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REANIMACIN INICIAL CON LQUIDOSGastn Ramos Quiroga

N Engl J Med 2013;369:1243-51.

N Engl J Med 2004;350:2247-56.Copyright 2004 Massachusetts Medical Society.

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JAMA. doi:10.1001/jama.2013.280502Published online October 9, 2013.

N Engl J Med 2014;371:1496-506.

protocol based care, as compared with usual care, resulted in increased use of central venous catheterization, intravenous fluids, vasoactive agents, and blood transfusions. The two protocol-based resuscitation approaches led to a small but transient improvement in blood pressure by the end of the resuscitation period but a higher requirement for intensive care and renal-replacement therapy. There were no significant differences in mortality, either overall or in a number of prespecified and post hoc subgroups.

N Engl J Med 2015;372:1301-11

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