Revolutionizing Allergy Treatment Current Trend in the Treatment & Management of Allergic Rhinitis.
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Transcript of Revolutionizing Allergy Treatment Current Trend in the Treatment & Management of Allergic Rhinitis.
Revolutionizing Allergy Treatment
Current Trend in the Treatment
&Management of Allergic
Rhinitis
2
Allergy Suffers in Canada
3 M
1.9 M0.4 M
3 M
2.9 M
Grass Ragweed Dust, Mite Cat Birch
3
Relative Prevalence of Allergen (%)
60
18
12
5
3
2
0 10 20 30 40 50 60 70
Pollen
Mites
Epithelia
Insects
Foodstuffs
Drugs
Sources: identified in allergic patients
4
Seasonal or Perennial Allergies
43%
56%
1%
Seasonal Perennial Not Sure
Allergies in America Exe. Summary; Aug. 23, 2007.
5
Allergic rhinitis is one of the most common diseases
About ten million Canadians suffer from seasonal allergies or seasonal allergic rhinitis
Fall is the worst time of the year. Shorter days and longer nights that start in mid-August stimulate pollination in the ragweed plant
Seasonal and perennial rhinitis affects 4 to 40% of the population and is increasing
Prevalence in 16-year-old children rose from 12 % to 23 % from 1958 to 1970
Allergic Rhinitis Affects many Canadian Allergic Rhinitis Affects many Canadian Adults and ChildrenAdults and Children
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Quality Of Life
More than 62 percent of sufferers say allergies
significantly impact their day-to-day lives, including
affecting sleep patterns and ability to perform at work.
Residents of Manitoba / Saskatchewan are affected the
most (69%), followed by Ontarians (66%), then
Quebecers (60%).
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Males Vs Female
67
55
0
10
20
30
40
50
60
70
Female Male
Females are impacted more severely
%
Allergy Season in CanadaAllergy Season in Canada
Province JanJan FebFeb MarMar AprilApril MayMay JuneJune JulyJuly AugAug Sept.Sept. OctOct NovNov DeDecc
BC
Prairies
Ontario
Quebec
Atlantic
All Prov. Molds Animal dander/ saliva House Dust Mite Cockroach
Grass Tree Ragweed Weed
9
Visit to the Health Care Practitioners
47
32
47
55 57
0
10
20
30
40
50
60
All Patients No Symptoms MildSymptoms
ModerateSymptoms
SevereSymptoms
N = 2500
Allergies in America Exe. Summary; Aug. 23, 2007.
Alle
rgy S
uff
ere
rs%
10
AR a Major Contributor to Health related Absenteeism
0 100 200 300 400 500 600
Allergic Rhinitis/ Hay Fever
Stress
Migraine
Depression
Arthritis/ Rheumatism
Anxiety Disorder
Respiratory Infection
Hypertension or High BP
Diabetes
Asthma
Coronary Heart Disease
Mean Annual Productivity Loss ($) Per Employee
*P<0.05 for Allergic rhinitis /hay fever vs. other conditions.Lamb CE, et al. Curr Med Res Opin. 2006; 22:1203-1210.
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AR Imposes a Significant Burden on Quality of Life
AR is Associated With:
Fatigue and daytime sleepiness Daily activity impairmentReduced work productivity Impaired cognitive functioningReduced learning abilitiesImpaired sleepImpaired quality of life
Marshall PS, et al. Psychosom Med. 2002;64:684-69; Stuck BA, et al. J Allergy Clin Immunol.2004;113:663-668; ousquet J, et al. J Allergy Clin Immunol. 2006;117:158-162; Tanner LA, et al.Am J Manag Care. 1999;5(suppl 4):S235-S247; Blanc PD, et al. J Clin Epidemiol. 2001;54:610-618; Wilken JA, et al. Ann allergy Asthma Immunol. 2002;89:372-380; Marshal PS, et al. Ann Allergy Asthma Immunol. 2000;84:403-410; Vuurman EFPM, et al. Ann Alllergy. 1993;71:121-126;Leger D, et al. Arch Intern Med. 2006;166:1744-1748.
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Use of OTC Medications
53
45
36
22
69
31
0
10
20
30
40
50
60
70
OTC Any Rx Rx NasalSpray
Other Rx Any Rx orOTC
Medication
NoMedication
AR
Su
ffere
rs W
ho U
sed
M
ed
icati
on
s in
Past
4 W
eeks
Allergies in America Exe. Summary; Aug. 31, 2007.
%
1313
Impact of Family History on Diagnosis of AR
No Family History
One Parent With AR
Both Parents With AR
57/334
(17.1%)
11/21
(52.4%)
31/120
(25.8%)
Total, N = 816
No Allergic diseases, n=449 (some children had more than one allergic disease)
Rhinitis, n = 99
Gerrard JW, et al. Ann Allergy. 1976;36:10-15.