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Foundation of Ingeniatrics

2001

First service for a Big Pharma GSK

2005

OneNeb® and Frialia® Launch

2010

Cellena® Launch

2011

Joint VentureZYXOGENTM

2010

Internationalbusiness starts

2002

World-wide Distribution Agreement AGILENT

2010

OPERATIONAL PLANTS: CHEMISTRY, FOOD, PHARMA

2011

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• Manufacturing for Agilent world-wide

• JDAs with major corporations

Fortune 500 Customers

• CRO & CMO services

• B2B Technology Transference: Spray Drying, NE-4

Pharma & Biotech

• Prosthesis Coating equipment manufacturing

• Cell Therapy equipment

Medical Devices

• Blood recount product manufacturing

Medical Technology

• Flow Spray Drying for Nutritional Supplements

• Evaporative cooling

Agrifood & Nut. Industry

• Ink microparticles production

• Mono-valve sprayer

Consumer Goods

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Research, Development, Engineering, Testing, Process Qualification &

Certified Manufacturing of ultra fine aerosols, particles, emulsions, capsules, foams, jets, bubbles and more

Proprietary Technology. Protected by 70+ international patents:

Flow Blurring® technology

Flow Focusing® technology

Electro Flow Focusing® technology

Concentric Flow Focusing® technology

Scale up. 3 pilot-plants, 2 assembly rooms:

Pharmaceutical (ISO Class 7) – Certified ISO 9001:2008, ISO 14001:2004, GMP in progress

Food (ISO Class 8) – Certified ISO 9001:2008, ISO 14001:2004

Chemistry – Certified ISO 9001:2008, ISO 14001:2004

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Proprietary Technology 70+ patents

Alliances & Partnerships

Easy Development of New Formulations

Innovation in existing Portfolio

Linear & Cost-Efficient Scalability

Simplicity

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3-D focusing of the jet by means of a mechanical process: pressurized air, gas or liquid.

No smashing, no electricity, no chemical process needed.

The same nozzle allows the direct production of selectable sizes within an ample range.

is able to very gently produce microparticles of

required composition and dimension, all the same as each other. The jet goes out through the outlet without touching it.

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Desired Size: for each way of administration

From mm down to several hundreds nm

Easy and simple: in just one step

High Accuracy: dose control, cost effective, CV < 8%

No sieving, filtering, no cyclones, no additional steps

Versatility: No limits on formulation, any liquid

We just need a liquid or a emulsion to make it flow

Validated for many different substances and shell materials

Very smooth mechanical process:

Extra stability and bioavailability

PRODUCTIVITY: Saving API you save money!11

cutting-edge technology to produce a spray of

extremely fine droplets within a desired range when monodispersion is not strictly required.

Consists in the micro-mixing of fluids using a reflux cell.

Pneumatic atomization with thehighest efficiency, up to 200 times more energy-saving.

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Droplet size: Easily adjustable drop size, up to tens of nm.

Versatility: Compatible with any liquids (suspensions, polymeric solutions…)

Simple geometry: Robust performance and low maintenance.

Scalability: easily adjustable to your production needs, scaling out

and/or up.

EFFICICIENCY: Saving ENERGY you save money!13

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Microcapsules“Spherical particles composed of various natural and syntheticmaterials with diameters in the micrometer range”.

High value applications

• Protection

• Dose control

• Novel administrations

• Combination of incompatibles

• Design of delivery profiles

• Stabilization

• New properties

High value industries

• Biotech

• Pharmaceuticals

• Chemicals

• Cosmetics

• Nutrition, Functional Foods

• Smart Textiles

• Medicine

• Diagnosis

EXPERTISE: Saving TIME you save money!

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0.9 microns 5 microns 15 microns 50 microns

350 microns 1500 microns

3500 microns

7000 microns

CONFIDENTIALITY: Your confidence is important for us!

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Polymeric solutions: organic, aqueous, with additives, drugs, dyes …

Emulsions: compounds with different natures: hydrophilic/hydrophobic, polar/non-polar, ...

Melted substances: waxes, gums, …

Suspensions: dispersions, nanoparticles, living cells, microorganisms, …

5 microns - /polystyrene

15 microns cinnamon flavour /wax

150 microns Cells /alginate

Suitable for different liquids and compositions

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MODULARITY: Same point in all nozzles! (Cellena, OneNeb, Spray Dryer)19

Flow Blurring®

Nebulizers for

spectrometry ICP-

OES and ICP-MS.

Marketed by Agilent Technologies

www.oneneb.com20

Increases production

Increases micrometric dispersion level

Scalable: easily adjustable to your capacity needs, scaling out and/or up

High operational robustness

Low energy consumption

Simplicity

Qualified for high concentrations and high viscosity: 0,9 up to 145.000cP

Simple geometry, Robust performance and lowmaintenance

Compatible with any liquids, suspensions, polymeric solutions and emulsions

Masterflow

EC-flow

NE-4

PreScis

FlowInn

Absolute blood count

Fast, sensitive, stable

Diseases: Bacterial infection, leucopoenia, some cancers, blood diseases, immune

system diseases, etc

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Coating of maxillary-facial implants

Coating distribution pattern

Droplet size control

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Own Flow Focusing®

Spray-Dryer

Cleanroom for Pharma

Different Pilot-plants for

Nutrition

Chemicals

SCALE-ABLE: Costs going down at higher rate than productivity up!

Intellectual Property Protection

Cost effective, Scale-able, practical, reliable atomization

Modular nozzles Flexible production system

Partner providing world-class Expertise and know-how to deliver user-friendly products and real solutions on time

Tangible products, profitable solutions

that define market leadership: Flow Focusing® Microencapsulation, Stepcount, Cellena®, Noricum, Nebulizers, F. Spray-Drying…

Save time, material and energy by:

Team readiness and know-how

Flow Focusing® advantages

Flow Blurring® advantages

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Our technological service offer Development & Production of high value microspheres based on our proprietary technology for Microencapsulation:

Study and evaluation of starting material.

Design of innovative solutions for the required application based on our technology.

Pre-formulation studies and technology fitting.

Microparticle characterization : morphology, composition, analytical methods, etc.

Initial studies: stability, drug delivery profiles…

Scale-up and microparticle production.PI Parque Plata. C/Camino Mozárabe, 4141900 Camas, Sevilla. España/Spain

T. (+34)954 081 214 F. (+34)955 98022527