Stem Cell Makers - Abcam · LEF/TCF LEF/TCF APC Wnt Cerberus WIF Dkk Frp AKT Dsh naked GLI-1 GLI-2...
Transcript of Stem Cell Makers - Abcam · LEF/TCF LEF/TCF APC Wnt Cerberus WIF Dkk Frp AKT Dsh naked GLI-1 GLI-2...
InducesDbx1 cellsDbx2 cells
Txn of WntIgf2GLI-1PDGFRαPtc-1
Txn of MycAxinCycD1TGF-1PPARγCD44MMP-7etc.
Vertebrates Fly
DE
LTA1
DE
LTA2
DE
LTA3
DE
LTA4
JAG
GE
D1
JAG
GE
D2
CO
NTA
CT
IN
NB
3
DE
LTA
SE
RR
AT
E
LAG
2
DSL1
C. elegans
NO
TCH
NO
TCH
TA
CE
NE
XT LR
P5/6
DA
LLY
DA
LLY - LIK
E
ME
GA
LIN
HIP
NIC
D
NIC
D
NICD
CycC, cdk8MAML
HATS
Hairless
Act-Ci Cos2
SuFu
SuFu SuFu
SuFu
SuFu
RepressorComplex
Fly
Vertebrates
Hes 1/3/5PreTαHey1/Hey2MAGCNPase
CBP, RBPjk (vertebrate)Su(H) (Fly)Lag 1 (C.elegans)
+Fbw7/Sel10
Proteosomaldegradation
?
CtBP
Slimb
KIF
Slimb
Rep-Ci
Fu
Act-Ci
Act-Ci
Act-Ci
Cos2
SuFu Fu
cAMPPS1/PS2 PEN-2 APH -1
+shh -shh
Smo Ptc
Shh
SKN
GAS-1
Dhh Ihh
Cadherin
FZ
P
P PUb UbUbUb
Proteosomaldegradation
Palmitate
Cholesterol
NCT
WNT
β-catenin
β-catenin
β-catenin
β-catenin
β-catenin
α-catenin
GBP/Frat
p120
CK1
PP2A
GSK3B
PKA
PKA
CK1
5gg
GSK3B
Axin
Pygo XSox17BCC9
CtBP
GrouchoSKIP
Syn3a CIR
SMRT
CtBP
LEF/TCF
LEF/TCF
APC
WntCerberus
WIF
Dkk
Frp
AKT Dsh
naked
GLI-2GLI-1 GLI-3
Groucho
CtBP
CSL
P P P P P
CSL
CSL
P
P+
Notch pathway shh pathway
wnt/β-catenin pathway
NUCLEUS
NeurogenesisSignaling Pathways: Notch | Shh | β-catenin