RIN 4 (RPM1 Interacting Protein)

By,Bharati Singh

RIN 4 (RPM1 Interacting Protein)

A small, A. thaliana protein, that along with RPM1 and RPS2 is localized to the plasma membrane

Effectors from P. syringae

HopF2

RIN4 AvrB

AvrRPM1

AvrRpt2

• Negative regulator of PTI (PAMP Triggered Immunity) and ETI (Effector Triggered Immunity)

To solve major problem in plant immunity ,Guard Hypothesis was put forward

H. Spoel et al. (2012) Nature Review

RIN4 regulates stomata during infection

Model of PAMP induced stomatal closure

Jun Liu et al.(2009), Max Planck Institute, Germany

Decoy model

• Current opinion tends to believe that RIN4 serves as a decoy to mimic the unknown real target of RIN4 interacted effectors to compete for binding with these effectors

Evolution of RIN4-RPM1/RPS2 mediated ETI

Wild Type Mutant Type

ETS

Hou et al. (2011), plant signaling & Behaviour

Decoy

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