Prisma Chart

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PubMed 247 returned ISI 367 returned EMBASE 893 returned 80 abstracts identified 66 abstracts identified 100 abstracts identified 130 abstracts screened 116 duplicates removed 82 full text review 48 excluded: 7 Language 3 Review articles 22 meeting abstracts/confe rence notes 16 Not relevant 63 studies included 19 excluded: 18 No genotypic data 1 data previously included

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PubMed 247 returnedISI367 returnedEMBASE893 returned80 abstracts identified66 abstracts identified100 abstracts identified130 abstracts screened116 duplicates removed82 full text review48 excluded:7 Language3 Review articles22 meeting abstracts/conference notes16 Not relevant

63 studies included19 excluded:18 No genotypic data1 data previously includedPubMed 247 returnedISI367 returnedEMBASE893 returned13 abstracts identified15 abstracts identified17 abstracts identified28 abstracts screened17 duplicates removed18 full text review10 excluded:1 Language3 Review articles4 meeting abstracts/conference notes2 Not relevant

18 studies included0 removed2