Macromolecules (Carbohydrates, Proteins, Lipids, Nucleic Acids)
*PROTEINS vs. NUCLEIC ACIDS - PROTEINS : Structural & Functional
-
Upload
lilah-buckner -
Category
Documents
-
view
23 -
download
4
description
Transcript of *PROTEINS vs. NUCLEIC ACIDS - PROTEINS : Structural & Functional
*PROTEINS vs. NUCLEIC ACIDS
- PROTEINS : Structural & Functional
- NUCLEIC ACIDS : Storage of information
The methods:
Computational
Experimental
The methods:
Computational
- Ab initio (from principles/from scracht)- Semi-empirical (from experiments) Experimental
The methods:
Computational
- Ab initio (from principles/from scracht)- Semi-empirical (from experiments) Experimental
!!! Interaction of matter with electromagnetic radiation: - EM - X-rays crystallography - NMR - CD
alamethicin
cytochrome c'
RNA-binding protein Rop
cro repressor from phage 434
Interleukin-2, human Growth Hormone, Granulocyte-macrophagecolony-stimulating factor (GM-CSF) and Interleukin-4.
homeodomain binding to DNA.
-sandwiches
-barrels
porin
SH2 domain
placental ribonuclease inhibitor
Ribonuclease-H
*PROTEINS vs. NUCLEIC ACIDS
*UNIQUENESS
*PROTEINS vs. NUCLEIC ACIDS
*UNIQUENESS
*MOLECULAR RECOGNITION EVENTS
http://www.chembio.uoguelph.ca/driguana/NMR/TOC.HTM
http://www.expasy.org/swissmod/course/text/chapter4.htm
http://www.rmn.ub.es
INTRODUCTION TO NMR:
*The concept of chemical shift
*Scalar coupling
Larmor equation: = Bo
Nupper -Bo/kT
= e Nlower
Larmor equation: = Bo