Researchers from the Dipartimento di Neuroscienze e Tecnologie Biomediche at the Universita degli Studi di Milano-Bicocca in Monza, Italy found that resveratrol can be used as an antineoplastic, to assist in chemotherapy treatments that kill cancer cells.

The study evaluated the anti-cellular death effects of resveratrol and examined the compound’s activity on the body’s cell cycle progression.

They found that resveratrol is able to halt the synthesis phase of the cell cycle. This “S-phase” is where DNA replication begins and DNA damage often occurs.

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o Red wine resveratrol can increase the levels of several important proteins in S-phase that control the progression of cells through the cell cycle and create cell checkpoints that can halt the cycle if there are problems. 

o Resveratrol supplements also decrease one of the proteins that is frequently observed in a variety of tumors and may contribute to the production of tumors.

o A Resveratrol dosage was shown to induce an S-phase block that prevents tumor mutations and expressions from entering into the next phases of the cell cycle, thereby preventing the mutation from continuing to grow.