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KALYNN M. SCHULZ Assistant Professor Anschutz Medical Campus │Building 500 │Mail Stop F546 │Aurora, Colorado 80045 │720-326-4746 Lab Website: https://kalynn-schulz.squarespace.com/info/

ACADEMIC APPOINTMENTS 2014-present Assistant Professor

Department of Psychiatry University of Colorado Anschutz Medical Campus

2012-2014 Instructor Department of Psychiatry

University of Colorado Anschutz Medical Campus

2012-present Research Biologist/Principal Investigator

Veterans Administration Medical Center of Denver 1055 Clermont Street Denver, CO 80220

2007-2012 Postdoctoral Fellow University of Colorado Anschutz Medical Campus Developmental Psychobiology Program Advisors: Dr. Bill Proctor, Dr. Karen Stevens, Dr. Cathy Adams, and Dr. Sherry Leonard

EDUCATION

2007 Ph.D. in Behavioral Neuroscience Michigan State University: East Lansing, MI August 2007 Advisor: Dr. Cheryl L. Sisk Dissertation Title: Sensitive periods in the development of male social behavior: the role of gonadal hormones during adolescence.

1998 B.A. in Psychology/Behavioral Neuroscience University of Minnesota, Morris: Morris, MN Advisor: Dr. Leslie R. Meek

PUBLICATIONS

1. Ramos I, Burke M.B., Zajkowski M.E., Adams C.E., and Schulz, K.M. (in preparation). Prenatal stress alters levels of alpha7 nAChRs in arcuate nucleus and ventromedial hypothalamus in a sex-specific manner: implications for sexual differentiation.

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2. Schulz, K.M., Pearson, J.N., Gasparrini, M.E., Brooks, K.R., Zajkowski, M.E., Kriesler, A.D., Leonard, S., and Stevens, K.E (2014). Dietary choline supplementation to dams during pregnancy and lactation mitigates the effects of in utero stress exposure on adult anxiety-related behaviors. Behavioural Brain Research.

3. Pearson, J.N., Schulz, K.M., and Patel, M. (2014). Specific alterations in the performance of learning and memory tasks in models of chemoconvulsant-induced status epilepticus. Epilepsy Research.

4. Schulz K.M., Andrud K.M., Burke M.B., Pearson J.N., Kreisler A.D., Stevens K.E., Leonard S., and Adams C.E.

(2013). The effects of prenatal stress on alpha4 beta2 and alpha7 hippocampal nicotinic acetylcholine receptor levels in adult offspring. Dev Neurobiol. 73(11):806-14.

5. Wu, P.H. and Schulz, K.M. (2012).Contributions of animal models to clinical treatment of addiction. ILAR J.

53(1):4-13

6. Delorme, K.C., Schulz, K.M., Salas-Ramirez, K.Y., and Sisk, C.L. (2012). Pubertal testosterone organizes regional volume and neuronal number in the medial amygdala of adult male Syrian hamsters. Brain Res.1460:33-40

7. Adams, C.E., Yonchek, J.C., Schulz, K.M., Graw, S.L., Stitzel, J., Teschke, P.U., Collins, A.C., and Stevens, K.E.

(2012). Decreased Chrna7 expression in mice is associated with decreases in hippocampal markers of inhibitory function: implications for neuropsychiatric diseases. Neuroscience. 5; 207:274-82.

8. Schulz, K.M., Pearson, J.N., Neeley, E.W., Berger, R., Leonard, S., Adams, C.E., and Stevens, K.E. (2011). Maternal

stress during pregnancy causes sex-specific alterations in offspring memory performance, social interactions, indices of anxiety, and body mass. Physiology and Behavior. 104(2):340-7.

9. Schulz, K.M., Molenda-Figuera, H.R., and Sisk, C.L (2009). Back to the Future: The Organizational-Activational

Hypothesis Adapted to Puberty and Adolescence. Horm and Behav. 55(5):597-604. 1.

10. Schulz, K.M., Zehr, J.L., Salas-Ramirez, K.Y., and Sisk, C.L (2009). The timing of exposure to testosterone before, during, or after adolescence determines behavioral responses to testosterone in adulthood. Endocrinology 150(8):3690-8.

11. Ahmed E.I., Zehr J.L., Schulz, K.M., Lorenz, B.H., Doncarlos, L.L., and Sisk, C.L. (2008). Pubertal hormones

modulate the addition of new neurons to sexually dimorphic brain regions. Nature Neuroscience. 11(9), 995-997.

12. Zehr, J.L., Nichols, L.R., Schulz, K.M., and Sisk, C.L. (2008). Adolescent development of neuron structure in

dentate gyrus granule cells of male Syrian hamsters. Dev Neurobiol. 68(14):1517-26. PMCID: PMC2676582

13. Sato, S.M., Schulz, K.M., Sisk, C.L., and Wood, R.I. (2008). Adolescents and androgens, receptors and rewards, Horm and Behav. 53(5), 647–658.

14. Meek, L.R., Schulz, K.M., & Keith, C.A (2006). Effects of prenatal stress on sexual partner preference in mice.

Physiol and Beh. 89(2):133-8

15. Schulz, K.M., Menard, T.A., Smith, D.A., Albers, H.E. and Sisk, C.L. (2006). Testicular hormone exposure during adolescence organizes flank marking behavior and vasopressin receptor binding in the lateral septum. Horm and Behav. 50(3): 477-483.

16. Schulz, K.M. and Sisk, C.L. (2006). Pubertal hormones, the adolescent brain, and the maturation of social

behaviors: Lessons from the Syrian Hamster. Mol Cell Endocrinol. 254-255: 120-6.

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17. Zehr, J.L., Todd, B.J., Schulz, K.M., McCarthy, M.M., & Sisk, C.L. (2006). Dendritic pruning of the medial amygdala during pubertal development of the male Syrian hamster. J.Neurobiol. 66, 578-590.

18. Schulz, K.M., Richardson, H.N., Zehr, J.L., Osetek, A.J., Menard, T.A. and Sisk, C.L. (2004). Gonadal hormones

masculinize and defeminize reproductive behaviors during puberty in the male Syrian hamster. Horm and Behav. 45(4): 242-249.

19. Schulz, K.M., Richardson, H.N., Romeo, R.D., Morris, J.A., Lookingland, K.J., and Sisk, C.L. (2003). Medial preoptic

area dopaminergic responses to female pheromones develop during puberty in the male Syrian hamster. Brain Res. 988(1-2): 139-145.

20. Romeo R.D., Schulz, K.M., Nelson A.L., Menard T.A. and Sisk C.L. (2003). Testosterone, puberty and the pattern

of male aggression in Syrian hamsters. Dev Psychobiol. 43(2): 102-8.

21. Sisk, C.L., Schulz, K.M., and Zehr, J.L. (2003). Puberty: A finishing school for male sexual behavior. Ann. N.Y. Acad. Sci. 1007: 189-198.

22. Meek, L.R., Schrump, S.E., Smith, D.A., Schulz, K.M., Dittel, P.L., Merkle, C.J. (2001). Female meadow voles

housed in long and short daylengths respond to exogenous estrogen with similar mating latencies. Physiol Behav 73:121-124.

HONORS 2013 Distinguished Alumni Award, University of Minnesota, Morris 2012 “2009-2011 Outstanding Paper” Hormones and Behavior

Back to the Future: The Organizational-Activational Hypothesis Adapted to Puberty and Adolescence

2012 Martin Reite Best Scientific Presentation Award, University of Colorado Anschutz 2008 Martin Reite Best Scientific Presentation Award, University of Colorado Anschutz 2006 NIH Research Festival Award Recipient, Washington, D.C. 2005 Young Investigator Award, Society for Behavioral Neuroendocrinology 2003 Travel Award, NYAS Conference on Adolescent Brain Development 2002 Travel Award, Society for Behavioral Neuroendocrinology 1998 Scholar of the College Award, University of Minnesota, Morris

GRANT SUPPORT Active Research Support 2012-2017 Career Development Award

“Gender-dependent effects of stress during adolescence on adult brain and behavior” Role: Principal Investigator $150,000 Direct Costs Annually Veterans Administration

Completed research support 2008-2012 Developmental Psychobiology Endowment Fund Award

University of Colorado Anschutz 2004-2007 Kirschstein-NRSA Predoctoral Individual Award, 2004-2007

NIMH 2003 Graduate Research Award

APF/COGDOP

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1997 Undergraduate Research Opportunity (UROP) Award University of Minnesota, Morris

1996 Undergraduate Research Opportunity (UROP) Award University of Minnesota, Morris

PROFESSIONAL MEMBERSHIPS 2001-present Society for Behavioral Neuroendocrinology (SBN) 2001-present Society for Neuroscience (SFN) 2010-present International Behavioral Neuroscience Society (IBNS) 2010-present Faculty for Undergraduate Neuroscience (FUN)

PROFESSIONAL SERVICE Ad Hoc Reviewer Hormones and Behavior, Physiology and Behavior, Psychoneuroendocrinology, Neurochemistry International, Hippocampus, Behavioural Brain Research, Toxicology Research and Neuroscience Department/university service 2008-2011 UC Denver Institutional Animal Care and Use Committee (IACUC) committee member 2008-2012 Developmental Psychobiology Research Group Retreat Planning Committee 2012-2013 Poster Judge Postdoctoral Research Day

TEACHING EXPERIENCE University of Colorado Anschutz Medical Campus 2012-present Course Facilitator, Basic Psychiatry Sequence 2014 Lecturer, NRSC 7614, Biological Basis of Psychiatric and Neurological Disorders,

“Neurodevelopmental Factors Contributing to Schizophrenia” 2014 Director, Schizophrenia Education & Training (SET) Undergraduate Research Program, Department of

Psychiatry 2014 Director, STARS Undergraduate Research Program, Dept. of Psychiatry Michigan State University Department of Psychology, East Lansing, MI 2001-2006 Teaching Assistant, Michigan State University Brain and Behavior Psychobiology of the Lifespan Statistical Methods Early Child Development

MENTORING EXPERIENCE Program Participation

Undergraduate Research Opportunities (UROP) mentor, University of Colorado Denver Schizophrenia Education & Training (SET) Undergraduate Program Mentor, Anschutz Medical STARS Undergraduate Research Program Mentor, Anschutz Medical Campus

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BRAiN Undergraduate Research Program Mentor, University of Colorado Anschutz Medical McNair Scholars Undergraduate Program Mentor, Michigan State University

Honors Theses Supervised

1. Kat Davis (2013-2014) The effects of prenatal stress on alpha7 nicotinic receptor levels in the basolateral amygdala in adulthood.

2. Maria Burke (2010-2011) The effects of prenatal stress on adult levels of hippocampal nicotinic acetylcholine receptor levels in adulthood.

3. Alison Kreisler (2009-2010) The effects of prenatal stress on hippocampal nicotinic acetylcholine receptor levels in adulthood.

4. Andrew Poole (2004-2007) The effects of pre- vs. post-pubertal ovariectomy on adult female lordosis behavior.

5. Elizabeth Hingst (2004-2007) Does dominance status predict the number of c-FOS positive hypothalamic vasopressin neurons in adult male hamsters?

6. Andrew Osetek (2003-2005) Pre- vs. post-pubertal gonadectomy on ventromedial hypothalamus regional volumes in adult males.

Independent Student Research Projects Supervised

7. Christina Gado (2014): The effects of prenatal and adolescent stress on adult fear conditioning and alpha7 nicotinic acetylcholine receptor levels in the basolateral amygdala.

8. Karen Vazquez (2014): The effects of prenatal stress on alpha7 nicotinic acetylcholine receptor levels in the basolateral and central amygdala.

9. Darcy Wisecup (2014): The effects of prenatal and adolescent stress on spatial memory in the Y maze task.

10. Megan Zajkowski (2013-present): The combined impact of prenatal and adolescent stress on adult social behaviors.

11. Tedla Tyndall (2013): Prenatal and adolescent stress effects on adult anxiety-related behavior in the elevated zero maze.

12. Isabella Ramos (2012-2014): The effects of prenatal stress on nicotinic receptor levels in the hypothalamus.

13. Chakeer Drake-Frazier (2012-2014): The effects of perinatal choline on the adult social behaviors of prenatally stressed rodents.

14. Mary Gasparrini (2009-2011) Can perinatal choline mitigate the deleterious effects of prenatal stress on adult anxiety-related behaviors?

15. Austin Young (2008) Does perinatal choline ameliorate the negative effects of prenatal stress on adult memory function?

16. Kayla Frazier (2008-2013) The effects of prenatal stress on markers of obesity in adulthood. 17. Jennifer Pearson (2008-2011) The effects of prenatal stress on cognitive function in adult male and

female rats. 18. Sara Hunter (2004-2006) The effects of adolescent testosterone on male hamster reproductive behavior. 19. Pamela Montalto (2004-2006) Does the timing of testosterone exposure during adolescence impact

mating behavior in adult male hamsters? 20. Tami Menard (2002-2004) Pre-vs. post-pubertal effects of testosterone on male agonistic behaviors.

PRESENTATIONS AND CONFERENCE ACTIVITIES Invited Talks and Colloquia

2014 “Dietary choline as a prenatal stress intervention?” American Psychosomatic Society, San Francisco CA

2013 “The effects of prenatal and adolescent stress on brain development and adult behavior.” Department of Psychology, University of Denver, Denver CO.

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2013 “Sensitive Periods of Development, Stress, and Psychopathology” Developmental Psychobiology Research Group, Anschutz Medical Campus, Aurora CO.

Poster Presentations

1. Schulz, K.M., Drake-Frazier, C., Burke, M.B., Frazier, K., Ramos, I., and Davis, K (2013). The combined impact of prenatal and adolescent stress exposure on adult anxiety-related behaviors. Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience 2013. Online.

2. Burke, M.B., Frazier, K., Drake-Frazier, C., Ramos, I., Davis, K., and Schulz, K.M (2013). The combined

effects of prenatal and adolescent stress on recognition of novel spatial locations in adulthood. Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience 2013. Online.

3. Burke, M.B., Ramos, I., Frazier K.R., Drake-Frazier, C., Davis, K., and Schulz, K.M (2013). The effects of

habituation to objects on the novelty preferences of rats. Atlanta, GA: Society for Behavioral Neuroendocrinology (SBN).

4. Frazier, K.R., Burke, M.B., Ramos, I., Drake-Frazier, C., Davis, K., and Schulz, K.M (2013). The effects of

adolescent stress exposure on bodyweight and food intake in adult female rats. Atlanta, GA: Society for Behavioral Neuroendocrinology (SBN).

5. Drake-Frazier, C., Burke, M.B., Ramos, I., Frazier K.R., Davis, K., and Schulz, K.M (2013). The combined

effects of prenatal and adolescent stress exposure on anxiety-related behaviors in adulthood. Atlanta, GA: Society for Behavioral Neuroendocrinology (SBN).

6. Schulz, K.M., Pearson, J.N., Gasparrini, M.E., Andrud, K.M., Frazier, K., Kreisler, A., Leonard, S., Adams,

C.A., and Stevens, K.E. (2012). Dietary choline supplementation to dams during pregnancy and lactation protects female offspring from the effects of in utero stress exposure on anxiety-related behaviors. Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience 2012. Online.

7. Burke, M.B., Schulz, K.M., Andrud, K.M., Pearson, J.N., Kreisler, A., Adams, C.A., Leonard, S., and

Stevens, K.E. (2012). Prenatal stress in rats alters hippocampal nicotinic acetylcholine receptor levels in adult offspring. Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience 2012. Online.

8. Schulz, K.M., Burke, M.B., Andrud, K.M., Pearson, J.N., Kreisler, A., Adams, C.A., Leonard, S., and Stevens, K.E. (2012). The effects of maternal stress in rats on offspring hippocampal alpha4 beta2 nicotinic receptor levels in adulthood. Society for Behavioral Neuroendocrinology (SBN), Madison, WI.

9. Schulz, K.M., Pearson, J.N., Neeley, E.W., Berger, R., Adams, C.A., Leonard, S., and Stevens, K.E. (2010).

10. Prenatal stress influences memory for object location and environmental context but not object

identity. Program No. 697.14. Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience 2010. Online.

11. Schulz, K.M., Pearson, J.N., Neeley, E.W., Berger, R., Adams, C.A., Leonard, S., and Stevens, K.E. (2010).

Prenatal stress influences memory for object location but not object identity. Neurobiology of Stress Workshop. Boulder Colorado.

12. Schulz, K.M., Pearson, J.N., Neeley, E.W., Berger, R., Leonard, S., and Stevens, K.E. (2009). Sex-

dependent effects of prenatal stress on social and anxiety-related behaviors in adult rats. Society for Behavioral Neuroendocrinology (SBN), East Lansing, MI.

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13. Schulz, K.M., Pearson, J.N., Neeley, E.W., Berger, R., Leonard, S., and Stevens, K.E. (2009). Prenatal stress differentially impacts the social and anxiety-related behaviors of adult males and females. Schizophrenia Bulletin, 35 Suppl. 1 (269-269).

14. Schulz, K.M., Pearson, J.N., Neeley, E.W., Berger, R., Adams, C.A., Leonard, S., and Stevens, K.E. (2008)

Prenatal stress impairs memory for novel object spatial locations in adulthood. Program No. 842.9 2008 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2008. Online

15. Schulz, K.M. Zehr, J.L., Salas-Ramirez, KM, and Sisk, C.L. (2007). Is adolescence a second sensitive period

for the organizing effects of testosterone on adult male reproductive behavior? Program No. 626.9. 2007 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2007. Online.

16. Zehr, J.L., Ahmed, E.I., Schulz, K.M. and Sisk, C.L. (2007). Hormonal influences on the adolescent

addition of new cells to the rat medial amygdala are sex and region specific. Program No. 294.16. 2007 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2007. Online.

17. Ahmed, E.I., Lorenz, B.H., Schulz, K.M., Zehr, J.L., DonCarlos, L.L., and Sisk, C.L. Sex differences in

neurogenesis during puberty in the rat hypothalamus. Program No 152.3. 2006 Neuroscience Meeting Planner. Atlanta, GA: Society for Neuroscience, 2006. Online.

18. Zehr J.L., Ahmed, E.I., Schulz, K.M., and Sisk, C.L. Sex differences in addition of new cells in the rat

medial amygdala during puberty. Program No. 152.2. 2006 Neuroscience Meeting Planner. Atlanta, GA: Society for Neuroscience, 2006. Online.

19. Schulz, K.M., Poole, A.D., Zehr, J.L., Hingst, E.S., and Sisk, C.L (2006). Estradiol defeminizes lordosis

behavior during adolescence in female Syrian hamsters. Society for Behavioral Neuroendocrinology, Pittsburg, PA.

20. Zehr, J.L., Nichols, L.R., Schulz, K.M., and Sisk, C.L. (2006). Adolescent pruning of neurons in the dentate

gyrus of male Syrian hamsters. Society for Behavioral Neuroendocrinology, Pittsburg, PA.

21. Schulz, K.M., Zehr, J.L., Osetek, A.J., Sisk, C.L. (2005). Exposure to gonadal hormones during puberty influences the cross-sectional area of the adult male ventromedial hypothalamus in response to estradiol and progesterone. Program No. 762.5. 2005 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2005. Online.

22. Ahmed, E.I., Schulz, K.M., Zehr, J.L., Sisk, C.L.(2005). Sex difference in the pubertal addition of new cells

in the rat anteroventral periventricular nucleus (AVPV). Program No. 761.11. 2005 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2005. Online.

23. Zehr, J. L., Todd, B. J., Schulz, K.M., McCarthy, M. M., & Sisk, C. L. (2005). Pubertal changes in the

neuronal structure and synaptic protein expression in the medial amygdala of male Syrian hamsters. Hormones & Behavior, 48: 135.

24. Schulz, K.M., Zehr, J.L., Hingst, E.S., Montalto, P.R., Poole, A.D., Sisk, C.L. (2004). Ovarian hormones

partially defeminize female lordosis behavior during puberty. Program No. 538.20. 2004 Abstract Viewer/Itinerary Planner. San Diego, CA: Society for Neuroscience, 2004. Online.

25. Zehr, J.L., Schulz, K.M., Sisk, C.L. (2004). Do gonadal steroids affect volume of the medial amygdala

during adolescent development? Program No. 757.3. 2004 Abstract Viewer/Itinerary Planner. San Diego, CA: Society for Neuroscience, 2004. Online.

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26. Schulz, K.M., Zehr, J.L., Osetek, A.J., and Sisk, C.L. (2003). Exposure to gonadal hormones during puberty defeminizes lordosis behavior in male Syrian hamsters. NYAS Conference on Adolescent Brain Development: Vulnerabilities and Opportunities.

27. Schulz, K.M., Zehr, J.L., Osetek, A.J., and Sisk, C.L. (2003) Gonadal hormones during puberty may

contribute to the defeminization of lordosis behavior in male Syrian hamsters. Horm Behav 44:76.

28. Menard, T.A., Schulz, K.M., Zehr, J.L., and Sisk, C.L. (2003) Testosterone increases flank marking in adult but not prepubertal male hamsters. Horm Behav 44: 63

29. Schulz, K.M., Richardson, H.N., Romeo, R.D., Morris, J., Lookingland, K.J., and Sisk, C.L. (2001). Female

pheromones elicit a dopaminergic response in the medial preoptic area (MPOA) in adult but not prepubertal male Syrian hamsters. Society for Neuroscience Abstracts,Vol. 27, Program No. 424.8, 2001.