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Transcript of SOPHIA COLLEGE (AUTONOMOUS) AFFLIATED TO …
SOPHIA COLLEGE (AUTONOMOUS)
AFFLIATED TO UNIVERSITY OF MUMBAI
SYLLABUS FOR M.Sc PART I ANALYTICAL CHEMISTRY
SEMESTER III AND IV
TO BE IMPLEMENTED FROM THE ACADEMIC YEAR 2020-21
Sr. No. Heading Particulars
1 Title of Course M.Sc. Chemistry Semester III and IV
2 Eligibility for Admission M.Sc Part I course completed
3 Passing marks Minimum D Grade or equivalent minimum marks for passing at the
Graduation level.
4 No. of Years/Semesters One year/Two semester
5 Level P.G. part-II
6 Pattern Semester
7 To be implemented from
Academic year
2020-2021
Dr. I. A. Mendes Prof. Santosh Haram
BOS, Chairperson Convener
FACULTY: SCIENCE
COURSE: M.Sc
SEMESTER III
Course Code Title of the paper
Unit Topic Credits
SMSCHE301
Quality in Analytical Chemistry
I Quality in Analytical Chemistry – I
4
II Quality in Analytical Chemistry – II
III Chromatographic Techniques - I
IV Chromatographic Techniques - I
SMSCHE302
Advanced
Instrumental Techniques
I Spectral Methods – I 4 II Spectral Methods - II
III Electroanalytical Techniques
IV Miscellaneous Techniques
SMSCHE303
Bioanalytical
Chemistry and Food Analysis
I Bioanalytical Chemistry
4
II Immunological methods
III Food Analysis – I
IV Food Analysis – II
SMSCHE304
Pharmaceutical
and Organic Analysis
I Pharmaceutical Analysis
4
II Drugs
III Forensic Science
IV Cosmetic Analysis
SMSCHEP301 SMSCHEP302 SMSCHEP303 SMSCHEP304
PRACTICALS
I Group A 8
(2 credits for each practical)
II Group B
III Group C
IV Group D
FACULTY: SCIENCE
COURSE: M.Sc
SEMESTER IV
Course Code Title of the paper Unit Topic Credits
SMSCHE401
Quality in Analytical Chemistry
I Separation Science 4 II Separation, Analysis
and Standardization of Herbal Products
III Green Chemistry
IV Chromatographic Techniques – II
SMSCHE402
Advanced
Instrumental Techniques
I Spectral Methods – III
4
II Spectral Methods – IV
III Radiochemical and Thermal methods
IV Hyphenated Techniques
SMSCHE403
Selected Topics
in Analytical Chemistry
I Effluent treatment 4 II Solid Waste
Management
III Plastics and Polymers
IV Metallurgy
SMSCHE404
Intellectual
Property Rights and
Cheminformatics
I Introduction to Intellectual Property
4
II Trade Agreements
III Introduction to Cheminformatics
IV Applications of Cheminformatics
SMSCHEP401 SMSCHEP402 SMSCHEP403 SMSCHEP404
PRACTICALS
I Group A 8
(2 credits for each practical)
II Group B
III Group C
IV Group D: Project Work
SEMESTER III
SMSCHE301: QUALITY IN ANALYTICAL CHEMISTRY
UNIT NO. TOPIC WEIGHTAGE
I
Quality In Analytical Chemistry – I
15
1.1 Sampling: Definition, types of sample, sampling plan,
quality of sample, subsampling, Sampling of raw
materials, intermediates and finished products.
Sample preparations – dissolution technology and
decomposition, storage of samples.
Pre-treatment of samples: soil, food and cosmetics. (8L)
1.2 Selection of the Method: sources of methods, factors
to consider when selecting a method, performance criteria
for methods used, reasons for incorrect analytical results,
method validation, and quality by design (PAT). (7L)
II
Quality In Analytical Chemistry - II
15
2.1 Measurement of uncertainty: Definition and
evaluation of uncertainty, putting uncertainty to use,
interpretation of results and improving the quality
of results. (4L)
2.2 Signal to noise: Signal to noise ratio, sources of
noise in instrumental analysis. Signal to noise
enhancement, hardware devices for noise reduction,
software methods for noise reduction. (6L)
2.3 Pharmaceutical Legislation: introduction to drug
acts, drug rules (schedules), concept of regulatory
affairs in pharmaceuticals, review of GLP and GMP
and their regulations for analytical labs, roles and
responsibilities of personnel, appropriate design and
placement of laboratory equipment, requirements for
maintenance and calibration. (5L)
III
Chromatographic Techniques –I 15
3.1 Ion exchange chromatography: Ion exchange
equilibria, breakthrough capacity, inorganic ion
exchangers, synthetic ion exchangers, chelating resins
and their applications for separation of inorganic and
organic compounds. (8L)
3.2 Ion chromatography: Principle, instrumentation with
special reference to separation and suppressor columns,
applications. (2L)
3.3 Exclusion chromatography : Theory, instrumentation
and applications of gel permeation chromatography,
retention behavior, inorganic molecular sieves,
determination of molecular weight of polymers, (5L)
IV
Chromatographic Techniques –II
15
4.1 Supercritical fluid Chromatography: Theory,
concept of critical state of matter and supercritical
state, types of supercritical fluids, instrumentation,
applications to environmental, food, pharmaceuticals
and polymeric analysis. (8L)
4.2 Affinity Chromatography: principle, instrumentation
and applications (4l)
4.3 Optimum pressure liquid chromatography (OPLC)
(3L)
List of books and references:
1. Quality in the analytical chemistry laboratory, E Prichard, John Wiley and sons
N.Y 1997.
2. Quality assurance in analytical Chemistry, W Funk, V Dammann, G. Donnevert
VCH Weinheim1995.
3. Amit S. Patil et. al.,Quality by Design (QbD) : A new concept for development of Quality pharmaceuticals, International Journal of Pharmaceutical Quality Assurance; 4(2); 13-19.
4. Lalit Singh and Vijay Sharma, Quality by Design (QbD) Approach in
Pharmaceuticals: Status, Challenges and Next Steps, Drug Delivery Letters, 2015,
5. 2-8. Quality in the analytical chemistry laboratory, E Prichard, John Wiley and sons N.Y
1997
6. Fundamentals of Analytical Chemistry, D. A. Skoog and D. M. West, Saonders,
College publication.
7. Chemical methods of separation, J A Dean, Van Nostrand Reinhold, 1969
8. Solvent extraction and ion exchange, J Marcus and A. S. Kertes Wiley INC 1969.
9. Analytical Chemistry, G. D. Christain, Wiley
10. Extraction Chromatography T. Braun, G. Ghersene, Elsevier Publications 1978.
11. Supercritical Fluid Extraction, Larry Taylor Wiley publishers N.Y. 1996
12. Ion exchange separation in analytical chemistry O Samuelson John Wiley 2nd edition
1963
13. Ion exchange chromatography Ed H.F Walton Howden, Hutchenson and Rossing 1976
14. Chromatographic and electrophoresis techniques I Smith Menemann Interscience 1960
SMSCHE302: ADVANCED INSTRUMENTAL TECHNIQUES
UNIT NO. TOPIC WEIGHTAGE
I
Spectral Methods I 15
1.1 Surface Analytical Techniques: Preparation of the
surface, difficulties involved in the surface analysis. (1L)
1.2 Principle, instrumentation and applications of the
following:
a. Secondary Ion mass spectroscopy. (4L)
b. Particle-Induced X-Ray Emission (5L)
c. Low-Energy Ion Scattering and Rutherford
Backscattering (5L)
II
Spectral Methods II
15
Principle, Instrumentation, and Applications of
2.1 Electron Spin Resonance Spectroscopy (ESR) (5L)
2.2 Mossbauer’s Spectroscopy (5L)
2.3 Atomic Emission Spectroscopy- based on plasma and
electrical discharge sources (5L)
III Electroanalytical Methods
15
Advanced Electroanalytical Techniques:-
3.1 Current Sampled (TAST) Polarography, Normal and
Differential Pulse Polarography (3L)
3.2 Potential Sweep methods- Linear Sweep Voltammetry
and Cyclic voltammetry. (3L)
3.3 Potential Step method- Chronoamperomertry (2L)
3.4 Controlled potential technique- Chronopotentiometry
(2L)
3.5 Stripping Voltammetry- anodic, cathodic, and
adsorption (2L)
3. 6 Chemically and electrolytically modified
electrodes and ultra-microelectrodes in voltammetry
(3L)
IV
Miscellaneous Techniques
15
Principle, Instrumentation and Applications of
4.1 Chemiluminesescence techniques (3L)
4.2 Chirooptical Methods : ORD, CD (5L)
4.3 Photoacoustic spectroscopy (3L)
4.4 Spectroelectrochemistry (4L)
List of books and references:
1. Analytical Chemistry, G. D. Christian, 4th Ed. John Wiley, New York (1986)
2. Fundamentals of Analytical Chemistry, D .A. Skoog and D. M. West and F. J. Holler
Holt- Saunders 6th Edition (1992)
3. Principles of Instrumental Analysis, D. A. Skoog, F. J. Holler and J.A. Niemann, 5th Edition (1998)
4. Instrumental Methods of Analysis, H. H. Willard, L. L. Merritt, Jr. J. A. Dean and F.
A. Settle Jr 6th Ed CBS (1986)
5. Instrumental Methods of Analysis, H. H. Willard, L. L. Merritt Jr, J. A. Dean and F. A.
Settle Jr 7th Ed CBS (1986)
6. Introduction to Instrumental Analysis, R. D. Braun, Mc Graw Hill (1987)
7. Electrochemical Methods, A. J. Bard and L.R. Faulkner, John Wiley, New York,
(1980)
8. Electroanalytical Chemistry, J.J . Lingane, 2nd Ed Interscience, New York (1958)
9. Modern Polarographic Methods in Analytical Chemistry, A. M. Bond, Marcel Dekker,
New York, 1980.
10. Electroanalytical Chemistry, Ed A. J. Bard and Marcel Dekker, New York, (A series of
volumes)
11. Techniques and mechanism of electrochemistry, P. A. Christian and A. Hamnett,
Blachie Academic and Professional (1994)
12. Wilson and Wilson’s Comprehensive Analytical Chemistry, Ed. G. Svehla. (A series of
Volumes)
13. Treatise on Analytical Chemistry, Eds. I. M. Kolthoff and Others, Interscience Pub. (A
series of volumes).
14. Standard Methods of Chemical Analysis, Eds. F. J. Welcher, Robert E. Krieger
Publishing Company, (A series of volumes)
15. Polarographic Methods in Analytical Chemistry, M. G. Arora, Anmol Publications
Pvt Ltd
16. Surface Analysis –The Principal Techniques, 2nd Edition Edited by John C.
Vickerman and Ian S. Gilmore 2009 John Wiley & Sons, Ltd. ISBN: 978-0-470-
01763-0
17. NMR, NQR, EPR, and Mössbauer Spectroscopy in Inorganic Chemistry R. V.
Parish. Ellis Horwood, Chichester
SMSCHE303: BIOANALYTICAL CHEMISTRY AND FOOD ANALYSIS
UNIT NO. TOPIC WEIGHTAGE
I
Bioanalytical Chemistry
15
1.1 Body Fluids
1.1.1 Composition of body fluids and detection of
abnormal levels of glucose, creatinine, uric acid in blood,
protein, ketone bodies and bilirubin in urine leading to
diagnosis of diseases. (5L)
1.1.2 Physiological and nutritional significance of
vitamins (water soluble and fat soluble) and minerals.
(5L)
1.1.3 Analytical techniques (including microbiological
techniques) for vitamins. (5L)
II
Immunological Methods
15
2.1 General processes of immune response, antigen-
antibody reactions, precipitation reactions, radio, enzyme
and fluoro-immuno assays.(8L)
2.2 Human Nutrition: Biological values and estimation of
enzymes, carbohydrates, proteins, essential amino acids
and lipids.(7L)
III Food Analysis – I 15
3.1 Fuel value of food and importance of food nutrients
(2L)
3.2 Food Additives – General idea about Food processing
and preservation, Chemical preservatives, fortifying
agents, emulsifiers, texturizing agents, flavours, colours,
artificial sweeteners, enzymes. Analysis of food products
for flavoring agents and colour. (5L)
3.3 Food Contaminants– Trace metals and pesticide
residues, contaminants from industrial wastes
(polychlorinated polyphenols, dioxins), toxicants formed
during food processing (aromatic hydrocarbons,
nitrosamines), veterinary drug residues and melamine
contaminants. (8L)
IV
Food Analysis - II
15
4.1.1 Food packaging – Introduction, types of packing
materials, properties and industrial requirements.(2L)
4.1. 2 Processing and Quality requirements of Milk and
milk products (cheese, butter and ice cream), vegetables
and fruits, meat and meat products. (6L)
4.2 Analysis of Milk – Fat content, proteins, acidity,
bacteriological quality and milk adulterants.(2L)
4.3 Analysis of Oils and Fats – acid value, sap value,
iodine value. Determination of rancidity and
antioxidants.(2L)
4.4 Analysis of spices (cloves, cinnamon, pepper,
mustard)
Determination of volatile oils and fixed oils.(3L)
List of books and References:
1. General, organic and biological chemistry, H. Stephen Stoker, Cengage Learning.
2. Advance dairy chemistry, vol 3, P. F. Fox, P. L. H. McSweeney Springer.
3. Physiological fluid dynamics vol 3, Nanjanagud Venkatanarayanasastry Chandrasekhara
Swamy Narosa Pub. House, 1992
4. Molecular Biological and Immunological Techniques and Applications for food, edited by
Bert Popping, Carmen Diaz-Amigo, Katrin Hoenicke, John Wiley & sons.
5. Food Analysis: Theory and practice, Yeshajahu Pomeranz, Clifton E. Meloan, Springer.
6. Principles of package development, Gribbin et al
7. Modern packaging Encyclopedia and planning guide, Macgra Wreyco.
8. Food Analysis, Edited by S. Suzanne Nielsen, Springer
9. Analytical Biochemistry, D, J. Homes and H. Peck, Longman (1983)
10. Bioanalytical Chemistry, S. R. Mikkelesen and E. Corton, John Wiley and sons 2004
11. Analysis of food and beverages, George Charalanbous, Accademic press 1978
SMSCHE304: ENVIRONMENTAL AND CERTAIN INDUSTRIALLY IMPORTANT
MATERIALS
UNIT NO. TOPIC WEIGHTAGE
I
Air Pollution 15
1.1 Sources, classification, pollutants and permissible
limits.(2L)
1.2 Sampling methods for air, flew gas ,Industrial
Exhaust, stag samples etc. (2L)
1.3 Importance of automobile exhaust control and its
limits(2L)
1.4 Sampling and analysis of: Particulate matter,
aerosols, ammonia and organic vapors. (3L)
1.5 Carbon credit and global issues related to air
pollution.(3L)
1.6 Greenhouse gases and their substitutes. (1L)
1.7 Environmental Legislation: role of pollution control
boards, article 48A and 51A, Motor Vehicle Act and
method of analysis with respect to PUC. (2L)
II
Water Quality Standards
15
2.1 Water: quality and requirements of potable water,
direct and indirect pollutants for potable water reservoirs,
quality of potable water from natural sources. (6L)
2.2 Bore well water quality and analytical parameters.
Quality of bottled mineral water (3L)
2.3 Process of purification of bore well water to bottled
mineral water. (2L)
2.4 Regulatory requirements for packaged drinking water
(4L)
III
Other Types of Pollution 15
3.1 Soil pollution and Soil Analysis : sources of soil
pollution and their control, sampling of soil,
determination of water holding capacity, determination
total nitrogen, ammonia and nitrates, fertility of soil and
effect of pollution on it, synthetic fertilizers and their long
term effect on soil quality. (6L)
3.2 Noise Pollution : sources, effects, methods of
measurements and control measures.(2L)
3.3 Thermal Pollution: definition, source, impact, control
measures, working of cooling towers and cooling ponds,
involved economy. (3L)
3.4 Radioactive pollutants: source, exposure hazards,
precautions in handling and safety, Long term effects.
(2L)
3.5 Environmental Audits: concept of audit, authorities,
evaluation methodology, benefits and certification (2L)
IV
Industrial Materials
15
4.1 Insecticides, Pesticides: definition, classification of
insecticides, pesticides. Biodegradation of insecticides
and pesticides (5L).
4.2 Soaps and Detergents: classification and composition,
qualitative analysis, quantitative analysis of detergents-
alkalinity, active ingredients and oxygen releasing
capacity. Biodegradable detergents (5L)
4.3 Petrochemical products: crude oils, fuels, and
calorific values, fractional distillation process and
fractions, properties of fuel, composition of fuel,
flashpoint, fire point, corrosion test, carbon residue
and impact on environment. (5L)
List of Books and References:
1. Environmental Chemistry, A. K. De, 2nd ED. Wiley (1989).
2. Environmental Pollution Analysis, S. M. Khopkar, John Wiely (1993).
3. Air Pollution Sampling And Analysis, Sharad Gokhale, IIT Guwahati, May 2009.
4. Environmental Pollution Analysis, S. M. Khopkar, New Age International publication
(2011).
5. Water And Water Pollution (hand book) Ed., Seonard’l Ciacere, Vol I to IV, Marcel
Dekker inc. N.York(1972)
6. Water pollution, Arvind kumar, APH publishing (2004)
7. Introduction to Potable Water Treatment Processes Simon Parsons, Bruce Jefferson,
Paperback publication.
8. Guidelines for drinking-water quality, Third edition, (incorporating first and second
addenda). WHO report.
9. Soil pollution, S.G. Misra and Dinesh Mani, APH Publishing Corporation, (2009).
10. Soil Pollution: origin, monitoring and remediation, Abrahim Mirsal, Springer (2010).
11. Noise Pollution, Donald F Anthrop, Lexington Books, (1973)
12. Noise Effects Handbook: A Desk Reference to Health and Welfare Effects of Noise
(1981) Available at NCL laboratories e- Library.
13. Chemistry, Emission Control, Radioactive Pollution and Indoor Air Quality Edited by
Nicolas Mazzeo, InTech Publications (2011).
14. Environmental Protection Against Radioactive Pollution: N. Birsen, Kairat K.
Kadyrzhanov, Springer publication , (2003).
15. Environmental law in India, Mohammad Naseem, Wolters Kluwer.
16. Environmental Protection, Law And Policy In India Kailash Thakur google books (1997).
17. Green chemistry An Introductory text, Mzike Lancaster, Royal Society of Chemistry
(2002)
18. Pesticide Analysis Ed K. G. Das, Dekker (1981)
19. Analytical, Agricultural Chemistry S. L Chpra J.S Kanwar Kalyani publication
20. Soil and plant Analysis C.S Piper , Hans Publication
SMSCHE304: PHARMACEUTICAL AND ORGANIC ANALYSIS
UNIT NO. TOPIC WEIGHTAGE
I
Pharmaceutical Analysis 15
1.1 General idea regarding the Pharmaceutical Industry,
definition and classification of drugs, introduction to
pharmaceutical formulations, classification of dosage
forms.
Role of FDA in pharmaceutical industries.(7L)
1.2 Sources of impurities in pharmaceutical products and
raw materials. (4L)
1.3 Standardization of finished products and their
characteristics, official methods of quality control. (4L)
II
Drugs
15
2.1 Analysis of compounds based on functional groups,
instrumental methods for analysis of drugs, assays
involving chromatographic separations, proximate assays,
assays of enzyme containing substances, biological and
microbiological assays and tests. (8L)
2.2 Limit tests, solubility tests, disintegration tests,
stability studies, impurity profile of drugs, bioequivalence
and bioavailability studies. Polymers in pharmaceuticals
and novel drug delivery systems.(7L)
III
Forensic Science 15
3.1 Analytical Chemistry in Forensic Science: General
idea.(2L) 3.2 Forensic Analysis: Blood, DNA profiling,
Hair analysis, Alcohol in body fluids, systematic drug
identification.(5L) 3.3 Analytical Toxicology: Isolation,
identification and determination of:
3.3.1 Narcotics: Heroin, morphine and cocaine.
3.3.2 Stimulants: Amphetamines and caffeine.
3.3.3 Depressants: Benzodiazepines, Barbiturates and
Mandrax.
3.3.4 Hallucinogens: LSD and Cannabis.
3.3.5 Metabolites of drugs in blood and urine of addicts.
3.3.6 Viscera, stomach wash, vomit and postmortem
blood for poisons like – cyanide, arsenic, mercury,
insecticides and pesticides. (8L)
IV
Cosmetic Analysis
15
4.1 Cosmetics: Introduction. Evaluation of cosmetic
materials, raw materials and additives. Formulation,
standards and methods of analysis.(2L)
4.2 Deodorants and antiperspirants: Al, Zn, Boric acid,
chlorides, sulphates, hexachlorophene, methanamine,
phenolsulphonates and urea.(3L)
4.3 Face powder: Fats, fatty acids, boric acid, barium
sulphate, Ca, Mg, Ti, Fe, oxides of Ti, Fe and Al
(total).(3L)
4.4 Hair tonic: 2,5-diaminotoluene, potassium borates,
sodium perborate, pyrogallol, resorcinol, salicylic acid,
dithioglycollic acid (in permanent wavers)(3L)
4.5 Creams and Lotions: Types of emulsions, chloroform
soluble materials, glycerol, pH emulsion, ash analysis,
nonvolatile matter (IR spectroscopy) (2L)
4.6 Lipsticks: General analysis, determination of -
nonvolatile matter, lakes and fillers, trichloroethylene-
acetone soluble contents.(2L)
References
1) Analytical Biochemistry, David J Holmes and Hazel Peck, Longman, 1983.
2) Bioanalytical Chemistry, Susan R Mikkelesen and Eduardo Cotton, John Wiley and Sons, 2004.
3) Analysis of food and beverages, George Charalanbous, Academic press, 1978.
4) Harry’s Cosmetology, 7th Ed, Longman Scientific Co.
5) Formulation and Function of Cosmetics, Joseph Stefan Jellinek, Wiley Interscience, 1971.
6) Cosmetic Technology, Edward Sagarin, Interscience Publishers, 1957.
7) Modern Cosmetics, Edgar George Thommsen, Francis Chilson, Drug and Cosmetic
Industry, 1947.
8) Encyclopedia of Industrial Chemical Analysis, Foster Dee Snell et al, Interscience Publishers, 1967.
9) Government of India Publications of Food, Drug and Cosmetic Act and Rules.
10) The Handbook of Drug Laws, M L Mehra, University Book Agency, Ahmedabad, 1997.
11) Chemical Analysis of Drugs, Takeru Higuchi, Interscience Publishers, 1995.
12) Text book of Pharmaceutical Analysis, Kenneth Antonio Connors, Wiley, 2001.
13) Food Processing and Preservation, B Sivasankar, Prentice - Hall of India Private Limited, 2007.
14) Food Additives, R M Pandey and S K Upadhyay, INTECH, Open Science/Open Minds. 15) Food Science, B Srilakshmi, New Age International (P) Ltd. Publishers, 2003.
16) Food Contaminants: Sources and Surveillance, Edited by C Creaser, R Purchase,
Elseiver, 1991.
17) The Chemical Analysis of Food and Food Products, Morris B Jacobs.
18) FSSAI (Food Safety and Standards Authority of India) Manuals of Methods of
Analysis of Foods (Oils and Fats, Milk and Milk Products, Food Additives), Ministry of Health and Family Welfare, Government of India.
19) Fundamentals of Urine and Body Fluid Analysis, Nancy A Brunzel, Elsevier health
Sciences, 2013.
20) Lab Manual on Blood analysis and Medical Diagnostics, Dr Gayatri Prakash, S
Chand and Company Ltd, New Delhi.
21) Manual of Medical Laboratory Techniques, S Ramakrishnan and K N Sulochana, Jaypee BrothersMedical Publishers (P) Ltd, 2012.
22) Indian Pharmacopeia, Volume I and II.
23) Forensic Chemistry, Suzanne Bell, Pearson Prentice Hall Publication, 2006.
24) Forensic Chemistry, David E Newton, Infobase Publishing, 2007.
25) Encyclopedia of Analytical Chemistry, Volume 3, Academic Press, 1995.
26) AOAC Volume I and II.
SEMESTER-III
PRACTICALS
SMSCHEP301 Group – A
1. Determination of the pK value of an indicator.
2. Determination of copper and bismuth in mixture by photometric titration.
3. Estimation of strong acid, weak acid and salt in the given mixture conductometrically.
4. Analysis of mixture of carbonate and bicarbonate (present in ppm range) using pHmetry.
5. Determination of copper by extractive photometry using diethyldithiocarbamate.
SMSCHEP302 Group – B
1. Estimation of drugs by non aqueous titration: Pyridoxine hydrochloride, Mebendazole.
2. Determination of percentage purity of methylene blue indicator.
3. Estimation of cholesterol and Uric acid in the given sample of blood serum
4. Estimation of fluoride in a tooth paste.
5. Determination of silica by molybdenum blue method.
SMSCHEP303 Group–C
1. Total reducing sugars before and after inversion in honey using: (a)Cole’s Ferricyanide (b) Lane - Eynon method.
2. Analysis of lactose in milk
3. Estimation of Caffeine in tea
4. Estimation of Vitamin C in lemon Juice/squash by Dichlorophenol-indophenol method
5. Iodine value of oil / fat
6. Analysis of alcoholic beverages (Beer) for alcohol content by distillation followed by specific gravity method, acidity by titration, total residue by evaporation.
SMSCHEP304 Group – D
1. To analyze Pyrolusite for: Fe by colorimetry and / or Mn by volumetry.
2. To analyze Magnelium for Mg by complexometry.
3. Analysis of Bauxite for Ti by colorimetry / Al by gravimetry / Fe (volumetry)
4. Analysis of water sample: Total hardness and salinity.
5. Analysis of water sample: Acidity and sulphate(Benzidine method).
SEMESTER IV
SMSCHE401: QUALITY IN ANALYTICAL CHEMISTRY
UNIT NO. TOPIC WEIGHTAGE
I
Separation Science 15
1.1 Membrane separation processes: operating principles
and applications of microfiltration, ultra filtration, reverse
osmosis, dialysis and electro-dialysis. (8L)
1.2 Applications of solvent extraction in Analytical
Chemistry. Recapitulation of solvent extraction, roles of
solvent extraction in analytical chemistry, solvent
extraction in sample preparation and pre-treatment steps,
solvent extraction as a means of analytical determination.
(7L)
II
Separation, Analysis and Standardization of Herbal
based products
15
2.1 Herbs as a raw material: Defination of herb, herbal
medicine, herbal medicinal products, herbal drug
preparation, sources of herbs, selection, identification and
authentication of herbal materials, drying and processing
of herbal raw materials. (6L)
2.2 Extracttion of herbal materials: Choice of solvent for
extraction, methods used for extraction and principles
involved in extraction. (3L)
2.3. Standardization of herbal formulation and herbal
extracts:
Standardization of herbal extracts as per WHO cGMP
guidelines, Physical, Chemical and Spectral and
toxixological standardization, qualitative and quantitative
estimations. (6L)
III
Green Chemistry 15
3.1 Principle and concepts of green chemistry: sustainable
development and green chemistry, atom economy,
examples of atom economic and atom uneconomic
reactions, reducing toxicity (4L)
3.2 Organic solvents: environmentally benign solutions,
solvent free systems, supercritical fluids (only
introduction) Ionic liquids as catalysts and solvents (4L)
3.3 Emerging Green Technologies: photochemical
reactions (advantages and challenges), examples.
Chemistry using microwaves, sonochemistry and
electrochemical synthesis. (4L)
3.4 Designing Greener Processes: Inherently Safer
Designs (ISD), Process intensification (PI) in-process
monitoring. (3L)
IV
Chromatographic Techniques –II
15
4.1 Electrophoresis: introduction, factors affecting
migration rate, supporting media (gel, paper, cellulose,
acetate, starch, polyacrylamide, agarose, sephedax and
thin layers) (2L)
4.2 Techniques of Electrophoresis: low and high
voltage, sds-page, continuous electrophoresis, capillary
electrophoresis, zone, gel, isoelectric focusing,
isotaechophoresis and miceller electro kinetic capillary
chromatography, instrumentation, detection and
applications. (8L)
4.3 Introduction to Nanotechnology: Analytical
techniques in nanotechnology, consequences of the
nanoscale, (nanoparticles morphology, electronic
structure, optical properties) one dimensional nano
materials (nanofilms, nanolayers), two dimensional
nanomaterials ( nanotubes, nanowires), three
dimensional nanomaterials (nanoparticles and quantum
dots). (5L)
List of Books and References:
1. Research Methodology: Methods & Techniques by C R Kothari, 2e, Wishwa
Publication, New Delhi
2. Research Methodology by D K Bhattacharyya, 1 e, Excel Books, New Delhi, 2003
3. How to Research by Loraine Blaxter, Christina Hughes and Molcolm Tight, Viva Books Pvt.Ltd., New Delhi
4. Chemical methods of separation, J A Dean, Van Nostrand Reinhold, 1969
5. Solvent extraction and ion exchange, J Marcus and A. S. Kertes Wiley INC 1969.
6. Extraction Chromatography, T. Braun, G. Ghersene, Elsevier Publications 1978.
7. Super critical fluid extraction, Larry Taylor Wiley publishers N.Y. 1996
8. Ion exchange separation in analytical chemistry, O Samuelson John Wiley 2nd ed 1963
9. Ion exchange chromatography, Ed H.F Walton Howden, Hutchenson and Rossing 1976
10. Chromatographic and electrophoresis techniques, I Smith Menemann Interscience 1960
11. Green chemistry and catalyst, R. A. Sheldon, Isabella Arends, Ulf Hanefeld Wiley
VCH verlag GmBH & co.
12. Sustainable residential development: planning and design for green neighborhoods.
Avi Friedman, McGraw Hill professional
SMSCHE402: ADVANCED INSTRUMENTAL TECHNIQUES
UNIT NO. TOPIC WEIGHTAGE
I
Spectral Methods III 15
1 NMR Spectroscopy
1.1 Theory and Instrumentation- recapitulation,
FTNMR, 2D NMR,- FID signal generation
mechanism, Techniques in 2D NMR- homo nuclear
correlation spectroscopy (COSY), total correlation
spectroscopy (TOCSY), heteronuclear correlation
(HETCOR) (9L)
1.2 Radio waves in imaging- principle instrumentation
and applications of MRI (3L)
1.3 Application of NMR to other nuclei C13, P31and
F19spectroscopy (3L)
II
Spectral Methods IV
15
2.1 Mass spectroscopy: recapitulation, correlation of
mass spectra with molecular structure- interpretation of
mass spectra, analytical information derived from mass
spectra- molecular identification, metastable peaks,
Fragmentation Reactions (9L)
2.2 Raman spectroscopy: Principle Theory
Instrumentation , techniques(SERS and Resonance
Raman) and Applications of Raman spectroscopy (6L)
III
Radiochemical and Thermal Methods
15
3.1 Activation analysis- NAA ,radiometric titrations and
radio-release methods (7L)
3.2 Thermal analysis- Principle, Interfacing ,
instrumentation and Applications of
(a) Simultaneous Thermal Analysis- TG-DTA and
TG-DSC
(b) Evolved gas analysis- TG-MS and TG-FTIR (8L)
IV Hyphenated Techniques 15
4.1 Concept of hyphenation, need for hyphenation,
possible hyphenations. ( 2 L )
4.2 Interfacing devices and applications of GC – MS, ICP
-MS, GC - IR,
Tandem Mass Spectrometry, LC – MS: HPLC-MS, CE-
MS. (13L)
List of Books and references:
1. Analytical Chemistry, G. D. Christian, 4th Ed. John Wiley, New York (1986)
2. Fundamentals of Analytical Chemistry, D. A. Skoog and D. M. West and F. J Holler Holt- Saunders 6th Edition (1998)
3. Principles of Instrumental Analysis, D. A. Skoog, F. J. Holler and J.A. Niemann 5 Ed.
4. Instrumental methods of Analysis, H. H. Willard, L. L. Merritt Jr, J. A. Dean and F. A.
5. Thermal methods of Analysis, P. J. Haines, Blackie Academic & Professional, London (1995)
6. Thermal Analysis, 3rd Edition W. W. Wendlandt, John Wiley, N.Y. (1986) nd
7. Principles and Practices of X-ray spectrometric Analysis, 2 Ed E. P. Bertain,
Plenum Press, NY, (1975)
8. Nuclear Analytical Chemistry, D. Bane, B. Forkman, B. Persson, Chartwell - Bratt
Ltd (1984)
9. Standard Methods of Chemical Analysis, Eds. F. J. Welcher, Robert E. Krieger
Publishing Company, A series of volumes
10. A Complete Introduction to Modern NMR Spectroscopy 1st Edition by Roger S.
Macomber
11. Spectrometric Identification of Organic Compounds Hardcover – by Robert
M.Silverstein Wiley
12. Tandem Techniques (Separation Science Series) 1st Edition by Raymond P. W. Scott John Wiley & Sons Ltd, 1997
13. Encyclopedia of Analytical Science, Editors-in-Chief: Paul Worsfold, Alan Townshend, and Colin Poole ISBN: 978-0-12-369397-6
14. Encyclopedia of Analytical Chemistry: Applications, Theory, and Instrumentation. Meyers Robert A Meyers
15. Introduction to Thermal Analysis Techniques and Applications Edited by Michael E. Brown
16. Principles and Applications of Thermal Analysis Edited by Paul Gabbott
SMSCHE403: SELECTED TOPICS IN ANALYTICAL CHEMISTRY
UNIT NO. TOPIC WEIGHTAGE
I
Effluent Treatment 15
1.1 Effluent treatment plant general construction and
process flow charts(3L)
1.2 Treatment and disposal of Sewage.(3L)
1.3. Effluent parameters for metallurgical industry.(2L)
1.4 Permissible limits for metal (example Cr,
As, Pb, Cd etc) traces in the effluent.(2L)
1.5 Recovery of metals from effluent, modern methods –
Electrodialysis, Electrodeposition and Ion Exchange
etc.(3L)
1.6 Recycle and reuse of process and treated (effluent)
water(2L)
II
Solid Waste Management
15
2.1 Solid waste management: objectives,
concept of recycle, reuse and recovery (3L)
2.2 Methods of solid waste disposal.(2L)
2.3 Treatment and disposal of sludge / dry cake (3L)
2.4 Managing non-decomposable solid wastes(2L)
2.5 Bio- medical waste : Introduction , Classification and
methods of disposal (5L)
III
Plastics and Polymers
15
3.1 Classification of plastic, determination of additives,
molecular weight distribution, analysis of plastic and
polymers based on styrene, vinyl chloride, ethylene,
acrylic and cellulosic plastics. (5L)
3.2 Metallic impurities in plastic and their determination,
(2L)
3.3 Impact of plastic on environment as pollutant.(2L)
3.4 Paints and pigments: Types of paints pigments,
determination of volatile and non - volatile components,
Flash point (significance and method of determination),
separation and analysis of pigments, binders and
thinners.(3L)
3.5 Role of Organo silicones in paints and their impact on
environment. (3L)
IV Metallurgy 15
4.1 Ores and minerals: Dressing of ores, pollution due to
metallurgical processes (ore dressing, calcination,
smelting ) (3L)
4.2 Chemical analysis of ores for principal constituents :
Galena, Pyrolusite, Bauxite, Hematite, Monazite (4L)
4.3 Alloys: definition, analysis of Cupronickel,
Magnelium, Steel And Stainless Steel, Bronze, Gun
metal.(4L)
4.4 Techniques of purification: Zone refining, analysis
of high purity materials like silicon, vacuum fusion
and extraction techniques. (4L)
List of Books and References:
1. Environmental Pollution Analysis, S. M. khopkar, New Age International publication
(2011).
2. Water and water pollution (hand book) Ed., Seonard’l Ciacere, Vol I to IV, Marcel
Dekker inc. N.Y.(1972)
3. Water pollution, Arvind kumar, APH publishing (2004)
4. Introduction to Potable Water Treatment Processes Simon Parsons, Bruce Jefferson,
Paperback publication.
5. Solid waste management, K Sasikumar and Sanoop Gopi Krishna PHI publication
(2009)
6. Solid waste management, Surendrakumar Northen Book Center (2009)rd
7. Handbook of chemical technology and pollution control 3 Edn Martin Hocking AP Publication (2005).
8 Fundamental Concepts of Environmental Chemistry, Second Edition G. S. Sodhi ,
Alpha Science, 2005
9. Chemical analysis of metals ; Sampling and analysis of metal bearing ores: American Society for Testing and Materials 1980 - Technology & Engineering
10. Manual of Procedures for Chemical and Instrumental Analysis of Ores, Minerals,
and Ore Dressing Products. Government of India Ministry of Steel & Mines, Indian Bureau of Mines, 1979.
11. Alloying: understanding the basics, edited by Joseph R. Davis, ASM International
(2001).
12. Zone refining and allied techniques, Norman L. Parr, G. Newnes Technology & Engineering (1960).
SMSCHE404 INTELLECTUAL PROPERTY RIGHTS AND CHEMINFORMATICS
Unit 1: [15L]
Introduction to Intellectual Property: [2L]
Historical Perspective, Different types of IP, Importance of protecting IP.
Patents:
[5L]
Historical Perspective, Basic and associated right, WIPO, PCT system,
Traditional Knowledge, Patents and Health care-balancing promoting
innovation with public health, Software patents and their importance for India.
Industrial Designs:
[2L]
Definition, How to obtain, features, International design registration.
Copyrights:
[2L]
Introduction, How to obtain, Differences from Patents.
Trade Marks:
[2L]
Introduction, How to obtain, Different types of marks – Collective marks,
certification marks, service marks, trade names etc.
Geographical Indications:
[2L]
Definition, rules for registration, prevention of illegal exploitation, importance
to India.
Unit 2:
[15L]
Trade Secrets:
[2L]
Introduction and Historical Perspectives, Scope of Protection, Risks involved
and legal aspects of Trade Secret Protection.
IP Infringement issue and enforcement:
[2L]
Role of Judiciary, Role of law enforcement agencies – Police, Customs etc.
Economic Value of Intellectual Property:
[2L]
Intangible assests and their valuation, Intellectual Property in the Indian context
– Various Laws in India Licensing and Technology transfer.
Different International agreements:
(a) World Trade Organization (WTO):
[5L]
(i) General Agreement on Tariffs and Trade (GATT), Trade
Related Intellectual Property Rights (TRIPS) agreement
(ii) General Agreement on Trade Related Services (GATS) Madrid
Protocol.
(iii) Berne Convention
(iv) Budapest Treaty
(b) Paris Convention
[6L]
WIPO and TRIPS, IPR and Plant Breeders Rights, IPR and Biodiversity.
Unit III: [15L]
Introduction to Cheminformatics:
[5L]
History and evolution of cheminformatics, Use of Cheminformatics,
Prospects of cheminformatics, Molecular modeling and structure elucidation.
Representation of molecules and chemical reactions:
[5L]
Nomenclature, Different types of notations, SMILES coding, Matrix
representations, Structure of Molfiles and Sdfiles, Libraries and toolkits,
Different electronic effects, Reaction classification.
Searching Chemical Structures:
[5L]
Full structure search, sub-structure search, basic ideas, similarity search, three
dimensional search methods, basics of computation of physical and chemical
data and structure descriptors, data visualization.
Unit IV:
[15L]
Applications:
Prediction of Properties of Compound, Linear Free Energy Relations,
Quantitative Structure – Property Relations, Descriptor Analysis, Model Building, Modeling Toxicity, Structure – Spectra
correlations, Prediction NMR, IR and Mass spectra, Computer Assisted Structure elucidations, Computer assisted Synthesis Design, Introduction to drug design, Target Identification and Validation, Lead Finding and Optimization, analysis of HTS data,
Virtual Screening, Design of Combinatorial Libraries, Ligandbased and Structure based Drug design, Application of Cheminformatics in Drug Design.
REFERENCES:
1. Andrew R. Leach & Valerie J. Gillet (2007) An Introduction to Cheminformatics. Springer: The Netherlands.
2. Gasteiger, J. & Engel, T. (2003) Cheminformatics: A textbook. Wiley–
VCH
3. Gupta, S. P. QSAR and Molecular Modeling. Springer-Anamaya
Pub.: New Delhi.
SMSCHE404: RESEARCH METHODOLGY
Unit 1: (15L)
Print:
Primary, Secondary and Tertiary sources.
Journals:
Journal abbreviations, abstracts, current titles, reviews, monographs, dictionaries, text-books, current contents,
Introduction to Chemical Abstracts and Beilstein, Subject Index, Substance Index, Author Index, Formula Index, and other Indices with examples.
Digital:
Web sources, E-journals, Journal access, TOC alerts, Hot articles, Citation Index, Impact factor, H-index, E-consortium, UGC infonet, E-books, Internet discussion groups and communities,
Blogs, preprint servers, Search engines, Scirus, Google Scholar, ChemIndustry, Wiki-databases, ChemSpider, Science Direct, SciFinder, Scopus.
Information Technology and Library Resources:
The Internet and World wide web, Internet resources for Chemistry,
finding and citing published information.
Unit II: DATA ANALYSIS (15L)
The Investigative Approach:
Making and recording Measurements, SI units and their use, Scientific
methods and design of experiments.
Analysis and Presentation of Data:
Descriptive statistics, choosing and using statistical tests, Chemometrics, Analysis of Variance (ANOVA), Correlation and regression, curve fitting, fitting of linear equations, simple linear
cases, weighted linear case, analysis of residuals, general polynomial fitting, linearizing transformations, exponential
function fit, r and its abuse, basic aspects of multiple linear regression analysis.
Unit III: METHODS OF SCIENTIFIC RESEARCH AND WRITING
SCIENTIFIC PAPERS (15L)
Reporting practical and project work, Writing literature surveys and
reviews, organizing a poster display, giving an oral presentation.
Writing Scientific Papers:
Justification for scientific contributions, bibliography,
description of methods, conclusions, the need for illustration, style, publications of scientific work, writing ethics, avoiding plagiarism.
Unit IV: CHEMICAL SAFETY & ETHICAL HANDLING OF
CHEMICALS (15L)
Safe working procedure and protective environment, protective
apparel, emergency procedure, first aid, laboratory ventilation, safe storage and use of hazardous chemicals, procedure for working with substances that pose hazards, flammable or explosive hazards, procedures for working with gases at pressures above or below atmospheric pressur, safe storage and disposal of
waste chemicals, recovery, recycling and reuse of laboratory chemicals, procedure for laboratory disposal of explosives, identification, verification and segregation of laboratory waste, disposal of chemicals in the sanitary sewer system, incineration and transportation of hazardous chemicals.
REFERENCES:
1. Dean, J. R., Jones, A. M., Holmes, D., Reed, R., Weyers, J., & Jones, A., (2011), Practical skills in Chemistry, 2nd Ed., Prentice Hall, Harlow.
2. Hibbert, D. B. & Gooding, J. J. (2006) Data Analysis for Chemistry Oxford University Press.
3. Topping, J., (1984) Errors of Observation and their Treatment 4th Ed., Chapman Hill, London.
4. Harris, D. C. (2007) Quantative Chemical Analysis 6th Ed., Freeman Chapters 3-5
5. Levie, R. De. (2001) How to use Excel in Analytical Chemistryand in general scientific data analysis Cambridge Universty Press.
6. Chemical Safety matters – IUPAC-IPCS, (1992) Cambridge
University Press.
7. OSU Safety manual 1.01
SEMESTER-IV
PRACTICALS
SMSCHEP401 Group – A
1. Determination of pK value of H3PO4 potentimetrically
2. Estimation of Na+ in dairy whitener by flame
photometry 3. Spectrophotometric determination of pH of buffer solution.
4. Simultaneous determination of Ti3+ and V5+ spectrophotometrically by H2O2 method
5. To analyze Bronze for Zn by complexometric method
SMSCHEP402 Group – B
1. Analysis of drugs by non aqueous titration: Glycine , Sodium Benzoate
2. Analysis of detergents: Active detergent matter, alkalinity and Oxygen releasing capacity
3. Determination of the purity of crystal violet
4. Estimation of Ca in Ca-pentathonate/calcium lactate tablets
5. Canned food: Limits test for tin/zinc
SMSCHEP403 Group–C
1. Analysis of Calcium, Iron and phosphorous in milk.
2. Determination of SAP value of oil.
3. Estimation of Aldehyde in lemon grass oil / Cinnamon oil
4. Estimation of Glucose by Folin-Wu method
5. Analysis of water sample : Mn2+ by colorimetric method
SMSCHEP404 Group – D
Project Evaluation
PAPER PATTERN FOR CHEMISTRY SEMESTER END EXAM MSc PART II (Semester III and IV)
Theory Examination
Theory examination of each paper is of 100 marks
Theory written paper is of 60 marks for two and half hours.
Internal in the form of presentations for 40 marks.
Q.1. Unit 1 (A): Attempt any two of the following. (2 out of 4) [8marks]
Unit 1 (B): Attempt any one of the following. (1 out of 2) [4 marks]
Q.2. Unit 2 (A): Attempt any two of the following. (2 out of 4) [8marks]
Unit 2 (B): Attempt any one of the following. (1 out of 2) [4 marks]
Q.3. Unit 3 (A): Attempt any two of the following. (2 out of 4) [8marks]
Unit 3 (B): Attempt any one of the following. (1 out of 2) [4 marks]
Q.4. Unit 4 (A): Attempt any two of the following. (2 out of 4) [8marks]
Unit 4 (B): Attempt any one of the following. (1 out of 2) [4 marks]
Q.5. Attempt any four of the following (4 out of 8) [12 marks]
(2 questions from each unit)
Practical Examination
Practical examination of each paper for 50 marks will be held for three and half hours.
(Semester III)
Practical examination of Paper I, II, III for 50 marks will be held for three and half hours
and Paper IV would be project evaluation of 50 marks. (Semester IV)
Practical 40M
Journal 5M
Viva-voce 5M
Total 50M