mL

Superox-C™

Stimulation of hyaluronic acid SyntheSiS

500 000

750 000

1 000 000

1 250 000

1 500 000

1 750 000

2 000 000

+104%+90%

+154%

Flu

ore

scen

ce in

ten

sity

0.4%TGF-β10ng/mL

0.2%Baseline

Superox-C™

Stimulation of Syndecan-i SyntheSiS

0

20

40

60

80

100

120

140

160

+40%

+57%+68%

+144%

+46%

Pro

-co

llag

en

I

pro

du

cti

on

(p

g/m

L)

TGF-β10 ng/mL

0.05% 0.1% 0.2% 0.4%

Superox-C™

Stimulation of pro-collagen i SyntheSiS

antioxidant activity

0

20

40

60

80

An

tio

xid

an

t eff

icacy (

%)

0.05% 0.2%0.1%

Superox-C™

+79%

+39%

+16%+15%

+29%

+54%

30 min. 24 hrs

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IMPROVEMENT OF SKIN LUMINOSITYGloss value is a parameter of the skin radiance. It defines the ability of the skin to reflect

the light, and is directly linked to the skin surface quality.

Test protocol

- 20 women volunteers (mean age of 37);

- Twice daily application of a cream with 2% Superox-C™ on split-face versus a placebo

during 30 days;

- Gloss value measurement with spectrocolorimeter at D0, D15 and D30.

Luminosity enhancement up to:

• 21% after 15 days

• 30% after 30 days

100% of the subjects demonstrated a positive effect.

IMPROVEMENT OF SKIN BRIGHTNESS AND SKIN TONE EVENNESSOn the best volunteer, color analysis using cross-polarized pictures were performed.

After one month, Superox-C™ produces up to;

• +1.7% Skin brightness induction (IWA*Newtone)

•-2.2% Skin redness reduction (a*)

• +14% Overall skin tone evenness improvement (H76)

Decrease the appearance of uneven skin tone for more beautiful and youthful looking skin.

Superox-C™ strenghtens the skin matrix and is proven effective to brighten the skin and enhance its radiance.

D0 D30

Skin surface

Surface normal

Illumination Photodetectors

-202468

1012141618

Vari

ati

on

of

glo

ss v

alu

e

(% v

s. D

0)

-0.8%

10%*

17%*

-0.4%

D15 D30

Skin gloSS value

Placebo 2% Superox-C™

* p<0.05

D0 D30

Features and benefits

Glossy skin serum 13.322.01 C148

Product descriptionINCI NAME SUPEROX-C™Glycerin (1) (and) Water (2) (and) Alcohol Denat. (3) (and) Terminalia Ferdinandiana Fruit Extract (4)

CAS SUPEROX-C™56-81-5 (1), 7732-18-5 (2), 64-17-5 (3), 1176234-54-0 (4)

EINECS SUPEROX-C™200-289-5 (1), 231-791-2 (2), 200-578-6 (3), - (4)

INCI NAME SUPEROX-C™AFGlycerin (1) (and) Water (2) (and) Terminalia Ferdinandiana Fruit Extract (3)

CAS SUPEROX-C™AF56-81-5 (1), 7732-18-5 (2), 1176234-54-0 (3)

EINECS SUPEROX-C™AF200-289-5 (1), 231-791-2 (2), - (3)

APPEARANCEPale yellow to yellow-brown liquid

FORMULATION Should be incorporated at the end of the formulation at a temperature below 40°C.

DOSAGE 1-2%

OPTIMUM pH 3.0-7.5

APPLICATIONS- Anti-aging care- Radiant care- Daily care- Sun care and after-sun care- Skin protection- Men care

COSMOS STATUS Superox-C™AF: Registered

CHINA-COMPLIANT

FEATURES BENEFITS

Kakadu plum thrives in extremely harmful UV environment

Highly efficient self-defense system

Extracted from unique Australian superfruit, the world’s richest source of vitamin C

Powerful antioxidant activity

Enhances the vitamin C effect by inducing the expression of vitamin C transporter SVCT-I

Increases the skin tone evenness and brightens the skin

Outstanding effect observed on 100% volunteers

- Increases skin luminosity

Fast action Significant clinical results after only 2 weeks

A C T I V E I N G R E D I E N T S S U P E R O X - C ™

Information and suggestions that may be provided by us, including with respect to the composition or use of our ingredients, are provided in good faith, based on the state of our current technical and scientific knowledge, but without any warranty as to their relevance, accuracy, completeness, presentation, use or otherwise. No express or implied license on patents or other intellectual property rights shall be deemed given as a result of such information or suggestions being provided. No warranty is given that the use (including the commercialization) of our ingredients, alone or in combination with other products, or the information and suggestions that we may provide are not infringing the intellectual property rights of any third party. Any person relying on the information and suggestions that we are providing shall do so at his/her own risk and we will therefore accept no liability whatsoever with respect thereto. Without liming the generality of the foregoing, any person using our ingredients in the formulation of his/her finished products is solely responsible for ensuring that the use made of our ingredients, the finished products that he is commercialising as well as their packaging, labelling, advertising materials and statements made by e.g., sales representatives and the claims he/she makes with respect to his/her finished products and the ingredients they contain comply with applicable laws and regulations and are not infringing third parties’ rights. We hereby disclaim any warranty of suitability of our ingredients for any purpose. Any user of our ingredients shall himself /herself determine the suitability of our ingredients for his intended use and, as the case may be, obtain the required regulatory approvals and/or freedom to operate for the commercialization of his/her finished products. Any information or suggestion that may be provided by us shall in no manner be interpreted as a legal or regulatory advice. Any person wishing to receive same shall consult his own legal or regulatory affair advisors for legal or regulatory advices.

www.lucasmeyercosmetics.cominfo@lucasmeyercosmetics.com—

* Distributed in France by Lucas Meyer Cosmetics.

pH: 4.5 - 5.5 - Viscosity (Rheo ELV 8, spindle 4, 6 rpm, 3 mn): 10 000 - 20 000 mPa.s

INGREDIENTS INCI NAMES %

A Deionized Water Water 81.17

Dermofeel™ PA-3* Sodium Phytate (and) Water (and) Alcohol 0.15

FDC Red 4 Solution 0.1% Water (and) CI 14700 0.28

Ecogel™ Lysolecithin (and) Sclerotium Gum (and) Xanthan Gum (and) Pullulan

2.00

B Dermofeel™ Sensolv* Isoamyl Laurate 1.00

Shea Butter Butyrospermum Parkii (Shea) Butter 3.00

Sweet Almond Oil Prunus Amygdalus Dulcis (Sweet Almond) Oil 3.00

Vitapherole E1000 Tocopherol (and) Helianthus Annuus (Sunflower) Seed Oil

0.20

C Dermosoft™ 1388* Fragrance 4.00

Superox-C™ Glycerin (and) Water (and) Alcohol Denat. (and) Terminalia Ferdinandiana Fruit Extract

2.00

WildBerry Harvest™ Glycerin (and) Water (and) Alcohol Denat. Tasmannia Lanceolata Fruit Extract (and) Syzygium Luehmannii Fruit Extract (and) Kunzea Pomifera Fruit Extract

2.00

Liftessence™ Nature PF Water (and) Glycerin (and) Cyathea CumingiiLeaf Extract

1.00

D SG 38237 Fragrance 0.20

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