PRP in Rotator cuff: Best Evidence
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PRP in Rotator Cuff
BEST EVIDENCE
Dr Htesh Gopalan U
Clinical Asst Professor, MOSCMM, Cochin
Editor, Orthopaedic Principles
Expert Advisor, OrthoEVIDENCE
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2006
Allan Mishra,Founder, BOS, LA
Mishra A, Pavelko T. Treatment of chronic elbow tendinosis with buffered platelet-rich plasma. Am J Sports Med. 2006;34:1774- 1778.
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Panacea?
Can it solve all?
•Head to Foot
•Different Pathology
•Healing with fibrosis
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PRP in Shoulder
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PRP in Rotator cuff
2 Scenarios
• Rotator cuff tendinitis/tendinosis
• Augmentation of rotator cuff repair
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AJSM 2013
Kesikburun S et al.. [LEVEL 1]
• 40 Patients
•PRP Vs Placebo [US guided]
• Outcomes: WO Rotator cuff index, shoulder pain and disability index
• No difference at one yr follow up
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Clin Rehabilitation 2013
Rha DW et al..[LEVEL 2]
• 39 patients
• PRP Vs Dry needling
• SPADI and ROM
• Significant difference only in flexion and internal rotation
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AJSM 2013
Jo CH et al.. [LEVEL 2]
• 48 Patients :Arthroscopic cuff repair
• Retear rate using MRI, ASES Score, Constant score, SST, SPADI
• Retear rates : 4 Vs 10
• Functional outcome similar in both groups
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PLoS One 2013
Zhang Q et al.. [LEVEL 1]
• PRP Augmentation in Arthroscopic repair
• 7 Studies : 6 RCT, 1 Prospective Cohort
• Constant score, ASES, UCLA
• Similar functional scores
• Decrease in retear rates in small to medium size tears
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J Shoulder Elbow 2013
Randelli et al.. [LEVEL 1]
• 26 patients
• Arthroscopic augmentation with PRP and Autologous thrombin
• No difference in retear rates
• Higher functional scores
• Less retraction in grade 1 and 2 tears
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J Shoulder Elbow 2014
Zumstein et al.. [LEVEL 2]
• 20 patients : Arthroscopic cuff repair
•Rotator cuff vascularity using ultra sound
•Rotator cuff quality using Sugaya classification
•Subjective shoulder value, Constant score, SST
•Results similar at 3 month follow up
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AJSM 2013
Weber SC et al.. [LEVEL 2]
• PRFM : Arthroscopic augmentation
• 60 patients
• SST, ASES, UCLA, Retear rates
• No significant difference
• Less UCLA score in PRFM group - ? Detrimental
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Arthroscopy 2013
Ruiz-Moneo P et al.. [LEVEL 2]
• 69 patients
• Arthroscopic augmentation with PRGF
• UCLA score, retear rates
• No significant difference
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JBJS Am 2012
Gumina et al.. [LEVEL 2]
• 76 patients
• Arthroscopic augmentation with platelet leucocyte membrane
• Reduced retear rates
• No difference in Constant scores
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Ortho Evidence Analysis
10 Trials = 578 patients
• ACE Reports
• Improvement in Constant scores only
• ASES, SPADI, UCLA scores : no difference
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OrthoEvidence
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Rotator cuff tendinitis/tendinosis
Evidence!!!
• PRP does not offer any benefit
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PRP in Cuff repair Augmentation
7 Trials = 379 patients
• Decreased retear rates in small to medium sized tears
• Not useful in large tears
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PRP in Cuff repair Augmentation
7 Trials = 379 patients
• Detrimental effect in 1 trial
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Why the Difference ?
Different PRP Products
• Volume of blood
• Spin cycles
• centrifuge rates
• Activator
• WBC and Platelet Concentrations
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CONCLUSION
• PRP beneficial for small to medium sized tears in augmentation following arthroscopic cuff repair
BUT…..