Pneumonia (Ventilator-associated [VAP] and non-ventilator ...
Small Animal Ventilator for Hyperpolarized Helium MRI
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Transcript of Small Animal Ventilator for Hyperpolarized Helium MRI
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Small Animal Ventilator for Hyperpolarized Helium MRI
Ashley Anderson III, Micah Brown, Matt Smith, Chris Wegener
Client: Dr. Sean FainAdvisor: Dr. Willis Tompkins
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MRI compatible ventilator system Deliver 20% O2 and 80% He-3 in
same breath Allows constant scanning of the He-3 in
MRI rather than every 4 breaths
Client Requirements
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Background - Helium MRI
Newer technique Same MRI scanner
Convention is H Here, tuned to Helium
(48.6 MHz) Breath of Helium Displays respiratory
channels
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Project Concept
• Each syringe feeds off of independent gas reservoirs
• Gas mixing occurs right before entering small animal
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First Generation Prototype
Currently in use in animal studies Only using one syringe Not compatible with small syringes
for mouse studies
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Modifications to G1
Reinforced syringe clips
Larger motor Eliminated
O2 chaser breath
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Calibration
Results using manometer testing. Graph shows small deviation from entered volumes.
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Second Generation Concept
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Second Generation Prototype
Created in Solidworks
Smaller components
Interchangeable syringes
Adjustable axle support
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Second Generation Prototype
Large motor Motor shielding Precision
machining Can be
disassembled
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From Solidworks to Reality
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Does it move?
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Did we meet client requirements?
Gear ratios allow the appropriate 80/20 gas output ratio
MRI Safe materials Motor shielded for RF Rat/Mouse
compatible
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Future Work
Calibration testing Volume delivery Timing
Software development Simultaneous 3He/O2 delivery Inspired time based on %Insp and RR Valve switching
Mixing testing (imaging)
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Questions?