September 2013 Mukesh K. Jain MD FAHA Ellery Sedgwick Jr. Chair & Distinguished Scientist Professor...
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Transcript of September 2013 Mukesh K. Jain MD FAHA Ellery Sedgwick Jr. Chair & Distinguished Scientist Professor...
September 2013
Mukesh K. Jain MD FAHAMukesh K. Jain MD FAHAEllery Sedgwick Jr. Chair & Distinguished ScientistEllery Sedgwick Jr. Chair & Distinguished Scientist
Professor of MedicineProfessor of MedicineDirector, Case Cardiovascular Institute (CVRI)Director, Case Cardiovascular Institute (CVRI)
CWRU School of MedicineCWRU School of Medicine
Scientific Director Scientific Director Harrington Discovery InstituteHarrington Discovery Institute
Chief Research OfficerChief Research OfficerHarrington Heart & Vascular InstituteHarrington Heart & Vascular Institute
University Hospitals Case Medical CenterUniversity Hospitals Case Medical Center
Physician-Scientists
President-elect ASCI
September 2013
• Established in 1908 to represent scientific elite in medicine
• Goals: Support physician-scientists Encourage scientific engagement by medical
trainees (MD-PhD) Oversees the Journal of Clinical Investigation (JCI)
• Members – 3,147 (117 outside USA) 19 Nobel Laureates31 Lasker Awardees537 Elected in the National Academy of
Sciences/Institute of Medicine
American Society for Clinical Investigation American Society for Clinical Investigation (ASCI)(ASCI)
September 2013
Physician-ScientistPhysician-Scientist
Transforms fundamental knowledge
into therapies
Establish new standards for thepractice of medicine
Able to move from bench tobedside and back
Implements standards of care into the community
Physician-Practitioner
September 2013
• 1971 Sutherland (hormone signaling)• 1982 Bergstrom, Samuelsson & Vane (prostaglandins)• 1985 Brown & Goldstein (cholesterol)• 1989 Varmus & Bishop (oncogenes)• 1994 Gilman & Rodbell (G-proteins)• 1997 Pruisner (prions)• 1998 Murad (nitric oxide)• 2003 Agre & McKinnon (channels)• 2005 Marshall & Warren (PUD/H. Pylori)• 2010 Edwards (IVF)• 2011 Beutler (Toll-receptors)• 2012 Yamanaka & Gurdon (stem cell)• 2012 Lefkowitz & Kobilka (GPCR)
Physician-Scientist ImpactPhysician-Scientist Impact
September 2013
Impact of MD-PhD Program
• Differentiating factor for academic medical centers and medical schools
• Attract premier students and faculty
• Attract patients who seek cutting edge, advanced or experimental therapies
• Enhanced research productivity, publication output and access to research funding
• Increase National/International Academic Recognition
September 2013
• First M.D./Ph.D. program (1956) in the U.S.
• Integrated program of biomedical research and clinical training
• 92 current students and 276 alumni
• 2 Nobel laureates (Gilman, G proteins; Murad, nitric oxide)
• Former U.S. Surgeon General and Director of the Center for Disease Control (D. Satcher)
• Current leadership:
Cliff Harding MD PhD- Director
Geroge Dubyak PhD – co-Director
Case Western Reserve University
September 2013
MD/PhD Program Not NIH Supported, U.S. and non U.S. Citizens
Medical Scientist Training Program NIH Funded and Audited, U.S. Citizens/permanent residentsMedical school (4 years): supported by NIH grantResearch (4 years) - student tuition plus stipend ($15,000-$20,000/year) paid by advisor through independent NIH funding
~12 students accepted per year at CWRU MSTP
Case Western Reserve University
• 85% of our alumni remain in biomedical research/academic medicine
– 71% are faculty in medical schools (not including clinical adjunct faculty)
– 2% at NIH or other research foundation
– 12% in biotech, pharma, industry
• Research recognition at national and international meetings
• Graduate with average of 2.8 first-authored & 5.3 total papers
• ~80% match into their 1st-choice residency (past 15 years)
Student Accomplishments
September 2013
Biochemistry Biomedical Engineering
Cancer BiologyCell Biology
EpidemiologyGeneticsPathology
Molecular Biology
CWRU Programs for MSTP students
Molecular VirologyNeurosciences
NutritionPathology
PharmacologyPhysiology and Biophysics
Systems Biology and Bioinformatics
September 2013
• University Program MD curriculum– Starts in July– Graduate school credit (IBIS courses)– Flexible afternoons – Problem based learning (Case Inquiry- “IQ groups”) + other small group
instruction, lectures• Integration of graduate school components– Graduate school courses (flexible afternoons)– Laboratory rotations (3 required) in summers or during fall or spring
semesters• Accelerated entry into Ph.D. phase– M2 curriculum ends late Feb/early March of year 2– Spring yr 2: grad course, M2 curric transitions to PhD lab, USMLE part I
MSTP Curriculum: First 2 years
September 2013
MSTP Curriculum: Ph.D. phase
• Graduate Program requirements:
– Additional coursework (minimized by credit for MD curriculum plus grad courses in years 1&2)
– Qualifying exam and/or thesis proposal
– Original research
– Publications (average 5-6 total & 2-3 first author; 1 first-authored paper required)
– Thesis defense
– Duration: Goal: 3-4 years (average 4 years)
– Total program time 8.0 yrs
• Integration of clinical training: MSTP Clinical Tutorial (longitudinal, 1 year required, 2 encouraged)
September 2013
• Enhance clinical skills during Ph.D. phase to prepare for Med year 3
– MSTP Clinical Tutorial– MSTP Clinical Refresher (optional)– Clinical electives prior to clinical core block
• Start Med year 3 at beginning of July, August (elective), September, October, November
– Other start dates possible but are not advantageous in schedule
• Can start non-core clinical electives at other flexible times.
MSTP Curriculum: years 3-4
September 2013
MD-PhD : Medical doctor + PhD
DMD-PhD: Dental doctor + PhD
DNP-PhD: Nursing + PhD
Beyond MSTP:Clinical and Translational Scientist Training Program (CTSTP)
September 2013
(1)CWRU provides technical expertise and oversight (full MD/PhD curriculum abroad)
(2) Hybrid Model (“Sandwich Program”) – MD or PhD component at CWRU
(3) Establish full MD-PhD program at CWRU
MSTP/MD-PhD International Partnership Models
September 2013
CWRU ranked 13th among
private institutions in federal
expenditures for science and
engineering research and
development (2012)
A World-Class Institution
September 2013
A World-Class Institution
Graduate/Professional Rankings:
• #14 in Biomedical Engineering• #5 in Health Law• #14 in Pediatrics• #16 in AIDS • #12 in Family Medicine• #15 in Nursing• #9 in Social Work• #3 in Organizational Behavior (Financial
Times)• #13 in International Law
U.S. News & World Report (2012)
September 2013
Partnerships with Ohio based world-class
corporate and cultural institutionsCleveland Clinic FoundationCleveland Museum of ArtCleveland Orchestra Dollar BankEaton CorporationForest City CorporationMedical MutualNASA Glenn Research CenterRock and Roll Hall of FameSherwin WilliamsSwagelok CompanyTime Warner Cable Business ClassTimken CompanyUniversity Hospitals of Cleveland
September 2013
Partnerships with International Corporations
China National Off-Shore Oil Company (China)
Arcelor Mittal (Luxembourg)AstraZeneca (United Kingdom)BP (United Kingdom)Boehringer Ingelheim GmbH (Germany)Kyocera Corporation (Japan)Luxottica Group, S.P.A. (Italy)Petrobras (Brazil)Philips Electronics (Netherlands)Rolls Royce Fuel Cell Systems (U.K.)Siemens AG (Germany)
September 2013
A World-Class Institution
Case Western Reserve University School of Medicine
DiversityMD•46% women•12% underrepresented groups
Graduate (MS and PhD)•55% women•20% international•11% underrepresented groups
Recruitment Efforts•Summer Medical Dental Education Program (SMDEP)•Summer Undergrad Research Internships with SOM Faculty•Postbac Research Education (PREP) Program
September 2013
• A medical practitioner that engages in research to change standard of care.
• Several models
Dr. Jain – 10% clinical; 80% basic research
Dr. Costa – 50% clinical; 40% translational research
Dr. Ponsky – 50% clinical; 20% clinical research
Definitions of Physician-ScientistsDefinitions of Physician-Scientists