Pyruvate Reactions
8
Pyruvate Reactions Three pathways
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Transcript of Pyruvate Reactions
Pyruvate
ReactionsThree pathways
Formation of Acetyl CoA
Aerobic Conditions
CH3 C
O
S CoA
Citric acid cycle starting point
Building block for fatty acid biosynthesis
Formation of Acetyl CoA
CH3 C
O
S CoA
CH3
CSO
CH2
CH2NH
C
O
CH2
CH2NH
C
O
CH2
CH2CH2
O
P
O
O- O
P
O
O-
O NO
CH2
OHOH
N
NN
NH2
Thioester
Formation of Acetyl CoA
Aerobic Conditions
CH3
C
O
SCoA
CH3
C
O
CO
O-
+ NAD+ + S CoAH
+ HNAD + CO2
pyruvate dehydrogenase complex
Formation of Lactate
Anaerobic Conditions
Lactate
CH3
CH C
OH O
O-
Oh, those
aching
muscles!
Formation of Lactate
Anaerobic Conditions
CH3
C
O
C
O
O-
+ NADH + H+
CH3
CH
OH
C
O
O-
+ NAD+
Lactate
dehydrogenase
Yeast Alcoholic Fermentation
CH3
C C
O O
O-+ H
+
CH3
C
O
H + CO2
pyruvate decarboxylase
CH3
C
O
H + NADH + H+
CH3
CH2
OH
+ NAD+
alcohol dehydrogenase
SummaryAerobic Pathway
• Net NADH production
from glycolysis
• Starts citric acid cycle &
further energy generation
Anaerobic Pathways
• No net NADH production
from glycolysis
• Energy generation: 2 ATP
from glycolysis
