Critical Advantage to Healthy Aging &

Performance:Benevia’s Superior Protein Source

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Protein Energy is the Most Important Nutrient in Aging & Performance.

•With inadequate or inefficient protein intake, muscle loss is accelerated and muscle strength and function decrease (J.Gerontol Med Sci 2002; 11:698)

•Muscle Loss naturally begins around the age of 30 and continues into our 60’s at a rate of 1 to 2% of loss each year and accelerates after 60 to as high as 3 to 5% loss annually. (J.Am. Ger. Soc 2003. 51: 1120-1124)

•Even healthy, physically active subjects lose muscle at ~1–2% per year after age 50. This means that by the time we reach 80, we may have lost up to 50% of muscle vs when we were 30. (Clin Nutr 2007; 26: 389-399)

•Whereas Osteoporosis is considered a disease of bone loss for women. Muscle loss is a critical ‘disease’ of aging that effect men and women equally (J. Lab Clin Med 2001; 137: 231-243)

Loss of Muscle Mass : #1 Factor that complicates our ability to Stay Healthy

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Percent loss of Strength & Energy seen in aging

•The aging shift of more Fat Mass vs Muscle, increases the level of Inflammation in our Bodies which is the underlying issue to why over 60% of people age 60 and over have at least one chronic health issue to manage. This is also why bone & joint movement becomes more strained (J.Am.Ger.Soc 2002; 50:889-896)

•By the time we are 60yrs our ability to maintain strength and ease of movement decreases by over 50% (J.Am.Ger.Soc 2004; 52:80-85)

Muscle Mass decreases result in over a 100% increase in fat Mass by the time we reach 70yrs vs when we were 25yrs old.

Loss of Muscle Mass : #1 Factor that complicates our ability to Stay Healthy

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Stresses of Aging require Higher Protein Amounts and Better sources

of Protein

Muscle loss as we age is a bigger problem than osteoporsis (i.e., bone loss). 80% of men and women 50 to 80 years experience moderate to severe muscle loss while 40% of women experience bone loss.

40% of individuals 50 & older do not consume the minimally recommended amount of protein and 100% of consumers require higher total amounts of protein (Am.J.Clin.Nutr 1989; 50:1231-1233)

Stresses of Aging require Higher Protein Amounts and Better sources

of Protein

Not all Protein Sources have the same ability to build muscle mass and strength. To overcome the resistance of aging, more potent forms of protein is required that can help grow muscle mass and strength. (Exp Geront. 2006; 41:215-219)

By 40 must include high levels of certain amino acids able to overcome the resistance muscles have as we age. This must include high levels of essential amino acids and especially one called Leucine Am.J.Physiol 2006; 291:381

Not All Proteins are Corrected Equally.

The Most Effective Protein Energy Source must Include specific combinations of essential amino acids including Leucine.

15 years of clinical research by leading scientists at the Reynolds Institute on Aging at the University of Arkansas for Medical Services and the USDA Center on Aging at Tufts University confirm these scientific facts

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Soy Casein Whey ViaLeuPro

Percent Change in Muscle Building by selected sources or blends of protein

To improve muscle building, specialized sources of protein with high levels of Leucine are Required (Am.J.Clin Nutr. 2006; 84:475-482)

Specialized Leucine Protein Blends are 4x more effective at overcoming the resistance of aging and building muscle faster. Exp.Geront. 2006;41:215-219)

High Levels of Leucine with Essential Amino Acids Overcome the muscles resistance to aging and help build stronger and more energetic muscle for active living

Muscle Building Capacity in Young vs Elderly with low vs high levels of Leucine and essential amino acid intake

<25 yr old > 40 yr old

Low Leu Hi Leu Low Leu Hi Leu

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High Leucine Protein Blends and Increased Total Protein Intake Help Muscle overcome the resistance to Aging.

3 year observation results of subjects consuming 5 different levels of protein daily, ranging from below RDA amount to slightly higher than RDA levels of intake. Those with higher protein intake (Quintile 5) show smallest amount of muscl e loss (AGS 2010 Seminar)

Eight to 16 weeks of supplementation with High Leucine Protein Blend results in Significant improvement in Muscle Functional tests of distance and time. On average a 20% improvement is seen with improved protein intake in 8 weeks of consumption of Benevia with ViaLeuPro (Am.J.Clin Nutr 2003; 78:250)

Specialized Protein Blends with High Leucine prevent and reduce the loss of lean muscle mass seen with aging and help build muscle energy and strength better than other protein sources available in food or nutritional supplements and replacements.

Results of Supplementation are seen in 4 to 8 weeks and longer

Summary Highlights on the Use of Superior Protein Sources

• Muscle Loss in aging is a major risk to health and active lifestyles and effects more people in the aging process than does osteoporosis,

• Increased protein intake from age 40 yrs is recommended to help avoid the loss of muscle mass and the resulting increase in fat mass seen after 50yrs of age,

• Not all protein sources and types are equal in building muscle during aging,

• Resistance of muscle to grow and become stronger in aging increases the loss of muscle and energy. However, superior protein sources with high levels of Leucine and other essential amino acids can overcome this age-related resistance,

• 4 to 8 weeks of supplementation of these superior protein blends will result in significant improvement and regain of muscle mass, strength & energy and function,

• Consumers of high intake of protein with Leucine and Essential Amino Acids have greater muscle mass, less bone loss and are able to maintain higher levels of active lifestyles and function – all associated with lower risks of disease

Six Critical Scientific Studies and Peer Reviewed Publications Support The Need and Benefit of Superior Protein Sources with Leucine & Essential Amino Acids

Study Type Findings Product Position Competitive

Difference

Role of Amino Acids in stimulation of protein synthesis

Human experimental 15-18g EAA as effective as 40g intact protein

Proprietary blend and volume control

Smaller volume with greater effect; non-milk

Response to 16wk supplement of EAA

Human Control Significant gains in functional performance

Effective and convenient use of blend

Specific outcome improvements

Effect of Age on Response to 7g EAA

Human Experimental Controls

Specific needs and response of aged vs youth

Age Specific Benefit and Effect

Specialized blends for target consumer

Comparisons of EAA’s & Leucine vs other proteins and products

Human experimental Dose and combination use

Optimal availability Superior stimulation of protein synthesis

Relationship of Protein Metabolism and Inflammatory Control

In Vivo and Human experimental

Omega-3 effect on inflammation and protein metabolism

Control of inflammation

Protein and Inflammatory control as synergistic benefit

Bed rest with EAA supplementation

Human Control Supplementation ameliorates effect of bed rest

Effective supplementation stops muscle loss

Specific Outcome improvements

Reference List and publications available at ‘www.gobenevia.com’

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