Stefan Pilz - Vitamin D und Krebs
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Transcript of Stefan Pilz - Vitamin D und Krebs
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Wirkung von Vitamin D bei Krebserkrankungen
Stefan PilzDepartment of Internal Medicine, Division of Endocrinology and
Metabolism, Medical University of Graz, AustriaDepartment of Epidemiology and Biostatistics, EMGO Institute for Health
and Care Research, VU University Amsterdam, The Netherlands
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OUTLINE
Sunlight (ultraviolet-B) exposure and cancer
Vitamin D deficiency and cancer risk
Outlook and conclusions
Anti-cancer effects of vitamin D
Vitamin D treatment and cancer
Sunlight (ultraviolet-B) exposure and cancer
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Vitamin D and sun
Reichrath J. British Journal of Dermatology, 2009; 161: 54-60
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Cancer and sunlight
Cancer Res 1:191-195, 1941 Apperly FL
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Cancer and sunlight
Apperly FL. Cancer Res 1:191-195, 1941
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Solar radiation and colon cancer
Int J Epidemiol 1980; 9:227-231
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UV-B and cancer mortality
Cancer 2002;94:1867-1875
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OUTLINE
Sunlight (ultraviolet-B) exposure and cancer
Vitamin D deficiency and cancer
Outlook and conclusions
Anti-cancer effects of vitamin D
Vitamin D treatment and cancer
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Vitamin D and melanoma
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Vitamin D and melanoma
„…there was no evidence for a
nything other than a
beneficial effe
ct for h
igher (vita
min D) levels“
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Vitamin D and cancer
47,800 men4,286 incident cancers2,025 cancer deaths
Largest study in this field
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Follow-up (years)
1086420
Cu
mu
lati
ve S
urv
ival
1.00
0.99
0.98
0.97
0.96
0.95
0.94
Q4 (High)Q3Q2Q1 (Low)
25-hydroxyvitamin D (ng/ml)
(N=95)
HR 0.49 (0.28-0.88)(fully adjusted model)
Pilz S et al, Cancer Epidemiol Biomarkers Prev 2008; 17: 1228-1233
Vitamin D and cancer mortality
Data from 3299 patients referred for coronary angiography and followed up for 7.7 years
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Vitamin D and colorectal cancer
Non-linear dose-response meta-analyses on circulating 25-
hydroxyvitamin D and risk of colorectal cancer
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Vitamin D and colorectal cancer
Dose-response meta-analyses of total (dietary + supplemental) vitamin D intake and risk of colorectal and colon cancer
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OUTLINE
Sunlight (ultraviolet-B) exposure and cancer
Vitamin D deficiency and cancer
Outlook and conclusions
Anti-cancer effects of vitamin D
Vitamin D treatment and cancer
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Anticancer effects of vitamin D
684-700
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Anticancer effects of vitamin D
JNCI J Natl Cancer Inst (1992) 84(17): 1355-1357
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OUTLINE
Sunlight (ultraviolet-B) exposure and cancer
Vitamin D deficiency and cancer risk
Outlook and conclusions
Anti-cancer effects of vitamin D
Vitamin D treatment and cancer
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Vitamin D and cancer incidence
Lappe J, et al. Am J Clin Nutr 2007;85:1586-91
A 4-year, population based, double-blind, randomized, placebo controlled trial among healthy postmenopausal women (n=1179) receiving 1400-1500 mg calcium/d (Ca-only), calcium plus 1100 IU vitamin D/d (Ca + D), or placebo
** P=0.01 *** P=0.005
RR 0.40**RR 0.23***
Entire study cohort Free of cancer at 1 years of intervention
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WHI-Study
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WHI-Study
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OUTLINE
Sunlight (ultraviolet-B) exposure and cancer
Vitamin D deficiency and cancer risk
Outlook and Conclusions
Anti-cancer effects of vitamin D
Vitamin D treatment and cancer
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Conclusion
Sunlight (ultraviolet-B exposure), which increases vitamin D synthesis in the skin, is associated with reduced cancer risk
Vitamin D exerts various anti-carcinogenic effects
Observational and interventional studies have partially but not consistently shown an association of a poor vitamin D status with increased cancer risk
Whether vitamin D supplementation is effective in the prevention and treatment of cancer remains to be further evaluated in large-scale randomized controlled trials but the promising data on vitamin D regarding cancer and various other health outcomes strongly argue that it is reasonable to prevent and treat vitamin D deficiency
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Thank you for your attention !